Real-time control of photobleaching trajectory during photodynamic therapy
Identifieur interne : 000972 ( Hal/Curation ); précédent : 000971; suivant : 000973Real-time control of photobleaching trajectory during photodynamic therapy
Auteurs : Jean-Baptiste Tylcz [France] ; Thierry Bastogne [France] ; Alexia Bourguignon [France] ; Sophie Pinel [France] ; Magali Toussaint [France] ; Céline Frochot [France] ; Muriel Barberi-Heyob [France]Source :
Abstract
Introduction: obstacles and challenges to the clinical use of the photodynamic therapy (PDT) are numerous: large inter-individual variability, heterogeneity of therapeutic predictability, lack of in vivo monitoring concerning the reactive oxygen species (ROS) production, etc. All of these factors affect in their ways the therapeutic response of the treatment and can lead to a wild uncertainty on its efficiency. Objective: to deal with these variability sources, we have designed and developed an innovative technology able to adapt in realtime the width of light impulses during the photodynamic therapy. The first objective is to accurately control the photobleaching trajectory of the photosensitizer during the treatment with a subsequent goal to improve the efficacy and reproducibility of this therapy.Methods: in this approach, the physician a priori defines the expected trajectory to be tracked by the photosensitizer photobleaching during the treatment. The photobleaching state of the PS is regularly measured during the treatment session and is used to change in real-time the illumination signal. This adaptive scheme of the photodynamic therapy has been implemented, tested and validated during in vitro tests.Results: these tests show that controlling the photobleaching trajectory is possible, confirming the technical feasibility of such an approach to deal with inter-individual variabilities in PDT. These results open new perspectives since the illumination signal can be different from a patient to another according to his individual response.Conclusions: this study has proven its interest by showing promising results in an in vitro context, which has to be confirmed by the current in vivo experiments. However, it is fair to say that in a near future, the proposed solution could lead, in fine, to an optimized and personalized PDT.
Url:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000972
Links to Exploration step
Hal:hal-01078940Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Real-time control of photobleaching trajectory during photodynamic therapy</title>
<author><name sortKey="Tylcz, Jean Baptiste" sort="Tylcz, Jean Baptiste" uniqKey="Tylcz J" first="Jean-Baptiste" last="Tylcz">Jean-Baptiste Tylcz</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Bastogne, Thierry" sort="Bastogne, Thierry" uniqKey="Bastogne T" first="Thierry" last="Bastogne">Thierry Bastogne</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Bourguignon, Alexia" sort="Bourguignon, Alexia" uniqKey="Bourguignon A" first="Alexia" last="Bourguignon">Alexia Bourguignon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Pinel, Sophie" sort="Pinel, Sophie" uniqKey="Pinel S" first="Sophie" last="Pinel">Sophie Pinel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Toussaint, Magali" sort="Toussaint, Magali" uniqKey="Toussaint M" first="Magali" last="Toussaint">Magali Toussaint</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno>
<idno type="RNSR">201320573K</idno>
<idno type="IdUnivLorraine">[UL]RQC--</idno>
<orgName>Laboratoire Réactions et Génie des Procédés</orgName>
<orgName type="acronym">LRGP</orgName>
<date type="start">2013-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lrgp.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7274" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01078940</idno>
<idno type="halId">hal-01078940</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-01078940</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-01078940</idno>
<date when="2014-05-25">2014-05-25</date>
<idno type="wicri:Area/Hal/Corpus">000972</idno>
<idno type="wicri:Area/Hal/Curation">000972</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Real-time control of photobleaching trajectory during photodynamic therapy</title>
<author><name sortKey="Tylcz, Jean Baptiste" sort="Tylcz, Jean Baptiste" uniqKey="Tylcz J" first="Jean-Baptiste" last="Tylcz">Jean-Baptiste Tylcz</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Bastogne, Thierry" sort="Bastogne, Thierry" uniqKey="Bastogne T" first="Thierry" last="Bastogne">Thierry Bastogne</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Bourguignon, Alexia" sort="Bourguignon, Alexia" uniqKey="Bourguignon A" first="Alexia" last="Bourguignon">Alexia Bourguignon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Pinel, Sophie" sort="Pinel, Sophie" uniqKey="Pinel S" first="Sophie" last="Pinel">Sophie Pinel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Toussaint, Magali" sort="Toussaint, Magali" uniqKey="Toussaint M" first="Magali" last="Toussaint">Magali Toussaint</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-211875" status="VALID"><idno type="IdRef">153068876</idno>
<idno type="RNSR">201320573K</idno>
<idno type="IdUnivLorraine">[UL]RQC--</idno>
<orgName>Laboratoire Réactions et Génie des Procédés</orgName>
<orgName type="acronym">LRGP</orgName>
<date type="start">2013-01-01</date>
<desc><address><addrLine>Université de Lorraine - ENSIC, 1 rue de Grandville BP 20451, 54001 Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://lrgp.univ-lorraine.fr/</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7274" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7274" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185180" status="VALID"><idno type="IdRef">03500472X</idno>
