Recent Advances in Drug Discovery from South African Marine Invertebrates
Identifieur interne : 000039 ( Pmc/Curation ); précédent : 000038; suivant : 000040Recent Advances in Drug Discovery from South African Marine Invertebrates
Auteurs : Michael T. Davies-Coleman [Afrique du Sud] ; Clinton G. L. VealeSource :
- Marine Drugs [ 1660-3397 ] ; 2015.
Abstract
Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm
Url:
DOI: 10.3390/md13106366
PubMed: 26473891
PubMed Central: 4626695
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent Advances in Drug Discovery from South African Marine Invertebrates</title><author><name sortKey="Davies Coleman, Michael T" sort="Davies Coleman, Michael T" uniqKey="Davies Coleman M" first="Michael T." last="Davies-Coleman">Michael T. Davies-Coleman</name><affiliation wicri:level="1"><nlm:aff id="af1-marinedrugs-13-06366">Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535</wicri:regionArea></affiliation></author><author><name sortKey="Veale, Clinton G L" sort="Veale, Clinton G L" uniqKey="Veale C" first="Clinton G. L." last="Veale">Clinton G. L. Veale</name><affiliation><nlm:aff id="af2-marinedrugs-13-06366">Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa; E-Mail:<email>C.Veale@ru.ac.za</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26473891</idno><idno type="pmc">4626695</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626695</idno><idno type="RBID">PMC:4626695</idno><idno type="doi">10.3390/md13106366</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000039</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000039</idno><idno type="wicri:Area/Pmc/Curation">000039</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000039</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent Advances in Drug Discovery from South African Marine Invertebrates</title><author><name sortKey="Davies Coleman, Michael T" sort="Davies Coleman, Michael T" uniqKey="Davies Coleman M" first="Michael T." last="Davies-Coleman">Michael T. Davies-Coleman</name><affiliation wicri:level="1"><nlm:aff id="af1-marinedrugs-13-06366">Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535</wicri:regionArea></affiliation></author><author><name sortKey="Veale, Clinton G L" sort="Veale, Clinton G L" uniqKey="Veale C" first="Clinton G. L." last="Veale">Clinton G. L. Veale</name><affiliation><nlm:aff id="af2-marinedrugs-13-06366">Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa; E-Mail:<email>C.Veale@ru.ac.za</email></nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm <italic>Cephalodiscus gilchristi</italic>, the ascidian <italic>Lissoclinum</italic> sp. and the sponge <italic>Topsentia pachastrelloides</italic>, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from <italic>C. gilchristi</italic> and <italic>Lissoclinum</italic> sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant <italic>Staphylococcus aureus</italic> (MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, <italic>cis</italic>-3,4-dihydrohamacanthin B and bromodeoxytopsentin from <italic>T. pachastrelloides</italic>, are compared.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Davies Coleman, M T" uniqKey="Davies Coleman M">M.T. Davies-Coleman</name></author><author><name sortKey="Beukes, D R" uniqKey="Beukes D">D.R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id><journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id><journal-id journal-id-type="publisher-id">marinedrugs</journal-id><journal-title-group><journal-title>Marine Drugs</journal-title></journal-title-group><issn pub-type="epub">1660-3397</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26473891</article-id><article-id pub-id-type="pmc">4626695</article-id><article-id pub-id-type="doi">10.3390/md13106366</article-id><article-id pub-id-type="publisher-id">marinedrugs-13-06366</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Recent Advances in Drug Discovery from South African Marine Invertebrates</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Davies-Coleman</surname><given-names>Michael T.</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-13-06366">1</xref><xref rid="c1-marinedrugs-13-06366" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Veale</surname><given-names>Clinton G. L.</given-names></name><xref ref-type="aff" rid="af2-marinedrugs-13-06366">2</xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Urban</surname><given-names>Sylvia</given-names></name><role>Academic Editor</role></contrib></contrib-group><aff id="af1-marinedrugs-13-06366"><label>1</label>Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa</aff><aff id="af2-marinedrugs-13-06366"><label>2</label>Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa; E-Mail:<email>C.Veale@ru.ac.za</email></aff><author-notes><corresp id="c1-marinedrugs-13-06366"><label>*</label>Author to whom correspondence should be addressed; E-Mail: <email>mdavies-coleman@uwc.ac.za</email>; Tel.: +27-21-959-2255.</corresp></author-notes><pub-date pub-type="epub"><day>14</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>10</month><year>2015</year></pub-date><volume>13</volume><issue>10</issue><fpage>6366</fpage><lpage>6383</lpage><history><date date-type="received"><day>25</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>29</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2015</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm <italic>Cephalodiscus gilchristi</italic>, the ascidian <italic>Lissoclinum</italic> sp. and the sponge <italic>Topsentia pachastrelloides</italic>, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from <italic>C. gilchristi</italic> and <italic>Lissoclinum</italic> sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant <italic>Staphylococcus aureus</italic> (MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, <italic>cis</italic>-3,4-dihydrohamacanthin B and bromodeoxytopsentin from <italic>T. pachastrelloides</italic>, are compared.</p></abstract><kwd-group><kwd>cephalostatin</kwd><kwd>mandelalide</kwd><kwd>methicillin resistant <italic>Staphylococcus aureus</italic></kwd><kwd>MRSA PK</kwd><kwd>bisindole alkaloids</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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