Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny.
Identifieur interne : 000038 ( PubMed/Checkpoint ); précédent : 000037; suivant : 000039Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny.
Auteurs : El Mouldi Garoui [Tunisie] ; Afef Troudi ; Hamadi Fetoui ; Nejla Soudani ; Tahia Boudawara ; Najiba ZeghalSource :
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie [ 1618-1433 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Antioxydants (administration et posologie), Antioxydants (pharmacocinétique), Antioxydants (usage thérapeutique), Cobalt (pharmacocinétique), Cobalt (toxicité), Effets différés de l'exposition prénatale aux facteurs de risque (), Effets différés de l'exposition prénatale aux facteurs de risque (métabolisme), Femelle, Grossesse, Lait (), Maladies du rein (), Maladies du rein (métabolisme), Marqueurs biologiques (analyse), Peroxydation lipidique (), Polluants environnementaux (pharmacocinétique), Polluants environnementaux (toxicité), Propolis (administration et posologie), Propolis (pharmacocinétique), Propolis (usage thérapeutique), Rat Wistar, Rats, Rein (), Rein (enzymologie), Stress oxydatif (), Tests de la fonction rénale.
- MESH :
- administration et posologie : Antioxydants, Propolis.
- analyse : Marqueurs biologiques.
- enzymologie : Rein.
- métabolisme : Effets différés de l'exposition prénatale aux facteurs de risque, Maladies du rein.
- pharmacocinétique : Antioxydants, Cobalt, Polluants environnementaux, Propolis.
- toxicité : Cobalt, Polluants environnementaux.
- usage thérapeutique : Antioxydants, Propolis.
- Animaux, Animaux nouveau-nés, Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Grossesse, Lait, Maladies du rein, Peroxydation lipidique, Rat Wistar, Rats, Rein, Stress oxydatif, Tests de la fonction rénale.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Antioxidants (administration & dosage), Antioxidants (pharmacokinetics), Antioxidants (therapeutic use), Biomarkers (analysis), Cobalt (pharmacokinetics), Cobalt (toxicity), Environmental Pollutants (pharmacokinetics), Environmental Pollutants (toxicity), Female, Kidney (drug effects), Kidney (enzymology), Kidney Diseases (chemically induced), Kidney Diseases (metabolism), Kidney Diseases (prevention & control), Kidney Function Tests, Lipid Peroxidation (drug effects), Milk (chemistry), Oxidative Stress (drug effects), Pregnancy, Prenatal Exposure Delayed Effects (chemically induced), Prenatal Exposure Delayed Effects (metabolism), Prenatal Exposure Delayed Effects (prevention & control), Propolis (administration & dosage), Propolis (pharmacokinetics), Propolis (therapeutic use), Rats, Rats, Wistar.
- MESH :
- chemical , administration & dosage : Antioxidants, Propolis.
- chemical , analysis : Biomarkers.
- chemical , pharmacokinetics : Antioxidants, Cobalt, Environmental Pollutants, Propolis.
- chemical , therapeutic use : Antioxidants, Propolis.
- chemical , toxicity : Cobalt, Environmental Pollutants.
- chemically induced : Kidney Diseases, Prenatal Exposure Delayed Effects.
- chemistry : Milk.
- drug effects : Kidney, Lipid Peroxidation, Oxidative Stress.
- enzymology : Kidney.
- metabolism : Kidney Diseases, Prenatal Exposure Delayed Effects.
- prevention & control : Kidney Diseases, Prenatal Exposure Delayed Effects.
- Animals, Animals, Newborn, Female, Kidney Function Tests, Pregnancy, Rats, Rats, Wistar.
Abstract
The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl(2) in drinking water; group 3 received 350 ppm CoCl(2) in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity. Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.
DOI: 10.1016/j.etp.2011.03.004
PubMed: 21507616
Affiliations:
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de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Lait</term><term>Maladies du rein</term><term>Peroxydation lipidique</term><term>Rat Wistar</term><term>Rats</term><term>Rein</term><term>Stress oxydatif</term><term>Tests de la fonction rénale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl(2) in drinking water; group 3 received 350 ppm CoCl(2) in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity. Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21507616</PMID><DateCreated><Year>2012</Year><Month>10</Month><Day>22</Day></DateCreated><DateCompleted><Year>2013</Year><Month>03</Month><Day>26</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1618-1433</ISSN><JournalIssue CitedMedium="Internet"><Volume>64</Volume><Issue>7-8</Issue><PubDate><Year>2012</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie</Title><ISOAbbreviation>Exp. Toxicol. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny.</ArticleTitle><Pagination><MedlinePgn>837-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.etp.2011.03.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0940-2993(11)00054-6</ELocationID><Abstract><AbstractText>The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl(2) in drinking water; group 3 received 350 ppm CoCl(2) in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity. Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier GmbH. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garoui</LastName><ForeName>El Mouldi</ForeName><Initials>el M</Initials><AffiliationInfo><Affiliation>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Troudi</LastName><ForeName>Afef</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fetoui</LastName><ForeName>Hamadi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Soudani</LastName><ForeName>Nejla</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Boudawara</LastName><ForeName>Tahia</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Zeghal</LastName><ForeName>Najiba</ForeName><Initials>N</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>Apr</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Exp Toxicol Pathol</MedlineTA><NlmUniqueID>9208920</NlmUniqueID><ISSNLinking>0940-2993</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004785">Environmental Pollutants</NameOfSubstance></Chemical><Chemical><RegistryNumber>3G0H8C9362</RegistryNumber><NameOfSubstance UI="D003035">Cobalt</NameOfSubstance></Chemical><Chemical><RegistryNumber>9009-62-5</RegistryNumber><NameOfSubstance UI="D011429">Propolis</NameOfSubstance></Chemical><Chemical><RegistryNumber>EVS87XF13W</RegistryNumber><NameOfSubstance UI="C018021">cobaltous chloride</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000831" MajorTopicYN="N">Animals, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003035" MajorTopicYN="N">Cobalt</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004785" MajorTopicYN="N">Environmental Pollutants</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007674" MajorTopicYN="N">Kidney Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007677" MajorTopicYN="N">Kidney Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008892" MajorTopicYN="N">Milk</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011297" MajorTopicYN="N">Prenatal Exposure Delayed Effects</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>5</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>12</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>3</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21507616</ArticleId><ArticleId IdType="pii">S0940-2993(11)00054-6</ArticleId><ArticleId IdType="doi">10.1016/j.etp.2011.03.004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><name sortKey="Fetoui, Hamadi" sort="Fetoui, Hamadi" uniqKey="Fetoui H" first="Hamadi" last="Fetoui">Hamadi Fetoui</name><name sortKey="Soudani, Nejla" sort="Soudani, Nejla" uniqKey="Soudani N" first="Nejla" last="Soudani">Nejla Soudani</name><name sortKey="Troudi, Afef" sort="Troudi, Afef" uniqKey="Troudi A" first="Afef" last="Troudi">Afef Troudi</name><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Garoui, El Mouldi" sort="Garoui, El Mouldi" uniqKey="Garoui E" first="El Mouldi" last="Garoui">El Mouldi Garoui</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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