CobaltMaghrebV1, PubMed, Checkpoint, bibRecord, 000019

Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.

Identifieur interne : 000019 ( PubMed/Checkpoint ); précédent : 000018; suivant : 000020

Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.

Auteurs : Hayley A. Mattison [États-Unis] ; Ashish A. Bagal [États-Unis] ; Michael Mohammadi [États-Unis] ; Nisha S. Pulimood ; Christian G. Reich [États-Unis] ; Bradley E. Alger [États-Unis] ; Joseph P Y. Kao [États-Unis] ; Scott M. Thompson [États-Unis]

Source :

Journal of neurophysiology [ 1522-1598 ] ; 2014.

RBID : pubmed:24760782

Descripteurs français

KwdFr :
- Acide glutamique (pharmacologie), Animaux, Calcium (métabolisme), Cellules pyramidales (), Cellules pyramidales (métabolisme), Cellules pyramidales (physiologie), Cobalt (pharmacologie), Mâle, Polyamines (pharmacologie), Potentiels post-synaptiques excitateurs, Rat Sprague-Dawley, Rats, Récepteur de l'AMPA (métabolisme), Région CA1 de l'hippocampe (cytologie), Région CA1 de l'hippocampe (métabolisme), Région CA1 de l'hippocampe (physiologie), Spermine (pharmacologie), Synapses (métabolisme), Synapses (physiologie), Épines dendritiques (métabolisme), Épines dendritiques (physiologie).
MESH :
- cytologie : Région CA1 de l'hippocampe.
- métabolisme : Calcium, Cellules pyramidales, Récepteur de l'AMPA, Région CA1 de l'hippocampe, Synapses, Épines dendritiques.
- pharmacologie : Acide glutamique, Cobalt, Polyamines, Spermine.
- physiologie : Cellules pyramidales, Région CA1 de l'hippocampe, Synapses, Épines dendritiques.
- Animaux, Cellules pyramidales, Mâle, Potentiels post-synaptiques excitateurs, Rat Sprague-Dawley, Rats.

English descriptors

KwdEn :
- Animals, CA1 Region, Hippocampal (cytology), CA1 Region, Hippocampal (metabolism), CA1 Region, Hippocampal (physiology), Calcium (metabolism), Cobalt (pharmacology), Dendritic Spines (metabolism), Dendritic Spines (physiology), Excitatory Postsynaptic Potentials, Glutamic Acid (pharmacology), Male, Polyamines (pharmacology), Pyramidal Cells (drug effects), Pyramidal Cells (metabolism), Pyramidal Cells (physiology), Rats, Rats, Sprague-Dawley, Receptors, AMPA (metabolism), Spermine (pharmacology), Synapses (metabolism), Synapses (physiology).
MESH :
- chemical , metabolism : Calcium, Receptors, AMPA.
- cytology : CA1 Region, Hippocampal.
- drug effects : Pyramidal Cells.
- metabolism : CA1 Region, Hippocampal, Dendritic Spines, Pyramidal Cells, Synapses.
- chemical , pharmacology : Cobalt, Glutamic Acid, Polyamines, Spermine.
- physiology : CA1 Region, Hippocampal, Dendritic Spines, Pyramidal Cells, Synapses.
- Animals, Excitatory Postsynaptic Potentials, Male, Rats, Rats, Sprague-Dawley.

Abstract

GluA2-lacking, calcium-permeable α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) have unique properties, but their presence at excitatory synapses in pyramidal cells is controversial. We have tested certain predictions of the model that such receptors are present in CA1 cells and show here that the polyamine spermine, but not philanthotoxin, causes use-dependent inhibition of synaptically evoked excitatory responses in stratum radiatum, but not s. oriens, in cultured and acute hippocampal slices. Stimulation of single dendritic spines by photolytic release of caged glutamate induced an N-methyl-d-aspartate receptor-independent, use- and spermine-sensitive calcium influx only at apical spines in cultured slices. Bath application of glutamate also triggered a spermine-sensitive influx of cobalt into CA1 cell dendrites in s. radiatum. Responses of single apical, but not basal, spines to photostimulation displayed prominent paired-pulse facilitation (PPF) consistent with use-dependent relief of cytoplasmic polyamine block. Responses at apical dendrites were diminished, and PPF was increased, by spermine. Intracellular application of pep2m, which inhibits recycling of GluA2-containing AMPARs, reduced apical spine responses and increased PPF. We conclude that some calcium-permeable, polyamine-sensitive AMPARs, perhaps lacking GluA2 subunits, are present at synapses on apical dendrites of CA1 pyramidal cells, which may allow distinct forms of synaptic plasticity and computation at different sets of excitatory inputs.

DOI: 10.1152/jn.00578.2013
PubMed: 24760782

Affiliations:

