Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces.
Identifieur interne : 000249 ( Main/Corpus ); précédent : 000248; suivant : 000250Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces.
Auteurs : Baoe Li ; Jianwei Ma ; Donghui Wang ; Xuanyong Liu ; Haipeng Li ; Linxi Zhou ; Chunyong Liang ; Hongshui WangSource :
- Biomaterials science [ 2047-4849 ] ; 2019.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Bacterial Agents (administration & dosage), Cell Line (MeSH), Cell Proliferation (drug effects), Escherichia coli (drug effects), Escherichia coli (growth & development), Metal Nanoparticles (administration & dosage), Mice (MeSH), Nanotubes (MeSH), Silver (administration & dosage), Staphylococcus aureus (drug effects), Staphylococcus aureus (growth & development), Titanium (administration & dosage).
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Silver, Titanium.
- administration & dosage : Metal Nanoparticles.
- drug effects : Cell Proliferation, Escherichia coli, Staphylococcus aureus.
- growth & development : Escherichia coli, Staphylococcus aureus.
- Animals, Cell Line, Mice, Nanotubes.
Abstract
Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO2 nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.
DOI: 10.1039/c9bm00862d
PubMed: 31355387
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pubmed:31355387Le document en format XML
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Tianjin 300130, China. wdh_81@163.com and State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Xuanyong" sort="Liu, Xuanyong" uniqKey="Liu X" first="Xuanyong" last="Liu">Xuanyong Liu</name><affiliation><nlm:affiliation>State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Haipeng" sort="Li, Haipeng" uniqKey="Li H" first="Haipeng" last="Li">Haipeng Li</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Linxi" sort="Zhou, Linxi" uniqKey="Zhou L" first="Linxi" last="Zhou">Linxi Zhou</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Liang, Chunyong" sort="Liang, Chunyong" uniqKey="Liang C" first="Chunyong" last="Liang">Chunyong Liang</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hongshui" sort="Wang, Hongshui" uniqKey="Wang H" first="Hongshui" last="Wang">Hongshui Wang</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31355387</idno><idno type="pmid">31355387</idno><idno type="doi">10.1039/c9bm00862d</idno><idno type="wicri:Area/Main/Corpus">000249</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000249</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces.</title><author><name sortKey="Li, Baoe" sort="Li, Baoe" uniqKey="Li B" first="Baoe" last="Li">Baoe Li</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jianwei" sort="Ma, Jianwei" uniqKey="Ma J" first="Jianwei" last="Ma">Jianwei Ma</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Donghui" sort="Wang, Donghui" uniqKey="Wang D" first="Donghui" last="Wang">Donghui Wang</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com and State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Xuanyong" sort="Liu, Xuanyong" uniqKey="Liu X" first="Xuanyong" last="Liu">Xuanyong Liu</name><affiliation><nlm:affiliation>State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Haipeng" sort="Li, Haipeng" uniqKey="Li H" first="Haipeng" last="Li">Haipeng Li</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Linxi" sort="Zhou, Linxi" uniqKey="Zhou L" first="Linxi" last="Zhou">Linxi Zhou</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Liang, Chunyong" sort="Liang, Chunyong" uniqKey="Liang C" first="Chunyong" last="Liang">Chunyong Liang</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hongshui" sort="Wang, Hongshui" uniqKey="Wang H" first="Hongshui" last="Wang">Hongshui Wang</name><affiliation><nlm:affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biomaterials science</title><idno type="eISSN">2047-4849</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Cell Line (MeSH)</term><term>Cell Proliferation (drug effects)</term><term>Escherichia coli (drug effects)</term><term>Escherichia coli (growth & development)</term><term>Metal Nanoparticles (administration & dosage)</term><term>Mice (MeSH)</term><term>Nanotubes (MeSH)</term><term>Silver (administration & dosage)</term><term>Staphylococcus aureus (drug effects)</term><term>Staphylococcus aureus (growth & development)</term><term>Titanium (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Silver</term><term>Titanium</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Escherichia coli</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Escherichia coli</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Mice</term><term>Nanotubes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO<sub>2</sub> nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31355387</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2047-4849</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>10</Issue><PubDate><Year>2019</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>Biomaterials science</Title><ISOAbbreviation>Biomater Sci</ISOAbbreviation></Journal><ArticleTitle>Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces.</ArticleTitle><Pagination><MedlinePgn>4075-4087</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c9bm00862d</ELocationID><Abstract><AbstractText>Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO<sub>2</sub> nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Baoe</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9542-3238</Identifier><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Jianwei</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Donghui</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1198-0978</Identifier><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com and State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xuanyong</ForeName><Initials>X</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9440-8143</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. xyliu@mail.sic.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Haipeng</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Linxi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Chunyong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hongshui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. wdh_81@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biomater Sci</MedlineTA><NlmUniqueID>101593571</NlmUniqueID><ISSNLinking>2047-4830</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="N">Metal Nanoparticles</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D043942" MajorTopicYN="Y">Nanotubes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="N">Titanium</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31355387</ArticleId><ArticleId IdType="doi">10.1039/c9bm00862d</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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