LrgpV1, Istex, Curation, bibRecord, 000205

On the metalation of 3-substituted and 3,6-disubstituted pyridazines

Identifieur interne : 000205 ( Istex/Curation ); précédent : 000204; suivant : 000206

On the metalation of 3-substituted and 3,6-disubstituted pyridazines

Auteurs : Alain Turck [France] ; Nelly Plé [France] ; Bruno Ndzi [France] ; Guy Quéguiner [France] ; Norbert Haider [Autriche] ; Herbert Schuller [Autriche] ; Gottfried Heinisch [Autriche]

Source :

Tetrahedron [ 0040-4020 ] ; 1993.

RBID : ISTEX:EBA4271A5D0A862AB45DA2E4DD7997AF7FF94B0F

English descriptors

KwdEn :
- Anal, Anal calcd, Calcd, Ch3cho, Colourless, Colourless crystals, Colourless sohd, Column chromatography, Eluent, Ethyl acetate, General procedure, Hexane, Ltmp, Metalation, Mmol, Nuxture, Obtamed, Phcho, Pyndazmes, Sodmm, Sohd, Tetrahydrofuran.
Teeft :
- Anal, Anal calcd, Calcd, Ch3cho, Colourless, Colourless crystals, Colourless sohd, Column chromatography, Eluent, Ethyl acetate, General procedure, Hexane, Ltmp, Metalation, Mmol, Nuxture, Obtamed, Phcho, Pyndazmes, Sodmm, Sohd, Tetrahydrofuran.

Abstract

Abstract: metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1–5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.

Url:

https://api.istex.fr/document/EBA4271A5D0A862AB45DA2E4DD7997AF7FF94B0F/fulltext/pdf

DOI: 10.1016/S0040-4020(01)86263-3

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1–5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.</div>
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On the metalation of 3-substituted and 3,6-disubstituted pyridazines

On the metalation of 3-substituted and 3,6-disubstituted pyridazines

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri