Comparison of 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection.
Identifieur interne : 004482 ( Main/Exploration ); précédent : 004481; suivant : 004483Comparison of 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection.
Auteurs : RBID : pubmed:8551884English descriptors
- KwdEn :
- MESH :
- chemical , diagnostic use : Ciprofloxacin, Indium Radioisotopes, Sodium Pertechnetate Tc 99m.
- radionuclide imaging : Bacterial Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Humans, Leukocytes, Middle Aged, Sensitivity and Specificity.
Abstract
Bacterial infection can pose a substantial diagnostic dilemma. Techniques involving radiolabelled leucocytes can pinpoint the site of inflammation. However, previous radiolabelling techniques have failed to distinguish between bacterial-mediated infection and non-bacterial inflammation. To overcome this difficulty, we have studied a radiopharmaceutical, technetium-99m (99mTc) Infecton, which is based on the antibiotic ciprofloxacin.
PubMed: 8551884
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection.</title><author><name sortKey="Vinjamuri, S" uniqKey="Vinjamuri S">S Vinjamuri</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield, London</wicri:regionArea></affiliation></author><author><name sortKey="Hall, A V" uniqKey="Hall A">A V Hall</name></author><author><name sortKey="Solanki, K K" uniqKey="Solanki K">K K Solanki</name></author><author><name sortKey="Bomanji, J" uniqKey="Bomanji J">J Bomanji</name></author><author><name sortKey="Siraj, Q" uniqKey="Siraj Q">Q Siraj</name></author><author><name sortKey="O Shaughnessy, E" uniqKey="O Shaughnessy E">E O'Shaughnessy</name></author><author><name sortKey="Das, S S" uniqKey="Das S">S S Das</name></author><author><name sortKey="Britton, K E" uniqKey="Britton K">K E Britton</name></author></titleStmt><publicationStmt><date when="1996">1996</date><idno type="RBID">pubmed:8551884</idno><idno type="pmid">8551884</idno><idno type="wicri:Area/Main/Corpus">004758</idno><idno type="wicri:Area/Main/Curation">004758</idno><idno type="wicri:Area/Main/Exploration">004482</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Bacterial Infections (radionuclide imaging)</term><term>Ciprofloxacin (diagnostic use)</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Leukocytes</term><term>Middle Aged</term><term>Sensitivity and Specificity</term><term>Sodium Pertechnetate Tc 99m (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Ciprofloxacin</term><term>Indium Radioisotopes</term><term>Sodium Pertechnetate Tc 99m</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Bacterial Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Leukocytes</term><term>Middle Aged</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bacterial infection can pose a substantial diagnostic dilemma. Techniques involving radiolabelled leucocytes can pinpoint the site of inflammation. However, previous radiolabelling techniques have failed to distinguish between bacterial-mediated infection and non-bacterial inflammation. To overcome this difficulty, we have studied a radiopharmaceutical, technetium-99m (99mTc) Infecton, which is based on the antibiotic ciprofloxacin.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8551884</PMID><DateCreated><Year>1996</Year><Month>02</Month><Day>16</Day></DateCreated><DateCompleted><Year>1996</Year><Month>02</Month><Day>16</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0140-6736</ISSN><JournalIssue CitedMedium="Print"><Volume>347</Volume><Issue>8996</Issue><PubDate><Year>1996</Year><Month>Jan</Month><Day>27</Day></PubDate></JournalIssue><Title>Lancet</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Comparison of 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection.</ArticleTitle><Pagination><MedlinePgn>233-5</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Bacterial infection can pose a substantial diagnostic dilemma. Techniques involving radiolabelled leucocytes can pinpoint the site of inflammation. However, previous radiolabelling techniques have failed to distinguish between bacterial-mediated infection and non-bacterial inflammation. To overcome this difficulty, we have studied a radiopharmaceutical, technetium-99m (99mTc) Infecton, which is based on the antibiotic ciprofloxacin.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used this agent to image bacterial infection in 56 patients (one twice) with known or suspected sites of infection. We then compared the imaging results of these patients with those from a radiolabelled leucocyte study.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">The concordance rate was 68% (39 out of 57 images). In 18 discordant results 99mTc Infecton was correctly positive in 8 out of 9 positive studies and correctly negative in 4 out of 9 negative studies. 4 out of 5 of the falsely negative studies were in patients who had taken antibiotics for over 7 days. We found that 99mTc Infecton gave better imaging results than radiolabelled leucocytes. Comparison between 99mTc Infecton and leucocyte imaging gave sensitivities of 84% and 81%, and specificities of 96% and 77%, respectively.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">We believe that the specificity 99mTc Infecton confers for bacterial infection and its ease of administration are the main advantages of this new agent.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vinjamuri</LastName><ForeName>S</ForeName><Initials>S</Initials><Affiliation>Department of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield, London, UK.</Affiliation></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>A V</ForeName><Initials>AV</Initials></Author><Author ValidYN="Y"><LastName>Solanki</LastName><ForeName>K K</ForeName><Initials>KK</Initials></Author><Author ValidYN="Y"><LastName>Bomanji</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Siraj</LastName><ForeName>Q</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>O'Shaughnessy</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Das</LastName><ForeName>S S</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Britton</LastName><ForeName>K E</ForeName><Initials>KE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ENGLAND</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>5E8K9I0O4U</RegistryNumber><NameOfSubstance>Ciprofloxacin</NameOfSubstance></Chemical><Chemical><RegistryNumber>A0730CX801</RegistryNumber><NameOfSubstance>Sodium Pertechnetate Tc 99m</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Ciprofloxacin</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Leukocytes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sodium Pertechnetate Tc 99m</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>1</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>1</Month><Day>27</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>1</Month><Day>27</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8551884</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004482 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004482 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:8551884
|texte= Comparison of 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8551884" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |