Update on thyroid eye disease and management
Identifieur interne : 000495 ( Pmc/Corpus ); précédent : 000494; suivant : 000496Update on thyroid eye disease and management
Auteurs : Erick D. Bothun ; Ryan A. Scheurer ; Andrew R. Harrison ; Michael S. LeeSource :
- Clinical Ophthalmology (Auckland, N.Z.) [ 1177-5467 ] ; 2009.
Abstract
Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age. The inflammation may parallel or remain isolated from a related inflammatory cascade in the thyroid called Graves’ disease. The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy. In this article, we will discuss this unique condition including the ophthalmic findings and management.
Url:
PubMed: 19898626
PubMed Central: 2770865
Links to Exploration step
PMC:2770865Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Update on thyroid eye disease and management</title>
<author><name sortKey="Bothun, Erick D" sort="Bothun, Erick D" uniqKey="Bothun E" first="Erick D" last="Bothun">Erick D. Bothun</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2-opth-3-543">Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scheurer, Ryan A" sort="Scheurer, Ryan A" uniqKey="Scheurer R" first="Ryan A" last="Scheurer">Ryan A. Scheurer</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harrison, Andrew R" sort="Harrison, Andrew R" uniqKey="Harrison A" first="Andrew R" last="Harrison">Andrew R. Harrison</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3-opth-3-543">Otolaryngology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Michael S" sort="Lee, Michael S" uniqKey="Lee M" first="Michael S" last="Lee">Michael S. Lee</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="af4-opth-3-543">Neurosurgery</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5-opth-3-543">Neurology, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19898626</idno>
<idno type="pmc">2770865</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770865</idno>
<idno type="RBID">PMC:2770865</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000495</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000495</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Update on thyroid eye disease and management</title>
<author><name sortKey="Bothun, Erick D" sort="Bothun, Erick D" uniqKey="Bothun E" first="Erick D" last="Bothun">Erick D. Bothun</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2-opth-3-543">Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scheurer, Ryan A" sort="Scheurer, Ryan A" uniqKey="Scheurer R" first="Ryan A" last="Scheurer">Ryan A. Scheurer</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harrison, Andrew R" sort="Harrison, Andrew R" uniqKey="Harrison A" first="Andrew R" last="Harrison">Andrew R. Harrison</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3-opth-3-543">Otolaryngology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Michael S" sort="Lee, Michael S" uniqKey="Lee M" first="Michael S" last="Lee">Michael S. Lee</name>
<affiliation><nlm:aff id="af1-opth-3-543">Departments of Ophthalmology</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=", and" id="af4-opth-3-543">Neurosurgery</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5-opth-3-543">Neurology, University of Minnesota, Minneapolis, Minnesota, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical Ophthalmology (Auckland, N.Z.)</title>
<idno type="ISSN">1177-5467</idno>
<idno type="eISSN">1177-5483</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age. The inflammation may parallel or remain isolated from a related inflammatory cascade in the thyroid called Graves’ disease. The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy. In this article, we will discuss this unique condition including the ophthalmic findings and management.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Burch, Hb" uniqKey="Burch H">HB Burch</name>
</author>
<author><name sortKey="Wartofsky, L" uniqKey="Wartofsky L">L Wartofsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bahn, Rs" uniqKey="Bahn R">RS Bahn</name>
</author>
<author><name sortKey="Dutton, Cm" uniqKey="Dutton C">CM Dutton</name>
</author>
<author><name sortKey="Natt, N" uniqKey="Natt N">N Natt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Werner, Sc" uniqKey="Werner S">SC Werner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamada, M" uniqKey="Yamada M">M Yamada</name>
</author>
<author><name sortKey="Li, Aw" uniqKey="Li A">AW Li</name>
</author>
<author><name sortKey="Wall, Jr" uniqKey="Wall J">JR Wall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bednarczuk, T" uniqKey="Bednarczuk T">T Bednarczuk</name>
</author>
<author><name sortKey="Gopinath, B" uniqKey="Gopinath B">B Gopinath</name>
</author>
<author><name sortKey="Ploski, R" uniqKey="Ploski R">R Ploski</name>
</author>
<author><name sortKey="Wall, Jr" uniqKey="Wall J">JR Wall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manji, N" uniqKey="Manji N">N Manji</name>
</author>
<author><name sortKey="Carr Smith, Jd" uniqKey="Carr Smith J">JD Carr-Smith</name>
</author>
<author><name sortKey="Boelaert, K" uniqKey="Boelaert K">K Boelaert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perros, P" uniqKey="Perros P">P Perros</name>
</author>
<author><name sortKey="Crombie, Al" uniqKey="Crombie A">AL Crombie</name>
</author>
<author><name sortKey="Matthews, Jn" uniqKey="Matthews J">JN Matthews</name>
</author>
<author><name sortKey="Kendall Taylor, P" uniqKey="Kendall Taylor P">P Kendall-Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rundle, Ff" uniqKey="Rundle F">FF Rundle</name>
</author>
<author><name sortKey="Wilson, Cw" uniqKey="Wilson C">CW Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfeilschifter, J" uniqKey="Pfeilschifter J">J Pfeilschifter</name>
</author>
<author><name sortKey="Ziegler, R" uniqKey="Ziegler R">R Ziegler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eckstein, A" uniqKey="Eckstein A">A Eckstein</name>
</author>
<author><name sortKey="Quadbeck, B" uniqKey="Quadbeck B">B Quadbeck</name>
</author>
<author><name sortKey="Mueller, G" uniqKey="Mueller G">G Mueller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartley, Gb" uniqKey="Bartley G">GB Bartley</name>
</author>
<author><name sortKey="Fatourechi, V" uniqKey="Fatourechi V">V Fatourechi</name>
</author>
<author><name sortKey="Kadrmas, Ef" uniqKey="Kadrmas E">EF Kadrmas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Koornneef, L" uniqKey="Koornneef L">L Koornneef</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
<author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Berghout, A" uniqKey="Berghout A">A Berghout</name>
</author>
<author><name sortKey="Van Der Gaag, R" uniqKey="Van Der Gaag R">R van der Gaag</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sergott, Rc" uniqKey="Sergott R">RC Sergott</name>
</author>
<author><name sortKey="Felberg, Nt" uniqKey="Felberg N">NT Felberg</name>
</author>
<author><name sortKey="Savino, Pj" uniqKey="Savino P">PJ Savino</name>
</author>
<author><name sortKey="Blizzard, Jj" uniqKey="Blizzard J">JJ Blizzard</name>
</author>
<author><name sortKey="Schatz, Nj" uniqKey="Schatz N">NJ Schatz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbard, Jp" uniqKey="Gilbard J">JP Gilbard</name>
</author>
<author><name sortKey="Farris, Rl" uniqKey="Farris R">RL Farris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dickinson, Aj" uniqKey="Dickinson A">AJ Dickinson</name>
</author>
<author><name sortKey="Perros, P" uniqKey="Perros P">P Perros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
<author><name sortKey="Perros, P" uniqKey="Perros P">P Perros</name>
</author>
<author><name sortKey="Kahaly, Gj" uniqKey="Kahaly G">GJ Kahaly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mckeag, D" uniqKey="Mckeag D">D McKeag</name>
</author>
<author><name sortKey="Lane, C" uniqKey="Lane C">C Lane</name>
</author>
<author><name sortKey="Lazarus, Jh" uniqKey="Lazarus J">JH Lazarus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
<author><name sortKey="Koornneef, L" uniqKey="Koornneef L">L Koornneef</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartley, Gb" uniqKey="Bartley G">GB Bartley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Terwee, Cb" uniqKey="Terwee C">CB Terwee</name>
</author>
<author><name sortKey="Gerding, Mn" uniqKey="Gerding M">MN Gerding</name>
</author>
<author><name sortKey="Dekker, Fw" uniqKey="Dekker F">FW Dekker</name>
</author>
<author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
<author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Koornneef, L" uniqKey="Koornneef L">L Koornneef</name>
</author>
<author><name sortKey="Berghout, A" uniqKey="Berghout A">A Berghout</name>
</author>
<author><name sortKey="Van Der Gaag, R" uniqKey="Van Der Gaag R">R van der Gaag</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
<author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Koornneef, L" uniqKey="Koornneef L">L Koornneef</name>
</author>
<author><name sortKey="Berghout, A" uniqKey="Berghout A">A Berghout</name>
</author>
<author><name sortKey="Van Der Gaag, R" uniqKey="Van Der Gaag R">R van der Gaag</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Bogazzi, F" uniqKey="Bogazzi F">F Bogazzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menconi, F" uniqKey="Menconi F">F Menconi</name>
</author>
<author><name sortKey="Marin, M" uniqKey="Marin M">M Marinò</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tallstedt, L" uniqKey="Tallstedt L">L Tallstedt</name>
</author>
<author><name sortKey="Lundell, G" uniqKey="Lundell G">G Lundell</name>
</author>
<author><name sortKey="T Rring, O" uniqKey="T Rring O">O Tørring</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Bogazzi, F" uniqKey="Bogazzi F">F Bogazzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Bogazzi, F" uniqKey="Bogazzi F">F Bogazzi</name>
</author>
<author><name sortKey="Panicucci, M" uniqKey="Panicucci M">M Panicucci</name>
</author>
<author><name sortKey="Lepri, A" uniqKey="Lepri A">A Lepri</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perros, P" uniqKey="Perros P">P Perros</name>
</author>
<author><name sortKey="Kendall Taylor, P" uniqKey="Kendall Taylor P">P Kendall-Taylor</name>
</author>
<author><name sortKey="Neoh, C" uniqKey="Neoh C">C Neoh</name>
</author>
<author><name sortKey="Frewin, S" uniqKey="Frewin S">S Frewin</name>
</author>
<author><name sortKey="Dickinson, J" uniqKey="Dickinson J">J Dickinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Are, Ja" uniqKey="O Are J">JA O’Hare</name>
</author>
<author><name sortKey="Georghegan, M" uniqKey="Georghegan M">M Georghegan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uddin, Jm" uniqKey="Uddin J">JM Uddin</name>
</author>
<author><name sortKey="Davies, Pd" uniqKey="Davies P">PD Davies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ebner, R" uniqKey="Ebner R">R Ebner</name>
</author>
<author><name sortKey="Devoto, Mh" uniqKey="Devoto M">MH Devoto</name>
</author>
<author><name sortKey="Weil, D" uniqKey="Weil D">D Weil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Tanda, Ml" uniqKey="Tanda M">ML Tanda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hart, Rh" uniqKey="Hart R">RH Hart</name>
</author>
<author><name sortKey="Kendall Taylor, P" uniqKey="Kendall Taylor P">P Kendall-Taylor</name>
</author>
<author><name sortKey="Crombie, A" uniqKey="Crombie A">A Crombie</name>
</author>
<author><name sortKey="Perros, P" uniqKey="Perros P">P Perros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marin, M" uniqKey="Marin M">M Marinó</name>
