Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma.
Identifieur interne : 001580 ( Main/Exploration ); précédent : 001579; suivant : 001581Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma.
Auteurs : RBID : pubmed:20686856English descriptors
- KwdEn :
- Animals, B-Cell Activating Factor (administration & dosage), B-Cell Activating Factor (blood), B-Cell Activating Factor (pharmacokinetics), Cell Death, Cell Line, Tumor, Chromatography, Thin Layer, Female, Humans, Indium Radioisotopes (administration & dosage), Indium Radioisotopes (blood), Indium Radioisotopes (pharmacokinetics), Injections, Intravenous, Lymphoma, B-Cell (blood), Lymphoma, B-Cell (pathology), Lymphoma, B-Cell (radiography), Lymphoma, B-Cell (radionuclide imaging), Mice, Mice, Inbred BALB C, Mice, SCID, Pentetic Acid (metabolism), Recombinant Fusion Proteins (administration & dosage), Recombinant Fusion Proteins (blood), Recombinant Fusion Proteins (pharmacokinetics), Ribosome Inactivating Proteins, Type 1 (administration & dosage), Ribosome Inactivating Proteins, Type 1 (blood), Ribosome Inactivating Proteins, Type 1 (pharmacokinetics), Staining and Labeling, Tissue Distribution, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
- MESH :
- chemical , administration & dosage : B-Cell Activating Factor, Indium Radioisotopes, Recombinant Fusion Proteins, Ribosome Inactivating Proteins, Type 1.
- chemical , blood : B-Cell Activating Factor, Indium Radioisotopes, Recombinant Fusion Proteins, Ribosome Inactivating Proteins, Type 1.
- chemical , metabolism : Pentetic Acid.
- chemical , pharmacokinetics : B-Cell Activating Factor, Indium Radioisotopes, Recombinant Fusion Proteins, Ribosome Inactivating Proteins, Type 1.
- blood : Lymphoma, B-Cell.
- pathology : Lymphoma, B-Cell.
- radiography : Lymphoma, B-Cell.
- radionuclide imaging : Lymphoma, B-Cell.
- Animals, Cell Death, Cell Line, Tumor, Chromatography, Thin Layer, Female, Humans, Injections, Intravenous, Mice, Mice, Inbred BALB C, Mice, SCID, Staining and Labeling, Tissue Distribution, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
Abstract
We examined the biodistribution and pharmacokinetics of (111)In-labeled rGel/BLyS, a gelonin toxin (rGel)-B lymphocyte stimulator (BLyS) fusion protein.
DOI: 10.1007/s11307-010-0391-0
PubMed: 20686856
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma.</title><author><name sortKey="Wen, Xiaoxia" uniqKey="Wen X">Xiaoxia Wen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030</wicri:regionArea></affiliation></author><author><name sortKey="Lyu, Mi Ae" uniqKey="Lyu M">Mi-Ae Lyu</name></author><author><name sortKey="Zhang, Rui" uniqKey="Zhang R">Rui Zhang</name></author><author><name sortKey="Lu, Wei" uniqKey="Lu W">Wei Lu</name></author><author><name sortKey="Huang, Qian" uniqKey="Huang Q">Qian Huang</name></author><author><name sortKey="Liang, Dong" uniqKey="Liang D">Dong Liang</name></author><author><name sortKey="Rosenblum, Michael G" uniqKey="Rosenblum M">Michael G Rosenblum</name></author><author><name sortKey="Li, Chun" uniqKey="Li C">Chun Li</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1007/s11307-010-0391-0</idno><idno type="RBID">pubmed:20686856</idno><idno type="pmid">20686856</idno><idno type="wicri:Area/Main/Corpus">001824</idno><idno type="wicri:Area/Main/Curation">001824</idno><idno type="wicri:Area/Main/Exploration">001580</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>B-Cell Activating Factor (administration & dosage)</term><term>B-Cell Activating Factor (blood)</term><term>B-Cell Activating Factor (pharmacokinetics)</term><term>Cell Death</term><term>Cell Line, Tumor</term><term>Chromatography, Thin Layer</term><term>Female</term><term>Humans</term><term>Indium Radioisotopes (administration & dosage)</term><term>Indium Radioisotopes (blood)</term><term>Indium Radioisotopes (pharmacokinetics)</term><term>Injections, Intravenous</term><term>Lymphoma, B-Cell (blood)</term><term>Lymphoma, B-Cell (pathology)</term><term>Lymphoma, B-Cell (radiography)</term><term>Lymphoma, B-Cell (radionuclide imaging)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, SCID</term><term>Pentetic Acid (metabolism)</term><term>Recombinant Fusion Proteins (administration & dosage)</term><term>Recombinant Fusion Proteins (blood)</term><term>Recombinant Fusion Proteins (pharmacokinetics)</term><term>Ribosome Inactivating Proteins, Type 1 (administration & dosage)</term><term>Ribosome Inactivating Proteins, Type 1 (blood)</term><term>Ribosome Inactivating Proteins, Type 1 (pharmacokinetics)</term><term>Staining and Labeling</term><term>Tissue Distribution</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>B-Cell Activating Factor</term><term>Indium Radioisotopes</term><term>Recombinant Fusion Proteins</term><term>Ribosome Inactivating Proteins, Type 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>B-Cell Activating Factor</term><term>Indium Radioisotopes</term><term>Recombinant Fusion Proteins</term><term>Ribosome