[Interaction of intermittent fasting on the cytotoxic effects of nickel in rats at puberty].
Identifieur interne : 000731 ( Main/Exploration ); précédent : 000730; suivant : 000732[Interaction of intermittent fasting on the cytotoxic effects of nickel in rats at puberty].
Auteurs : Najla Hfaïedh [Tunisie] ; Mohamed Salah Allaqui ; Françoise Croute ; Jean-Pierre Soleilhavoup ; Kamel Jammoussi ; Fatma Makni Ayadi ; Abdelaziz Kammoun ; Abdelfattah El FekiSource :
- Comptes rendus biologies [ 1631-0691 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , toxicity : Nickel.
- chemical , urine : Creatinine.
- drug effects : Kidney.
- pathology : Kidney.
- physiology : Fasting, Sexual Maturation.
- Animals, Female, Male, Rats, Rats, Wistar, Sex Characteristics.
Abstract
This study has been undertaken with the aim of determining if intermittent fasting can be considered as a malnutrition that amplifies, according to numerous authors, the cytotoxic effects of environmental pollutants. We have used 200 male and female rats of 'Wistar' descent (BW approximately 180 g). These rats are distributed into two groups: some nourished daily (N) and others nourished one day over two (J) during a month. By the end of this month, each group is itself split into two subgroups, the first one receiving tap water as drinkable water (group NO and JO); the other one receiving the water enriched by the chloride of nickel at the rate of 100 mg NiCl2 per litre (groups NNi and JNi). Intermittent fasting goes on parallel to treatment during 2, 4, 10, 16, 30 and 60 days. For the exploration of the protein of stress (HSP) and of the metallothioneines (MT), the nickel is administered by injection at the rate of 4 mg NiCl2 per kg during 1 and 5 days. Our results show that the mineral seric and renal balance does not vary in conditions of intermittent fasting compared with conditions of normal nutrition. Our study show than that nickel induced a renal deficiency by decreasing the creatinemia and uraemia rate, which is confirmed by the histological study, and induced a decrease in the induction of the HSP73 and in the synthesis of the (MT). The association of nickel with intermittent fasting would inhibit these effects. In conclusion, intermittent fasting does not manifest itself as a malnutrition that amplifies the nickel's effects. Nevertheless, it seems that the calorific lack provoked by intermittent fasting is beneficial to the body by increasing its performances against the cytotoxic effects induced by nickel.
DOI: 10.1016/j.crvi.2005.03.001
PubMed: 15992748
Affiliations:
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Le document en format XML
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intermittent fasting on the cytotoxic effects of nickel in rats at puberty].</title><author><name sortKey="Hfaiedh, Najla" sort="Hfaiedh, Najla" uniqKey="Hfaiedh N" first="Najla" last="Hfaïedh">Najla Hfaïedh</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'écophysiologie animale, faculté des sciences de Sfax, BP 802, 3018 Sfax, Tunisie.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratoire d'écophysiologie animale, faculté des sciences de Sfax, BP 802, 3018 Sfax</wicri:regionArea><wicri:noRegion>3018 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Allaqui, Mohamed Salah" sort="Allaqui, Mohamed Salah" uniqKey="Allaqui M" first="Mohamed Salah" last="Allaqui">Mohamed Salah Allaqui</name></author><author><name sortKey="Croute, Francoise" sort="Croute, Francoise" uniqKey="Croute F" first="Françoise" last="Croute">Françoise Croute</name></author><author><name sortKey="Soleilhavoup, Jean Pierre" sort="Soleilhavoup, Jean 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xml:lang="en"><term>Animals</term><term>Creatinine (urine)</term><term>Fasting (physiology)</term><term>Female</term><term>Kidney (drug effects)</term><term>Kidney (pathology)</term><term>Male</term><term>Nickel (toxicity)</term><term>Rats</term><term>Rats, Wistar</term><term>Sex Characteristics</term><term>Sexual Maturation (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Nickel</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Creatinine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fasting</term><term>Sexual Maturation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term><term>Sex Characteristics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study has been undertaken with the aim of determining if intermittent fasting can be considered as a malnutrition that amplifies, according to numerous authors, the cytotoxic effects of environmental pollutants. We have used 200 male and female rats of 'Wistar' descent (BW approximately 180 g). These rats are distributed into two groups: some nourished daily (N) and others nourished one day over two (J) during a month. By the end of this month, each group is itself split into two subgroups, the first one receiving tap water as drinkable water (group NO and JO); the other one receiving the water enriched by the chloride of nickel at the rate of 100 mg NiCl2 per litre (groups NNi and JNi). Intermittent fasting goes on parallel to treatment during 2, 4, 10, 16, 30 and 60 days. For the exploration of the protein of stress (HSP) and of the metallothioneines (MT), the nickel is administered by injection at the rate of 4 mg NiCl2 per kg during 1 and 5 days. Our results show that the mineral seric and renal balance does not vary in conditions of intermittent fasting compared with conditions of normal nutrition. Our study show than that nickel induced a renal deficiency by decreasing the creatinemia and uraemia rate, which is confirmed by the histological study, and induced a decrease in the induction of the HSP73 and in the synthesis of the (MT). The association of nickel with intermittent fasting would inhibit these effects. In conclusion, intermittent fasting does not manifest itself as a malnutrition that amplifies the nickel's effects. Nevertheless, it seems that the calorific lack provoked by intermittent fasting is beneficial to the body by increasing its performances against the cytotoxic effects induced by nickel.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Allaqui, Mohamed Salah" sort="Allaqui, Mohamed Salah" uniqKey="Allaqui M" first="Mohamed Salah" last="Allaqui">Mohamed Salah Allaqui</name><name sortKey="Croute, Francoise" sort="Croute, Francoise" uniqKey="Croute F" first="Françoise" last="Croute">Françoise Croute</name><name sortKey="El Feki, Abdelfattah" sort="El Feki, Abdelfattah" uniqKey="El Feki A" first="Abdelfattah" last="El Feki">Abdelfattah El Feki</name><name sortKey="Jammoussi, Kamel" sort="Jammoussi, Kamel" uniqKey="Jammoussi K" first="Kamel" last="Jammoussi">Kamel Jammoussi</name><name sortKey="Kammoun, Abdelaziz" sort="Kammoun, Abdelaziz" uniqKey="Kammoun A" first="Abdelaziz" last="Kammoun">Abdelaziz Kammoun</name><name sortKey="Makni Ayadi, Fatma" sort="Makni Ayadi, Fatma" uniqKey="Makni Ayadi F" first="Fatma" last="Makni Ayadi">Fatma Makni Ayadi</name><name sortKey="Soleilhavoup, Jean Pierre" sort="Soleilhavoup, Jean Pierre" uniqKey="Soleilhavoup J" first="Jean-Pierre" last="Soleilhavoup">Jean-Pierre Soleilhavoup</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Hfaiedh, Najla" sort="Hfaiedh, Najla" uniqKey="Hfaiedh N" first="Najla" last="Hfaïedh">Najla Hfaïedh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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