Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats.
Identifieur interne : 001061 ( Main/Exploration ); précédent : 001060; suivant : 001062Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats.
Auteurs : RBID : pubmed:21233592English descriptors
- KwdEn :
- Administration, Inhalation, Animals, Female, Indium (blood), Indium (toxicity), Inhalation Exposure (adverse effects), Macrophages, Alveolar (drug effects), Macrophages, Alveolar (pathology), Male, Pulmonary Alveolar Proteinosis (chemically induced), Pulmonary Alveolar Proteinosis (pathology), Pulmonary Fibrosis (chemically induced), Pulmonary Fibrosis (pathology), Rats, Rats, Inbred F344, Time Factors, Tin Compounds (blood), Tin Compounds (toxicity).
- MESH :
- chemical , blood : Indium, Tin Compounds.
- chemical , toxicity : Indium, Tin Compounds.
- adverse effects : Inhalation Exposure.
- chemically induced : Pulmonary Alveolar Proteinosis, Pulmonary Fibrosis.
- drug effects : Macrophages, Alveolar.
- pathology : Macrophages, Alveolar, Pulmonary Alveolar Proteinosis, Pulmonary Fibrosis.
- Administration, Inhalation, Animals, Female, Male, Rats, Rats, Inbred F344, Time Factors.
Abstract
Two- and 13-week inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) were characterized for risk assessments of workers exposed to ITO.
PubMed: 21233592
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats.</title><author><name sortKey="Nagano, Kasuke" uniqKey="Nagano K">Kasuke Nagano</name><affiliation><nlm:affiliation>Japan Bioassay Research Center, Japan Industrial Safety and Health Association.</nlm:affiliation><wicri:noCountry code="subField">Japan Industrial Safety and Health Association</wicri:noCountry></affiliation></author><author><name sortKey="Gotoh, Kaoru" uniqKey="Gotoh K">Kaoru Gotoh</name></author><author><name sortKey="Kasai, Tatsuya" uniqKey="Kasai T">Tatsuya Kasai</name></author><author><name sortKey="Aiso, Shigetoshi" uniqKey="Aiso S">Shigetoshi Aiso</name></author><author><name sortKey="Nishizawa, Tomoshi" uniqKey="Nishizawa T">Tomoshi Nishizawa</name></author><author><name sortKey="Ohnishi, Makoto" uniqKey="Ohnishi M">Makoto Ohnishi</name></author><author><name sortKey="Ikawa, Naoki" uniqKey="Ikawa N">Naoki Ikawa</name></author><author><name sortKey="Eitaki, Yoko" uniqKey="Eitaki Y">Yoko Eitaki</name></author><author><name sortKey="Yamada, Kenichi" uniqKey="Yamada K">Kenichi Yamada</name></author><author><name sortKey="Arito, Heihachiro" uniqKey="Arito H">Heihachiro Arito</name></author><author><name sortKey="Fukushima, Shoji" uniqKey="Fukushima S">Shoji Fukushima</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="RBID">pubmed:21233592</idno><idno type="pmid">21233592</idno><idno type="wicri:Area/Main/Corpus">001612</idno><idno type="wicri:Area/Main/Curation">001612</idno><idno type="wicri:Area/Main/Exploration">001061</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Inhalation</term><term>Animals</term><term>Female</term><term>Indium (blood)</term><term>Indium (toxicity)</term><term>Inhalation Exposure (adverse effects)</term><term>Macrophages, Alveolar (drug effects)</term><term>Macrophages, Alveolar (pathology)</term><term>Male</term><term>Pulmonary Alveolar Proteinosis (chemically induced)</term><term>Pulmonary Alveolar Proteinosis (pathology)</term><term>Pulmonary Fibrosis (chemically induced)</term><term>Pulmonary Fibrosis (pathology)</term><term>Rats</term><term>Rats, Inbred F344</term><term>Time Factors</term><term>Tin Compounds (blood)</term><term>Tin Compounds (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Indium</term><term>Tin Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Indium</term><term>Tin Compounds</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Inhalation Exposure</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Pulmonary Alveolar Proteinosis</term><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages, Alveolar</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Macrophages, Alveolar</term><term>Pulmonary Alveolar Proteinosis</term><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Inhalation</term><term>Animals</term><term>Female</term><term>Male</term><term>Rats</term><term>Rats, Inbred F344</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two- and 13-week inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) were characterized for risk assessments of workers exposed to ITO.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21233592</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>20</Day></DateCreated><DateCompleted><Year>2011</Year><Month>08</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1348-9585</ISSN><JournalIssue CitedMedium="Internet"><Volume>53</Volume><Issue>2</Issue><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>Journal of occupational health</Title><ISOAbbreviation>J Occup Health</ISOAbbreviation></Journal><ArticleTitle>Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats.</ArticleTitle><Pagination><MedlinePgn>51-63</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Two- and 13-week inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) were characterized for risk assessments of workers exposed to ITO.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">F344 rats of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk at 0, 0.1 or 1 mg/m(3). An aerosol generator and inhalation exposure system was constructed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Blood and lung contents of indium were elevated in a dose-related manner in the ITO- and IO-exposed rats. ITO and IO particles were deposited in the lung, mediastinal lymph node and nasal-associated lymphoid tissue. Exposures to ITO and IO induced alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and alveolar epithelial hyperplasia in addition to increased lung weight. ITO affected the lung more severely than IO did. Fibrosis of alveolar wall developed and some of these lesions worsened at the end of the 26-week post-exposure period.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Persistent pulmonary lesions including alveolar proteinosis and macrophage infiltration occurred after 2- and 13-week inhalation exposures of rats to ITO and IO. Fibrosis of alveolar wall developed later. These lesions occurred after ITO exposure at the same concentration as the current occupational exposure limit in the USA and at blood indium levels below the biological exposure index in Japan for indium.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nagano</LastName><ForeName>Kasuke</ForeName><Initials>K</Initials><Affiliation>Japan Bioassay Research Center, Japan Industrial Safety and Health Association.</Affiliation></Author><Author ValidYN="Y"><LastName>Gotoh</LastName><ForeName>Kaoru</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kasai</LastName><ForeName>Tatsuya</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Aiso</LastName><ForeName>Shigetoshi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Nishizawa</LastName><ForeName>Tomoshi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Ohnishi</LastName><ForeName>Makoto</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ikawa</LastName><ForeName>Naoki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Eitaki</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Yamada</LastName><ForeName>Kenichi</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Arito</LastName><ForeName>Heihachiro</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Fukushima</LastName><ForeName>Shoji</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>01</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>J Occup Health</MedlineTA><NlmUniqueID>9616320</NlmUniqueID><ISSNLinking>1341-9145</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Tin Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>4OO9KME22D</RegistryNumber><NameOfSubstance>indium oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>71243-84-0</RegistryNumber><NameOfSubstance>indium tin oxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Administration, Inhalation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Inhalation Exposure</DescriptorName><QualifierName MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Macrophages, Alveolar</DescriptorName><QualifierName MajorTopicYN="N">drug effects</QualifierName><QualifierName MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pulmonary Alveolar Proteinosis</DescriptorName><QualifierName MajorTopicYN="N">chemically induced</QualifierName><QualifierName MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pulmonary Fibrosis</DescriptorName><QualifierName MajorTopicYN="N">chemically induced</QualifierName><QualifierName MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats, Inbred F344</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tin Compounds</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>1</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">JST.JSTAGE/joh/L10128</ArticleId><ArticleId IdType="pubmed">21233592</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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