Inactivating Proteins, Type 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Pentetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>B-Cell Activating Factor</term><term>Indium Radioisotopes</term><term>Recombinant Fusion Proteins</term><term>Ribosome Inactivating Proteins, Type 1</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Lymphoma, B-Cell</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphoma, B-Cell</term></keywords><keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Lymphoma, B-Cell</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Lymphoma, B-Cell</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Death</term><term>Cell Line, Tumor</term><term>Chromatography, Thin Layer</term><term>Female</term><term>Humans</term><term>Injections, Intravenous</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, SCID</term><term>Staining and Labeling</term><term>Tissue Distribution</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the biodistribution and pharmacokinetics of (111)In-labeled rGel/BLyS, a gelonin toxin (rGel)-B lymphocyte stimulator (BLyS) fusion protein.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20686856</PMID><DateCreated><Year>2011</Year><Month>07</Month><Day>01</Day></DateCreated><DateCompleted><Year>2011</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2014</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1860-2002</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging</Title><ISOAbbreviation>Mol Imaging Biol</ISOAbbreviation></Journal><ArticleTitle>Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma.</ArticleTitle><Pagination><MedlinePgn>721-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11307-010-0391-0</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">We examined the biodistribution and pharmacokinetics of (111)In-labeled rGel/BLyS, a gelonin toxin (rGel)-B lymphocyte stimulator (BLyS) fusion protein.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">rGel/BLyS was labeled with In-111 through DTPA with a labeling efficiency >95%. Biodistribution/imaging studies were obtained in severe-combined immunodeficiency mice bearing diffuse large B cell lymphoma OCI-Ly10. Pharmacokinetic studies were performed in BALB/c mice.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In vitro, DTPA-conjugated rGel/BLyS displayed selective cytotoxicity against OCI-Ly10 cells and mantle cell lymphoma JeKo cells. In vivo, rGel/BLyS exhibited a tri-exponential disposition with a rapid initial mean distribution followed by an extensive mean distribution and a long terminal elimination phase. At 48 h after injection, uptake of the radiotracer in tumors was 1.25 %ID/g, with a tumor-to-blood ratio of 13. Tumors were clearly visualized at 24-72 h post-injection. Micro-SPECT-CT images and ex vivo analyses confirmed the accumulation of rGel/BLyS in OCI-Ly10 tumors.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">(111)In-DTPA-rGel/BLyS are distributed to B cell tumors and induce apoptosis in tumors. Preclinical antitumor studies using rGel/BLyS should use a twice-per-week treatment schedule.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Xiaoxia</ForeName><Initials>X</Initials><Affiliation>Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.</Affiliation></Author><Author ValidYN="Y"><LastName>Lyu</LastName><ForeName>Mi-Ae</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Rui</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Qian</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Dong</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Rosenblum</LastName><ForeName>Michael G</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chun</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA016672</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, N.I.H., Extramural</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Imaging Biol</MedlineTA><NlmUniqueID>101125610</NlmUniqueID><ISSNLinking>1536-1632</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>B-Cell Activating Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Recombinant Fusion Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Ribosome Inactivating Proteins, Type 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>75037-46-6</RegistryNumber><NameOfSubstance>GEL protein, Gelonium multiflorum</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">B-Cell Activating Factor</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chromatography, Thin Layer</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Injections, Intravenous</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lymphoma, B-Cell</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="N">radiography</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, SCID</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Recombinant Fusion Proteins</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Ribosome Inactivating Proteins, Type 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