Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.
Identifieur interne : 000191 ( PubMed/Checkpoint ); précédent : 000190; suivant : 000192Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.
Auteurs : D. Chognot [France] ; J L Six ; M. Leonard ; F. Bonneaux ; C. Vigneron ; Édith Dellacherie [France]Source :
- Journal of colloid and interface science [ 0021-9797 ] ; 2003.
Abstract
Different water-soluble MPEO-PLA diblock copolymers with various alpha-methoxy-omega-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.
PubMed: 14643246
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université de Lorraine
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:14643246Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.</title><author><name sortKey="Chognot, D" sort="Chognot, D" uniqKey="Chognot D" first="D" last="Chognot">D. Chognot</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Six, J L" sort="Six, J L" uniqKey="Six J" first="J L" last="Six">J L Six</name></author><author><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M" last="Leonard">M. Leonard</name></author><author><name sortKey="Bonneaux, F" sort="Bonneaux, F" uniqKey="Bonneaux F" first="F" last="Bonneaux">F. Bonneaux</name></author><author><name sortKey="Vigneron, C" sort="Vigneron, C" uniqKey="Vigneron C" first="C" last="Vigneron">C. Vigneron</name></author><author><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E" last="Dellacherie">Édith Dellacherie</name><affiliation><country>France</country><placeName><settlement type="city">Nancy</settlement><region type="region" nuts="2">Grand Est</region><region type="region" nuts="2">Lorraine (région)</region></placeName><orgName type="laboratoire" n="5">Laboratoire réactions et génie des procédés</orgName><orgName type="university">Université de Lorraine</orgName><orgName type="institution">Centre national de la recherche scientifique</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14643246</idno><idno type="pmid">14643246</idno><idno type="wicri:Area/PubMed/Corpus">000199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000199</idno><idno type="wicri:Area/PubMed/Curation">000199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000199</idno><idno type="wicri:Area/PubMed/Checkpoint">000199</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000199</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.</title><author><name sortKey="Chognot, D" sort="Chognot, D" uniqKey="Chognot D" first="D" last="Chognot">D. Chognot</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Six, J L" sort="Six, J L" uniqKey="Six J" first="J L" last="Six">J L Six</name></author><author><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M" last="Leonard">M. Leonard</name></author><author><name sortKey="Bonneaux, F" sort="Bonneaux, F" uniqKey="Bonneaux F" first="F" last="Bonneaux">F. Bonneaux</name></author><author><name sortKey="Vigneron, C" sort="Vigneron, C" uniqKey="Vigneron C" first="C" last="Vigneron">C. Vigneron</name></author><author><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E" last="Dellacherie">Édith Dellacherie</name><affiliation><country>France</country><placeName><settlement type="city">Nancy</settlement><region type="region" nuts="2">Grand Est</region><region type="region" nuts="2">Lorraine (région)</region></placeName><orgName type="laboratoire" n="5">Laboratoire réactions et génie des procédés</orgName><orgName type="university">Université de Lorraine</orgName><orgName type="institution">Centre national de la recherche scientifique</orgName></affiliation></author></analytic><series><title level="j">Journal of colloid and interface science</title><idno type="ISSN">0021-9797</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Different water-soluble MPEO-PLA diblock copolymers with various alpha-methoxy-omega-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="PubMed-not-MEDLINE"><PMID Version="1">14643246</PMID><DateCreated><Year>2003</Year><Month>12</Month><Day>03</Day></DateCreated><DateCompleted><Year>2004</Year><Month>09</Month><Day>22</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0021-9797</ISSN><JournalIssue CitedMedium="Print"><Volume>268</Volume><Issue>2</Issue><PubDate><Year>2003</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of colloid and interface science</Title><ISOAbbreviation>J Colloid Interface Sci</ISOAbbreviation></Journal><ArticleTitle>Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.</ArticleTitle><Pagination><MedlinePgn>441-7</MedlinePgn></Pagination><Abstract><AbstractText>Different water-soluble MPEO-PLA diblock copolymers with various alpha-methoxy-omega-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chognot</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Six</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Leonard</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bonneaux</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Vigneron</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Dellacherie</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Colloid Interface Sci</MedlineTA><NlmUniqueID>0043125</NlmUniqueID><ISSNLinking>0021-9797</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>12</Month><Day>4</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>12</Month><Day>4</Day><Hour>5</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>12</Month><Day>4</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14643246</ArticleId><ArticleId IdType="pii">S0021979703005915</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Nancy</li></settlement><orgName><li>Centre national de la recherche scientifique</li><li>Laboratoire réactions et génie des procédés</li><li>Université de Lorraine</li></orgName></list><tree><noCountry><name sortKey="Bonneaux, F" sort="Bonneaux, F" uniqKey="Bonneaux F" first="F" last="Bonneaux">F. Bonneaux</name><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M" last="Leonard">M. Leonard</name><name sortKey="Six, J L" sort="Six, J L" uniqKey="Six J" first="J L" last="Six">J L Six</name><name sortKey="Vigneron, C" sort="Vigneron, C" uniqKey="Vigneron C" first="C" last="Vigneron">C. Vigneron</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Chognot, D" sort="Chognot, D" uniqKey="Chognot D" first="D" last="Chognot">D. Chognot</name></region><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E" last="Dellacherie">Édith Dellacherie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/LrgpV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000191 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000191 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= LrgpV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:14643246
|texte= Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:14643246" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LrgpV1
| This area was generated with Dilib version V0.6.32. |  |