In vivo detection of stem cells grafted in infarcted rat myocardium.
Identifieur interne : 002D46 ( Main/Exploration ); précédent : 002D45; suivant : 002D47In vivo detection of stem cells grafted in infarcted rat myocardium.
Auteurs : RBID : pubmed:15872356English descriptors
- KwdEn :
- Animals, Image Enhancement (methods), Indium Radioisotopes (diagnostic use), Male, Myocardial Infarction (radionuclide imaging), Myocardial Infarction (surgery), Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Stem Cell Transplantation (methods), Stem Cells (radionuclide imaging), Technetium Tc 99m Sestamibi (diagnostic use), Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- chemical , diagnostic use : Indium Radioisotopes, Technetium Tc 99m Sestamibi.
- methods : Image Enhancement, Stem Cell Transplantation, Tomography, Emission-Computed, Single-Photon.
- radionuclide imaging : Myocardial Infarction, Stem Cells.
- surgery : Myocardial Infarction.
- Animals, Male, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity.
Abstract
The evaluation of stem cell-mediated cardiomyoplasty by noninvasive in vivo imaging is critical for its clinical application. We hypothesized that dual-tracer small-animal SPECT would allow simultaneous imaging of (99m)Tc-sestamibi to assess myocardial perfusion and of (111)In-labeled stem cells to delineate stem cell engraftment.
PubMed: 15872356
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vivo detection of stem cells grafted in infarcted rat myocardium.</title><author><name sortKey="Zhou, Rong" uniqKey="Zhou R">Rong Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Daniel H" uniqKey="Thomas D">Daniel H Thomas</name></author><author><name sortKey="Qiao, Hui" uniqKey="Qiao H">Hui Qiao</name></author><author><name sortKey="Bal, Harshali S" uniqKey="Bal H">Harshali S Bal</name></author><author><name sortKey="Choi, Seok Rye" uniqKey="Choi S">Seok-Rye Choi</name></author><author><name sortKey="Alavi, Abass" uniqKey="Alavi A">Abass Alavi</name></author><author><name sortKey="Ferrari, Victor A" uniqKey="Ferrari V">Victor A Ferrari</name></author><author><name sortKey="Kung, Hank F" uniqKey="Kung H">Hank F Kung</name></author><author><name sortKey="Acton, Paul D" uniqKey="Acton P">Paul D Acton</name></author></titleStmt><publicationStmt><date when="2005">2005</date><idno type="RBID">pubmed:15872356</idno><idno type="pmid">15872356</idno><idno type="wicri:Area/Main/Corpus">002F09</idno><idno type="wicri:Area/Main/Curation">002F09</idno><idno type="wicri:Area/Main/Exploration">002D46</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Image Enhancement (methods)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Male</term><term>Myocardial Infarction (radionuclide imaging)</term><term>Myocardial Infarction (surgery)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Stem Cell Transplantation (methods)</term><term>Stem Cells (radionuclide imaging)</term><term>Technetium Tc 99m Sestamibi (diagnostic use)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Technetium Tc 99m Sestamibi</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Enhancement</term><term>Stem Cell Transplantation</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Myocardial Infarction</term><term>Stem Cells</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The evaluation of stem cell-mediated cardiomyoplasty by noninvasive in vivo imaging is critical for its clinical application. We hypothesized that dual-tracer small-animal SPECT would allow simultaneous imaging of (99m)Tc-sestamibi to assess myocardial perfusion and of (111)In-labeled stem cells to delineate stem cell engraftment.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15872356</PMID><DateCreated><Year>2005</Year><Month>05</Month><Day>05</Day></DateCreated><DateCompleted><Year>2005</Year><Month>06</Month><Day>24</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0161-5505</ISSN><JournalIssue CitedMedium="Print"><Volume>46</Volume><Issue>5</Issue><PubDate><Year>2005</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>In vivo detection of stem cells grafted in infarcted rat myocardium.</ArticleTitle><Pagination><MedlinePgn>816-22</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">The evaluation of stem cell-mediated cardiomyoplasty by noninvasive in vivo imaging is critical for its clinical application. We hypothesized that dual-tracer small-animal SPECT would allow simultaneous imaging of (99m)Tc-sestamibi to assess myocardial perfusion and of (111)In-labeled stem cells to delineate stem cell engraftment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Three to 4 million rat embryonic cardiomyoblasts (H9c2 cells) were labeled with 11.1-14.8 MBq (0.3-0.4 mCi) of (111)In-oxyquinoline and then injected into the border zones of infarcted myocardium of rats. (111)In images were acquired with a SPECT scanner 2, 24, 48, 72, and 96 h after the stem cells were injected into the infarcted myocardium. To visualize the perfusion deficit in the infarcted myocardium, we injected 74 MBq (2 mCi) of (99m)Tc-sestamibi (Cardiolite) intravenously 48 h after grafting. Dual-isotope pinhole SPECT was used to image (99m)Tc-sestamibi uptake simultaneously with (111)In to delineate retention of (111)In-labeled stem cells. The presence of labeled stem cells was confirmed by autoradiography and histology.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">SPECT of (99m)Tc-sestamibi was used to delineate perfusion deficits and infarcted myocardium. Bull's-eye plots indicated that the (111)In signal from the labeled stem cells overlapped the perfusion deficits identified from the (99m)Tc-sestamibi images. The (111)In signal associated with the radiolabeled stem cells could be detected with SPECT of the heart for 96 h after engraftment.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study demonstrated the feasibility of using dual-isotope pinhole SPECT for high-resolution detection of perfusion deficits with (99m)Tc-sestamibi and with (111)In-labeled stem cells grafted into the region of the infarct.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Rong</ForeName><Initials>R</Initials><Affiliation>Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.</Affiliation></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Daniel H</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Qiao</LastName><ForeName>Hui</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Bal</LastName><ForeName>Harshali S</ForeName><Initials>HS</Initials></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Seok-Rye</ForeName><Initials>SR</Initials></Author><Author ValidYN="Y"><LastName>Alavi</LastName><ForeName>Abass</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ferrari</LastName><ForeName>Victor A</ForeName><Initials>VA</Initials></Author><Author ValidYN="Y"><LastName>Kung</LastName><ForeName>Hank F</ForeName><Initials>HF</Initials></Author><Author ValidYN="Y"><LastName>Acton</LastName><ForeName>Paul D</ForeName><Initials>PD</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>EB 000301</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB 001809</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB 002473</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 EB002473-01</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 EB002473-02</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType>Evaluation Studies</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, N.I.H., Extramural</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType><PublicationType>Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>971Z4W1S09</RegistryNumber><NameOfSubstance>Technetium Tc 99m Sestamibi</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1117-23</RefSource><PMID Version="1">10749705</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2785-90</RefSource><PMID Version="1">10716999</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 2000 Jul 28;478(1-2):151-8</RefSource><PMID Version="1">10922488</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neoplasia. 2000 Jan-Apr;2(1-2):118-38</RefSource><PMID Version="1">10933072</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2001 Mar 30;88(6):563-9</RefSource><PMID 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MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Image Enhancement</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Myocardial Infarction</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Stem Cell Transplantation</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Stem Cells</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Technetium Tc 99m Sestamibi</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS76120</OtherID><OtherID Source="NLM">PMC2579781</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>5</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>6</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>5</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">46/5/816</ArticleId><ArticleId IdType="pubmed">15872356</ArticleId><ArticleId IdType="pmc">PMC2579781</ArticleId><ArticleId IdType="mid">NIHMS76120</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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