CMOS image sensor-based immunodetection by refractive-index change.
Identifieur interne : 000F69 ( Main/Exploration ); précédent : 000F68; suivant : 000F70CMOS image sensor-based immunodetection by refractive-index change.
Auteurs : RBID : pubmed:22975915English descriptors
- KwdEn :
- MESH :
- chemical , analysis : C-Reactive Protein, Troponin I.
- chemical , chemistry : Indium, Oxides.
- chemistry : Metal Nanoparticles.
- Antigen-Antibody Reactions, Biosensing Techniques, Semiconductors.
Abstract
A complementary metal oxide semiconductor (CMOS) image sensor is an intriguing technology for the development of a novel biosensor. Indeed, the CMOS image sensor mechanism concerning the detection of the antigen-antibody (Ag-Ab) interaction at the nanoscale has been ambiguous so far. To understand the mechanism, more extensive research has been necessary to achieve point-of-care diagnostic devices. This research has demonstrated a CMOS image sensor-based analysis of cardiovascular disease markers, such as C-reactive protein (CRP) and troponin I, Ag-Ab interactions on indium nanoparticle (InNP) substrates by simple photon count variation. The developed sensor is feasible to detect proteins even at a fg/mL concentration under ordinary room light. Possible mechanisms, such as dielectric constant and refractive-index changes, have been studied and proposed. A dramatic change in the refractive index after protein adsorption on an InNP substrate was observed to be a predominant factor involved in CMOS image sensor-based immunoassay.
PubMed: 22975915
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CMOS image sensor-based immunodetection by refractive-index change.</title><author><name sortKey="Devadhasan, Jasmine P" uniqKey="Devadhasan J">Jasmine P Devadhasan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bionanotechnology, Gachon University, Gyeonggi-Do, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Bionanotechnology, Gachon University, Gyeonggi-Do</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Sanghyo" uniqKey="Kim S">Sanghyo Kim</name></author></titleStmt><publicationStmt><date when="2012">2012</date><idno type="RBID">pubmed:22975915</idno><idno type="pmid">22975915</idno><idno type="wicri:Area/Main/Corpus">000A48</idno><idno type="wicri:Area/Main/Curation">000A48</idno><idno type="wicri:Area/Main/Exploration">000F69</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen-Antibody Reactions</term><term>Biosensing Techniques</term><term>C-Reactive Protein (analysis)</term><term>Indium (chemistry)</term><term>Metal Nanoparticles (chemistry)</term><term>Oxides (chemistry)</term><term>Semiconductors</term><term>Troponin I (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term><term>Troponin I</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Indium</term><term>Oxides</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Antigen-Antibody Reactions</term><term>Biosensing Techniques</term><term>Semiconductors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A complementary metal oxide semiconductor (CMOS) image sensor is an intriguing technology for the development of a novel biosensor. Indeed, the CMOS image sensor mechanism concerning the detection of the antigen-antibody (Ag-Ab) interaction at the nanoscale has been ambiguous so far. To understand the mechanism, more extensive research has been necessary to achieve point-of-care diagnostic devices. This research has demonstrated a CMOS image sensor-based analysis of cardiovascular disease markers, such as C-reactive protein (CRP) and troponin I, Ag-Ab interactions on indium nanoparticle (InNP) substrates by simple photon count variation. The developed sensor is feasible to detect proteins even at a fg/mL concentration under ordinary room light. Possible mechanisms, such as dielectric constant and refractive-index changes, have been studied and proposed. A dramatic change in the refractive index after protein adsorption on an InNP substrate was observed to be a predominant factor involved in CMOS image sensor-based immunoassay.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22975915</PMID><DateCreated><Year>2012</Year><Month>09</Month><Day>14</Day></DateCreated><DateCompleted><Year>2013</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1348-2246</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>9</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Analytical sciences : the international journal of the Japan Society for Analytical Chemistry</Title><ISOAbbreviation>Anal Sci</ISOAbbreviation></Journal><ArticleTitle>CMOS image sensor-based immunodetection by refractive-index change.</ArticleTitle><Pagination><MedlinePgn>875-80</MedlinePgn></Pagination><Abstract><AbstractText>A complementary metal oxide semiconductor (CMOS) image sensor is an intriguing technology for the development of a novel biosensor. Indeed, the CMOS image sensor mechanism concerning the detection of the antigen-antibody (Ag-Ab) interaction at the nanoscale has been ambiguous so far. To understand the mechanism, more extensive research has been necessary to achieve point-of-care diagnostic devices. This research has demonstrated a CMOS image sensor-based analysis of cardiovascular disease markers, such as C-reactive protein (CRP) and troponin I, Ag-Ab interactions on indium nanoparticle (InNP) substrates by simple photon count variation. The developed sensor is feasible to detect proteins even at a fg/mL concentration under ordinary room light. Possible mechanisms, such as dielectric constant and refractive-index changes, have been studied and proposed. A dramatic change in the refractive index after protein adsorption on an InNP substrate was observed to be a predominant factor involved in CMOS image sensor-based immunoassay.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Devadhasan</LastName><ForeName>Jasmine P</ForeName><Initials>JP</Initials><Affiliation>Department of Bionanotechnology, Gachon University, Gyeonggi-Do, Republic of Korea.</Affiliation></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sanghyo</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Anal Sci</MedlineTA><NlmUniqueID>8511078</NlmUniqueID><ISSNLinking>0910-6340</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Oxides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Troponin I</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance>C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Antigen-Antibody Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Biosensing Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Metal Nanoparticles</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Oxides</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Semiconductors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Troponin I</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">DN/JST.JSTAGE/analsci/28.875</ArticleId><ArticleId IdType="pubmed">22975915</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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