Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit.
Identifieur interne : 000001 ( PubMed/Corpus ); précédent : 000000; suivant : 000002Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit.
Auteurs : Amel Hanini ; Mohamed El Massoudi ; Julie Gavard ; Kamel Kacem ; Souad Ammar ; Ouajdi SouilemSource :
- Environmental toxicology and pharmacology [ 1872-7077 ] ; 2016.
Abstract
The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated in vitro and in vivo in animal before any clinical application. In this study we aim to synthesize and characterize such objects using polyol process in order to assess its nanotoxicological profile in vitro as well as in vivo. The produced particles consist of a cobalt-zinc ferrite phase corresponding to the Zn0.8Co0.2Fe2O4 composition. They are isotropic in shape single crystals of 8nm in size. The thermal variation of their dc-magnetization confirms their superparamagnetic behavior. In vitro, acute exposure (4h) to them (100μgmL(-1)) induced an important decrease of healthy Human Umbilical Vein Endothelial Cells (HUVECs) viability. In vivo investigation in New-Zealand rabbits revealed that they lead to tissue toxicities; in lungs, liver and kidneys. Our investigations report, for the first time as far as we know, that SFN exhibit harmful properties in human cells and mammals.
DOI: 10.1016/j.etap.2016.06.010
PubMed: 27375215
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Electronic address: hanini.amel@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Massoudi, Mohamed El" sort="Massoudi, Mohamed El" uniqKey="Massoudi M" first="Mohamed El" last="Massoudi">Mohamed El Massoudi</name><affiliation><nlm:affiliation>Laboratoire de Valoristaion des Bio-Géo-Resources, Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, Sidi Thabet, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Gavard, Julie" sort="Gavard, Julie" uniqKey="Gavard J" first="Julie" last="Gavard">Julie Gavard</name><affiliation><nlm:affiliation>Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR-8104, INSERM U1016, 75005 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kacem, Kamel" sort="Kacem, Kamel" uniqKey="Kacem K" first="Kamel" last="Kacem">Kamel Kacem</name><affiliation><nlm:affiliation>Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Ammar, Souad" sort="Ammar, Souad" uniqKey="Ammar S" first="Souad" last="Ammar">Souad Ammar</name><affiliation><nlm:affiliation>Laboratoire Interface Traitement, Organisation et Dynamique des Systèmes (ITODYS), Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR-7086, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Souilem, Ouajdi" sort="Souilem, Ouajdi" uniqKey="Souilem O" first="Ouajdi" last="Souilem">Ouajdi Souilem</name><affiliation><nlm:affiliation>Laboratoire de Valoristaion des Bio-Géo-Resources, Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, Sidi Thabet, Tunisia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27375215</idno><idno type="pmid">27375215</idno><idno type="doi">10.1016/j.etap.2016.06.010</idno><idno type="wicri:Area/PubMed/Corpus">000001</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000001</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit.</title><author><name sortKey="Hanini, Amel" sort="Hanini, Amel" uniqKey="Hanini A" first="Amel" last="Hanini">Amel Hanini</name><affiliation><nlm:affiliation>Laboratoire Interface Traitement, Organisation et Dynamique des Systèmes (ITODYS), Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR-7086, Paris, France; Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, Tunisia; Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR-8104, INSERM U1016, 75005 Paris, France. Electronic address: hanini.amel@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Massoudi, Mohamed El" sort="Massoudi, Mohamed El" uniqKey="Massoudi M" first="Mohamed El" last="Massoudi">Mohamed El Massoudi</name><affiliation><nlm:affiliation>Laboratoire de Valoristaion des Bio-Géo-Resources, Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, Sidi Thabet, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Gavard, Julie" sort="Gavard, Julie" uniqKey="Gavard J" first="Julie" last="Gavard">Julie Gavard</name><affiliation><nlm:affiliation>Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR-8104, INSERM U1016, 75005 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kacem, Kamel" sort="Kacem, Kamel" uniqKey="Kacem K" first="Kamel" last="Kacem">Kamel Kacem</name><affiliation><nlm:affiliation>Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Ammar, Souad" sort="Ammar, Souad" uniqKey="Ammar S" first="Souad" last="Ammar">Souad Ammar</name><affiliation><nlm:affiliation>Laboratoire Interface Traitement, Organisation et Dynamique des Systèmes (ITODYS), Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR-7086, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Souilem, Ouajdi" sort="Souilem, Ouajdi" uniqKey="Souilem O" first="Ouajdi" last="Souilem">Ouajdi Souilem</name><affiliation><nlm:affiliation>Laboratoire de Valoristaion des Bio-Géo-Resources, Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, Sidi Thabet, Tunisia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Environmental toxicology and pharmacology</title><idno type="eISSN">1872-7077</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated