Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease.
Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease.
Auteurs : Rim Khlifi [France] ; Pablo Olmedo ; Fernando Gil ; Bouthaina Hammami ; Amel Hamza-ChaffaiSource :
- Environmental science and pollution research international [ 1614-7499 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Adult, Cadmium (blood), Cadmium (toxicity), Case-Control Studies, Environmental Exposure (adverse effects), Environmental Exposure (analysis), Environmental Pollutants (toxicity), Female, Humans, Male, Middle Aged, Nasopharyngeal Neoplasms (chemically induced), Nasopharyngeal Neoplasms (epidemiology), Nickel (blood), Nickel (toxicity), Occupational Exposure (adverse effects), Occupational Exposure (analysis), Odds Ratio, Risk Factors, Smoking (adverse effects), Tunisia (epidemiology).
- MESH :
- chemical , blood : Cadmium, Nickel.
- chemical , toxicity : Cadmium, Environmental Pollutants, Nickel.
- geographic , epidemiology : Tunisia.
- adverse effects : Environmental Exposure, Occupational Exposure, Smoking.
- analysis : Environmental Exposure, Occupational Exposure.
- chemically induced : Nasopharyngeal Neoplasms.
- epidemiology : Nasopharyngeal Neoplasms.
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Odds Ratio, Risk Factors.
Abstract
Nasosinusal polyposis (NSP) is a chronic inflammatory disease of the nasal mucosa. Although the pathophysiology underlying NSP formation is not fully understood, environmental factors appear to be contributed the development of this disease. A case-control study of Tunisian patients was examined to assess the levels of cadmium (Cd) and nickel (Ni) in blood and reparse the association between the exposure to these metals and the risk of nasosinusal polyposis disease. Mean blood levels of Cd in patients (2.2 ± 12.8 μg/L) were significantly higher than those of controls (0.5 ± 0.7 μg/L). Levels of blood Cd were positively correlated with tobacco smoking and chewing among controls. The Cd and Ni concentrations among control (p = 0.001) and patient (p = 0.018) tobacco consumers (smoking, chewing, and shisha) were significantly higher than those nonconsumers. Additionally, Ni blood levels of patient and control smokers were significantly higher than those of nonsmokers. Cd levels in blood samples of NSP patients occupationally exposed for more than 14 years were eight times higher than that of nonexposed. Drinking water was also found to be incriminated as exposure sources. Among risk factors, shisha consumption, environmental exposure, and occupational exposure presented the most significant association with NSP disease (odds ratio (OR) = 14.1, 10.1, and 1.7, respectively). High levels of blood Cd (OR = 3.5) were strongly associated with NSP disease (p = 0.027). Ni blood levels were shown to be associated with the four stages of polyps in both nasal cavities (right and left) (p < 0.05). This investigation suggested a potential role of toxic metals in the mechanism of NSP disease development. Exposure assessment investigations encompassing a wider population are needed.
DOI: 10.1007/s11356-014-3619-8
PubMed: 25253060
Affiliations:
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last="Gil">Fernando Gil</name></author><author><name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25253060</idno><idno type="pmid">25253060</idno><idno type="doi">10.1007/s11356-014-3619-8</idno><idno type="wicri:Area/PubMed/Corpus">000032</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000032</idno><idno type="wicri:Area/PubMed/Curation">000032</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000032</idno><idno type="wicri:Area/PubMed/Checkpoint">000032</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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Pollutants</term><term>Nickel</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term><term>Occupational Exposure</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Environmental Exposure</term><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Nasopharyngeal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Nasopharyngeal Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Risk Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nasosinusal polyposis (NSP) is a chronic inflammatory disease of the nasal mucosa. Although the pathophysiology underlying NSP formation is not fully understood, environmental factors appear to be contributed the development of this disease. A case-control study of Tunisian patients was examined to assess the levels of cadmium (Cd) and nickel (Ni) in blood and reparse the association between the exposure to these metals and the risk of nasosinusal polyposis disease. Mean blood levels of Cd in patients (2.2 ± 12.8 μg/L) were significantly higher than those of controls (0.5 ± 0.7 μg/L). Levels of blood Cd were positively correlated with tobacco smoking and chewing among controls. The Cd and Ni concentrations among control (p = 0.001) and patient (p = 0.018) tobacco consumers (smoking, chewing, and shisha) were significantly higher than those nonconsumers. Additionally, Ni blood levels of patient and control smokers were significantly higher than those of nonsmokers. Cd levels in blood samples of NSP patients occupationally exposed for more than 14 years were eight times higher than that of nonexposed. Drinking water was also found to be incriminated as exposure sources. Among risk factors, shisha consumption, environmental exposure, and occupational exposure presented the most significant association with NSP disease (odds ratio (OR) = 14.1, 10.1, and 1.7, respectively). High levels of blood Cd (OR = 3.5) were strongly associated with NSP disease (p = 0.027). Ni blood levels were shown to be associated with the four stages of polyps in both nasal cavities (right and left) (p < 0.05). This investigation suggested a potential role of toxic metals in the mechanism of NSP disease development. Exposure assessment investigations encompassing a wider population are needed.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name><name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name></noCountry><country name="France"><noRegion><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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