Biological significance of localized Type IV scirrhous gastric cancer.
Identifieur interne : 000081 ( PubMed/Corpus ); précédent : 000080; suivant : 000082Biological significance of localized Type IV scirrhous gastric cancer.
Auteurs : Kazuya Endo ; Masato Sakurai ; Eiji Kusumoto ; Hideo Uehara ; Shohei Yamaguchi ; Norifumi Tsutsumi ; Koji IkejiriSource :
- Oncology letters [ 1792-1074 ] ; 2012.
Abstract
The prognosis of type IV scirrhous gastric cancer (SGC) is extremely poor. Linitis plastica (LP), the so-called 'leather bottle stomach', is believed to be a typical case of SGC, which is usually diagnosed as a far-advanced gastric cancer. The pathogenesis of this disease remains unclear. Although typical SGC often invades the entire stomach, atypical cases show SGC localized to one region of the stomach. The aim of the present study was to investigate localized SGC (LSGC) and its biological significance. A total of 509 patients with advanced gastric cancer who underwent gastrectomy were evaluated. These patients were divided into three groups as follows: 19 patients with type IV scirrhous lesions invading the whole stomach (defined as LP), 60 patients with type IV scirrhous lesions localized in less than two thirds of the stomach (defined as LSGC) and the remaining 430 patients with all other types of gastric cancer (OGC), and then clinicopathologically compared. Results showed that LP had deeper invasion (p=0.006), more frequent peritoneal dissemination including positive cytology (p=0.01 and p=0.018) and lower curability (p=0.03) compared with LSGC, whereas LSGC showed a higher malignant potential in a number of clinicopathological factors compared with OGC. Univariate analysis showed that survival in patients with LP was significantly poorer than in those with LSGC (p=0.002) whose survival was, in turn, inferior to those with OGC. By contrast, LSGC was not a prognostic factor in SGC according to the multivariate analysis. The findings of this study suggested that the malignant status of LSGC differs from that of LP, and that curative gastrectomy is effective in improving the outcome for LSGC but not for LP, as LSGC may represent the prelinitis condition.
DOI: 10.3892/ol.2011.454
PubMed: 22740862
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biological significance of localized Type IV scirrhous gastric cancer.</title><author><name sortKey="Endo, Kazuya" sort="Endo, Kazuya" uniqKey="Endo K" first="Kazuya" last="Endo">Kazuya Endo</name><affiliation><nlm:affiliation>Department of Surgery, Center for Gastroenterology, Fukuoka 810-8563, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sakurai, Masato" sort="Sakurai, Masato" uniqKey="Sakurai M" first="Masato" last="Sakurai">Masato Sakurai</name></author><author><name sortKey="Kusumoto, Eiji" sort="Kusumoto, Eiji" uniqKey="Kusumoto E" first="Eiji" last="Kusumoto">Eiji Kusumoto</name></author><author><name sortKey="Uehara, Hideo" sort="Uehara, Hideo" uniqKey="Uehara H" first="Hideo" last="Uehara">Hideo Uehara</name></author><author><name sortKey="Yamaguchi, Shohei" sort="Yamaguchi, Shohei" uniqKey="Yamaguchi S" first="Shohei" last="Yamaguchi">Shohei Yamaguchi</name></author><author><name sortKey="Tsutsumi, Norifumi" sort="Tsutsumi, Norifumi" uniqKey="Tsutsumi N" first="Norifumi" last="Tsutsumi">Norifumi Tsutsumi</name></author><author><name sortKey="Ikejiri, Koji" sort="Ikejiri, Koji" uniqKey="Ikejiri K" first="Koji" last="Ikejiri">Koji Ikejiri</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.3892/ol.2011.454</idno><idno type="RBID">pubmed:22740862</idno><idno type="pmid">22740862</idno><idno type="wicri:Area/PubMed/Corpus">000081</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000081</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biological significance of localized Type IV scirrhous gastric cancer.</title><author><name sortKey="Endo, Kazuya" sort="Endo, Kazuya" uniqKey="Endo K" first="Kazuya" last="Endo">Kazuya Endo</name><affiliation><nlm:affiliation>Department of Surgery, Center for Gastroenterology, Fukuoka 810-8563, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sakurai, Masato" sort="Sakurai, Masato" uniqKey="Sakurai M" first="Masato" last="Sakurai">Masato Sakurai</name></author><author><name sortKey="Kusumoto, Eiji" sort="Kusumoto, Eiji" uniqKey="Kusumoto E" first="Eiji" last="Kusumoto">Eiji Kusumoto</name></author><author><name sortKey="Uehara, Hideo" sort="Uehara, Hideo" uniqKey="Uehara H" first="Hideo" last="Uehara">Hideo Uehara</name></author><author><name sortKey="Yamaguchi, Shohei" sort="Yamaguchi, Shohei" uniqKey="Yamaguchi S" first="Shohei" last="Yamaguchi">Shohei Yamaguchi</name></author><author><name sortKey="Tsutsumi, Norifumi" sort="Tsutsumi, Norifumi" uniqKey="Tsutsumi N" first="Norifumi" last="Tsutsumi">Norifumi Tsutsumi</name></author><author><name sortKey="Ikejiri, Koji" sort="Ikejiri, Koji" uniqKey="Ikejiri K" first="Koji" last="Ikejiri">Koji Ikejiri</name></author></analytic><series><title level="j">Oncology letters</title><idno type="ISSN">1792-1074</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The prognosis of type IV scirrhous gastric cancer (SGC) is extremely poor. Linitis plastica (LP), the so-called 'leather bottle stomach', is believed to be a typical case of SGC, which is usually diagnosed as a far-advanced gastric cancer. The pathogenesis