Concentrations of Cu, Cd, Ni, and Pb in the blood and tissues of cancerous persons in a Pakistani population
Identifieur interne : 000B50 ( Istex/Corpus ); précédent : 000B49; suivant : 000B51Concentrations of Cu, Cd, Ni, and Pb in the blood and tissues of cancerous persons in a Pakistani population
Auteurs : Muhammad Ashraf Tariq ; Muhammad Ashraf Qamar-Un-Nisa ; Amtal FatimaSource :
- Science of the Total Environment [ 0048-9697 ] ; 1995.
Abstract
The Cu, Cd, Ni, and Pb contents of blood and tissue samples of some cancer patients in a Pakistani population were measured by atomic absorption spectroscopy. The results were compared with those found in the blood samples of healthy controls selected from persons with known previous health record. The trace element contents were found to be different in various cancer types, age groups, and between males and females. The results of this investigation showed that the average Cd and Ni concentrations were higher in the blood of cancer patients as compared to controls. Copper levels in the blood of male cancer patients were higher than the controls and the opposite was the case for females. The concentration levels of Pb in the blood were almost the same in all groups. In cancerous tissues the concentrations of Cu were found to be lower as compared to the unaffected part of the same organ of the same patient. The relationship of Cd and Ni to carcinogenesis is well established now and their abnormal levels could indicate an exposure to them. Changes in copper levels could be due to the altered metabolic requirements of the subjects under biological stress i.e. presence of cancer.
Url:
DOI: 10.1016/0048-9697(95)04823-5
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The results were compared with those found in the blood samples of healthy controls selected from persons with known previous health record. The trace element contents were found to be different in various cancer types, age groups, and between males and females. The results of this investigation showed that the average Cd and Ni concentrations were higher in the blood of cancer patients as compared to controls. Copper levels in the blood of male cancer patients were higher than the controls and the opposite was the case for females. The concentration levels of Pb in the blood were almost the same in all groups. In cancerous tissues the concentrations of Cu were found to be lower as compared to the unaffected part of the same organ of the same patient. The relationship of Cd and Ni to carcinogenesis is well established now and their abnormal levels could indicate an exposure to them. 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The results were compared with those found in the blood samples of healthy controls selected from persons with known previous health record. The trace element contents were found to be different in various cancer types, age groups, and between males and females. The results of this investigation showed that the average Cd and Ni concentrations were higher in the blood of cancer patients as compared to controls. Copper levels in the blood of male cancer patients were higher than the controls and the opposite was the case for females. The concentration levels of Pb in the blood were almost the same in all groups. In cancerous tissues the concentrations of Cu were found to be lower as compared to the unaffected part of the same organ of the same patient. The relationship of Cd and Ni to carcinogenesis is well established now and their abnormal levels could indicate an exposure to them. Changes in copper levels could be due to the altered metabolic requirements of the subjects under biological stress i.e. presence of cancer.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Carcinogenesis</ce:text></ce:keyword><ce:keyword><ce:text>Trace elements</ce:text></ce:keyword><ce:keyword><ce:text>Copper</ce:text></ce:keyword><ce:keyword><ce:text>Cadmium</ce:text></ce:keyword><ce:keyword><ce:text>Nickel</ce:text></ce:keyword><ce:keyword><ce:text>Lead</ce:text></ce:keyword><ce:keyword><ce:text>Atomic absorption determination</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Concentrations of Cu, Cd, Ni, and Pb in the blood and tissues of cancerous persons in a Pakistani population</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Concentrations of Cu, Cd, Ni, and Pb in the blood and tissues of cancerous persons in a Pakistani population</title></titleInfo><name type="personal"><namePart type="given">Muhammad Ashraf</namePart><namePart type="family">Tariq</namePart><affiliation>Institute of Chemistry, University of the Punjab, New Campus, Lahore, Pakistan</affiliation><description>Corresponding author, present address: Camin Cargo Control, 230 Marion Ave., Linden, NJ 07036, USA.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Qamar-un-Nisa</namePart><affiliation>Institute of Chemistry, University of the Punjab, New Campus, Lahore, Pakistan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amtal</namePart><namePart type="family">Fatima</namePart><affiliation>Institute of Chemistry, University of the Punjab, New Campus, Lahore, Pakistan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The Cu, Cd, Ni, and Pb contents of blood and tissue samples of some cancer patients in a Pakistani population were measured by atomic absorption spectroscopy. The results were compared with those found in the blood samples of healthy controls selected from persons with known previous health record. The trace element contents were found to be different in various cancer types, age groups, and between males and females. The results of this investigation showed that the average Cd and Ni concentrations were higher in the blood of cancer patients as compared to controls. Copper levels in the blood of male cancer patients were higher than the controls and the opposite was the case for females. The concentration levels of Pb in the blood were almost the same in all groups. In cancerous tissues the concentrations of Cu were found to be lower as compared to the unaffected part of the same organ of the same patient. The relationship of Cd and Ni to carcinogenesis is well established now and their abnormal levels could indicate an exposure to them. Changes in copper levels could be due to the altered metabolic requirements of the subjects under biological stress i.e. presence of cancer.</abstract><subject><genre>Keywords</genre><topic>Carcinogenesis</topic><topic>Trace elements</topic><topic>Copper</topic><topic>Cadmium</topic><topic>Nickel</topic><topic>Lead</topic><topic>Atomic absorption determination</topic></subject><relatedItem type="host"><titleInfo><title>Science of the Total Environment</title></titleInfo><titleInfo type="abbreviated"><title>STOTEN</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19951208</dateIssued></originInfo><identifier type="ISSN">0048-9697</identifier><identifier type="PII">S0048-9697(00)X0015-0</identifier><part><date>19951208</date><detail type="volume"><number>175</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>84</end></extent><extent unit="pages"><start>43</start><end>48</end></extent></part></relatedItem><identifier type="istex">9CE78BD6E25BAA35829BF2BA2B243A8311AE9B8E</identifier><identifier type="DOI">10.1016/0048-9697(95)04823-5</identifier><identifier type="PII">0048-9697(95)04823-5</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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