</author>
<author><name sortKey="Morabito, E" uniqKey="Morabito E">E Morabito</name>
</author>
<author><name sortKey="Brunetto, Mr" uniqKey="Brunetto M">MR Brunetto</name>
</author>
<author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
<author><name sortKey="Marocci, C" uniqKey="Marocci C">C Marocci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ben Simon, Gj" uniqKey="Ben Simon G">GJ Ben Simon</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Mccann, Jd" uniqKey="Mccann J">JD McCann</name>
</author>
<author><name sortKey="Goldberg, Ra" uniqKey="Goldberg R">RA Goldberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kahaly, Gj" uniqKey="Kahaly G">GJ Kahaly</name>
</author>
<author><name sortKey="Pitz, S" uniqKey="Pitz S">S Pitz</name>
</author>
<author><name sortKey="Hommel, G" uniqKey="Hommel G">G Hommel</name>
</author>
<author><name sortKey="Dittmar, M" uniqKey="Dittmar M">M Dittmar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Geest, Rj" uniqKey="Van Geest R">RJ Van Geest</name>
</author>
<author><name sortKey="Sasim, Iv" uniqKey="Sasim I">IV Sasim</name>
</author>
<author><name sortKey="Koppeschaar, Hp" uniqKey="Koppeschaar H">HP Koppeschaar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Panicucci, M" uniqKey="Panicucci M">M Panicucci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldberg, Ra" uniqKey="Goldberg R">RA Goldberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wakelkamp, Im" uniqKey="Wakelkamp I">IM Wakelkamp</name>
</author>
<author><name sortKey="Baldeschi, L" uniqKey="Baldeschi L">L Baldeschi</name>
</author>
<author><name sortKey="Saeed, P" uniqKey="Saeed P">P Saeed</name>
</author>
<author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Koornneef, L" uniqKey="Koornneef L">L Koornneef</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
<author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Berghout, A" uniqKey="Berghout A">A Berghout</name>
</author>
<author><name sortKey="Van Der Gaag, R" uniqKey="Van Der Gaag R">R van der Gaag</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scott, Ab" uniqKey="Scott A">AB Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uddin, Jm" uniqKey="Uddin J">JM Uddin</name>
</author>
<author><name sortKey="Davies, Pd" uniqKey="Davies P">PD Davies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gorman, Ca" uniqKey="Gorman C">CA Gorman</name>
</author>
<author><name sortKey="Garrity, Ja" uniqKey="Garrity J">JA Garrity</name>
</author>
<author><name sortKey="Fatourechi, V" uniqKey="Fatourechi V">V Fatourechi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Blank, L" uniqKey="Blank L">L Blank</name>
</author>
<author><name sortKey="Berghout, A" uniqKey="Berghout A">A Berghout</name>
</author>
<author><name sortKey="Koornneef, L" uniqKey="Koornneef L">L Koornneef</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
<author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Bogazzi, F" uniqKey="Bogazzi F">F Bogazzi</name>
</author>
<author><name sortKey="Bruno Bossio, G" uniqKey="Bruno Bossio G">G Bruno-Bossio</name>
</author>
<author><name sortKey="Lepri, A" uniqKey="Lepri A">A Lepri</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Van Kempen Harteveld, Ml" uniqKey="Van Kempen Harteveld M">ML van Kempen-Harteveld</name>
</author>
<author><name sortKey="Garcia, Mb" uniqKey="Garcia M">MB García</name>
</author>
<author><name sortKey="Koppeschaar, Hp" uniqKey="Koppeschaar H">HP Koppeschaar</name>
</author>
<author><name sortKey="Tick, L" uniqKey="Tick L">L Tick</name>
</author>
<author><name sortKey="Terwee, Cb" uniqKey="Terwee C">CB Terwee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bradley, Ea" uniqKey="Bradley E">EA Bradley</name>
</author>
<author><name sortKey="Gower, Ew" uniqKey="Gower E">EW Gower</name>
</author>
<author><name sortKey="Bradley, Dj" uniqKey="Bradley D">DJ Bradley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kahaly, Gj" uniqKey="Kahaly G">GJ Kahaly</name>
</author>
<author><name sortKey="Rosler, Hp" uniqKey="Rosler H">HP Rösler</name>
</author>
<author><name sortKey="Pitz, S" uniqKey="Pitz S">S Pitz</name>
</author>
<author><name sortKey="Hommel, G" uniqKey="Hommel G">G Hommel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakahara, H" uniqKey="Nakahara H">H Nakahara</name>
</author>
<author><name sortKey="Noguchi, S" uniqKey="Noguchi S">S Noguchi</name>
</author>
<author><name sortKey="Murakami, N" uniqKey="Murakami N">N Murakami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wakelkamp, Im" uniqKey="Wakelkamp I">IM Wakelkamp</name>
</author>
<author><name sortKey="Tan, H" uniqKey="Tan H">H Tan</name>
</author>
<author><name sortKey="Saeed, P" uniqKey="Saeed P">P Saeed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marquez, Sd" uniqKey="Marquez S">SD Marquez</name>
</author>
<author><name sortKey="Lum, Bl" uniqKey="Lum B">BL Lum</name>
</author>
<author><name sortKey="Mcdougall, Ir" uniqKey="Mcdougall I">IR McDougall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baldeschi, L" uniqKey="Baldeschi L">L Baldeschi</name>
</author>
<author><name sortKey="Macandie, K" uniqKey="Macandie K">K MacAndie</name>
</author>
<author><name sortKey="Koetsier, E" uniqKey="Koetsier E">E Koetsier</name>
</author>
<author><name sortKey="Blank, Le" uniqKey="Blank L">LE Blank</name>
</author>
<author><name sortKey="Wiersinga, Wm" uniqKey="Wiersinga W">WM Wiersinga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Baldeschi, L" uniqKey="Baldeschi L">L Baldeschi</name>
</author>
<author><name sortKey="Dickinson, Aj" uniqKey="Dickinson A">AJ Dickinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silver, Rd" uniqKey="Silver R">RD Silver</name>
</author>
<author><name sortKey="Harrison, Ar" uniqKey="Harrison A">AR Harrison</name>
</author>
<author><name sortKey="Goding, Gs" uniqKey="Goding G">GS Goding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldberg, Ra" uniqKey="Goldberg R">RA Goldberg</name>
</author>
<author><name sortKey="Kim, Aj" uniqKey="Kim A">AJ Kim</name>
</author>
<author><name sortKey="Kerivan, Km" uniqKey="Kerivan K">KM Kerivan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forbes, G" uniqKey="Forbes G">G Forbes</name>
</author>
<author><name sortKey="Gorman, Ca" uniqKey="Gorman C">CA Gorman</name>
</author>
<author><name sortKey="Brennan, Md" uniqKey="Brennan M">MD Brennan</name>
</author>
<author><name sortKey="Gehring, Dg" uniqKey="Gehring D">DG Gehring</name>
</author>
<author><name sortKey="Ilstrup, Dm" uniqKey="Ilstrup D">DM Ilstrup</name>
</author>
<author><name sortKey="Earnest, F" uniqKey="Earnest F">F Earnest</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trokel, S" uniqKey="Trokel S">S Trokel</name>
</author>
<author><name sortKey="Kazim, M" uniqKey="Kazim M">M Kazim</name>
</author>
<author><name sortKey="Moore, S" uniqKey="Moore S">S Moore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nunery, Wr" uniqKey="Nunery W">WR Nunery</name>
</author>
<author><name sortKey="Nunery, Cw" uniqKey="Nunery C">CW Nunery</name>
</author>
<author><name sortKey="Martin, Rt" uniqKey="Martin R">RT Martin</name>
</author>
<author><name sortKey="Truong, Tv" uniqKey="Truong T">TV Truong</name>
</author>
<author><name sortKey="Osborn, Dr" uniqKey="Osborn D">DR Osborn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shorr, N" uniqKey="Shorr N">N Shorr</name>
</author>
<author><name sortKey="Seiff, Sr" uniqKey="Seiff S">SR Seiff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lueder, Gt" uniqKey="Lueder G">GT Lueder</name>
</author>
<author><name sortKey="Scott, We" uniqKey="Scott W">WE Scott</name>
</author>
<author><name sortKey="Kutschke, Pj" uniqKey="Kutschke P">PJ Kutschke</name>
</author>
<author><name sortKey="Keech, Rv" uniqKey="Keech R">RV Keech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartalena, L" uniqKey="Bartalena L">L Bartalena</name>
</author>
<author><name sortKey="Pinchera, A" uniqKey="Pinchera A">A Pinchera</name>
</author>
<author><name sortKey="Marcocci, C" uniqKey="Marcocci C">C Marcocci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prummel, Mf" uniqKey="Prummel M">MF Prummel</name>
</author>
<author><name sortKey="Mourits, Mp" uniqKey="Mourits M">MP Mourits</name>
</author>
<author><name sortKey="Berghout, A" uniqKey="Berghout A">A Berghout</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Fassi, D" uniqKey="El Fassi D">D El Fassi</name>
</author>
<author><name sortKey="Nielsen, Ch" uniqKey="Nielsen C">CH Nielsen</name>
</author>
<author><name sortKey="Hasselbalch, Hc" uniqKey="Hasselbalch H">HC Hasselbalch</name>
</author>
<author><name sortKey="Hegedus, L" uniqKey="Hegedus L">L Hegedüs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paridaens, D" uniqKey="Paridaens D">D Paridaens</name>
</author>
<author><name sortKey="Van Den Bosch, Wa" uniqKey="Van Den Bosch W">WA van den Bosch</name>
</author>
<author><name sortKey="Van Der Loos, Tl" uniqKey="Van Der Loos T">TL van der Loos</name>
</author>
<author><name sortKey="Krenning, Ep" uniqKey="Krenning E">EP Krenning</name>
</author>
<author><name sortKey="Van Hagen, Pm" uniqKey="Van Hagen P">PM van Hagen</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Ophthalmol</journal-id>
<journal-id journal-id-type="publisher-id">Clinical Ophthalmology</journal-id>
<journal-title-group><journal-title>Clinical Ophthalmology (Auckland, N.Z.)</journal-title>
</journal-title-group>
<issn pub-type="ppub">1177-5467</issn>
<issn pub-type="epub">1177-5483</issn>
<publisher><publisher-name>Dove Medical Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19898626</article-id>
<article-id pub-id-type="pmc">2770865</article-id>
<article-id pub-id-type="publisher-id">opth-3-543</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Update on thyroid eye disease and management</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bothun</surname>
<given-names>Erick D</given-names>
</name>
<xref ref-type="aff" rid="af1-opth-3-543">1</xref>
<xref ref-type="aff" rid="af2-opth-3-543">2</xref>
<xref ref-type="corresp" rid="c1-opth-3-543"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scheurer</surname>
<given-names>Ryan A</given-names>
</name>
<xref ref-type="aff" rid="af1-opth-3-543">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harrison</surname>
<given-names>Andrew R</given-names>
</name>
<xref ref-type="aff" rid="af1-opth-3-543">1</xref>
<xref ref-type="aff" rid="af3-opth-3-543">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Michael S</given-names>
</name>
<xref ref-type="aff" rid="af1-opth-3-543">1</xref>
<xref ref-type="aff" rid="af4-opth-3-543">4</xref>
<xref ref-type="aff" rid="af5-opth-3-543">5</xref>
</contrib>
</contrib-group>
<aff id="af1-opth-3-543"><label>1</label>
Departments of Ophthalmology</aff>
<aff id="af2-opth-3-543"><label>2</label>
Pediatrics</aff>
<aff id="af3-opth-3-543"><label>3</label>
Otolaryngology</aff>
<aff id="af4-opth-3-543"><label>4</label>
Neurosurgery, and</aff>
<aff id="af5-opth-3-543"><label>5</label>
Neurology, University of Minnesota, Minneapolis, Minnesota, USA</aff>
<author-notes><corresp id="c1-opth-3-543">Correspondence: Erick D Bothun, Department of Ophthalmology, University of Minnesota, MMC 493, 420 Delaware Street SE, Minneapolis, MN 55455–5501, USA, Tel +1 (612) 625 4400, Fax +1 (612) 626 3119, Email
<email>bothu003@umn.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2009</year>
</pub-date>
<pmc-comment>Dove Press titles changed from ppub to collections in 2009.