<idno type="RNSR">200112440X</idno>
<idno type="IdUnivLorraine">[UL]RSA--</idno>
<orgName>Centre de Recherche en Automatique de Nancy</orgName>
<orgName type="acronym">CRAN</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.cran.univ-lorraine.fr</ref>
</desc>
<listRelation><relation active="#struct-413289" type="direct"></relation>
<relation name="UMR7039" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-413289" type="direct"><org type="institution" xml:id="struct-413289" status="VALID"><idno type="IdRef">157040569</idno>
<idno type="IdUnivLorraine">[UL]100--</idno>
<orgName>Université de Lorraine</orgName>
<orgName type="acronym">UL</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lorraine.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7039" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno>
<idno type="IdRef">02636817X</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc><address><country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Introduction: obstacles and challenges to the clinical use of the photodynamic therapy (PDT) are numerous: large inter-individual variability, heterogeneity of therapeutic predictability, lack of in vivo monitoring concerning the reactive oxygen species (ROS) production, etc. All of these factors affect in their ways the therapeutic response of the treatment and can lead to a wild uncertainty on its efficiency. Objective: to deal with these variability sources, we have designed and developed an innovative technology able to adapt in realtime the width of light impulses during the photodynamic therapy. The first objective is to accurately control the photobleaching trajectory of the photosensitizer during the treatment with a subsequent goal to improve the efficacy and reproducibility of this therapy.Methods: in this approach, the physician a priori defines the expected trajectory to be tracked by the photosensitizer photobleaching during the treatment. The photobleaching state of the PS is regularly measured during the treatment session and is used to change in real-time the illumination signal. This adaptive scheme of the photodynamic therapy has been implemented, tested and validated during in vitro tests.Results: these tests show that controlling the photobleaching trajectory is possible, confirming the technical feasibility of such an approach to deal with inter-individual variabilities in PDT. These results open new perspectives since the illumination signal can be different from a patient to another according to his individual response.Conclusions: this study has proven its interest by showing promising results in an in vitro context, which has to be confirmed by the current in vivo experiments. However, it is fair to say that in a near future, the proposed solution could lead, in fine, to an optimized and personalized PDT.</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Real-time control of photobleaching trajectory during photodynamic therapy</title>
<author role="aut"><persName><forename type="first">Jean-Baptiste</forename>
<surname>Tylcz</surname>
</persName>
<email></email>
<idno type="halauthor">782904</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Thierry</forename>
<surname>Bastogne</surname>
</persName>
<email></email>
<idno type="halauthor">140180</idno>
<affiliation ref="#struct-185180"></affiliation>
<affiliation ref="#struct-205119"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexia</forename>
<surname>Bourguignon</surname>
</persName>
<email></email>
<idno type="halauthor">1092458</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sophie</forename>
<surname>Pinel</surname>
</persName>
<email></email>
<idno type="halauthor">89498</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Magali</forename>
<surname>Toussaint</surname>
</persName>
<email></email>
<idno type="halauthor">773584</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Céline</forename>
<surname>Frochot</surname>
</persName>
<email></email>
<idno type="halauthor">133064</idno>
<affiliation ref="#struct-211875"></affiliation>
<affiliation ref="#struct-73720"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Muriel</forename>
<surname>Barberi-Heyob</surname>
</persName>
<email></email>
<idno type="halauthor">89501</idno>
<affiliation ref="#struct-185180"></affiliation>
<affiliation ref="#struct-73720"></affiliation>
</author>
<editor role="depositor"><persName><forename>Thierry</forename>
<surname>Bastogne</surname>
</persName>
<email>thierry.bastogne@cran.uhp-nancy.fr</email>
</editor>
</titleStmt>
<editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2014-10-30 17:16:50</date>
<date type="whenModified">2016-05-11 01:06:10</date>
<date type="whenReleased">2014-10-31 08:50:59</date>
<date type="whenProduced">2014-05-25</date>
<date type="whenEndEmbargoed">2014-10-30</date>
<ref type="file" target="https://hal.archives-ouvertes.fr/hal-01078940/document"><date notBefore="2014-10-30"></date>
</ref>
<ref type="file" subtype="author" n="1" target="https://hal.archives-ouvertes.fr/hal-01078940/file/Abstract_ICPA2014_2.pdf"><date notBefore="2014-10-30"></date>
</ref>
</edition>
<respStmt><resp>contributor</resp>
<name key="112171"><persName><forename>Thierry</forename>
<surname>Bastogne</surname>
</persName>
<email>thierry.bastogne@cran.uhp-nancy.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt><distributor>CCSD</distributor>
<idno type="halId">hal-01078940</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-01078940</idno>
<idno type="halBibtex">tylcz:hal-01078940</idno>
<idno type="halRefHtml">International Congress on Photodynamic Applications, ICPA 2014, May 2014, Dundee, United Kingdom. 2014</idno>