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Le document en format XML

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<term>CA1 Region, Hippocampal (cytology)</term>
<term>CA1 Region, Hippocampal (metabolism)</term>
<term>CA1 Region, Hippocampal (physiology)</term>
<term>Calcium (metabolism)</term>
<term>Cobalt (pharmacology)</term>
<term>Dendritic Spines (metabolism)</term>
<term>Dendritic Spines (physiology)</term>
<term>Excitatory Postsynaptic Potentials</term>
<term>Glutamic Acid (pharmacology)</term>
<term>Male</term>
<term>Polyamines (pharmacology)</term>
<term>Pyramidal Cells (drug effects)</term>
<term>Pyramidal Cells (metabolism)</term>
<term>Pyramidal Cells (physiology)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Receptors, AMPA (metabolism)</term>
<term>Spermine (pharmacology)</term>
<term>Synapses (metabolism)</term>
<term>Synapses (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide glutamique (pharmacologie)</term>
<term>Animaux</term>
<term>Calcium (métabolisme)</term>
<term>Cellules pyramidales ()</term>
<term>Cellules pyramidales (métabolisme)</term>
<term>Cellules pyramidales (physiologie)</term>
<term>Cobalt (pharmacologie)</term>
<term>Mâle</term>
<term>Polyamines (pharmacologie)</term>
<term>Potentiels post-synaptiques excitateurs</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Récepteur de l'AMPA (métabolisme)</term>
<term>Région CA1 de l'hippocampe (cytologie)</term>
<term>Région CA1 de l'hippocampe (métabolisme)</term>
<term>Région CA1 de l'hippocampe (physiologie)</term>
<term>Spermine (pharmacologie)</term>
<term>Synapses (métabolisme)</term>
<term>Synapses (physiologie)</term>
<term>Épines dendritiques (métabolisme)</term>
<term>Épines dendritiques (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term>
<term>Receptors, AMPA</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Région CA1 de l'hippocampe</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>CA1 Region, Hippocampal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pyramidal Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CA1 Region, Hippocampal</term>
<term>Dendritic Spines</term>
<term>Pyramidal Cells</term>
<term>Synapses</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcium</term>
<term>Cellules pyramidales</term>
<term>Récepteur de l'AMPA</term>
<term>Région CA1 de l'hippocampe</term>
<term>Synapses</term>
<term>Épines dendritiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide glutamique</term>
<term>Cobalt</term>
<term>Polyamines</term>
<term>Spermine</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cobalt</term>
<term>Glutamic Acid</term>
<term>Polyamines</term>
<term>Spermine</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules pyramidales</term>
<term>Région CA1 de l'hippocampe</term>
<term>Synapses</term>
<term>Épines dendritiques</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>CA1 Region, Hippocampal</term>
<term>Dendritic Spines</term>
<term>Pyramidal Cells</term>
<term>Synapses</term>
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<term>Excitatory Postsynaptic Potentials</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
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<term>Cellules pyramidales</term>
<term>Mâle</term>
<term>Potentiels post-synaptiques excitateurs</term>
<term>Rat Sprague-Dawley</term>
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<front><div type="abstract" xml:lang="en">GluA2-lacking, calcium-permeable α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) have unique properties, but their presence at excitatory synapses in pyramidal cells is controversial. We have tested certain predictions of the model that such receptors are present in CA1 cells and show here that the polyamine spermine, but not philanthotoxin, causes use-dependent inhibition of synaptically evoked excitatory responses in stratum radiatum, but not s. oriens, in cultured and acute hippocampal slices. Stimulation of single dendritic spines by photolytic release of caged glutamate induced an N-methyl-d-aspartate receptor-independent, use- and spermine-sensitive calcium influx only at apical spines in cultured slices. Bath application of glutamate also triggered a spermine-sensitive influx of cobalt into CA1 cell dendrites in s. radiatum. Responses of single apical, but not basal, spines to photostimulation displayed prominent paired-pulse facilitation (PPF) consistent with use-dependent relief of cytoplasmic polyamine block. Responses at apical dendrites were diminished, and PPF was increased, by spermine. Intracellular application of pep2m, which inhibits recycling of GluA2-containing AMPARs, reduced apical spine responses and increased PPF. We conclude that some calcium-permeable, polyamine-sensitive AMPARs, perhaps lacking GluA2 subunits, are present at synapses on apical dendrites of CA1 pyramidal cells, which may allow distinct forms of synaptic plasticity and computation at different sets of excitatory inputs.</div>
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<Day>16</Day>
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<DateCompleted><Year>2015</Year>
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<Day>15</Day>
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<Title>Journal of neurophysiology</Title>
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<ArticleTitle>Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.</ArticleTitle>
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<Abstract><AbstractText>GluA2-lacking, calcium-permeable α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) have unique properties, but their presence at excitatory synapses in pyramidal cells is controversial. We have tested certain predictions of the model that such receptors are present in CA1 cells and show here that the polyamine spermine, but not philanthotoxin, causes use-dependent inhibition of synaptically evoked excitatory responses in stratum radiatum, but not s. oriens, in cultured and acute hippocampal slices. Stimulation of single dendritic spines by photolytic release of caged glutamate induced an N-methyl-d-aspartate receptor-independent, use- and spermine-sensitive calcium influx only at apical spines in cultured slices. Bath application of glutamate also triggered a spermine-sensitive influx of cobalt into CA1 cell dendrites in s. radiatum. Responses of single apical, but not basal, spines to photostimulation displayed prominent paired-pulse facilitation (PPF) consistent with use-dependent relief of cytoplasmic polyamine block. Responses at apical dendrites were diminished, and PPF was increased, by spermine. Intracellular application of pep2m, which inhibits recycling of GluA2-containing AMPARs, reduced apical spine responses and increased PPF. We conclude that some calcium-permeable, polyamine-sensitive AMPARs, perhaps lacking GluA2 subunits, are present at synapses on apical dendrites of CA1 pyramidal cells, which may allow distinct forms of synaptic plasticity and computation at different sets of excitatory inputs.</AbstractText>
<CopyrightInformation>Copyright © 2014 the American Physiological Society.</CopyrightInformation>
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<ForeName>Michael</ForeName>
<Initials>M</Initials>
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</AffiliationInfo>
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   |texte=   Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.
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Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.

Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.

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