Biodegradable nanoparticles made from polylactide-grafted dextran copolymers.
Identifieur interne : 000F12 ( Main/Exploration ); précédent : 000F11; suivant : 000F13Biodegradable nanoparticles made from polylactide-grafted dextran copolymers.
Auteurs : C. Nouvel [France] ; J. Raynaud ; E. Marie ; Édith Dellacherie [France] ; J-L Six ; A. DurandSource :
- Journal of colloid and interface science [ 1095-7103 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Dextranase.
- Dextrane, Excipients, Hydrolyse, Matériaux revêtus, biocompatibles, Nanoparticules, Polyesters, Test de matériaux.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Coated Materials, Biocompatible, Dextrans, Polyesters.
- chemical , metabolism : Dextranase.
- chemical : Excipients.
- chemistry : Nanoparticles.
- Hydrolysis, Materials Testing.
Abstract
Polysaccharide-covered polyester nanoparticles were prepared using the emulsion/solvent evaporation process. The core of the nanoparticles was made either of PLA or of a blend of polylactide and polylactide-grafted dextran copolymer in various proportions. The surface of the nanoparticles was covered by dextran chains via the use of water-soluble polylactide-grafted dextrans as polymeric stabilizers during the emulsification step. The characteristics of the nanoparticles (size, surface coverage, thickness of superficial layer, colloidal stability) were correlated to the structural parameters (length and number of polylactide grafts) of the copolymers as well as to their surface active properties. The complete biodegradability of the nanoparticles was evaluated by considering the rate of hydrolysis of polylactide grafts in phosphate buffer and the rate of enzymatic degradation of dextran backbone by dextranase.
DOI: 10.1016/j.jcis.2008.10.069
PubMed: 19022457
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université de Lorraine
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Le document en format XML
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The core of the nanoparticles was made either of PLA or of a blend of polylactide and polylactide-grafted dextran copolymer in various proportions. The surface of the nanoparticles was covered by dextran chains via the use of water-soluble polylactide-grafted dextrans as polymeric stabilizers during the emulsification step. The characteristics of the nanoparticles (size, surface coverage, thickness of superficial layer, colloidal stability) were correlated to the structural parameters (length and number of polylactide grafts) of the copolymers as well as to their surface active properties. 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