Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies.
Identifieur interne : 002145 ( Main/Exploration ); précédent : 002144; suivant : 002146Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies.
Auteurs : RBID : pubmed:17387742English descriptors
- KwdEn :
- Adolescent, Adult, Brain Neoplasms (chemistry), Brain Neoplasms (pathology), Brain Neoplasms (radionuclide imaging), Brain Neoplasms (radiotherapy), Child, Child, Preschool, Cranial Irradiation (adverse effects), Diagnosis, Differential, Female, Humans, Indium Radioisotopes (diagnostic use), Infant, Magnetic Resonance Imaging, Male, Neoplasm Recurrence, Local (radionuclide imaging), Predictive Value of Tests, Radiation Injuries (etiology), Radiation Injuries (radionuclide imaging), Receptors, Somatostatin (analysis), Retrospective Studies, Sensitivity and Specificity, Somatostatin (analogs & derivatives), Somatostatin (diagnostic use), Tomography, Emission-Computed, Single-Photon, Tumor Markers, Biological (analysis).
- MESH :
- chemical , analogs & derivatives : Somatostatin.
- chemical , analysis : Receptors, Somatostatin, Tumor Markers, Biological.
- chemical , diagnostic use : Indium Radioisotopes, Somatostatin.
- adverse effects : Cranial Irradiation.
- chemistry : Brain Neoplasms.
- etiology : Radiation Injuries.
- pathology : Brain Neoplasms.
- radionuclide imaging : Brain Neoplasms, Neoplasm Recurrence, Local, Radiation Injuries.
- radiotherapy : Brain Neoplasms.
- Adolescent, Adult, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon.
Abstract
Somatostatin receptor scintigraphy (SRS) has been successfully used in imaging PBTs and, as a functional imaging modality, may be better able to differentiate tumor from scar/necrosis. This retrospective study evaluates the role of SRS in post-treatment surveillance of PBTs.
DOI: 10.1002/pbc.21194
PubMed: 17387742
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies.</title><author><name sortKey="Khanna, Geetika" uniqKey="Khanna G">Geetika Khanna</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. geetika-khanna@uiowa.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea></affiliation></author><author><name sortKey="O Dorisio, M Sue" uniqKey="O Dorisio M">M Sue O'Dorisio</name></author><author><name sortKey="Menda, Yusuf" uniqKey="Menda Y">Yusuf Menda</name></author><author><name sortKey="Glasier, Charles" uniqKey="Glasier C">Charles Glasier</name></author><author><name sortKey="Deyoung, Barry" uniqKey="Deyoung B">Barry Deyoung</name></author><author><name sortKey="Smith, Brian J" uniqKey="Smith B">Brian J Smith</name></author><author><name sortKey="Graham, Michael" uniqKey="Graham M">Michael Graham</name></author><author><name sortKey="Juweid, Malik" uniqKey="Juweid M">Malik Juweid</name></author></titleStmt><publicationStmt><date when="2008">2008</date><idno type="doi">10.1002/pbc.21194</idno><idno type="RBID">pubmed:17387742</idno><idno type="pmid">17387742</idno><idno type="wicri:Area/Main/Corpus">002842</idno><idno type="wicri:Area/Main/Curation">002842</idno><idno type="wicri:Area/Main/Exploration">002145</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Brain Neoplasms (chemistry)</term><term>Brain Neoplasms (pathology)</term><term>Brain Neoplasms (radionuclide imaging)</term><term>Brain Neoplasms (radiotherapy)</term><term>Child</term><term>Child, Preschool</term><term>Cranial Irradiation (adverse effects)</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Neoplasm Recurrence, Local (radionuclide imaging)</term><term>Predictive Value of Tests</term><term>Radiation Injuries (etiology)</term><term>Radiation Injuries (radionuclide imaging)</term><term>Receptors, Somatostatin (analysis)</term><term>Retrospective Studies</term><term>Sensitivity and Specificity</term><term>Somatostatin (analogs & derivatives)</term><term>Somatostatin (diagnostic use)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tumor Markers, Biological (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Somatostatin</term><term>Tumor Markers, Biological</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Somatostatin</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cranial Irradiation</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Brain Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Radiation Injuries</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain Neoplasms</term><term>Neoplasm Recurrence, Local</term><term>Radiation Injuries</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Brain Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Predictive Value of Tests</term><term>Retrospective Studies</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Somatostatin receptor scintigraphy (SRS) has been successfully used in imaging PBTs and, as a functional imaging modality, may be better able to differentiate tumor from scar/necrosis. This retrospective study evaluates the role of SRS in post-treatment surveillance of PBTs.