Fake ppub written to satisfy Coll Date Type=ppub</pmc-comment>
<pub-date pub-type="ppub"><year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>10</month>
<year>2009</year>
</pub-date>
<volume>3</volume>
<fpage>543</fpage>
<lpage>551</lpage>
<history><date date-type="received"><day>14</day>
<month>10</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© 2009 Bothun et al, publisher and licensee Dove Medical Press Ltd.</copyright-statement>
<license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age. The inflammation may parallel or remain isolated from a related inflammatory cascade in the thyroid called Graves’ disease. The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy. In this article, we will discuss this unique condition including the ophthalmic findings and management.</p>
</abstract>
<kwd-group><kwd>Graves’ disease</kwd>
<kwd>thyroid eye disease</kwd>
<kwd>proptosis</kwd>
<kwd>orbital decompression</kwd>
<kwd>enlarged extraocular muscles</kwd>
</kwd-group>
</article-meta>
</front>
<body><sec><title>Pathogenesis and epidemiology</title>
<p>The overwhelming majority (90%) of thyroid eye disease (TED) cases are associated with hyperthyroidism, while the rest are either euthyroid or hypothyroid.<xref ref-type="bibr" rid="b1-opth-3-543">1</xref>
Cross-reactivity against shared antigen(s) in thyroid and orbital tissue is most likely responsible for the autoimmune ophthalmologic reaction. Antibodies involving the thyroid-stimulating hormone (TSH) receptor may drive the pathogenesis of this inflammation.<xref ref-type="bibr" rid="b2-opth-3-543">2</xref>
Autoreactive T lymphocytes migrate into the orbital soft tissue, fat and musculature reacting with the shared thyroid and orbital antigen(s). The inflammation results in anatomical changes including eyelid retraction (NOSPECS class I) and redness and swelling of periorbital tissues (class II) including the eyelids, conjunctiva, and caruncle.<xref ref-type="bibr" rid="b3-opth-3-543">3</xref>
,<xref ref-type="bibr" rid="b4-opth-3-543">4</xref>
Secretion of a cytokine cascade stimulates fibroblast proliferation and secretion of glycosaminoglycans resulting in proptosis (class III) from retro-orbital fat expansion and extraocular muscle swelling. The expansion of orbital tissues may lead to the severe motility disorders (class IV), corneal exposure (class V) and optic nerve damage (class VI). Eventually this process results in fibrosis of the extraocular musculature and permanent restriction of eye and lid movements.</p>
<p>Both endogenous (genetic factors, increased age, male sex) and exogenous factors (smoking, thyroid dysfunction, and radioiodine treatment) likely contribute to the development or severity of TED.<xref ref-type="bibr" rid="b5-opth-3-543">5</xref>
,<xref ref-type="bibr" rid="b6-opth-3-543">6</xref>
Approximately half of Graves’ disease patients experience ophthalmic manifestations, with sight-threatening disease in 3% to 5% of cases.<xref ref-type="bibr" rid="b7-opth-3-543">7</xref>
The heterogeneous manifestations and variable course of TED may greatly affect the quality of life in affected patients.</p>
<p>Although TED is a heterogeneous genetic disorder, finding a common genetic loci remains elusive. Candidate genes include human leukocyte antigen (HLA, 6p21–3), cytotoxic T-lymphocyte antigen-4 (CTLA-4, 2q33), tumor necrosis factor (TNF, 6p21–3), interferon-γ, 12q14), intercellular adhesion molecule-1 (ICAM-1, 19p13), and thyroid stimulating hormone receptor gene (TSH-R, 14q13).<xref ref-type="bibr" rid="b5-opth-3-543">5</xref>
TED exhibits a female to male ratio of 4:1; however, more severe disease occurs among affected elderly males.<xref ref-type="bibr" rid="b8-opth-3-543">8</xref>
</p>
</sec>
<sec><title>Course of disease</title>
<p>Thyroid eye disease typically has an inflammatory, active phase subsiding over one to two years (range 6 months to 5 years) into a fibrotic, inactive phase (<xref ref-type="fig" rid="f1-opth-3-543">Figure 1</xref>
).<xref ref-type="bibr" rid="b9-opth-3-543">9</xref>
After the inflammation subsides, patients may suffer permanent structural changes around the eyes requiring treatment. Active inflammation recurs in about 1% of patients after months to years of inactivity. Unfortunately, no reliable test or sign exists to determine when the inactive phase has begun. These patients return for repeat evaluations to document changes in symptoms or clinical findings. Stable clinical findings for 6 months suggest that the patient has passed from the active to the inactive phase. It is important to recognize every patient’s course of TED is different and unique. Some may have minimal signs while others have sudden onset of severe complications such as severe diplopia, proptosis and vision loss.</p>
<p>Smoking has a strong relationship with the course and severity of thyroid eye disease. The relationship is dose-responsive between cigarette use and probability of developing thyroid eye disease.<xref ref-type="bibr" rid="b10-opth-3-543">10</xref>
Smoking is associated with an increased risk of ophthalmic disease after radioiodine therapy and worse or delayed outcomes for treatment of thyroid eye disease.<xref ref-type="bibr" rid="b11-opth-3-543">11</xref>
</p>
</sec>
<sec sec-type="results"><title>Clinical findings</title>
<p>Ophthalmic findings are generally bilateral, but may present unilaterally or asymmetrically.<xref ref-type="bibr" rid="b1-opth-3-543">1</xref>
The presence of pre-existing autoimmune thyroid disease increases suspicion for TED, but isolated eye findings may represent the presenting manifestations of thyroid disorders. The classic presentation in the setting of acute Graves’ disease involves thyrotoxicosis, goiter and bilateral exophthalmos. In one cohort of 120 TED patients, clinical features included: eyelid retraction 91%, exophthalmos 62%, extraocular muscle dysfunction 43%, ocular pain 30%, lacrimation 23%, and optic nerve disease 6%.<xref ref-type="bibr" rid="b12-opth-3-543">12</xref>
</p>
<p>The earliest findings in TED usually involve mild soft tissue inflammation. Early symptoms include foreign body sensation, excessive tearing from dry eye, conjunctival or eyelid redness and swelling, blurred vision, and retro-orbital pain. Dilated conjunctival vasculature, keratoconjunctivitis, and corneal staining may be seen on slit lamp examination.</p>
<p>As the orbital inflammation progresses in severity, swelling of the extraocular muscles (EOM) or orbital soft tissue often manifests as chemosis, lid edema and ocular proptosis.<xref ref-type="bibr" rid="b13-opth-3-543">13</xref>
The EOM may become visible as blood vessels over their anterior portion show prominence. Such vessel engorgement overlying the lateral rectus has been described as a sign of activity;<xref ref-type="bibr" rid="b14-opth-3-543">14</xref>
however this may persist during the inactive disease phase.<xref ref-type="bibr" rid="b13-opth-3-543">13</xref>
Poor venous drainage secondary to the congestive mass effect behind the eyes may contribute to redness and swelling of the eyelids, conjunctiva, and caruncle. Involvement of the levator palpebrae results in eyelid retraction and the characteristic “stare” of TED (<xref ref-type="fig" rid="f2-opth-3-543">Figure 2</xref>
). This appearance is often exaggerated by the presence of exophthalmos. Progressive proptosis with eyelid retraction and meibomian gland inflammation may worsen corneal exposure and progress to corneal ulceration and perforation.<xref ref-type="bibr" rid="b15-opth-3-543">15</xref>
,<xref ref-type="bibr" rid="b16-opth-3-543">16</xref>
Inflammation and scarring of the EOM can cause strabismus and ophthalmoplegia. In mild cases, patients might feel a pulling sensation around the eyes. With more advanced disease, horizontal, vertical and torsional strabismus and double vision ensues (<xref ref-type="fig" rid="f3-opth-3-543">Figure 3</xref>
). Asymmetric EOM restriction manifests as incomitant deviations with diplopia in eccentric gazes, ie, sidegaze esotropia or upgaze hypotropia with medial or inferior involvement respectively. In severe cases the restrictive, incomitant strabismus occurs in primary gaze and patients complain of constant double vision. In addition to vertical and torsional tropias, inferior rectus involvement may lead to a poor Bell’s phenomenon with increased risk of corneal exposure. Diffuse orbital and EOM restriction may lead to intermittent spiking or chronic elevation of intraocular pressure. Intraocular pressures should regularly be tested in both primary and upgaze. Strabismus may develop at any stage in the disease or secondary to orbital changes after decompression surgery. In addition, vertical rectus strabismus surgery may cause iatrogenic eyelid retraction and worsen corneal exposure.</p>
<p>With severe inflammation, the expansion of soft tissues confined within the bony orbit and swelling of the muscles at the apex of the orbit may compress the optic nerve causing dysthyroid optic neuropathy (<xref ref-type="fig" rid="f4-opth-3-543">Figure 4</xref>
).<xref ref-type="bibr" rid="b17-opth-3-543">17</xref>
Although early symptoms include progressive blurring of vision and fading of colors in one or both eyes, visual acuity may be preserved in a minority of patients with optic neuropathy.<xref ref-type="bibr" rid="b18-opth-3-543">18</xref>
Of note, when optic neuropathy occurs the degree of proptosis often does not correlate. Presumably, this occurs when the enlarged EOM expand to compress the optic nerve instead of producing exophthalmos. Signs of optic neuropathy include decrease in visual acuity, visual field, and color vision along with the development of an afferent pupillary defect. Bilateral, simultaneous optic neuropathy can occur which would eliminate a relative afferent pupillary defect. The optic disc may be normal or edematous. Without detection through serial screenings and subsequent prompt treatment, permanent optic atrophy and visual loss may occur.</p>
<p>Careful evaluation of TED patients presenting to an ophthalmologist allows for quantitative assessment disease activity and severity.<xref ref-type="bibr" rid="b17-opth-3-543">17</xref>
Activity of thyroid eye disease can be assessed with the Clinical Activity Score (<xref ref-type="table" rid="t2-opth-3-543">Table 2</xref>
).<xref ref-type="bibr" rid="b19-opth-3-543">19</xref>
The clinical features of inflammation are graded based upon comparison with photographs to improve objectivity.<xref ref-type="bibr" rid="b17-opth-3-543">17</xref>
