The exposure of bacteria to CdTe-core quantum dots: the importance of surface chemistry on cytotoxicity.
Identifieur interne : 000123 ( PubMed/Curation ); précédent : 000122; suivant : 000124The exposure of bacteria to CdTe-core quantum dots: the importance of surface chemistry on cytotoxicity.
Auteurs : Raphaël Schneider [France] ; Cécile Wolpert ; Hélène Guilloteau ; Lavinia Balan ; Jacques Lambert ; Christophe MerlinSource :
- Nanotechnology [ 1361-6528 ] ; 2009.
Descripteurs français
- KwdFr :
- Bacillus subtilis (), Bacillus subtilis (physiologie), Bactéries à Gram négatif (), Bactéries à Gram négatif (physiologie), Boîtes quantiques, Composés du cadmium (), Composés du cadmium (métabolisme), Composés du cadmium (pharmacologie), Forme de la cellule (), Glutathion (), Prolifération cellulaire (), Propriétés de surface, Stabilité de médicament, Survie cellulaire (), Tellure (), Tellure (pharmacologie), Thioglycolates ().
- MESH :
- métabolisme : Composés du cadmium.
- pharmacologie : Composés du cadmium, Tellure.
- physiologie : Bacillus subtilis, Bactéries à Gram négatif.
- Bacillus subtilis, Bactéries à Gram négatif, Boîtes quantiques, Composés du cadmium, Forme de la cellule, Glutathion, Prolifération cellulaire, Propriétés de surface, Stabilité de médicament, Survie cellulaire, Tellure, Thioglycolates.
English descriptors
- KwdEn :
- Bacillus subtilis (drug effects), Bacillus subtilis (physiology), Cadmium Compounds (chemistry), Cadmium Compounds (metabolism), Cadmium Compounds (pharmacology), Cell Proliferation (drug effects), Cell Shape (drug effects), Cell Survival (drug effects), Drug Stability, Glutathione (chemistry), Gram-Negative Bacteria (drug effects), Gram-Negative Bacteria (physiology), Quantum Dots, Surface Properties, Tellurium (chemistry), Tellurium (pharmacology), Thioglycolates (chemistry).
- MESH :
- chemical , chemistry : Cadmium Compounds, Glutathione, Tellurium, Thioglycolates.
- drug effects : Bacillus subtilis, Cell Proliferation, Cell Shape, Cell Survival, Gram-Negative Bacteria.
- chemical , metabolism : Cadmium Compounds.
- chemical , pharmacology : Cadmium Compounds, Tellurium.
- physiology : Bacillus subtilis, Gram-Negative Bacteria.
- Drug Stability, Quantum Dots, Surface Properties.
Abstract
A series of water-soluble CdTe-core quantum dots (QDs) with diameters below 5.0 nm and functionalized at their surface with polar ligands such as thioglycolic acid (TGA) or the tripeptide glutathione (GSH) were synthesized and characterized by UV-vis absorption spectroscopy, their photoluminescence measurements, atomic force microscopy (AFM) and transmission electron microscopy (TEM). Because cell elongations and growth inhibitions were observed during labeling experiments, the cytotoxicity of CdTe-core QDs was investigated. Using growth inhibition tests combining different bacterial strains with different CdTe-core QDs, it was possible to demonstrate that the cytotoxicity of QDs towards bacteria depends on exposure concentrations, surface chemistry and coating, and that it varied with the strain considered. Growth inhibition tests carried out with heavy-metal-resistant bacteria, as well as ICP-AES analyses of cadmium species released by CdTe@TGA QDs, demonstrated that the leakage of Cd2+ is not the main source of QD toxicity. Our study suggests that QD cytotoxicity is rather due to the formation of TeO2 and probably the existence of CdO formed by surface oxidation. In this respect, QDs possessing a CdO shell appeared very toxic.