<idno type="halRef">International Congress on Photodynamic Applications, ICPA 2014, May 2014, Dundee, United Kingdom. 2014</idno>
</publicationStmt>
<seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
<idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
<idno type="stamp" n="CRAN">Centre de Recherche en Automatique de Nancy</idno>
<idno type="stamp" n="IECN">IECL - Institut Elie Cartan de Lorraine</idno>
<idno type="stamp" n="INRIA-LORRAINE">INRIA Nancy - Grand Est</idno>
<idno type="stamp" n="INRIA-NANCY-GRAND-EST">INRIA Nancy - Grand Est</idno>
<idno type="stamp" n="CRAN-SBS" p="CRAN">CRAN-SBS</idno>
<idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
<idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
<idno type="stamp" n="LRGP-UL">LRGP</idno>
<idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno>
<idno type="stamp" n="INRIA2">INRIA 2</idno>
</seriesStmt>
<notesStmt><note type="audience" n="2">International</note>
<note type="invited" n="0">No</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
<note type="proceedings" n="1">Yes</note>
</notesStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Real-time control of photobleaching trajectory during photodynamic therapy</title>
<author role="aut"><persName><forename type="first">Jean-Baptiste</forename>
<surname>Tylcz</surname>
</persName>
<idno type="halAuthorId">782904</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Thierry</forename>
<surname>Bastogne</surname>
</persName>
<idno type="halAuthorId">140180</idno>
<affiliation ref="#struct-185180"></affiliation>
<affiliation ref="#struct-205119"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexia</forename>
<surname>Bourguignon</surname>
</persName>
<idno type="halAuthorId">1092458</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sophie</forename>
<surname>Pinel</surname>
</persName>
<idno type="halAuthorId">89498</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Magali</forename>
<surname>Toussaint</surname>
</persName>
<idno type="halAuthorId">773584</idno>
<affiliation ref="#struct-185180"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Céline</forename>
<surname>Frochot</surname>
</persName>
<idno type="halAuthorId">133064</idno>
<affiliation ref="#struct-211875"></affiliation>
<affiliation ref="#struct-73720"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Muriel</forename>
<surname>Barberi-Heyob</surname>
</persName>
<idno type="halAuthorId">89501</idno>
<affiliation ref="#struct-185180"></affiliation>
<affiliation ref="#struct-73720"></affiliation>
</author>
</analytic>
<monogr><idno type="localRef">SBS</idno>
<idno type="localRef">INRIA BIGS</idno>
<meeting><title>International Congress on Photodynamic Applications, ICPA 2014</title>
<date type="start">2014-05-25</date>
<date type="end">2014-05-28</date>
<settlement>Dundee</settlement>
<country key="GB">United Kingdom</country>
</meeting>
<imprint><date type="datePub">2014-05-25</date>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><classCode scheme="halDomain" n="spi.auto">Engineering Sciences [physics]/Automatic</classCode>
<classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
<classCode scheme="halTypology" n="COMM">Conference papers</classCode>
</textClass>
<abstract xml:lang="en">Introduction: obstacles and challenges to the clinical use of the photodynamic therapy (PDT) are numerous: large inter-individual variability, heterogeneity of therapeutic predictability, lack of in vivo monitoring concerning the reactive oxygen species (ROS) production, etc. All of these factors affect in their ways the therapeutic response of the treatment and can lead to a wild uncertainty on its efficiency. Objective: to deal with these variability sources, we have designed and developed an innovative technology able to adapt in realtime the width of light impulses during the photodynamic therapy. The first objective is to accurately control the photobleaching trajectory of the photosensitizer during the treatment with a subsequent goal to improve the efficacy and reproducibility of this therapy.Methods: in this approach, the physician a priori defines the expected trajectory to be tracked by the photosensitizer photobleaching during the treatment. The photobleaching state of the PS is regularly measured during the treatment session and is used to change in real-time the illumination signal. This adaptive scheme of the photodynamic therapy has been implemented, tested and validated during in vitro tests.Results: these tests show that controlling the photobleaching trajectory is possible, confirming the technical feasibility of such an approach to deal with inter-individual variabilities in PDT. These results open new perspectives since the illumination signal can be different from a patient to another according to his individual response.Conclusions: this study has proven its interest by showing promising results in an in vitro context, which has to be confirmed by the current in vivo experiments. However, it is fair to say that in a near future, the proposed solution could lead, in fine, to an optimized and personalized PDT.</abstract>
</profileDesc>
</hal>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/LrgpV1/Data/Hal/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000972 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Curation/biblio.hfd -nk 000972 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Lorraine |area= LrgpV1 |flux= Hal |étape= Curation |type= RBID |clé= Hal:hal-01078940 |texte= Real-time control of photobleaching trajectory during photodynamic therapy }}
![]() | This area was generated with Dilib version V0.6.32. | ![]() |