Severity may be assessed using the NOSPECS classification; this mnemonic for evaluation assists in differentiation of mild, moderate, and severe disease (<xref ref-type="table" rid="t1-opth-3-543">Table 1</xref>
).<xref ref-type="bibr" rid="b3-opth-3-543">3</xref>
,<xref ref-type="bibr" rid="b20-opth-3-543">20</xref>
Impairment of quality of life can be elicited with the Graves’-ophthalmopathy specific QOL questionnaire (GO-QoL).<xref ref-type="bibr" rid="b21-opth-3-543">21</xref>
Initial laboratory studies include bloodwork for thyroid stimulating hormone (TSH), thyroid stimulating immunoglobulin (TSIG), thyroid peroxidase (TPO) antibody, and TSH receptor antibody.</p>
<p>Lastly, radiographic imaging using CT, MRI, or ultrasound may aid in the diagnosis of thyroid eye disease. CT scanning is the modality of choice to evaluate dysthyroid optic neuropathy and the planning of surgical intervention. Findings often include enlargement of orbital fat or musculature with sparing of insertions. The inferior and medial recti are most commonly affected. Other finding on imaging include intracranial prolapse of fat through the superior orbital fissure, straightening of the optic nerve or impingement of apical musculature on the optic nerve.</p>
<p>The differential diagnosis for the clinical features of thyroid eye disease includes infectious and inflamamatory orbital conditions such as orbital myositis, idiopathic orbital inflammatory syndrome, and orbital cellulitis. Rarer conditions include orbital neoplasms and carotid artery – cavernous sinus fistulas. New onset diplopia may result from cranial nerve palsies, internuclear ophthalmoplegia, or myasthenia gravis.</p>
</sec>
<sec><title>Management</title>
<p>Patients with Graves’ ophthalmopathy should be managed by a coordinated team of primary care physicians, endocrinologists, and ophthalmologists with specialty experience in managing TED. This typically involves a neuro-ophthalmologist, an orbital surgeon, and a strabismus surgeon. The complicated nature of treatment often requires coordination of medical, surgical and radiation therapy.<xref ref-type="bibr" rid="b22-opth-3-543">22</xref>
Uncontrolled thyroid function is associated with more severe thyroid eye disease.<xref ref-type="bibr" rid="b23-opth-3-543">23</xref>
,<xref ref-type="bibr" rid="b24-opth-3-543">24</xref>
However, antithyroid drugs and surgical subtotal/near-total thyroidectomy therapies typically do not improve the ophthalmic disease course.<xref ref-type="bibr" rid="b25-opth-3-543">25</xref>
,<xref ref-type="bibr" rid="b26-opth-3-543">26</xref>
In fact, radioiodine therapy for Graves’ disease can exacerbate ophthalmic disease; particularly in the context of smoking, active disease, or elevated TSH-receptor autoantibodies.<xref ref-type="bibr" rid="b27-opth-3-543">27</xref>
,<xref ref-type="bibr" rid="b28-opth-3-543">28</xref>
Administration of steroids during and following radioiodine therapy decreases the risk of exacerbation in patients with active TED.<xref ref-type="bibr" rid="b29-opth-3-543">29</xref>
When radioiodine is administered to patients with inactive TED, risk of eye disease exacerbation is minimal.<xref ref-type="bibr" rid="b30-opth-3-543">30</xref>
</p>
<p>Ophthalmologic treatment must be tailored to the patient’s quality of life, psycho-social effects, and severity and stage of disease. Smoking cessation is mandatory in all phases because it worsens outcome and represents a modifiable risk factor.<xref ref-type="bibr" rid="b31-opth-3-543">31</xref>
Mild, early disease does not require surgical or immunomodulating therapy and clinicians may choose to wait and monitor signs. Management can be symptomatic with lubricating eye drops and ointments for corneal exposure and temporary prisms for diplopia.<xref ref-type="bibr" rid="b32-opth-3-543">32</xref>
Serial examinations are necessary to screen for progression of disease and determination of stability. Moderately severe or severe worsening of orbital congestion and/or severe proptosis can occur with concurrent dysthyroid disease or many years after well-controlled thyroid function from Graves’ disease. When sight is threatened from optic neuropathy or corneal breakdown, urgent referral is necessary to initiate “rescue” therapy, often with glucocorticoid administration and/or orbital decompression. Once the chronic inflammation associated with TED becomes quiescent and a period of stability is noted, “rehabilitative” surgical therapies may be considered.</p>
</sec>
<sec><title>Rescue therapy</title>
<p>When moderate to severe TED is present, early “rescue” intervention may be indicated. Indications for “rescue” include evidence of optic neuropathy, signficant proptosis and extensive exposure keratopathy. Urgent “rescue” treatment, either alone or a combination, includes corticosteroids, surgical orbital decompression, and orbital radiation.</p>
<p>Severe thyroid eye disease is often treated initially with glucocorticoids. The efficacy and tolerability of intravenous administration (IV) is superior to oral or local injection. Oral glucocorticoids, typically prednisone 60 to 100 mg/day, must be taken over an extended period of time.<xref ref-type="bibr" rid="b33-opth-3-543">33</xref>
,<xref ref-type="bibr" rid="b34-opth-3-543">34</xref>
With oral glucocorticoids, bisphosphonates should be considered for limitation of osteoporosis.<xref ref-type="bibr" rid="b35-opth-3-543">35</xref>
Intravenous glucocorticoids pulse therapy may be more effective and better tolerated than oral glucocorticoids.<xref ref-type="bibr" rid="b36-opth-3-543">36</xref>
Marcocci et al found optic neuropathy improved in 11 of 14 patients receiving IV steroids vs 3 of 9 taking glucocorticoids orally. Additionally, the final Clinical Activity Score convalesced IV as compared to the oral glucocorticoid treated group. Improvement in symptoms generally occurs after 1 to 2 weeks of high dose intravenous glucocorticoids.<xref ref-type="bibr" rid="b37-opth-3-543">37</xref>
Rarely adverse effects have included reports of acute liver damage and failure at high doses.<xref ref-type="bibr" rid="b38-opth-3-543">38</xref>
For this reason, it is recommended to confine the cumulative glucocorticoid dose to less than 8 g<xref ref-type="bibr" rid="b39-opth-3-543">39</xref>
(<xref ref-type="table" rid="t2-opth-3-543">Table 2</xref>
).<xref ref-type="bibr" rid="b36-opth-3-543">36</xref>
,<xref ref-type="bibr" rid="b40-opth-3-543">40</xref>
,<xref ref-type="bibr" rid="b41-opth-3-543">41</xref>
</p>
<p>Alternatively, some surgeons feel intraorbital injection of glucocorticoids provide relief of ophthalmologic symptoms with minimal systemic side effects.<xref ref-type="bibr" rid="b34-opth-3-543">34</xref>
A dose of 20 mg triamcinolone (Kenalog<sup>®</sup>
40 mg/mL) monthly is injected into the inferior lateral quadrant of the orbit. There is disagreement,<xref ref-type="bibr" rid="b42-opth-3-543">42</xref>
however, between data comparing injections to other forms of steroid administration.<xref ref-type="bibr" rid="b43-opth-3-543">43</xref>
</p>
<p>Orbital decompression has been a mainstay in historical treatment for TED. Medical therapies have come to replace surgical for the initial management of certain cases of dysthyroid optic neuropathy although both are efficacious.<xref ref-type="bibr" rid="b44-opth-3-543">44</xref>
When contraindications exist to medical management or disease is refractory to trial of glucocorticoids and radiation, urgent surgical decompression is necessary. Decompression for optic neuropathy traditionally involves removal of the medial and inferior walls.<xref ref-type="bibr" rid="b45-opth-3-543">45</xref>
Access to these structures is achieved through transconjunctival or transcaruncular incisions. Otolaryngology may also decompress the posterior medial orbit through a transphenoidal approach. Removal of sufficient posterior bone is important for decompressing optic neuropathy.</p>
<p>The use of botulinum toxin for dysmotility in TED was first described by Scott.<xref ref-type="bibr" rid="b46-opth-3-543">46</xref>
Early in the disease course, a botulinum extraocular muscle injection may temporarily improve motility. However as the disease progresses and the musculature becomes more fibrotic, lasting effects are often limited. Botulinum administration to the levator complex has been shown to temporarily improve lid retraction and corneal exposure.<xref ref-type="bibr" rid="b47-opth-3-543">47</xref>
</p>
<p>The data surrounding use of external ionizing orbital radiation is mixed. Clinical application of such therapy for dysthyroid optic neuropathy lacks conclusive support. Orbital radiation in the active disease phase showed no efficacy in one report.<xref ref-type="bibr" rid="b48-opth-3-543">48</xref>
Radiation is equally as effective as oral glucocorticoids,<xref ref-type="bibr" rid="b49-opth-3-543">49</xref>
yet the combination of treatments provide better results than either individual therapy.<xref ref-type="bibr" rid="b50-opth-3-543">50</xref>
In trials approximately 60% of patients respond to radiation.<xref ref-type="bibr" rid="b51-opth-3-543">51</xref>
A recent report reviewing orbital radiation found improvement in extraocular motility; however, no evidence of improvement in proptosis, eyelid retraction, or soft tissue swelling.<xref ref-type="bibr" rid="b52-opth-3-543">52</xref>
Lower doses of radiation, 1 Gy per week for 20 weeks, have been shown to be equally effective and better tolerated than higher doses, 20 Gy per orbit over 2 weeks.<xref ref-type="bibr" rid="b53-opth-3-543">53</xref>
,<xref ref-type="bibr" rid="b54-opth-3-543">54</xref>
Safety of orbital radiation is encouraging; new onset of definite radiation retinopathy is 1% to 2% over 10 years.<xref ref-type="bibr" rid="b55-opth-3-543">55</xref>
Absolute contraindications include diabetic retinopathy and severe hypertension, while young age represents a relative contraindication.<xref ref-type="bibr" rid="b56-opth-3-543">56</xref>
Fortunately, radiation therapy does not appear to compromise future surgical therapies.<xref ref-type="bibr" rid="b57-opth-3-543">57</xref>
</p>
<p>Rehabilitative surgical therapy, as described below, is best initiated after six months of stable, inactive thyroid eye disease.<xref ref-type="bibr" rid="b58-opth-3-543">58</xref>
If decompression surgery is performed in the active phase, additional decompression may be necessary due to inflammatory changes that persist post-operatively. Additionally, spontaneous remission of symptoms is possible with resolution of the active phase. Wise timing could, therefore, spare patients from unnecessary procedures.</p>
</sec>
<sec><title>Rehabilitative surgical therapy</title>
