Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In.
Identifieur interne : 002022 ( Main/Exploration ); précédent : 002021; suivant : 002023Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In.
Auteurs : RBID : pubmed:19289423English descriptors
- KwdEn :
- Animals, Cell Line, Tumor, Cell Survival, DNA, Antisense (administration & dosage), DNA, Antisense (chemistry), Drug Carriers (administration & dosage), Female, Indium Radioisotopes (administration & dosage), Indium Radioisotopes (chemistry), Mice, Mice, Nude, Nanoparticles (administration & dosage), Nanoparticles (chemistry), Neoplasms (pathology), Neoplasms (radiotherapy), Radiopharmaceuticals (administration & dosage), Radiopharmaceuticals (chemistry), Streptavidin (administration & dosage), Streptavidin (chemistry), Treatment Outcome.
- MESH :
- chemical , administration & dosage : DNA, Antisense, Drug Carriers, Indium Radioisotopes, Radiopharmaceuticals, Streptavidin.
- chemical , chemistry : DNA, Antisense, Indium Radioisotopes, Radiopharmaceuticals, Streptavidin.
- administration & dosage : Nanoparticles.
- chemistry : Nanoparticles.
- pathology : Neoplasms.
- radiotherapy : Neoplasms.
- Animals, Cell Line, Tumor, Cell Survival, Female, Mice, Mice, Nude, Treatment Outcome.
Abstract
When antisense oligomers are intracellular, they migrate to and are retained in the nucleus of tumor cells and therefore may be used to carry Auger electron-emitting radionuclides such as (111)In for effective tumor radiotherapy.
DOI: 10.2967/jnumed.108.056366
PubMed: 19289423
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In.</title><author><name sortKey="Liu, Xinrong" uniqKey="Liu X">Xinrong Liu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yi" uniqKey="Wang Y">Yi Wang</name></author><author><name sortKey="Nakamura, Kayoko" uniqKey="Nakamura K">Kayoko Nakamura</name></author><author><name sortKey="Kawauchi, Sumi" uniqKey="Kawauchi S">Sumi Kawauchi</name></author><author><name sortKey="Akalin, Ali" uniqKey="Akalin A">Ali Akalin</name></author><author><name sortKey="Cheng, Dengfeng" uniqKey="Cheng D">Dengfeng Cheng</name></author><author><name sortKey="Chen, Ling" uniqKey="Chen L">Ling Chen</name></author><author><name sortKey="Rusckowski, Mary" uniqKey="Rusckowski M">Mary Rusckowski</name></author><author><name sortKey="Hnatowich, Donald J" uniqKey="Hnatowich D">Donald J Hnatowich</name></author></titleStmt><publicationStmt><date when="2009">2009</date><idno type="doi">10.2967/jnumed.108.056366</idno><idno type="RBID">pubmed:19289423</idno><idno type="pmid">19289423</idno><idno type="wicri:Area/Main/Corpus">001F75</idno><idno type="wicri:Area/Main/Curation">001F75</idno><idno type="wicri:Area/Main/Exploration">002022</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Cell Survival</term><term>DNA, Antisense (administration & dosage)</term><term>DNA, Antisense (chemistry)</term><term>Drug Carriers (administration & dosage)</term><term>Female</term><term>Indium Radioisotopes (administration & dosage)</term><term>Indium Radioisotopes (chemistry)</term><term>Mice</term><term>Mice, Nude</term><term>Nanoparticles (administration & dosage)</term><term>Nanoparticles (chemistry)</term><term>Neoplasms (pathology)</term><term>Neoplasms (radiotherapy)</term><term>Radiopharmaceuticals (administration & dosage)</term><term>Radiopharmaceuticals (chemistry)</term><term>Streptavidin (administration & dosage)</term><term>Streptavidin (chemistry)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>DNA, Antisense</term><term>Drug Carriers</term><term>Indium Radioisotopes</term><term>Radiopharmaceuticals</term><term>Streptavidin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Antisense</term><term>Indium Radioisotopes</term><term>Radiopharmaceuticals</term><term>Streptavidin</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Cell Survival</term><term>Female</term><term>Mice</term><term>Mice, Nude</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">When antisense oligomers are intracellular, they migrate to and are retained in the nucleus of tumor cells and therefore may be used to carry Auger electron-emitting radionuclides such as (111)In for effective tumor radiotherapy.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19289423</PMID><DateCreated><Year>2009</Year><Month>04</Month><Day>02</Day></DateCreated><DateCompleted><Year>2009</Year><Month>06</Month><Day>22</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0161-5505</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>4</Issue><PubDate><Year>2009</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In.</ArticleTitle><Pagination><MedlinePgn>582-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2967/jnumed.108.056366</ELocationID><Abstract><AbstractText Label="UNLABELLED">When antisense oligomers are intracellular, they migrate to and are retained in the nucleus of tumor cells and therefore may be used to carry Auger electron-emitting radionuclides such as (111)In for effective tumor radiotherapy.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Our nanoparticle consists of streptavidin that links 3 biotinylated components: the antiHer2 antibody trastuzumab (to improve pharmacokinetics), the tat peptide (to improve cell membrane transport), and the (111)In-labeled antiRIalpha messenger RNA antisense morpholino (MORF) oligomer.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">As evidence of unimpaired function, tumor cell and nuclear accumulations were orders of magnitude higher after incubation with (99m)Tc-MORF/tat/trastuzumab than after incubation with free (99m)Tc-MORF and significantly higher with the antisense than with the sense MORF. In mice, tumor and normal-tissue accumulations of the (99m)Tc-MORF/tat/trastuzumab nanoparticle were comparable to those of free (99m)Tc-trastuzumab, confirming the improved pharmacokinetics due to the trastuzumab component. Although kidneys, liver, and other normal tissues also accumulated the nanoparticle, immunohistochemical evaluation of tissue sections in mice receiving the Cy3-MORF/tat/trastuzumab nanoparticle showed evidence of nuclear accumulation only in tumor tissue. In a dose escalation study, as measured by the surviving fraction, the nanoparticle significantly increased the kill of SK-BR-3 breast cancer Her2+/RIalpha+ cells, compared with all controls.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Significant radiation-induced antisense-mediated cytotoxicity of tumor cells in vitro was achieved using an Auger electron-emitting antisense MORF oligomer administered as a member of a 3-component streptavidin-delivery nanoparticle.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xinrong</ForeName><Initials>X</Initials><Affiliation>Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.</Affiliation></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Kayoko</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kawauchi</LastName><ForeName>Sumi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Akalin</LastName><ForeName>Ali</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Dengfeng</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ling</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Rusckowski</LastName><ForeName>Mary</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hnatowich</LastName><ForeName>Donald J</ForeName><Initials>DJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21CA129591</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, N.I.H., Extramural</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType><PublicationType>Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>DNA, Antisense</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Drug Carriers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>9013-20-1</RegistryNumber><NameOfSubstance>Streptavidin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">DNA, Antisense</DescriptorName><QualifierName MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Drug Carriers</DescriptorName><QualifierName MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Nude</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Nanoparticles</DescriptorName><QualifierName MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">pathology</QualifierName><QualifierName MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Streptavidin</DescriptorName><QualifierName MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2009</Year><Month>3</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>6</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">jnumed.108.056366</ArticleId><ArticleId IdType="doi">10.2967/jnumed.108.056366</ArticleId><ArticleId IdType="pubmed">19289423</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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