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17387742</PMID><DateCreated><Year>2008</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>2008</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2009</Year><Month>01</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1545-5017</ISSN><JournalIssue CitedMedium="Internet"><Volume>50</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Pediatric blood & cancer</Title><ISOAbbreviation>Pediatr Blood Cancer</ISOAbbreviation></Journal><ArticleTitle>Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies.</ArticleTitle><Pagination><MedlinePgn>561-6</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Somatostatin receptor scintigraphy (SRS) has been successfully used in imaging PBTs and, as a functional imaging modality, may be better able to differentiate tumor from scar/necrosis. This retrospective study evaluates the role of SRS in post-treatment surveillance of PBTs.</AbstractText><AbstractText Label="PROCEDURE" NlmCategory="METHODS">Twenty children (age range: 7 months to 24 years, mean: 9 years) with known brain malignancies underwent serial SRS and MRI. The sensitivity and specificity of SRS and MRI were compared for surveillance scanning using patient outcome as the reference standard. Somatostatin receptors (sstrs) expression was determined by immunohistochemistry (IHC) of available tumor specimens.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">SRS was true positive (TP) in 15 of 16 patients with proven disease found post-resection (n = 5) or during follow-up (n = 11). In contrast, MRI was positive in 12 of these 16 patients and equivocal in another two patients where it could not distinguish between radiation necrosis and tumor recurrence. The two patients with false negative (FN) MRI and proven disease were positive by SRS. SRS was negative in all four patients with no evidence of disease by follow-up (mean follow-up = 58 months). The only patient with a FN SRS (TP by MRI) was one without IHC evidence of sstrs. SRS was TP in 7/7 tumors with IHC documented sstrs.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">SRS is a useful adjunct to MRI for post-treatment surveillance of sstr-positive PBTs, particularly when MRI is equivocal.</AbstractText><CopyrightInformation>(c) 2007 Wiley-Liss, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khanna</LastName><ForeName>Geetika</ForeName><Initials>G</Initials><Affiliation>Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. geetika-khanna@uiowa.edu</Affiliation></Author><Author ValidYN="Y"><LastName>O'Dorisio</LastName><ForeName>M Sue</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Menda</LastName><ForeName>Yusuf</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Glasier</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Deyoung</LastName><ForeName>Barry</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Brian J</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Graham</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Juweid</LastName><ForeName>Malik</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Evaluation Studies</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Blood Cancer</MedlineTA><NlmUniqueID>101186624</NlmUniqueID><ISSNLinking>1545-5009</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Receptors, Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Tumor Markers, Biological</NameOfSubstance></Chemical><Chemical><RegistryNumber>138661-02-6</RegistryNumber><NameOfSubstance>pentetreotide</NameOfSubstance></Chemical><Chemical><RegistryNumber>51110-01-1</RegistryNumber><NameOfSubstance>Somatostatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Brain Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="N">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cranial Irradiation</DescriptorName><QualifierName MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiation Injuries</DescriptorName><QualifierName MajorTopicYN="N">etiology</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Receptors, Somatostatin</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Somatostatin</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tumor Markers, Biological</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>3</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>2</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>3</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/pbc.21194</ArticleId><ArticleId IdType="pubmed">17387742</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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