Blood nickel and chromium levels in association with smoking and occupational exposure among head and neck cancer patients in Tunisia.
Identifieur interne : 000134 ( Main/Exploration ); précédent : 000133; suivant : 000135Blood nickel and chromium levels in association with smoking and occupational exposure among head and neck cancer patients in Tunisia.
Auteurs : Rim Khlifi [France] ; Pablo Olmedo ; Fernando Gil ; Molka Feki-Tounsi ; Amine Chakroun ; Ahmed Rebai ; Amel Hamza-ChaffaiSource :
- Environmental science and pollution research international [ 1614-7499 ] ; 2013.
Descripteurs français
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Aged, Chromium (blood), Environmental Monitoring, Environmental Pollutants (blood), Female, Head and Neck Neoplasms (blood), Head and Neck Neoplasms (epidemiology), Humans, Male, Middle Aged, Nickel (blood), Occupational Exposure (statistics & numerical data), Smoking (blood), Smoking (epidemiology), Tunisia (epidemiology).
- MESH :
- chemical , blood : Chromium, Environmental Pollutants, Nickel.
- geographic , epidemiology : Tunisia.
- blood : Head and Neck Neoplasms, Smoking.
- epidemiology : Head and Neck Neoplasms, Smoking.
- statistics & numerical data : Occupational Exposure.
- Aged, Environmental Monitoring, Female, Humans, Male, Middle Aged.
Abstract
Chronic exposure to chromium (Cr) and nickel (Ni) has long been recognized as being capable to increase head and neck cancer (HNC) incidence among exposed human populations. This study represents the first biomonitoring of Cr and Ni exposure in Tunisia and focuses on a possible association with HNC risk. The aim of the present study was to evaluate the concentrations of Cr and Ni in the blood of HNC patients and controls. Metals blood levels of 169 HNC patients and 351 controls were determined using a Perkin-Elmer Analyst 800 Atomic Absorption Spectrometer. Mean blood levels of Cr and Ni in HNC cases (52.15 and 111.60 μg/L, respectively) were significantly higher than those of controls (37.04 and 30.50 μg/L, respectively). Cases' blood levels of Cr and Ni were significantly higher than those of controls after controlling for the other risk factors of HNC, including smoking, shisha consumption, occupational exposure, and nearby environment (P<0.05). Among these risk factors, smoking and occupational exposure presented the most significant association with HNC (odds ratio (OR)=6.54 and 7.66, respectively, P<0.001). Cr and Ni levels in blood sample of cases and controls that are smoker/occupationally exposed were higher than that of non-smoker/non-occupationally exposed (P<0.05). Smokers who are occupationally exposed present the most significant association with HNC (OR=25.08, P<0.0001). High levels of blood Cr (OR=2.09) and high levels of blood Ni (OR=8.87) were strongly associated with HNC after other potential confounders were controlled (P=0.004 and P<0.0001, respectively). This study suggested a potential role of Cr and Ni in the mechanism of HNC development.
DOI: 10.1007/s11356-013-1466-7
PubMed: 23625117
Affiliations:
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Le document en format XML
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uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name></author><author><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name></author><author><name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23625117</idno><idno type="pmid">23625117</idno><idno type="doi">10.1007/s11356-013-1466-7</idno><idno type="wicri:Area/PubMed/Corpus">000065</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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last="Chakroun">Amine Chakroun</name></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name></author></analytic><series><title level="j">Environmental science and pollution research international</title><idno type="eISSN">1614-7499</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Chromium (blood)</term><term>Environmental Monitoring</term><term>Environmental Pollutants (blood)</term><term>Female</term><term>Head and Neck Neoplasms (blood)</term><term>Head and Neck Neoplasms (epidemiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nickel (blood)</term><term>Occupational Exposure (statistics & numerical data)</term><term>Smoking (blood)</term><term>Smoking (epidemiology)</term><term>Tunisia (epidemiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Chromium</term><term>Environmental Pollutants</term><term>Nickel</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Head and Neck Neoplasms</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Head and Neck Neoplasms</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Environmental Monitoring</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic exposure to chromium (Cr) and nickel (Ni) has long been recognized as being capable to increase head and neck cancer (HNC) incidence among exposed human populations. This study represents the first biomonitoring of Cr and Ni exposure in Tunisia and focuses on a possible association with HNC risk. The aim of the present study was to evaluate the concentrations of Cr and Ni in the blood of HNC patients and controls. Metals blood levels of 169 HNC patients and 351 controls were determined using a Perkin-Elmer Analyst 800 Atomic Absorption Spectrometer. Mean blood levels of Cr and Ni in HNC cases (52.15 and 111.60 μg/L, respectively) were significantly higher than those of controls (37.04 and 30.50 μg/L, respectively). Cases' blood levels of Cr and Ni were significantly higher than those of controls after controlling for the other risk factors of HNC, including smoking, shisha consumption, occupational exposure, and nearby environment (P<0.05). Among these risk factors, smoking and occupational exposure presented the most significant association with HNC (odds ratio (OR)=6.54 and 7.66, respectively, P<0.001). Cr and Ni levels in blood sample of cases and controls that are smoker/occupationally exposed were higher than that of non-smoker/non-occupationally exposed (P<0.05). Smokers who are occupationally exposed present the most significant association with HNC (OR=25.08, P<0.0001). High levels of blood Cr (OR=2.09) and high levels of blood Ni (OR=8.87) were strongly associated with HNC after other potential confounders were controlled (P=0.004 and P<0.0001, respectively). This study suggested a potential role of Cr and Ni in the mechanism of HNC development.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></noCountry><country name="France"><noRegion><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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