Parental Age and Autism Spectrum Disorders
Identifieur interne : 000226 ( Ncbi/Curation ); précédent : 000225; suivant : 000227Parental Age and Autism Spectrum Disorders
Auteurs : Erik Thorlund Parner ; Simon Baron-Cohen ; Marlene B. Lauritsen ; Meta J Rgensen ; Laura A. Schieve ; Marshalyn Yeargin-Allsopp ; Carsten ObelSource :
- Annals of epidemiology [ 1047-2797 ] ; 2012.
Abstract
We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design.
Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10.
A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10–1.34) to 1.65 (1.09–2.48) depending on combinations of parental age categories; <35, 35–39, and 40+ years). For mothers younger than 35 years, the risk of ASD increased with increasing father’s age group. For fathers younger than 35 years, the risk of ASD increased with increasing maternal age.
We found an association between parental age and ASD in the cohort study, but the combined underlying mechanisms through which paternal and maternal age impact ASD risk do not seem to act synergistically. The results of the sibling analysis suggest that the association between parental age and ASD found in the cohort study cannot be accounted for by common genetic and environmental factors.
Url:
DOI: 10.1016/j.annepidem.2011.12.006
PubMed: 22277122
PubMed Central: 4562461
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PMC:4562461Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parental Age and Autism Spectrum Disorders</title><author><name sortKey="Parner, Erik Thorlund" sort="Parner, Erik Thorlund" uniqKey="Parner E" first="Erik Thorlund" last="Parner">Erik Thorlund Parner</name></author><author><name sortKey="Baron Cohen, Simon" sort="Baron Cohen, Simon" uniqKey="Baron Cohen S" first="Simon" last="Baron-Cohen">Simon Baron-Cohen</name></author><author><name sortKey="Lauritsen, Marlene B" sort="Lauritsen, Marlene B" uniqKey="Lauritsen M" first="Marlene B." last="Lauritsen">Marlene B. Lauritsen</name></author><author><name sortKey="J Rgensen, Meta" sort="J Rgensen, Meta" uniqKey="J Rgensen M" first="Meta" last="J Rgensen">Meta J Rgensen</name></author><author><name sortKey="Schieve, Laura A" sort="Schieve, Laura A" uniqKey="Schieve L" first="Laura A." last="Schieve">Laura A. Schieve</name></author><author><name sortKey="Yeargin Allsopp, Marshalyn" sort="Yeargin Allsopp, Marshalyn" uniqKey="Yeargin Allsopp M" first="Marshalyn" last="Yeargin-Allsopp">Marshalyn Yeargin-Allsopp</name></author><author><name sortKey="Obel, Carsten" sort="Obel, Carsten" uniqKey="Obel C" first="Carsten" last="Obel">Carsten Obel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22277122</idno><idno type="pmc">4562461</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562461</idno><idno type="RBID">PMC:4562461</idno><idno type="doi">10.1016/j.annepidem.2011.12.006</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000158</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000158</idno><idno type="wicri:Area/Pmc/Curation">000158</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000158</idno><idno type="wicri:Area/Pmc/Checkpoint">000049</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000049</idno><idno type="wicri:Area/Ncbi/Merge">000226</idno><idno type="wicri:Area/Ncbi/Curation">000226</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parental Age and Autism Spectrum Disorders</title><author><name sortKey="Parner, Erik Thorlund" sort="Parner, Erik Thorlund" uniqKey="Parner E" first="Erik Thorlund" last="Parner">Erik Thorlund Parner</name></author><author><name sortKey="Baron Cohen, Simon" sort="Baron Cohen, Simon" uniqKey="Baron Cohen S" first="Simon" last="Baron-Cohen">Simon Baron-Cohen</name></author><author><name sortKey="Lauritsen, Marlene B" sort="Lauritsen, Marlene B" uniqKey="Lauritsen M" first="Marlene B." last="Lauritsen">Marlene B. Lauritsen</name></author><author><name sortKey="J Rgensen, Meta" sort="J Rgensen, Meta" uniqKey="J Rgensen M" first="Meta" last="J Rgensen">Meta J Rgensen</name></author><author><name sortKey="Schieve, Laura A" sort="Schieve, Laura A" uniqKey="Schieve L" first="Laura A." last="Schieve">Laura A. Schieve</name></author><author><name sortKey="Yeargin Allsopp, Marshalyn" sort="Yeargin Allsopp, Marshalyn" uniqKey="Yeargin Allsopp M" first="Marshalyn" last="Yeargin-Allsopp">Marshalyn Yeargin-Allsopp</name></author><author><name sortKey="Obel, Carsten" sort="Obel, Carsten" uniqKey="Obel C" first="Carsten" last="Obel">Carsten Obel</name></author></analytic><series><title level="j">Annals of epidemiology</title><idno type="ISSN">1047-2797</idno><idno type="eISSN">1873-2585</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>PURPOSE</title><p id="P1">We sought to study the possible association between parental age and autism spectrum disorder (ASD) by using both a cohort design and a sibling design.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">Our cohort included all singleton births in Denmark from January 1, 1980, through December 31, 2003, a total of 1,311,736 children. Cases of ASDs were obtained from the Danish National Psychiatric Register using International Classification of Diseases (ICD)-8 and ICD-10.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">A total of 9556 children were diagnosed with an ASD. Both maternal and paternal age were associated with a greater risk of ASD in the offspring (hazard ratios ranging from 1.21 (1.10–1.34) to 1.65 (1.09–2.48) depending on combinations of parental age categories; <35, 35–39, and 40+ years). For mothers younger than 35 years, the risk of ASD increased with increasing father’s age group. For fathers younger than 35 years, the risk of ASD increased with increasing maternal age.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P4">We found an association between parental age and ASD in the cohort study, but the combined underlying mechanisms through which paternal and maternal age impact ASD risk do not seem to act synergistically. The results of the sibling analysis suggest that the association between parental age and ASD found in the cohort study cannot be accounted for by common genetic and environmental factors.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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