of this disease remains unclear. Although typical SGC often invades the entire stomach, atypical cases show SGC localized to one region of the stomach. The aim of the present study was to investigate localized SGC (LSGC) and its biological significance. A total of 509 patients with advanced gastric cancer who underwent gastrectomy were evaluated. These patients were divided into three groups as follows: 19 patients with type IV scirrhous lesions invading the whole stomach (defined as LP), 60 patients with type IV scirrhous lesions localized in less than two thirds of the stomach (defined as LSGC) and the remaining 430 patients with all other types of gastric cancer (OGC), and then clinicopathologically compared. Results showed that LP had deeper invasion (p=0.006), more frequent peritoneal dissemination including positive cytology (p=0.01 and p=0.018) and lower curability (p=0.03) compared with LSGC, whereas LSGC showed a higher malignant potential in a number of clinicopathological factors compared with OGC. Univariate analysis showed that survival in patients with LP was significantly poorer than in those with LSGC (p=0.002) whose survival was, in turn, inferior to those with OGC. By contrast, LSGC was not a prognostic factor in SGC according to the multivariate analysis. The findings of this study suggested that the malignant status of LSGC differs from that of LP, and that curative gastrectomy is effective in improving the outcome for LSGC but not for LP, as LSGC may represent the prelinitis condition.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">22740862</PMID><DateCreated><Year>2012</Year><Month>6</Month><Day>28</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1792-1074</ISSN><JournalIssue CitedMedium="Print"><Volume>3</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Oncology letters</Title><ISOAbbreviation>Oncol Lett</ISOAbbreviation></Journal><ArticleTitle>Biological significance of localized Type IV scirrhous gastric cancer.</ArticleTitle><Pagination><MedlinePgn>94-99</MedlinePgn></Pagination><Abstract><AbstractText>The prognosis of type IV scirrhous gastric cancer (SGC) is extremely poor. Linitis plastica (LP), the so-called 'leather bottle stomach', is believed to be a typical case of SGC, which is usually diagnosed as a far-advanced gastric cancer. The pathogenesis of this disease remains unclear. Although typical SGC often invades the entire stomach, atypical cases show SGC localized to one region of the stomach. The aim of the present study was to investigate localized SGC (LSGC) and its biological significance. A total of 509 patients with advanced gastric cancer who underwent gastrectomy were evaluated. These patients were divided into three groups as follows: 19 patients with type IV scirrhous lesions invading the whole stomach (defined as LP), 60 patients with type IV scirrhous lesions localized in less than two thirds of the stomach (defined as LSGC) and the remaining 430 patients with all other types of gastric cancer (OGC), and then clinicopathologically compared. Results showed that LP had deeper invasion (p=0.006), more frequent peritoneal dissemination including positive cytology (p=0.01 and p=0.018) and lower curability (p=0.03) compared with LSGC, whereas LSGC showed a higher malignant potential in a number of clinicopathological factors compared with OGC. Univariate analysis showed that survival in patients with LP was significantly poorer than in those with LSGC (p=0.002) whose survival was, in turn, inferior to those with OGC. By contrast, LSGC was not a prognostic factor in SGC according to the multivariate analysis. The findings of this study suggested that the malignant status of LSGC differs from that of LP, and that curative gastrectomy is effective in improving the outcome for LSGC but not for LP, as LSGC may represent the prelinitis condition.</AbstractText></Abstract><AuthorList><Author><LastName>Endo</LastName><ForeName>Kazuya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Surgery, Center for Gastroenterology, Fukuoka 810-8563, Japan.</Affiliation></AffiliationInfo></Author><Author><LastName>Sakurai</LastName><ForeName>Masato</ForeName><Initials>M</Initials></Author><Author><LastName>Kusumoto</LastName><ForeName>Eiji</ForeName><Initials>E</Initials></Author><Author><LastName>Uehara</LastName><ForeName>Hideo</ForeName><Initials>H</Initials></Author><Author><LastName>Yamaguchi</LastName><ForeName>Shohei</ForeName><Initials>S</Initials></Author><Author><LastName>Tsutsumi</LastName><ForeName>Norifumi</ForeName><Initials>N</Initials></Author><Author><LastName>Ikejiri</LastName><ForeName>Koji</ForeName><Initials>K</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>10</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Oncol Lett</MedlineTA><NlmUniqueID>101531236</NlmUniqueID><ISSNLinking>1792-1074</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>6</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>10</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="epublish"><Year>2011</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.3892/ol.2011.454</ArticleId><ArticleId IdType="pii">ol-03-01-0094</ArticleId><ArticleId IdType="pubmed">22740862</ArticleId><ArticleId IdType="pmc">PMC3362335</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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