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Chemistry and Biology of Bengamides and Bengazoles, Bioactive Natural Products from Jaspis Sponges

Identifieur interne : 000510 ( Pmc/Curation ); précédent : 000509; suivant : 000511

Chemistry and Biology of Bengamides and Bengazoles, Bioactive Natural Products from Jaspis Sponges

Auteurs : Cristina García-Ruiz ; Francisco Sarabia

Source :

RBID : PMC:3967228

Abstract

Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biological profiles, including antitumor, antibiotic and anthelmintic properties. As a consequence, intense research activity has been devoted to these compounds from both chemical and biological standpoints. This review describes in detail the research into these classes of natural products and the benefits they offer in chemistry and biology.


Url:
DOI: 10.3390/md12031580
PubMed: 24646945
PubMed Central: 3967228

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PMC:3967228

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<p>Sponges corresponding to the
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family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biological profiles, including antitumor, antibiotic and anthelmintic properties. As a consequence, intense research activity has been devoted to these compounds from both chemical and biological standpoints. This review describes in detail the research into these classes of natural products and the benefits they offer in chemistry and biology.</p>
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</TEI>
<pmc article-type="review-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id>
<journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id>
<journal-id journal-id-type="publisher-id">marinedrugs</journal-id>
<journal-title-group>
<journal-title>Marine Drugs</journal-title>
</journal-title-group>
<issn pub-type="epub">1660-3397</issn>
<publisher>
<publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">24646945</article-id>
<article-id pub-id-type="pmc">3967228</article-id>
<article-id pub-id-type="doi">10.3390/md12031580</article-id>
<article-id pub-id-type="publisher-id">marinedrugs-12-01580</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Review</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Chemistry and Biology of Bengamides and Bengazoles, Bioactive Natural Products from
<italic>Jaspis</italic>
Sponges</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>García-Ruiz</surname>
<given-names>Cristina</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sarabia</surname>
<given-names>Francisco</given-names>
</name>
<xref rid="c1-marinedrugs-12-01580" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-marinedrugs-12-01580">Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos s/n., Málaga 29071, Spain; E-Mail:
<email>crisgarcia@uma.es</email>
</aff>
<author-notes>
<corresp id="c1-marinedrugs-12-01580">
<label>*</label>
Author to whom correspondence should be addressed; E-Mail:
<email>frsarabia@uma.es</email>
; Tel.: +34-952-134-258; Fax: +34-952-131-941.</corresp>
</author-notes>
<pub-date pub-type="epub">
<day>18</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection">
<month>3</month>
<year>2014</year>
</pub-date>
<volume>12</volume>
<issue>3</issue>
<fpage>1580</fpage>
<lpage>1622</lpage>
<history>
<date date-type="received">
<day>30</day>
<month>12</month>
<year>2013</year>
</date>
<date date-type="rev-recd">
<day>24</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>2</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>© 2014 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement>
<copyright-year>2014</copyright-year>
<license>
<license-p>
<pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract>
<p>Sponges corresponding to the
<italic>Jaspidae</italic>
family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures and impressive biological profiles, including antitumor, antibiotic and anthelmintic properties. As a consequence, intense research activity has been devoted to these compounds from both chemical and biological standpoints. This review describes in detail the research into these classes of natural products and the benefits they offer in chemistry and biology.</p>
</abstract>
<kwd-group>
<kwd>bengamides</kwd>
<kwd>bengazoles</kwd>
<kwd>antitumor</kwd>
<kwd>analogues</kwd>
<kwd>total synthesis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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