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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy</title><author><name sortKey="Allal, A S" sort="Allal, A S" uniqKey="Allal A" first="A S" last="Allal">A S Allal</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Division of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Sprangers, M A G" sort="Sprangers, M A G" uniqKey="Sprangers M" first="M A G" last="Sprangers">M A G. Sprangers</name><affiliation><nlm:aff id="aff3">Department of Medical Psychology, Academic Medical Center, 1105 Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Laurencet, F" sort="Laurencet, F" uniqKey="Laurencet F" first="F" last="Laurencet">F. Laurencet</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Division of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Reymond, M A" sort="Reymond, M A" uniqKey="Reymond M" first="M A" last="Reymond">M A Reymond</name><affiliation><nlm:aff id="aff1">Department of Surgery, University Hospital of Geneva, 1211 Geneva 14, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kurtz, J M" sort="Kurtz, J M" uniqKey="Kurtz J" first="J M" last="Kurtz">J M Kurtz</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Division of Radiation Oncology</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10408404</idno><idno type="pmc">2363100</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363100</idno><idno type="RBID">PMC:2363100</idno><idno type="doi">10.1038/sj.bjc.6690567</idno><date when="1999">1999</date><idno type="wicri:Area/Pmc/Corpus">000000</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000000</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy</title><author><name sortKey="Allal, A S" sort="Allal, A S" uniqKey="Allal A" first="A S" last="Allal">A S Allal</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Division of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Sprangers, M A G" sort="Sprangers, M A G" uniqKey="Sprangers M" first="M A G" last="Sprangers">M A G. Sprangers</name><affiliation><nlm:aff id="aff3">Department of Medical Psychology, Academic Medical Center, 1105 Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Laurencet, F" sort="Laurencet, F" uniqKey="Laurencet F" first="F" last="Laurencet">F. Laurencet</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Division of Radiation Oncology</nlm:aff></affiliation></author><author><name sortKey="Reymond, M A" sort="Reymond, M A" uniqKey="Reymond M" first="M A" last="Reymond">M A Reymond</name><affiliation><nlm:aff id="aff1">Department of Surgery, University Hospital of Geneva, 1211 Geneva 14, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kurtz, J M" sort="Kurtz, J M" uniqKey="Kurtz J" first="J M" last="Kurtz">J M Kurtz</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Division of Radiation Oncology</nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study was conducted to assess long-term Quality of Life (QOL) in patients treated by radiotherapy with or without chemotherapy for anal carcinomas. Patients with a maximum age of 80 years, and who were alive at least 3 years following completion of treatment with a functioning anal sphincter and without active disease, were selected for this study. Of 52 such patients identified, 41 (79%) were evaluable. There were 35 females and six males with a median age of 71 years (55–80). The median follow-up interval was 116 months (range 37–218). QOL was assessed using two self-rating questionnaires developed by the European Organization for Research and Treatment of Cancer: one for cancer-specific QOL (EORTC QLQ-C30) and one for site-specific QOL (EORTC QLQ-CR38). For the function scales a higher score represents a higher level of functioning (100 being the best score), whereas for the symptom scales a higher score indicates a higher level of symptomatology/problems (0 being the best score). For the QLQ-C30, the functional scale scores ranged from 71 (global quality of life) to 85 (role function) and the symptom scale scores from 6 (nausea-vomiting) to 28 (diarrhoea). For the QLQ-CR38 module the functional scale scores ranged from 13 (sexual functioning) to 74 (body image) and for the symptom scale scores from 5 (weight loss) to 66 (sexual dysfunction in males). None of the functional and symptom scale scores seemed to be better in patients with longer follow-up. In patients treated with sphincter conservation for anal carcinomas, long-term QOL as measured by the EORTC QLQ-C30 and QLQ-CR38 appears to be acceptable, with the exception of diarrhoea and perhaps sexual function. Moreover, the subset of patients who presented with severe complications and/or anal dysfunction showed poorer scores in most scales. © 1999 Cancer Research Campaign</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-comment> Original-type: ra</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10408404</article-id><article-id pub-id-type="pmc">2363100</article-id><article-id pub-id-type="pii">6690567</article-id><article-id pub-id-type="doi">10.1038/sj.bjc.6690567</article-id><article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject></subj-group></article-categories><title-group><article-title>Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Allal</surname><given-names>A S</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sprangers</surname><given-names>M A G</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Laurencet</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Reymond</surname><given-names>M A</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Kurtz</surname><given-names>J M</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Division of Radiation Oncology and<label>2</label>Department of Surgery, University Hospital of Geneva, 1211 Geneva 14, Switzerland</aff><aff id="aff3"><label>3</label>Department of Medical Psychology, Academic Medical Center, 1105 Amsterdam, The Netherlands</aff><pub-date pub-type="ppub"><month>07</month><year>1999</year></pub-date><volume>80</volume><issue>10</issue><fpage>1588</fpage><lpage>1594</lpage><history><date date-type="received"><day>02</day><month>11</month><year>1998</year></date><date date-type="rev-recd"><day>10</day><month>02</month><year>1999</year></date><date date-type="accepted"><day>22</day><month>02</month><year>1999</year></date></history><copyright-statement>Copyright 1999, Cancer Research Campaign</copyright-statement><copyright-year>1999</copyright-year><permissions><copyright-holder>Cancer Research Campaign</copyright-holder></permissions><abstract><p>This study was conducted to assess long-term Quality of Life (QOL) in patients treated by radiotherapy with or without chemotherapy for anal carcinomas. Patients with a maximum age of 80 years, and who were alive at least 3 years following completion of treatment with a functioning anal sphincter and without active disease, were selected for this study. Of 52 such patients identified, 41 (79%) were evaluable. There were 35 females and six males with a median age of 71 years (55–80). The median follow-up interval was 116 months (range 37–218). QOL was assessed using two self-rating questionnaires developed by the European Organization for Research and Treatment of Cancer: one for cancer-specific QOL (EORTC QLQ-C30) and one for site-specific QOL (EORTC QLQ-CR38). For the function scales a higher score represents a higher level of functioning (100 being the best score), whereas for the symptom scales a higher score indicates a higher level of symptomatology/problems (0 being the best score). For the QLQ-C30, the functional scale scores ranged from 71 (global quality of life) to 85 (role function) and the symptom scale scores from 6 (nausea-vomiting) to 28 (diarrhoea). For the QLQ-CR38 module the functional scale scores ranged from 13 (sexual functioning) to 74 (body image) and for the symptom scale scores from 5 (weight loss) to 66 (sexual dysfunction in males). None of the functional and symptom scale scores seemed to be better in patients with longer follow-up. In patients treated with sphincter conservation for anal carcinomas, long-term QOL as measured by the EORTC QLQ-C30 and QLQ-CR38 appears to be acceptable, with the exception of diarrhoea and perhaps sexual function. Moreover, the subset of patients who presented with severe complications and/or anal dysfunction showed poorer scores in most scales. © 1999 Cancer Research Campaign</p></abstract><kwd-group><kwd>anal carcinoma</kwd><kwd>quality of life</kwd><kwd>radiotherapy</kwd><kwd>chemotherapy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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