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[Pediatric nasopharyngeal carcinoma: Anatomoclinic aspects, therapeutic results and evolutive particularities].

Identifieur interne : 000053 ( PubMed/Curation ); précédent : 000052; suivant : 000054

[Pediatric nasopharyngeal carcinoma: Anatomoclinic aspects, therapeutic results and evolutive particularities].

Auteurs : M. Frikha [Tunisie] ; N. Toumi ; L. Ghorbel ; H. Ben Salah ; A. Khabir ; H. Karray ; R. Gargouri ; T. Boudawara ; A. Ghorbel ; J. Daoud

Source :

RBID : pubmed:20347607

Descripteurs français

English descriptors

Abstract

We retrospectively analyzed anatomoclinic, therapeutic and evolutive particularities of 74 young patients (< or =20 years) with nasopharyngeal carcinoma treated between 1993 and 2005.

DOI: 10.1016/j.canrad.2010.01.003
PubMed: 20347607

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pubmed:20347607

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<div type="abstract" xml:lang="en">We retrospectively analyzed anatomoclinic, therapeutic and evolutive particularities of 74 young patients (< or =20 years) with nasopharyngeal carcinoma treated between 1993 and 2005.</div>
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<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">We retrospectively analyzed anatomoclinic, therapeutic and evolutive particularities of 74 young patients (< or =20 years) with nasopharyngeal carcinoma treated between 1993 and 2005.</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Initial work-up included a fiberoptic nasofibroscopy with biopsy, tomodensitometry and/or MRI of nasopharynx and neck, chest X-ray, abdominal ultrasonography and bone scan. Patients were treated with either primary chemotherapy (epirubicin and cisplatin) followed by radiotherapy or concomitant radiochemotherapy (five fluorouracil and cisplatin). Radiotherapy was delivered to a total dose of 70 to 75 Gy to nasopharynx and involved cervical lymph nodes and 50 Gy to the remainder cervical areas.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The median age was 16 years. Sixty-three percent of patients had undifferentiated tumors. Sixty-six percent had locally advanced tumor. With a median follow-up of 107 months, one patient presented a local relapse, 24 patients developed distant metastases with a median delay of 7 months. The 5 years overall survival and disease-free survival were 66 and 65 %. Late complications were dominated by dry mouth and endocrine disorders.</AbstractText>
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