<p>Rehabilitative surgical therapies are implemented for stable, inactive TED. Such surgical therapy typically involves orbital decompression, strabismus surgery, eyelid repositioning and blepharoplasty. Patients with mild disease may only require one of these restorative procedures. Conversely, patients with severe disease may require all three types of surgery in succession as needed. The order of these procedures is important because decompression may alter or create strabismus, and strabismus surgery on vertical recti can alter eyelid positioning.</p>
<sec><title>Orbital decompression surgery</title>
<p>Traditional indications for decompression involved predominantly optic neuropathy and severe exposure keratopathy. Currently medical therapy including external beam radiotherapy may be considered prior to decompression for optic neuropathy. Proptosis has expanded as a surgical indication to include decompression for cosmesis; and decompression is often utilized to provide relief of congestion. Orbital decompression involves either removal of or thinning of any combination of orbital wall surfaces in addition to removal of orbital fat. In bony decompression, additional space is created for soft tissues to prolapse, often into the ethmoid or maxillary sinuses, temporal fossa, and/or cranial cavity. Removal of the inferior wall with the medial, inferomedial and lateral, balanced medial and lateral, and deep lateral wall decompression are common techniques. Alteration of the orbital vault structure can lead to new onset of diplopia.</p>
<p>In patients lacking diplopia before surgery a medial and lateral balanced decompression has been advocated. The objective of this technique is to decrease morbidity including hypoglobus and imbalanced motility. Endoscopic medial and external lateral technique has been shown to provide effective orbital decompression and compares favorably to 3-wall decompression.<xref ref-type="bibr" rid="b59-opth-3-543">59</xref>
</p>
<p>Deep lateral wall decompression has reportedly reduced proptosis as much as 6 mm. (<xref ref-type="fig" rid="f5-opth-3-543">Figures 5, 6</xref>
) Lateral wall decompression alone has a low rate of new onset diplopia of approximately 7%, with reports as low as 2.6%.<xref ref-type="bibr" rid="b39-opth-3-543">39</xref>
Complications of deep lateral decompression include cerebrospinal fluid leaks. A volume expansion of 5.6 cc may be achieved with this procedure alone.<xref ref-type="bibr" rid="b60-opth-3-543">60</xref>
Deep lateral decompression may also be combined with removal of other walls as needed.</p>
</sec>
<sec><title>Fat decompression</title>
<p>Removal of intraconal fat reduces congestive orbitopathy, proptosis, and may improve preoperative diplopia. Selection of patients is important and CT or MRI is useful in assessing those with predominantly fatty or muscular soft tissue enlargement.<xref ref-type="bibr" rid="b61-opth-3-543">61</xref>
Patients with orbital fat expansion experience better outcomes from fat-only decompression than patients with predominantly extraocular muscle enlargement. Decompression typically involves the inferolateral and superomedial compartments with removal of 3–6 cc of intraconal fat. Safety has been verified with proper selection of patients with orbital fat volume expansion, and new onset diplopia is rare.<xref ref-type="bibr" rid="b62-opth-3-543">62</xref>
Intraconal fat debulking may be utilized alone or in combination with bony decompression.</p>
</sec>
<sec><title>Strabismus</title>
<p>Thyroid eye disease patients often develop diplopia and strabismus requiring surgical correction. The restrictions in motility are most commonly hypotropia or esotropia caused by inferior and medial rectus involvement respectively. Strabismus may present with the onset of orbitopathy or as a direct result of decompression surgery. Patients with preoperative diplopia undergoing inferior and medial wall decompression may experience worsening.<xref ref-type="bibr" rid="b63-opth-3-543">63</xref>
Surgical correction of strabismus is, therefore, planned after decompression. The primary goal of strabismus surgery in TED is restoration of single binocular vision in primary gaze and reading position. (<xref ref-type="fig" rid="f6-opth-3-543">Figures 7, 8</xref>
) Managing patient expectations is important and the surgeon should counsel that single binocular vision in all fields may not be possible. Resection of extraocular muscles is rarely recommended due to the fibrosis and restriction of musculature. Muscle recession on adjustable sutures are frequently utilized since results are more unpredictable compared to the pediatric population.<xref ref-type="bibr" rid="b64-opth-3-543">64</xref>
A single surgery functions sufficiently in 85% of cases with reoperation or prism use in the remainder.<xref ref-type="bibr" rid="b65-opth-3-543">65</xref>
Approximately 25% of all TED patients use prisms or adopt an abnormal head positioning after surgery.</p>
</sec>
<sec><title>Eyelid repositioning and blepharoplasty</title>
<p>Surgery for lengthening eyelids and reducing retraction is frequently performed for patients. Benefits include improvement in symptoms of corneal exposure and appearance. Eyelid repositioning should take place after orbital decompression and strabismus surgeries since vertical rectus surgery may alter eyelid position.<xref ref-type="bibr" rid="b66-opth-3-543">66</xref>
(<xref ref-type="fig" rid="f7-opth-3-543">Figures 9, 10</xref>
) Patients with TED often develop significant fatty prolapse and dermatochalasis of the eyelids requiring blepharoplasty. This procedure may be performed in concert with eyelid repositioning, but often is performed later as a separate procedure.</p>
</sec>
<sec><title>Future therapies</title>
<p>Controversial therapies include a variety of other immunomodulatory agents. Cyclosporine has been shown to work synergistically when used with glucocorticoids.<xref ref-type="bibr" rid="b67-opth-3-543">67</xref>
Other research suggests that agents including rituximab and etanercept may be beneficial.<xref ref-type="bibr" rid="b68-opth-3-543">68</xref>
,<xref ref-type="bibr" rid="b69-opth-3-543">69</xref>
Agents with less proven value include azathioprine, ciamexone, iv immunoglobulin, and somatostatin analogs. There is hope for future use of therapies targeting the immune system and the pathophysiologic mechanism of thyroid eye disease, however, no conclusive data yet exists.</p>
</sec>
</sec>
<sec sec-type="conclusions"><title>Summary</title>
<p>Patients with thyroid eye disease necessitate serial examinations and at times intensive specialty care for the ocular manifestations of this disfiguring and potentially blinding disorder. At the University of Minnesota such care is orchestrated by the Center for Thyroid Eye Disease where patients are cared for at each clinical visit by a neuro-ophthalmologist, orbital and oculoplastic surgeon, and strabismologist. Through this multispecialty approach, the patient’s strategic management and outcome are maximized.</p>
</sec>
</body>
<back><ack><p>Supported, in part, by an unrestricted Departmental grant from Research to Prevent Blindness, Inc., New York, NY, USA.</p>
</ack>
<fn-group><fn><p><bold>Disclosures</bold>
</p>
<p>The authors disclose no conflicts of interest.</p>
</fn>
</fn-group>
<ref-list><title>References</title>
<ref id="b1-opth-3-543"><label>1.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burch</surname>
<given-names>HB</given-names>
</name>
<name><surname>Wartofsky</surname>
<given-names>L</given-names>
</name>
</person-group>
<article-title>Graves’ ophthalmopathy: current concepts regarding pathogenesis and management</article-title>
<source>Endocr Rev</source>
<year>1993</year>
<volume>14</volume>
<issue>6</issue>
<fpage>747</fpage>
<lpage>793</lpage>
<pub-id pub-id-type="pmid">8119236</pub-id>
</mixed-citation>
</ref>
<ref id="b2-opth-3-543"><label>2.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bahn</surname>
<given-names>RS</given-names>
</name>
<name><surname>Dutton</surname>
<given-names>CM</given-names>
</name>
<name><surname>Natt</surname>
<given-names>N</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Thyrotropin receptor expression in Graves’ orbital adipose/connective tissues: potential autoantigen in Graves’ ophthalmopathy</article-title>
<source>J Clin Endocrinol Metab</source>
<year>1998</year>
<volume>83</volume>
<issue>3</issue>
<fpage>998</fpage>
<lpage>1002</lpage>
<pub-id pub-id-type="pmid">9506762</pub-id>
</mixed-citation>
</ref>
<ref id="b3-opth-3-543"><label>3.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Werner</surname>
<given-names>SC</given-names>
</name>
</person-group>
<article-title>Classification of the eye changes of Grave’s disease</article-title>
<source>J Clin Endocrinol Metab</source>
<year>1969</year>
<volume>29</volume>
<issue>7</issue>
<fpage>982</fpage>
<lpage>984</lpage>
<pub-id pub-id-type="pmid">5819411</pub-id>
</mixed-citation>
</ref>
<ref id="b4-opth-3-543"><label>4.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yamada</surname>
<given-names>M</given-names>
</name>
<name><surname>Li</surname>
<given-names>AW</given-names>
</name>
<name><surname>Wall</surname>
<given-names>JR</given-names>
</name>
</person-group>
<article-title>Thyroid-associated ophthalmopathy: clinical features, pathogenesis, and management</article-title>
<source>Crit Rev Clin Lab Sci</source>
<year>2000</year>
<volume>37</volume>
<issue>6</issue>
<fpage>523</fpage>
<lpage>549</lpage>
<pub-id pub-id-type="pmid">11192331</pub-id>
</mixed-citation>
</ref>
<ref id="b5-opth-3-543"><label>5.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bednarczuk</surname>
<given-names>T</given-names>
</name>
<name><surname>Gopinath</surname>
<given-names>B</given-names>
</name>
<name><surname>Ploski</surname>
<given-names>R</given-names>
</name>
<name><surname>Wall</surname>
<given-names>JR</given-names>
</name>
</person-group>
<article-title>Susceptibility genes in Graves’ ophthalmopathy: searching for a needle in a haystack?</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>2007</year>
<volume>67</volume>
<issue>1</issue>
<fpage>3</fpage>
<lpage>19</lpage>
<pub-id pub-id-type="pmid">17521325</pub-id>
</mixed-citation>
</ref>
<ref id="b6-opth-3-543"><label>6.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Manji</surname>
<given-names>N</given-names>
</name>
<name><surname>Carr-Smith</surname>
<given-names>JD</given-names>
</name>
<name><surname>Boelaert</surname>
<given-names>K</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype</article-title>
<source>J Clin Endocrinol Metab</source>
