On the metalation of 3-substituted and 3,6-disubstituted pyridazines
Identifieur interne : 000205 ( Istex/Curation ); précédent : 000204; suivant : 000206On the metalation of 3-substituted and 3,6-disubstituted pyridazines
Auteurs : Alain Turck [France] ; Nelly Plé [France] ; Bruno Ndzi [France] ; Guy Quéguiner [France] ; Norbert Haider [Autriche] ; Herbert Schuller [Autriche] ; Gottfried Heinisch [Autriche]Source :
- Tetrahedron [ 0040-4020 ] ; 1993.
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Abstract
Abstract: metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1–5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.
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DOI: 10.1016/S0040-4020(01)86263-3
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<front><div type="abstract" xml:lang="en">Abstract: metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1–5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.</div>
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