A new method for the radiochemical purity measurement of ¹¹¹In-pentetreotide.
Identifieur interne : 001629 ( Main/Exploration ); précédent : 001628; suivant : 001630A new method for the radiochemical purity measurement of ¹¹¹In-pentetreotide.
Auteurs : RBID : pubmed:21946620English descriptors
- KwdEn :
- Chromatography, Thin Layer (methods), Citric Acid, Glass, Glucose (analogs & derivatives), Humans, Indium Radioisotopes, Radiochemistry (methods), Radiopharmaceuticals (analysis), Radiopharmaceuticals (standards), Reproducibility of Results, Silica Gel, Somatostatin (analogs & derivatives), Somatostatin (analysis), Somatostatin (standards).
- MESH :
- chemical , analogs & derivatives : Glucose, Somatostatin.
- chemical , analysis : Radiopharmaceuticals, Somatostatin.
- chemical , standards : Radiopharmaceuticals, Somatostatin.
- chemical : Citric Acid, Indium Radioisotopes, Silica Gel.
- methods : Chromatography, Thin Layer, Radiochemistry.
- Glass, Humans, Reproducibility of Results.
Abstract
The recommended method for the measurement of radiochemical purity (RCP) of ¹¹¹In-labelled pentetreotide is thin-layer chromatography with a silica gel as the stationary phase and a 0.1 N sodium citrate solution (pH 5) as the mobile phase. According to the supplier's instructions, the mobile phase must be prepared before the test is carried out, and the recommended stationary phase is off-market. We propose a new method for RCP measurement in which the mobile phase is acid citrate dextrose, solution A, which does not need to be prepared beforehand, and thin-layer chromatography is performed with a silica gel-impregnated glass fibre sheet as the stationary phase. We used both methods to measure the percentages of radiopharmaceutical and impurities.
DOI: 10.1097/MNM.0b013e32834a7003
PubMed: 21946620
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A new method for the radiochemical purity measurement of ¹¹¹In-pentetreotide.</title><author><name sortKey="Salgado Garcia, Carlos" uniqKey="Salgado Garcia C">Carlos Salgado-Garcia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, Radiopharmacy Unit, Hospital Juan Ramon Jimenez, Huelva, Spain. carlos.salgado.garcia@gmail.com</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nuclear Medicine, Radiopharmacy Unit, Hospital Juan Ramon Jimenez, Huelva</wicri:regionArea></affiliation></author><author><name sortKey="Montoza Aguado, Manuel" uniqKey="Montoza Aguado M">Manuel Montoza-Aguado</name></author><author><name sortKey="Luna Alcaide, Ana B" uniqKey="Luna Alcaide A">Ana B Luna-Alcaide</name></author><author><name sortKey="Segovia Gonzalez, Maria M" uniqKey="Segovia Gonzalez M">Maria M Segovia-Gonzalez</name></author><author><name sortKey="De Mora, Elena Sanchez" uniqKey="De Mora E">Elena Sanchez de Mora</name></author><author><name sortKey="Lopez Martin, Juana" uniqKey="Lopez Martin J">Juana Lopez-Martin</name></author><author><name sortKey="Ramos Font, Carlos" uniqKey="Ramos Font C">Carlos Ramos-Font</name></author><author><name sortKey="Jimenez Heffernan, Amelia" uniqKey="Jimenez Heffernan A">Amelia Jimenez-Heffernan</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1097/MNM.0b013e32834a7003</idno><idno type="RBID">pubmed:21946620</idno><idno type="pmid">21946620</idno><idno type="wicri:Area/Main/Corpus">001138</idno><idno type="wicri:Area/Main/Curation">001138</idno><idno type="wicri:Area/Main/Exploration">001629</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromatography, Thin Layer (methods)</term><term>Citric Acid</term><term>Glass</term><term>Glucose (analogs & derivatives)</term><term>Humans</term><term>Indium Radioisotopes</term><term>Radiochemistry (methods)</term><term>Radiopharmaceuticals (analysis)</term><term>Radiopharmaceuticals (standards)</term><term>Reproducibility of Results</term><term>Silica Gel</term><term>Somatostatin (analogs & derivatives)</term><term>Somatostatin (analysis)</term><term>Somatostatin (standards)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Glucose</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Radiopharmaceuticals</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="standards" xml:lang="en"><term>Radiopharmaceuticals</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Citric Acid</term><term>Indium Radioisotopes</term><term>Silica Gel</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Thin Layer</term><term>Radiochemistry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Glass</term><term>Humans</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recommended method for the measurement of radiochemical purity (RCP) of ¹¹¹In-labelled pentetreotide is thin-layer chromatography with a silica gel as the stationary phase and a 0.1 N sodium citrate solution (pH 5) as the mobile phase. According to the supplier's instructions, the mobile phase must be prepared before the test is carried out, and the recommended stationary phase is off-market. We propose a new method for RCP measurement in which the mobile phase is acid citrate dextrose, solution A, which does not need to be prepared beforehand, and thin-layer chromatography is performed with a silica gel-impregnated glass fibre sheet as the stationary phase. We used both methods to measure the percentages of radiopharmaceutical and impurities.