in vitro and in vivo in animal before any clinical application. In this study we aim to synthesize and characterize such objects using polyol process in order to assess its nanotoxicological profile in vitro as well as in vivo. The produced particles consist of a cobalt-zinc ferrite phase corresponding to the Zn0.8Co0.2Fe2O4 composition. They are isotropic in shape single crystals of 8nm in size. The thermal variation of their dc-magnetization confirms their superparamagnetic behavior. In vitro, acute exposure (4h) to them (100μgmL(-1)) induced an important decrease of healthy Human Umbilical Vein Endothelial Cells (HUVECs) viability. In vivo investigation in New-Zealand rabbits revealed that they lead to tissue toxicities; in lungs, liver and kidneys. Our investigations report, for the first time as far as we know, that SFN exhibit harmful properties in human cells and mammals.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27375215</PMID><DateCreated><Year>2016</Year><Month>7</Month><Day>20</Day></DateCreated><DateRevised><Year>2016</Year><Month>7</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7077</ISSN><JournalIssue CitedMedium="Internet"><Volume>45</Volume><PubDate><Year>2016</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Environmental toxicology and pharmacology</Title><ISOAbbreviation>Environ. Toxicol. Pharmacol.</ISOAbbreviation></Journal><ArticleTitle>Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit.</ArticleTitle><Pagination><MedlinePgn>321-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.etap.2016.06.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1382-6689(16)30148-X</ELocationID><Abstract><AbstractText>The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated in vitro and in vivo in animal before any clinical application. In this study we aim to synthesize and characterize such objects using polyol process in order to assess its nanotoxicological profile in vitro as well as in vivo. The produced particles consist of a cobalt-zinc ferrite phase corresponding to the Zn0.8Co0.2Fe2O4 composition. They are isotropic in shape single crystals of 8nm in size. The thermal variation of their dc-magnetization confirms their superparamagnetic behavior. In vitro, acute exposure (4h) to them (100μgmL(-1)) induced an important decrease of healthy Human Umbilical Vein Endothelial Cells (HUVECs) viability. In vivo investigation in New-Zealand rabbits revealed that they lead to tissue toxicities; in lungs, liver and kidneys. Our investigations report, for the first time as far as we know, that SFN exhibit harmful properties in human cells and mammals.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hanini</LastName><ForeName>Amel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratoire Interface Traitement, Organisation et Dynamique des Systèmes (ITODYS), Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR-7086, Paris, France; Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, Tunisia; Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR-8104, INSERM U1016, 75005 Paris, France. Electronic address: hanini.amel@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Massoudi</LastName><ForeName>Mohamed El</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Laboratoire de Valoristaion des Bio-Géo-Resources, Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, Sidi Thabet, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gavard</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR-8104, INSERM U1016, 75005 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kacem</LastName><ForeName>Kamel</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Unité de Physiologie Intégrée, Laboratoire de Pathologies Vasculaires, Faculté des Sciences de Bizerte, Université de Carthage, Jarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ammar</LastName><ForeName>Souad</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratoire Interface Traitement, Organisation et Dynamique des Systèmes (ITODYS), Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR-7086, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souilem</LastName><ForeName>Ouajdi</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Laboratoire de Valoristaion des Bio-Géo-Resources, Ecole Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, Sidi Thabet, Tunisia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>Jun</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Environ Toxicol Pharmacol</MedlineTA><NlmUniqueID>9612020</NlmUniqueID><ISSNLinking>1382-6689</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cobalt-Zinc ferrite nanoparticles</Keyword><Keyword MajorTopicYN="N">Cytotoxicity</Keyword><Keyword MajorTopicYN="N">Endothelial cell</Keyword><Keyword MajorTopicYN="N">New Zealand rabbits</Keyword><Keyword MajorTopicYN="N">Polyol process</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>6</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>6</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27375215</ArticleId><ArticleId IdType="pii">S1382-6689(16)30148-X</ArticleId><ArticleId IdType="doi">10.1016/j.etap.2016.06.010</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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