DOI: 10.1088/0957-4484/20/22/225101
PubMed: 19433881
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uniqKey="Guilloteau H" first="Hélène" last="Guilloteau">Hélène Guilloteau</name></author><author><name sortKey="Balan, Lavinia" sort="Balan, Lavinia" uniqKey="Balan L" first="Lavinia" last="Balan">Lavinia Balan</name></author><author><name sortKey="Lambert, Jacques" sort="Lambert, Jacques" uniqKey="Lambert J" first="Jacques" last="Lambert">Jacques Lambert</name></author><author><name sortKey="Merlin, Christophe" sort="Merlin, Christophe" uniqKey="Merlin C" first="Christophe" last="Merlin">Christophe Merlin</name></author></analytic><series><title level="j">Nanotechnology</title><idno type="eISSN">1361-6528</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacillus subtilis (drug effects)</term><term>Bacillus subtilis (physiology)</term><term>Cadmium Compounds (chemistry)</term><term>Cadmium Compounds (metabolism)</term><term>Cadmium Compounds 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de médicament</term><term>Survie cellulaire ()</term><term>Tellure ()</term><term>Tellure (pharmacologie)</term><term>Thioglycolates ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cadmium Compounds</term><term>Glutathione</term><term>Tellurium</term><term>Thioglycolates</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bacillus subtilis</term><term>Cell Proliferation</term><term>Cell Shape</term><term>Cell Survival</term><term>Gram-Negative Bacteria</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cadmium Compounds</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Composés du cadmium</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Composés du cadmium</term><term>Tellure</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cadmium Compounds</term><term>Tellurium</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bacillus subtilis</term><term>Bactéries à Gram négatif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bacillus subtilis</term><term>Gram-Negative Bacteria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Stability</term><term>Quantum Dots</term><term>Surface Properties</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Bacillus subtilis</term><term>Bactéries à Gram négatif</term><term>Boîtes quantiques</term><term>Composés du cadmium</term><term>Forme de la cellule</term><term>Glutathion</term><term>Prolifération cellulaire</term><term>Propriétés de surface</term><term>Stabilité de médicament</term><term>Survie cellulaire</term><term>Tellure</term><term>Thioglycolates</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A series of water-soluble CdTe-core quantum dots (QDs) with diameters below 5.0 nm and functionalized at their surface with polar ligands such as thioglycolic acid (TGA) or the tripeptide glutathione (GSH) were synthesized and characterized by UV-vis absorption spectroscopy, their photoluminescence measurements, atomic force microscopy (AFM) and transmission electron microscopy (TEM). Because cell elongations and growth inhibitions were observed during labeling experiments, the cytotoxicity of CdTe-core QDs was investigated. Using growth inhibition tests combining different bacterial strains with different CdTe-core QDs, it was possible to demonstrate that the cytotoxicity of QDs towards bacteria depends on exposure concentrations, surface chemistry and coating, and that it varied with the strain considered. Growth inhibition tests carried out with heavy-metal-resistant bacteria, as well as ICP-AES analyses of cadmium species released by CdTe@TGA QDs, demonstrated that the leakage of Cd2+ is not the main source of QD toxicity. Our study suggests that QD cytotoxicity is rather due to the formation of TeO2 and probably the existence of CdO formed by surface oxidation. In this respect, QDs possessing a CdO shell appeared very toxic.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19433881</PMID><DateCreated><Year>2009</Year><Month>05</Month><Day>13</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1361-6528</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>22</Issue><PubDate><Year>2009</Year><Month>Jun</Month><Day>3</Day></PubDate></JournalIssue><Title>Nanotechnology</Title><ISOAbbreviation>Nanotechnology</ISOAbbreviation></Journal><ArticleTitle>The exposure of bacteria to CdTe-core quantum dots: the importance of surface chemistry on cytotoxicity.</ArticleTitle><Pagination><MedlinePgn>225101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1088/0957-4484/20/22/225101</ELocationID><Abstract><AbstractText>A series of water-soluble CdTe-core quantum dots (QDs) with diameters below 5.0 nm and functionalized at their surface with polar ligands such as thioglycolic acid (TGA) or the tripeptide glutathione (GSH) were synthesized and characterized by UV-vis absorption spectroscopy, their photoluminescence measurements, atomic force microscopy (AFM) and transmission electron microscopy (TEM). Because cell elongations and growth inhibitions were observed during labeling experiments, the cytotoxicity of CdTe-core QDs was investigated. Using growth inhibition tests combining different bacterial strains with different CdTe-core QDs, it was possible to demonstrate that the cytotoxicity of QDs towards bacteria depends on exposure concentrations, surface chemistry and coating, and that it varied with the strain considered. Growth inhibition tests carried out with heavy-metal-resistant bacteria, as well as ICP-AES analyses of cadmium species released by CdTe@TGA QDs, demonstrated that the leakage of Cd2+ is not the main source of QD toxicity. Our study suggests that QD cytotoxicity is rather due to the formation of TeO2 and probably the existence of CdO formed by surface oxidation. In this respect, QDs possessing a CdO shell appeared very toxic.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Raphaël</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>DCPR, Département de Chimie Physique de Réactions, Nancy Université, CNRS, 1 rue Grandville, BP 20451, F-54001 Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolpert</LastName><ForeName>Cécile</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Guilloteau</LastName><ForeName>Hélène</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Balan</LastName><ForeName>Lavinia</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>Jacques</ForeName><Initials>J</Initials></Author><Author 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