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21946620</PMID><DateCreated><Year>2011</Year><Month>11</Month><Day>02</Day></DateCreated><DateCompleted><Year>2012</Year><Month>03</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5628</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>12</Issue><PubDate><Year>2011</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Nuclear medicine communications</Title><ISOAbbreviation>Nucl Med Commun</ISOAbbreviation></Journal><ArticleTitle>A new method for the radiochemical purity measurement of ¹¹¹In-pentetreotide.</ArticleTitle><Pagination><MedlinePgn>1241-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MNM.0b013e32834a7003</ELocationID><Abstract><AbstractText Label="OBJECTIVES AND METHODS" NlmCategory="OBJECTIVE">The recommended method for the measurement of radiochemical purity (RCP) of ¹¹¹In-labelled pentetreotide is thin-layer chromatography with a silica gel as the stationary phase and a 0.1 N sodium citrate solution (pH 5) as the mobile phase. According to the supplier's instructions, the mobile phase must be prepared before the test is carried out, and the recommended stationary phase is off-market. We propose a new method for RCP measurement in which the mobile phase is acid citrate dextrose, solution A, which does not need to be prepared beforehand, and thin-layer chromatography is performed with a silica gel-impregnated glass fibre sheet as the stationary phase. We used both methods to measure the percentages of radiopharmaceutical and impurities.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The range of RCP values obtained was 98.0-99.9% (mean=99.3%) by the standard method and 98.1-99.9% (mean=99.2%) by the new method. We observed no differences between the RCP values of both methods (P=0.070).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The proposed method is suitable for RCP testing because it yields results that are in good agreement with those of the standard method and because it is easier to perform as the mobile-phase solution need not be prepared in advance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Salgado-Garcia</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><Affiliation>Department of Nuclear Medicine, Radiopharmacy Unit, Hospital Juan Ramon Jimenez, Huelva, Spain. carlos.salgado.garcia@gmail.com</Affiliation></Author><Author ValidYN="Y"><LastName>Montoza-Aguado</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Luna-Alcaide</LastName><ForeName>Ana B</ForeName><Initials>AB</Initials></Author><Author ValidYN="Y"><LastName>Segovia-Gonzalez</LastName><ForeName>Maria M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>de Mora</LastName><ForeName>Elena Sanchez</ForeName><Initials>ES</Initials></Author><Author ValidYN="Y"><LastName>Lopez-Martin</LastName><ForeName>Juana</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ramos-Font</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Jimenez-Heffernan</LastName><ForeName>Amelia</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucl Med Commun</MedlineTA><NlmUniqueID>8201017</NlmUniqueID><ISSNLinking>0143-3636</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>fiberglass</NameOfSubstance></Chemical><Chemical><RegistryNumber>13838-07-8</RegistryNumber><NameOfSubstance>acid citrate dextrose</NameOfSubstance></Chemical><Chemical><RegistryNumber>138661-02-6</RegistryNumber><NameOfSubstance>pentetreotide</NameOfSubstance></Chemical><Chemical><RegistryNumber>2968PHW8QP</RegistryNumber><NameOfSubstance>Citric Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>51110-01-1</RegistryNumber><NameOfSubstance>Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>60650-90-0</RegistryNumber><NameOfSubstance>Silica Gel</NameOfSubstance></Chemical><Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber><NameOfSubstance>Glucose</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Chromatography, Thin Layer</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Citric Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Glass</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Glucose</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiochemistry</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">analysis</QualifierName><QualifierName MajorTopicYN="Y">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Silica Gel</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Somatostatin</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">analysis</QualifierName><QualifierName MajorTopicYN="N">standards</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1097/MNM.0b013e32834a7003</ArticleId><ArticleId IdType="pubmed">21946620</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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