<year>2006</year>
<volume>91</volume>
<issue>12</issue>
<fpage>4873</fpage>
<lpage>4880</lpage>
<pub-id pub-id-type="pmid">16968788</pub-id>
</mixed-citation>
</ref>
<ref id="b7-opth-3-543"><label>7.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Management of Graves’ ophthalmopathy: reality and perspectives</article-title>
<source>Endocr Rev</source>
<year>2000</year>
<volume>21</volume>
<issue>2</issue>
<fpage>168</fpage>
<lpage>199</lpage>
<pub-id pub-id-type="pmid">10782363</pub-id>
</mixed-citation>
</ref>
<ref id="b8-opth-3-543"><label>8.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Perros</surname>
<given-names>P</given-names>
</name>
<name><surname>Crombie</surname>
<given-names>AL</given-names>
</name>
<name><surname>Matthews</surname>
<given-names>JN</given-names>
</name>
<name><surname>Kendall-Taylor</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title>Age and gender influence the severity of thyroid-associated ophthalmopathy: a study of 101 patients attending a combined thyroid-eye clinic</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>1993</year>
<volume>38</volume>
<issue>4</issue>
<fpage>367</fpage>
<lpage>372</lpage>
<pub-id pub-id-type="pmid">8319368</pub-id>
</mixed-citation>
</ref>
<ref id="b9-opth-3-543"><label>9.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rundle</surname>
<given-names>FF</given-names>
</name>
<name><surname>Wilson</surname>
<given-names>CW</given-names>
</name>
</person-group>
<article-title>Development and course of exophthalmos and ophthalmoplegia in Graves’ disease with special reference to the effect of thyroidectomy</article-title>
<source>Clin Sci</source>
<year>1945</year>
<volume>5</volume>
<fpage>177</fpage>
<lpage>194</lpage>
</mixed-citation>
</ref>
<ref id="b10-opth-3-543"><label>10.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pfeilschifter</surname>
<given-names>J</given-names>
</name>
<name><surname>Ziegler</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Smoking and endocrine ophthalmopathy: impact of smoking severity and current vs lifetime cigarette consumption</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>1996</year>
<volume>45</volume>
<issue>4</issue>
<fpage>477</fpage>
<lpage>481</lpage>
<pub-id pub-id-type="pmid">8959089</pub-id>
</mixed-citation>
</ref>
<ref id="b11-opth-3-543"><label>11.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eckstein</surname>
<given-names>A</given-names>
</name>
<name><surname>Quadbeck</surname>
<given-names>B</given-names>
</name>
<name><surname>Mueller</surname>
<given-names>G</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Impact of smoking on the response to treatment of thyroid associated ophthalmopathy</article-title>
<source>Br J Ophthalmol</source>
<year>2003</year>
<volume>87</volume>
<issue>6</issue>
<fpage>773</fpage>
<lpage>776</lpage>
<pub-id pub-id-type="pmid">12770979</pub-id>
</mixed-citation>
</ref>
<ref id="b12-opth-3-543"><label>12.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartley</surname>
<given-names>GB</given-names>
</name>
<name><surname>Fatourechi</surname>
<given-names>V</given-names>
</name>
<name><surname>Kadrmas</surname>
<given-names>EF</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Clinical features of Graves’ ophthalmopathy in an incidence cohort</article-title>
<source>Am J Ophthalmol</source>
<year>1996</year>
<volume>121</volume>
<issue>3</issue>
<fpage>284</fpage>
<lpage>290</lpage>
<pub-id pub-id-type="pmid">8597271</pub-id>
</mixed-citation>
</ref>
<ref id="b13-opth-3-543"><label>13.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Koornneef</surname>
<given-names>L</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Berghout</surname>
<given-names>A</given-names>
</name>
<name><surname>van der Gaag</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Clinical criteria for the assessment of disease activity in Graves’ ophthalmopathy: a novel approach</article-title>
<source>Br J Ophthalmol</source>
<year>1989</year>
<volume>73</volume>
<issue>8</issue>
<fpage>639</fpage>
<lpage>644</lpage>
<pub-id pub-id-type="pmid">2765444</pub-id>
</mixed-citation>
</ref>
<ref id="b14-opth-3-543"><label>14.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sergott</surname>
<given-names>RC</given-names>
</name>
<name><surname>Felberg</surname>
<given-names>NT</given-names>
</name>
<name><surname>Savino</surname>
<given-names>PJ</given-names>
</name>
<name><surname>Blizzard</surname>
<given-names>JJ</given-names>
</name>
<name><surname>Schatz</surname>
<given-names>NJ</given-names>
</name>
</person-group>
<article-title>Graves’ ophthalmopathy – immunologic parameters related to corticosteroid therapy</article-title>
<source>Invest Ophthalmol Vis Sci</source>
<year>1981</year>
<volume>20</volume>
<fpage>173</fpage>
<lpage>182</lpage>
<pub-id pub-id-type="pmid">6970185</pub-id>
</mixed-citation>
</ref>
<ref id="b15-opth-3-543"><label>15.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gilbard</surname>
<given-names>JP</given-names>
</name>
<name><surname>Farris</surname>
<given-names>RL</given-names>
</name>
</person-group>
<article-title>Ocular surface drying and tear film osmolarity in thyroid eye disease</article-title>
<source>Acta Ophthalmol (Copenh)</source>
<year>1983</year>
<volume>61</volume>
<issue>1</issue>
<fpage>108</fpage>
<lpage>116</lpage>
<pub-id pub-id-type="pmid">6687972</pub-id>
</mixed-citation>
</ref>
<ref id="b16-opth-3-543"><label>16.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dickinson</surname>
<given-names>AJ</given-names>
</name>
<name><surname>Perros</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title>Controversies in the clinical evaluation of active thyroid-associated orbitopathy: use of a detailed protocol with comparative photographs for objective assessment</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>2001</year>
<volume>55</volume>
<issue>3</issue>
<fpage>283</fpage>
<lpage>303</lpage>
<pub-id pub-id-type="pmid">11589671</pub-id>
</mixed-citation>
</ref>
<ref id="b17-opth-3-543"><label>17.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Perros</surname>
<given-names>P</given-names>
</name>
<name><surname>Kahaly</surname>
<given-names>GJ</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Clinical assessment of patients with Graves’ orbitopathy: the European Group on Graves’ Orbitopathy recommendations to generalists, specialists and clinical researchers</article-title>
<source>Eur J Endocrinol</source>
<year>2006</year>
<volume>155</volume>
<issue>3</issue>
<fpage>387</fpage>
<lpage>389</lpage>
<pub-id pub-id-type="pmid">16914591</pub-id>
</mixed-citation>
</ref>
<ref id="b18-opth-3-543"><label>18.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>McKeag</surname>
<given-names>D</given-names>
</name>
<name><surname>Lane</surname>
<given-names>C</given-names>
</name>
<name><surname>Lazarus</surname>
<given-names>JH</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Clinical features of dysthyroid optic neuropathy: a European Group on Graves’ Orbitopathy (EUGOGO) survey</article-title>
<source>Br J Ophthalmol</source>
<year>2007</year>
<volume>91</volume>
<issue>4</issue>
<fpage>455</fpage>
<lpage>458</lpage>
<pub-id pub-id-type="pmid">17035276</pub-id>
</mixed-citation>
</ref>
<ref id="b19-opth-3-543"><label>19.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Koornneef</surname>
<given-names>L</given-names>
</name>
</person-group>
<article-title>Clinical activity score as a guide in the management of patients with Graves’ ophthalmopathy</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>1997</year>
<volume>47</volume>
<issue>1</issue>
<fpage>9</fpage>
<lpage>14</lpage>
<pub-id pub-id-type="pmid">9302365</pub-id>
</mixed-citation>
</ref>
<ref id="b20-opth-3-543"><label>20.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartley</surname>
<given-names>GB</given-names>
</name>
</person-group>
<article-title>Evolution of classification systems for Graves’ ophthalmopathy</article-title>
<source>Ophthal Plast Reconstr Surg</source>
<year>1995</year>
<volume>11</volume>
<issue>4</issue>
<fpage>229</fpage>
<lpage>237</lpage>
</mixed-citation>
</ref>
<ref id="b21-opth-3-543"><label>21.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Terwee</surname>
<given-names>CB</given-names>
</name>
<name><surname>Gerding</surname>
<given-names>MN</given-names>
</name>
<name><surname>Dekker</surname>
<given-names>FW</given-names>
</name>
<name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
</person-group>
<article-title>Development of a disease specific quality of life questionnaire for patients with Graves’ ophthalmopathy: the GO-QOL</article-title>
<source>Br J Ophthalmol</source>
<year>1998</year>
<volume>82</volume>
<issue>7</issue>
<fpage>773</fpage>
<lpage>779</lpage>
<pub-id pub-id-type="pmid">9924370</pub-id>
</mixed-citation>
</ref>
<ref id="b22-opth-3-543"><label>22.</label>
<mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
</person-group>
<article-title>Combined thyroid-eye clinics</article-title>
<person-group person-group-type="editor"><name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Kahaly</surname>
<given-names>GJ</given-names>
</name>
</person-group>
<source>Graves’ Orbitopathy: A Multidisciplinary Approach</source>
<publisher-loc>Basel</publisher-loc>
<publisher-name>Karger</publisher-name>
<year>2007</year>
<fpage>96</fpage>
<lpage>99</lpage>
</mixed-citation>
</ref>
<ref id="b23-opth-3-543"><label>23.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Koornneef</surname>
<given-names>L</given-names>
</name>
<name><surname>Berghout</surname>
<given-names>A</given-names>
</name>
<name><surname>van der Gaag</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Amelioration of eye changes of Graves’ ophthalmopathy by achieving euthyroidism</article-title>
<source>Acta Endocrinol (Copenh)</source>
<year>1989</year>
<volume>121</volume>
<issue>Suppl 2</issue>
<fpage>S185</fpage>
<lpage>S190</lpage>
</mixed-citation>
</ref>
<ref id="b24-opth-3-543"><label>24.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Koornneef</surname>
<given-names>L</given-names>
</name>
<name><surname>Berghout</surname>
<given-names>A</given-names>
</name>
<name><surname>van der Gaag</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Effect of abnormal thyroid function on the severity of Graves’ ophthalmopathy</article-title>
<source>Arch Intern Med</source>
<year>1990</year>
<volume>150</volume>
<issue>5</issue>
<fpage>1098</fpage>
<lpage>1101</lpage>
<pub-id pub-id-type="pmid">1691908</pub-id>
</mixed-citation>
</ref>
<ref id="b25-opth-3-543"><label>25.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Bogazzi</surname>
