Parametric images of antibody pharmacokinetics based on serial quantitative whole-body imaging and blood sampling.
Identifieur interne : 002604 ( Main/Exploration ); précédent : 002603; suivant : 002605Parametric images of antibody pharmacokinetics based on serial quantitative whole-body imaging and blood sampling.
Auteurs : RBID : pubmed:17673426English descriptors
- KwdEn :
- MESH :
- chemical , diagnostic use : Indium Radioisotopes.
- chemical , pharmacokinetics : Antibodies, Monoclonal.
- Humans, Models, Biological, Radiation Dosage, Radioimmunodetection.
Abstract
We present a method for pharmacokinetic modeling of distributions of (111)In-labeled monoclonal antibodies (mAbs) on individual pixels of planar scintillation-camera images.
DOI: 10.2967/jnumed.107.039503
PubMed: 17673426
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parametric images of antibody pharmacokinetics based on serial quantitative whole-body imaging and blood sampling.</title><author><name sortKey="Gleisner, Katarina Sj Green" uniqKey="Gleisner K">Katarina Sjögreen Gleisner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Radiation Physics, Clinical Sciences, Lund University Hospital, Lund, Sweden. katarina.sjogreen@med.lu.se</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Radiation Physics, Clinical Sciences, Lund University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Nickel, Mattias" uniqKey="Nickel M">Mattias Nickel</name></author><author><name sortKey="Linden, Ola" uniqKey="Linden O">Ola Lindén</name></author><author><name sortKey="Erlandsson, Kjell" uniqKey="Erlandsson K">Kjell Erlandsson</name></author><author><name sortKey="Wing Rdh, Karin" uniqKey="Wing Rdh K">Karin Wingårdh</name></author><author><name sortKey="Strand, Sven Erik" uniqKey="Strand S">Sven-Erik Strand</name></author></titleStmt><publicationStmt><date when="2007">2007</date><idno type="doi">10.2967/jnumed.107.039503</idno><idno type="RBID">pubmed:17673426</idno><idno type="pmid">17673426</idno><idno type="wicri:Area/Main/Corpus">002712</idno><idno type="wicri:Area/Main/Curation">002712</idno><idno type="wicri:Area/Main/Exploration">002604</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (pharmacokinetics)</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Models, Biological</term><term>Radiation Dosage</term><term>Radioimmunodetection</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Models, Biological</term><term>Radiation Dosage</term><term>Radioimmunodetection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We present a method for pharmacokinetic modeling of distributions of (111)In-labeled monoclonal antibodies (mAbs) on individual pixels of planar scintillation-camera images.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17673426</PMID><DateCreated><Year>2007</Year><Month>08</Month><Day>03</Day></DateCreated><DateCompleted><Year>2007</Year><Month>09</Month><Day>20</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0161-5505</ISSN><JournalIssue CitedMedium="Print"><Volume>48</Volume><Issue>8</Issue><PubDate><Year>2007</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Parametric images of antibody pharmacokinetics based on serial quantitative whole-body imaging and blood sampling.</ArticleTitle><Pagination><MedlinePgn>1369-78</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">We present a method for pharmacokinetic modeling of distributions of (111)In-labeled monoclonal antibodies (mAbs) on individual pixels of planar scintillation-camera images.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The method is applied to 2 sets of clinical whole-body images, each consisting of 6 consecutive images acquired over a week. Quantification is performed on a pixel basis, yielding images in units of Bq/pixel. The images acquired on the different occasions are registered using a nonrigid method, and for each pixel location a time-activity curve is obtained for which kinetic modeling is performed. The (111)In-mAb is assumed to be located in either the vascular or the extravascular space. The vascular content is assumed to follow the global blood kinetics as determined from blood samples, together with a model parameter alpha that describes the fraction of the whole-body blood volume present in the particular pixel. The rate of change of the extravascular compartment is described by a linear 1-tissue-compartment model with 2 rate constants, K'1 and k2, reflecting extravasation and washout, respectively. The model is optimized for each pixel position with regard to the values of the 3 parameters (alpha, K'1, and k2), resulting in 3 parametric images. From these, images of the cumulated activity in vascular and extravascular spaces are calculated, as is an image of the rate-constants ratio, which is closely related to the volume of distribution.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The resulting parametric images are analyzed in terms of the appearance of the time-activity curves at various locations. Results also include interpretation of the parametric images in their clinical context, and the location of regions that exhibit high extravasation and a low washout rate is compared with confirmed malignant sites.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Parametric imaging allows the study and analysis of the spatial and temporal distributions of mAbs simultaneously. Parametric imaging enhances regions where the pharmacokinetics differ from the surrounding tissue and provides a tool to detect and locate unexpected kinetic behavior, which is sometimes characteristic of malignant tissue. For dosimetry in radionuclide therapy, parametric imaging offers a less biased means of analyzing serial mAb images than traditional region-of-interest-based analysis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gleisner</LastName><ForeName>Katarina Sjögreen</ForeName><Initials>KS</Initials><Affiliation>Department of Medical Radiation Physics, Clinical Sciences, Lund University Hospital, Lund, Sweden. katarina.sjogreen@med.lu.se</Affiliation></Author><Author ValidYN="Y"><LastName>Nickel</LastName><ForeName>Mattias</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lindén</LastName><ForeName>Ola</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Erlandsson</LastName><ForeName>Kjell</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Wingårdh</LastName><ForeName>Karin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Strand</LastName><ForeName>Sven-Erik</ForeName><Initials>SE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiation Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radioimmunodetection</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>9</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">48/8/1369</ArticleId><ArticleId IdType="doi">10.2967/jnumed.107.039503</ArticleId><ArticleId IdType="pubmed">17673426</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002604 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002604 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:17673426
|texte= Parametric images of antibody pharmacokinetics based on serial quantitative whole-body imaging and blood sampling.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17673426" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |