Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces.
Identifieur interne : 000249 ( Main/Corpus ); précédent : 000248; suivant : 000250Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces.
Auteurs : Baoe Li ; Jianwei Ma ; Donghui Wang ; Xuanyong Liu ; Haipeng Li ; Linxi Zhou ; Chunyong Liang ; Hongshui WangSource :
- Biomaterials science [ 2047-4849 ] ; 2019.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Bacterial Agents (administration & dosage), Cell Line (MeSH), Cell Proliferation (drug effects), Escherichia coli (drug effects), Escherichia coli (growth & development), Metal Nanoparticles (administration & dosage), Mice (MeSH), Nanotubes (MeSH), Silver (administration & dosage), Staphylococcus aureus (drug effects), Staphylococcus aureus (growth & development), Titanium (administration & dosage).
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Silver, Titanium.
- administration & dosage : Metal Nanoparticles.
- drug effects : Cell Proliferation, Escherichia coli, Staphylococcus aureus.
- growth & development : Escherichia coli, Staphylococcus aureus.
- Animals, Cell Line, Mice, Nanotubes.
Abstract
Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO2 nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.
DOI: 10.1039/c9bm00862d
PubMed: 31355387
Links to Exploration step
pubmed:31355387Le document en format XML
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<author><name sortKey="Wang, Donghui" sort="Wang, Donghui" uniqKey="Wang D" first="Donghui" last="Wang">Donghui Wang</name>
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<author><name sortKey="Wang, Donghui" sort="Wang, Donghui" uniqKey="Wang D" first="Donghui" last="Wang">Donghui Wang</name>
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<author><name sortKey="Liu, Xuanyong" sort="Liu, Xuanyong" uniqKey="Liu X" first="Xuanyong" last="Liu">Xuanyong Liu</name>
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<author><name sortKey="Liang, Chunyong" sort="Liang, Chunyong" uniqKey="Liang C" first="Chunyong" last="Liang">Chunyong Liang</name>
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<series><title level="j">Biomaterials science</title>
<idno type="eISSN">2047-4849</idno>
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<term>Cell Line (MeSH)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Escherichia coli (drug effects)</term>
<term>Escherichia coli (growth & development)</term>
<term>Metal Nanoparticles (administration & dosage)</term>
<term>Mice (MeSH)</term>
<term>Nanotubes (MeSH)</term>
<term>Silver (administration & dosage)</term>
<term>Staphylococcus aureus (drug effects)</term>
<term>Staphylococcus aureus (growth & development)</term>
<term>Titanium (administration & dosage)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Silver</term>
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<term>Escherichia coli</term>
<term>Staphylococcus aureus</term>
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<term>Staphylococcus aureus</term>
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<front><div type="abstract" xml:lang="en">Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO<sub>2</sub>
nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.</div>
</front>
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<Abstract><AbstractText>Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO<sub>2</sub>
nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.</AbstractText>
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