Three-dimensional visualisation of the large bowel: a potential tool for assessing targeted drug delivery and colonic pathology
Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080Three-dimensional visualisation of the large bowel: a potential tool for assessing targeted drug delivery and colonic pathology
Auteurs : RBID : ISTEX:259_1995_Article_BF00808416.pdfEnglish descriptors
Abstract
A study has been undertaken to assess the feasibility of three-dimensional imaging of the dispersion of a non-absorbable tracer released into the colon of normal subjects. Six healthy volunteers were selected who were participating in a scintigraphic study designed to assess the spreading of 1 MBq indium-111 Amberlite resin delivered from a delayed capsule system targeted to release in the ascending colon. In each case subjects were imaged using a rotating gamma camera over a data collection period of approximately 20 min. Three-dimensional volume rendered images demonstrated good visualisation of the dispersion of the tracer throughout the ascending, transverse and descending colon and provided good anatomical visualisation of the shape of the colon, not previously apparent from the planar views. The present study demonstrates for the first time, the successful three-dimensional imaging of a radiolabelled tracer dispersed throughout the colon and opens up the prospects for more detailed study of quantification of the volume and distribution of tracers contained within the colon.
DOI: 10.1007/BF00808416
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<record><TEI><teiHeader><fileDesc><titleStmt><title>Three-dimensional visualisation of the large bowel: a potential tool for assessing targeted drug delivery and colonic pathology</title><author><name>A. C. Perkins</name><affiliation wicri:level="1"><mods:affiliation>Nuclear Medicine Clinic, Department of Medical Physics, University Hospital Nottingham, NG7 2UH, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuclear Medicine Clinic, Department of Medical Physics, University Hospital Nottingham, NG7 2UH</wicri:regionArea><wicri:noRegion>NG7 2UH</wicri:noRegion></affiliation></author><author><name>C. Mann</name><affiliation wicri:level="1"><mods:affiliation>Nuclear Medicine Clinic, Department of Medical Physics, University Hospital Nottingham, NG7 2UH, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuclear Medicine Clinic, Department of Medical Physics, University Hospital Nottingham, NG7 2UH</wicri:regionArea><wicri:noRegion>NG7 2UH</wicri:noRegion></affiliation></author><author><name>C. G. Wilson</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmaceutical Sciences, Royal College, University of Strathclyde, G1 1XW, Glasgow, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmaceutical Sciences, Royal College, University of Strathclyde, G1 1XW, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1995_Article_BF00808416.pdf</idno><date when="1995">1995</date><idno type="doi">10.1007/BF00808416</idno><idno type="wicri:Area/Main/Corpus">000725</idno><idno type="wicri:Area/Main/Curation">000725</idno><idno type="wicri:Area/Main/Exploration">000079</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Colon</term><term>Drug targeting</term><term>Indium-111 resin</term><term>Three-dimensional imaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">A study has been undertaken to assess the feasibility of three-dimensional imaging of the dispersion of a non-absorbable tracer released into the colon of normal subjects. Six healthy volunteers were selected who were participating in a scintigraphic study designed to assess the spreading of 1 MBq indium-111 Amberlite resin delivered from a delayed capsule system targeted to release in the ascending colon. In each case subjects were imaged using a rotating gamma camera over a data collection period of approximately 20 min. Three-dimensional volume rendered images demonstrated good visualisation of the dispersion of the tracer throughout the ascending, transverse and descending colon and provided good anatomical visualisation of the shape of the colon, not previously apparent from the planar views. The present study demonstrates for the first time, the successful three-dimensional imaging of a radiolabelled tracer dispersed throughout the colon and opens up the prospects for more detailed study of quantification of the volume and distribution of tracers contained within the colon.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="7c152a8f15f6f5370c5e953a0d29d3b6ad5d7367"><titleInfo lang="eng"><title>Three-dimensional visualisation of the large bowel: a potential tool for assessing targeted drug delivery and colonic pathology</title></titleInfo><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Perkins</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Nuclear Medicine Clinic, Department of Medical Physics, University Hospital Nottingham, NG7 2UH, UK</affiliation></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Mann</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Nuclear Medicine Clinic, Department of Medical Physics, University Hospital Nottingham, NG7 2UH, UK</affiliation></name><name type="personal"><namePart type="given">C. G.</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Pharmaceutical Sciences, Royal College, University of Strathclyde, G1 1XW, Glasgow, UK</affiliation></name><typeOfResource>text</typeOfResource><genre>Short Communication</genre><genre>Brief Communication</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1995-04-06</dateCreated><dateValid encoding="w3cdtf">2004-11-28</dateValid><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">A study has been undertaken to assess the feasibility of three-dimensional imaging of the dispersion of a non-absorbable tracer released into the colon of normal subjects. Six healthy volunteers were selected who were participating in a scintigraphic study designed to assess the spreading of 1 MBq indium-111 Amberlite resin delivered from a delayed capsule system targeted to release in the ascending colon. In each case subjects were imaged using a rotating gamma camera over a data collection period of approximately 20 min. Three-dimensional volume rendered images demonstrated good visualisation of the dispersion of the tracer throughout the ascending, transverse and descending colon and provided good anatomical visualisation of the shape of the colon, not previously apparent from the planar views. The present study demonstrates for the first time, the successful three-dimensional imaging of a radiolabelled tracer dispersed throughout the colon and opens up the prospects for more detailed study of quantification of the volume and distribution of tracers contained within the colon.</abstract><subject lang="eng"><genre>Key words</genre><topic>Colon</topic><topic>Indium-111 resin</topic><topic>Three-dimensional imaging</topic><topic>Drug targeting</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1995</partNumber><partNumber>Volume: 22</partNumber><partNumber>Number: 9</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1995-09-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 24</identifier><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00808416</identifier><identifier type="matrixNumber">Art11</identifier><identifier type="local">BF00808416</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>1035</start><end>1038</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin><recordIdentifier>259_1995_Article_BF00808416.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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