<given-names>F</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Relation between therapy for hyperthyroidism and the course of Graves’ ophthalmopathy</article-title>
<source>N Engl J Med</source>
<year>1998</year>
<volume>338</volume>
<issue>2</issue>
<fpage>73</fpage>
<lpage>78</lpage>
<pub-id pub-id-type="pmid">9420337</pub-id>
</mixed-citation>
</ref>
<ref id="b26-opth-3-543"><label>26.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Menconi</surname>
<given-names>F</given-names>
</name>
<name><surname>Marinò</surname>
<given-names>M</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Effects of total thyroid ablation versus near-total thyroidectomy alone on mild to moderate Graves’ orbitopathy treated with intravenous glucocorticoids</article-title>
<source>J Clin Endocrinol Metab</source>
<year>2007</year>
<volume>92</volume>
<issue>5</issue>
<fpage>1653</fpage>
<lpage>1658</lpage>
<pub-id pub-id-type="pmid">17299076</pub-id>
</mixed-citation>
</ref>
<ref id="b27-opth-3-543"><label>27.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tallstedt</surname>
<given-names>L</given-names>
</name>
<name><surname>Lundell</surname>
<given-names>G</given-names>
</name>
<name><surname>Tørring</surname>
<given-names>O</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Occurrence of ophthalmopathy after treatment for Graves’ hyperthyroidism. The Thyroid Study Group</article-title>
<source>N Engl J Med</source>
<year>1992</year>
<volume>326</volume>
<issue>26</issue>
<fpage>1733</fpage>
<lpage>1738</lpage>
<pub-id pub-id-type="pmid">1489388</pub-id>
</mixed-citation>
</ref>
<ref id="b28-opth-3-543"><label>28.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Bogazzi</surname>
<given-names>F</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Relation between therapy for hyperthyroidism and the course of Graves’ ophthalmopathy</article-title>
<source>N Engl J Med</source>
<year>1998</year>
<volume>338</volume>
<issue>2</issue>
<fpage>73</fpage>
<lpage>78</lpage>
<pub-id pub-id-type="pmid">9420337</pub-id>
</mixed-citation>
</ref>
<ref id="b29-opth-3-543"><label>29.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Bogazzi</surname>
<given-names>F</given-names>
</name>
<name><surname>Panicucci</surname>
<given-names>M</given-names>
</name>
<name><surname>Lepri</surname>
<given-names>A</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>Use of corticosteroids to prevent progression of Graves’ ophthalmopathy after radioiodine therapy for hyperthyroidism</article-title>
<source>N Engl J Med</source>
<year>1989</year>
<volume>321</volume>
<issue>20</issue>
<fpage>1349</fpage>
<lpage>1352</lpage>
<pub-id pub-id-type="pmid">2811943</pub-id>
</mixed-citation>
</ref>
<ref id="b30-opth-3-543"><label>30.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Perros</surname>
<given-names>P</given-names>
</name>
<name><surname>Kendall-Taylor</surname>
<given-names>P</given-names>
</name>
<name><surname>Neoh</surname>
<given-names>C</given-names>
</name>
<name><surname>Frewin</surname>
<given-names>S</given-names>
</name>
<name><surname>Dickinson</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>A prospective study of the effects of radioiodine therapy for hyperthyroidism in patients with minimally active graves’ ophthalmopathy</article-title>
<source>J Clin Endocrinol Metab</source>
<year>2005</year>
<volume>90</volume>
<issue>9</issue>
<fpage>5321</fpage>
<lpage>5323</lpage>
<pub-id pub-id-type="pmid">15985483</pub-id>
</mixed-citation>
</ref>
<ref id="b31-opth-3-543"><label>31.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>O’Hare</surname>
<given-names>JA</given-names>
</name>
<name><surname>Georghegan</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>Cigarette smoking as a promoter of Graves’ disease</article-title>
<source>Eur J Intern Med</source>
<year>1993</year>
<volume>4</volume>
<fpage>289</fpage>
<lpage>292</lpage>
</mixed-citation>
</ref>
<ref id="b32-opth-3-543"><label>32.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uddin</surname>
<given-names>JM</given-names>
</name>
<name><surname>Davies</surname>
<given-names>PD</given-names>
</name>
</person-group>
<article-title>Treatment of upper eyelid retraction associated with thyroid eye disease with subconjunctival botulinum toxin injection</article-title>
<source>Ophthalmology</source>
<year>2002</year>
<volume>109</volume>
<issue>6</issue>
<fpage>1183</fpage>
<lpage>1187</lpage>
<pub-id pub-id-type="pmid">12045064</pub-id>
</mixed-citation>
</ref>
<ref id="b33-opth-3-543"><label>33.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>Treating severe Graves’ ophthalmopathy</article-title>
<source>Baillieres Clin Endocrinol Metab</source>
<year>1997</year>
<volume>11</volume>
<issue>3</issue>
<fpage>521</fpage>
<lpage>526</lpage>
<pub-id pub-id-type="pmid">9532337</pub-id>
</mixed-citation>
</ref>
<ref id="b34-opth-3-543"><label>34.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ebner</surname>
<given-names>R</given-names>
</name>
<name><surname>Devoto</surname>
<given-names>MH</given-names>
</name>
<name><surname>Weil</surname>
<given-names>D</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Treatment of thyroid associated ophthalmopathy with periocular injections of triamcinolone</article-title>
<source>Br J Ophthalmol</source>
<year>2004</year>
<volume>88</volume>
<issue>11</issue>
<fpage>1380</fpage>
<lpage>1386</lpage>
<pub-id pub-id-type="pmid">15489477</pub-id>
</mixed-citation>
</ref>
<ref id="b35-opth-3-543"><label>35.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Management of Graves’ ophthalmopathy: reality and perspectives</article-title>
<source>Endocr Rev</source>
<year>2000</year>
<volume>21</volume>
<issue>2</issue>
<fpage>168</fpage>
<lpage>199</lpage>
<pub-id pub-id-type="pmid">10782363</pub-id>
</mixed-citation>
</ref>
<ref id="b36-opth-3-543"><label>36.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Tanda</surname>
<given-names>ML</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves’ ophthalmopathy: results of a prospective, single-blind, randomized study</article-title>
<source>J Clin Endocrinol Metab</source>
<year>2001</year>
<volume>86</volume>
<issue>8</issue>
<fpage>3562</fpage>
<lpage>3567</lpage>
<pub-id pub-id-type="pmid">11502779</pub-id>
</mixed-citation>
</ref>
<ref id="b37-opth-3-543"><label>37.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hart</surname>
<given-names>RH</given-names>
</name>
<name><surname>Kendall-Taylor</surname>
<given-names>P</given-names>
</name>
<name><surname>Crombie</surname>
<given-names>A</given-names>
</name>
<name><surname>Perros</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title>Early response to intravenous glucocorticoids for severe thyroid-associated ophthalmopathy predicts treatment outcome</article-title>
<source>J Ocul Pharmacol Ther</source>
<year>2005</year>
<volume>21</volume>
<issue>4</issue>
<fpage>328</fpage>
<lpage>336</lpage>
<pub-id pub-id-type="pmid">16117697</pub-id>
</mixed-citation>
</ref>
<ref id="b38-opth-3-543"><label>38.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marinó</surname>
<given-names>M</given-names>
</name>
<name><surname>Morabito</surname>
<given-names>E</given-names>
</name>
<name><surname>Brunetto</surname>
<given-names>MR</given-names>
</name>
<name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
<name><surname>Marocci</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Acute and severe liver damage associated with intravenous glucocorticoid pulse therapy in patients with Graves’ ophthalmopathy</article-title>
<source>Thyroid</source>
<year>2004</year>
<volume>14</volume>
<issue>5</issue>
<fpage>403</fpage>
<lpage>406</lpage>
<pub-id pub-id-type="pmid">15186621</pub-id>
</mixed-citation>
</ref>
<ref id="b39-opth-3-543"><label>39.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ben Simon</surname>
<given-names>GJ</given-names>
</name>
<name><surname>Wang</surname>
<given-names>L</given-names>
</name>
<name><surname>McCann</surname>
<given-names>JD</given-names>
</name>
<name><surname>Goldberg</surname>
<given-names>RA</given-names>
</name>
</person-group>
<article-title>Primary-gaze diplopia in patients with thyroid-related orbitopathy undergoing deep lateral orbital decompression with intraconal fat debulking: a retrospective analysis of treatment outcome</article-title>
<source>Thyroid</source>
<year>2004</year>
<volume>14</volume>
<issue>5</issue>
<fpage>379</fpage>
<lpage>383</lpage>
<pub-id pub-id-type="pmid">15186616</pub-id>
</mixed-citation>
</ref>
<ref id="b40-opth-3-543"><label>40.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kahaly</surname>
<given-names>GJ</given-names>
</name>
<name><surname>Pitz</surname>
<given-names>S</given-names>
</name>
<name><surname>Hommel</surname>
<given-names>G</given-names>
</name>
<name><surname>Dittmar</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>Randomized, single blind trial of intravenous versus oral steroid monotherapy in Graves’ orbitopathy</article-title>
<source>J Clin Endocrinol Metab</source>
<year>2005</year>
<volume>90</volume>
<issue>9</issue>
<fpage>5234</fpage>
<lpage>5240</lpage>
<pub-id pub-id-type="pmid">15998777</pub-id>
</mixed-citation>
</ref>
<ref id="b41-opth-3-543"><label>41.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Geest</surname>
<given-names>RJ</given-names>
</name>
<name><surname>Sasim</surname>
<given-names>IV</given-names>
</name>
<name><surname>Koppeschaar</surname>
<given-names>HP</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Methylprednisolone pulse therapy for patients with moderately severe Graves' orbitopathy: a prospective, randomized, placebo-controlled study</article-title>
<source>Eur J Endocrinol</source>
<year>2008</year>
<volume>158</volume>
<issue>2</issue>
<fpage>229</fpage>
<lpage>237</lpage>
<pub-id pub-id-type="pmid">18230831</pub-id>
</mixed-citation>
</ref>
<ref id="b42-opth-3-543"><label>42.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Panicucci</surname>
<given-names>M</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Orbital cobalt irradiation combined with retrobulbar or systemic corticosteroids for Graves’ ophthalmopathy: a comparative study</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>1987</year>
<volume>27</volume>
<issue>1</issue>
<fpage>33</fpage>
<lpage>42</lpage>
<pub-id pub-id-type="pmid">3308192</pub-id>
</mixed-citation>
</ref>
<ref id="b43-opth-3-543"><label>43.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goldberg</surname>
<given-names>RA</given-names>
</name>
</person-group>
<article-title>Editorial: Orbital steroid injections</article-title>
