A transparent nanostructured optical biosensor.
Identifieur interne : 000251 ( Main/Exploration ); précédent : 000250; suivant : 000252A transparent nanostructured optical biosensor.
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Abstract
Herein we report a new transparent nanostructured Fabry-Perot interferometer (FPI) device. The unique features of the nanostructured optical device can be summarized as the following: (i) optically transparent nanostructured optical device; (ii) simple and inexpensive for fabrication; (iii) easy to be fabricated and scaled up as an arrayed format. These features overcome the existing barriers for the current nanopore-based interferometric optical biosensors by measuring the transmitted optical signals rather than the reflected optical signals, thereby facilitating the optical testing significantly for the arrayed biosensors and thus paving the way for their potential for high throughput biodetection applications. The optically transparent nanostructures (i.e., anodic aluminum oxide nanopores) inside the FPI devices are fabricated from 2.2 microm thick lithographically patterned Al thin film on an indium tin oxide (ITO) glass substrate using a two-step anodization process. Utilizing the binding between Protein A and porcine immunoglobulin G (IgG) as a model, the detection of the bioreaction between biomolecules has been demonstrated successfully. Experiments found that the lowest detection concentration of proteins is in the range of picomolar level using current devices, which can be easily tuned into the range of femtomolar level by optimizing the performance of devices.
PubMed: 24734529
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A transparent nanostructured optical biosensor.</title><author><name sortKey="He, Yuan" uniqKey="He Y">Yuan He</name></author><author><name sortKey="Li, Xiang" uniqKey="Li X">Xiang Li</name></author><author><name sortKey="Que, Long" uniqKey="Que L">Long Que</name></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="RBID">pubmed:24734529</idno><idno type="pmid">24734529</idno><idno type="wicri:Area/Main/Corpus">000063</idno><idno type="wicri:Area/Main/Curation">000063</idno><idno type="wicri:Area/Main/Exploration">000251</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Equipment Design</term><term>Equipment Failure Analysis</term><term>Immunoassay (instrumentation)</term><term>Interferometry (instrumentation)</term><term>Microchemistry (instrumentation)</term><term>Nanotechnology (instrumentation)</term><term>Refractometry (instrumentation)</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Immunoassay</term><term>Interferometry</term><term>Microchemistry</term><term>Nanotechnology</term><term>Refractometry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Equipment Design</term><term>Equipment Failure Analysis</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Herein we report a new transparent nanostructured Fabry-Perot interferometer (FPI) device. The unique features of the nanostructured optical device can be summarized as the following: (i) optically transparent nanostructured optical device; (ii) simple and inexpensive for fabrication; (iii) easy to be fabricated and scaled up as an arrayed format. These features overcome the existing barriers for the current nanopore-based interferometric optical biosensors by measuring the transmitted optical signals rather than the reflected optical signals, thereby facilitating the optical testing significantly for the arrayed biosensors and thus paving the way for their potential for high throughput biodetection applications. The optically transparent nanostructures (i.e., anodic aluminum oxide nanopores) inside the FPI devices are fabricated from 2.2 microm thick lithographically patterned Al thin film on an indium tin oxide (ITO) glass substrate using a two-step anodization process. Utilizing the binding between Protein A and porcine immunoglobulin G (IgG) as a model, the detection of the bioreaction between biomolecules has been demonstrated successfully. Experiments found that the lowest detection concentration of proteins is in the range of picomolar level using current devices, which can be easily tuned into the range of femtomolar level by optimizing the performance of devices.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24734529</PMID><DateCreated><Year>2014</Year><Month>04</Month><Day>16</Day></DateCreated><DateCompleted><Year>2014</Year><Month>05</Month><Day>01</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">1550-7033</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of biomedical nanotechnology</Title><ISOAbbreviation>J Biomed Nanotechnol</ISOAbbreviation></Journal><ArticleTitle>A transparent nanostructured optical biosensor.</ArticleTitle><Pagination><MedlinePgn>767-74</MedlinePgn></Pagination><Abstract><AbstractText>Herein we report a new transparent nanostructured Fabry-Perot interferometer (FPI) device. The unique features of the nanostructured optical device can be summarized as the following: (i) optically transparent nanostructured optical device; (ii) simple and inexpensive for fabrication; (iii) easy to be fabricated and scaled up as an arrayed format. These features overcome the existing barriers for the current nanopore-based interferometric optical biosensors by measuring the transmitted optical signals rather than the reflected optical signals, thereby facilitating the optical testing significantly for the arrayed biosensors and thus paving the way for their potential for high throughput biodetection applications. The optically transparent nanostructures (i.e., anodic aluminum oxide nanopores) inside the FPI devices are fabricated from 2.2 microm thick lithographically patterned Al thin film on an indium tin oxide (ITO) glass substrate using a two-step anodization process. Utilizing the binding between Protein A and porcine immunoglobulin G (IgG) as a model, the detection of the bioreaction between biomolecules has been demonstrated successfully. Experiments found that the lowest detection concentration of proteins is in the range of picomolar level using current devices, which can be easily tuned into the range of femtomolar level by optimizing the performance of devices.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiang</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Que</LastName><ForeName>Long</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Biomed Nanotechnol</MedlineTA><NlmUniqueID>101230869</NlmUniqueID><ISSNLinking>1550-7033</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Equipment Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Equipment Failure Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunoassay</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Interferometry</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Microchemistry</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Nanotechnology</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Refractometry</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>5</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24734529</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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