<source>Br J Ophthalmol</source>
<year>2004</year>
<volume>88</volume>
<issue>11</issue>
<fpage>1359</fpage>
<lpage>1360</lpage>
<pub-id pub-id-type="pmid">15489472</pub-id>
</mixed-citation>
</ref>
<ref id="b44-opth-3-543"><label>44.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wakelkamp</surname>
<given-names>IM</given-names>
</name>
<name><surname>Baldeschi</surname>
<given-names>L</given-names>
</name>
<name><surname>Saeed</surname>
<given-names>P</given-names>
</name>
<name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
</person-group>
<article-title>Surgical or medical decompression as a first-line treatment of optic neuropathy in Graves‘ ophthalmopathy? A randomized controlled trial</article-title>
<source>Clin Endocrinol (Oxf)</source>
<year>2005</year>
<volume>63</volume>
<issue>3</issue>
<fpage>323</fpage>
<lpage>328</lpage>
<pub-id pub-id-type="pmid">16117821</pub-id>
</mixed-citation>
</ref>
<ref id="b45-opth-3-543"><label>45.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Koornneef</surname>
<given-names>L</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
<name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Berghout</surname>
<given-names>A</given-names>
</name>
<name><surname>van der Gaag</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Orbital decompression for Graves’ ophthalmopathy by inferomedial, by inferomedial plus lateral, and by coronal approach</article-title>
<source>Ophthalmology</source>
<year>1990</year>
<volume>97</volume>
<issue>5</issue>
<fpage>636</fpage>
<lpage>641</lpage>
<pub-id pub-id-type="pmid">2342809</pub-id>
</mixed-citation>
</ref>
<ref id="b46-opth-3-543"><label>46.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scott</surname>
<given-names>AB</given-names>
</name>
</person-group>
<article-title>Injection treatment of endocrine orbital myopathy</article-title>
<source>Doc Ophthalmol</source>
<year>1984</year>
<volume>58</volume>
<issue>1</issue>
<fpage>141</fpage>
<lpage>145</lpage>
<pub-id pub-id-type="pmid">6489104</pub-id>
</mixed-citation>
</ref>
<ref id="b47-opth-3-543"><label>47.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uddin</surname>
<given-names>JM</given-names>
</name>
<name><surname>Davies</surname>
<given-names>PD</given-names>
</name>
</person-group>
<article-title>Treatment of upper eyelid retraction associated with thyroid eye disease with subconjunctival botulinum toxin injection</article-title>
<source>Ophthalmology</source>
<year>2002</year>
<volume>109</volume>
<issue>6</issue>
<fpage>1183</fpage>
<lpage>1187</lpage>
<pub-id pub-id-type="pmid">12045064</pub-id>
</mixed-citation>
</ref>
<ref id="b48-opth-3-543"><label>48.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gorman</surname>
<given-names>CA</given-names>
</name>
<name><surname>Garrity</surname>
<given-names>JA</given-names>
</name>
<name><surname>Fatourechi</surname>
<given-names>V</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A prospective, randomized, double-blind, placebo-controlled study of orbital radiotherapy for Graves’ ophthalmopathy</article-title>
<source>Ophthalmology</source>
<year>2001</year>
<volume>108</volume>
<issue>9</issue>
<fpage>1523</fpage>
<lpage>1534</lpage>
<pub-id pub-id-type="pmid">11535445</pub-id>
</mixed-citation>
</ref>
<ref id="b49-opth-3-543"><label>49.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Blank</surname>
<given-names>L</given-names>
</name>
<name><surname>Berghout</surname>
<given-names>A</given-names>
</name>
<name><surname>Koornneef</surname>
<given-names>L</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
</person-group>
<article-title>Randomized double-blind trial of prednisone versus radio-therapy in Graves’ ophthalmopathy</article-title>
<source>Lancet</source>
<year>1993</year>
<volume>342</volume>
<issue>8877</issue>
<fpage>949</fpage>
<lpage>954</lpage>
<pub-id pub-id-type="pmid">8105213</pub-id>
</mixed-citation>
</ref>
<ref id="b50-opth-3-543"><label>50.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
<name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Bogazzi</surname>
<given-names>F</given-names>
</name>
<name><surname>Bruno-Bossio</surname>
<given-names>G</given-names>
</name>
<name><surname>Lepri</surname>
<given-names>A</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>Orbital radiotherapy combined with high dose systemic glucocorticoids for Graves’ ophthalmopathy is more effective than radiotherapy alone: results of a prospective randomized study</article-title>
<source>J Endocrinol Invest</source>
<year>1991</year>
<volume>14</volume>
<issue>10</issue>
<fpage>853</fpage>
<lpage>860</lpage>
<pub-id pub-id-type="pmid">1802923</pub-id>
</mixed-citation>
</ref>
<ref id="b51-opth-3-543"><label>51.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>van Kempen-Harteveld</surname>
<given-names>ML</given-names>
</name>
<name><surname>García</surname>
<given-names>MB</given-names>
</name>
<name><surname>Koppeschaar</surname>
<given-names>HP</given-names>
</name>
<name><surname>Tick</surname>
<given-names>L</given-names>
</name>
<name><surname>Terwee</surname>
<given-names>CB</given-names>
</name>
</person-group>
<article-title>Radiotherapy for Graves’ orbitopathy: randomised placebo-controlled study</article-title>
<source>Lancet</source>
<year>2000</year>
<volume>355</volume>
<issue>9214</issue>
<fpage>1505</fpage>
<lpage>1509</lpage>
<pub-id pub-id-type="pmid">10801172</pub-id>
</mixed-citation>
</ref>
<ref id="b52-opth-3-543"><label>52.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bradley</surname>
<given-names>EA</given-names>
</name>
<name><surname>Gower</surname>
<given-names>EW</given-names>
</name>
<name><surname>Bradley</surname>
<given-names>DJ</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Orbital radiation for graves ophthalmopathy: a report by the American Academy of Ophthalmology</article-title>
<source>Ophthalmology</source>
<year>2008</year>
<volume>115</volume>
<issue>2</issue>
<fpage>398</fpage>
<lpage>409</lpage>
<pub-id pub-id-type="pmid">18082885</pub-id>
</mixed-citation>
</ref>
<ref id="b53-opth-3-543"><label>53.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kahaly</surname>
<given-names>GJ</given-names>
</name>
<name><surname>Rösler</surname>
<given-names>HP</given-names>
</name>
<name><surname>Pitz</surname>
<given-names>S</given-names>
</name>
<name><surname>Hommel</surname>
<given-names>G</given-names>
</name>
</person-group>
<article-title>Low- versus high-dose radiotherapy for Graves’ ophthalmopathy: a randomized, single blind trial</article-title>
<source>J Clin Endocrinol Metab</source>
<year>2000</year>
<volume>85</volume>
<issue>1</issue>
<fpage>102</fpage>
<lpage>108</lpage>
<pub-id pub-id-type="pmid">10634372</pub-id>
</mixed-citation>
</ref>
<ref id="b54-opth-3-543"><label>54.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nakahara</surname>
<given-names>H</given-names>
</name>
<name><surname>Noguchi</surname>
<given-names>S</given-names>
</name>
<name><surname>Murakami</surname>
<given-names>N</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Graves ophthalmopathy: MR evaluation of 10-Gy versus 24-Gy irradiation combined with systemic corticosteroids</article-title>
<source>Radiology</source>
<year>1995</year>
<volume>196</volume>
<issue>3</issue>
<fpage>857</fpage>
<lpage>862</lpage>
<pub-id pub-id-type="pmid">7644656</pub-id>
</mixed-citation>
</ref>
<ref id="b55-opth-3-543"><label>55.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wakelkamp</surname>
<given-names>IM</given-names>
</name>
<name><surname>Tan</surname>
<given-names>H</given-names>
</name>
<name><surname>Saeed</surname>
<given-names>P</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Orbital irradiation for Graves’ ophthalmopathy: Is it safe? A long-term follow-up study</article-title>
<source>Ophthalmology</source>
<year>2004</year>
<volume>111</volume>
<issue>8</issue>
<fpage>1557</fpage>
<lpage>1562</lpage>
<pub-id pub-id-type="pmid">15288988</pub-id>
</mixed-citation>
</ref>
<ref id="b56-opth-3-543"><label>56.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marquez</surname>
<given-names>SD</given-names>
</name>
<name><surname>Lum</surname>
<given-names>BL</given-names>
</name>
<name><surname>McDougall</surname>
<given-names>IR</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Long-term results of irradiation for patients with progressive Graves’ ophthalmopathy</article-title>
<source>Int J Radiat Oncol Biol Phys</source>
<year>2001</year>
<volume>51</volume>
<issue>3</issue>
<fpage>766</fpage>
<lpage>774</lpage>
<pub-id pub-id-type="pmid">11697323</pub-id>
</mixed-citation>
</ref>
<ref id="b57-opth-3-543"><label>57.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baldeschi</surname>
<given-names>L</given-names>
</name>
<name><surname>MacAndie</surname>
<given-names>K</given-names>
</name>
<name><surname>Koetsier</surname>
<given-names>E</given-names>
</name>
<name><surname>Blank</surname>
<given-names>LE</given-names>
</name>
<name><surname>Wiersinga</surname>
<given-names>WM</given-names>
</name>
</person-group>
<article-title>The influence of previous orbital irradiation on the outcome of rehabilitative decompression surgery in graves orbitopathy</article-title>
<source>Am J Ophthalmol</source>
<year>2008</year>
<volume>145</volume>
<issue>3</issue>
<fpage>534</fpage>
<lpage>540</lpage>
<pub-id pub-id-type="pmid">18191092</pub-id>
</mixed-citation>
</ref>
<ref id="b58-opth-3-543"><label>58.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Baldeschi</surname>
<given-names>L</given-names>
</name>
<name><surname>Dickinson</surname>
<given-names>AJ</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Consensus statement of the European group on Graves‘ orbitopathy (EUGOGO) on management of Graves‘ orbitopathy</article-title>
<source>Thyroid</source>
<year>2008</year>
<volume>18</volume>
<issue>3</issue>
<fpage>333</fpage>
<lpage>346</lpage>
<pub-id pub-id-type="pmid">18341379</pub-id>
</mixed-citation>
</ref>
<ref id="b59-opth-3-543"><label>59.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Silver</surname>
<given-names>RD</given-names>
</name>
<name><surname>Harrison</surname>
<given-names>AR</given-names>
</name>
<name><surname>Goding</surname>
<given-names>GS</given-names>
</name>
</person-group>
<article-title>Combined endoscopic medial and external lateral orbital decompression for progressive thyroid eye disease</article-title>
<source>Otolaryngol Head Neck Surg</source>
<year>2006</year>
<volume>134</volume>
<issue>2</issue>
<fpage>260</fpage>
<lpage>266</lpage>
<pub-id pub-id-type="pmid">16455375</pub-id>
</mixed-citation>
</ref>
<ref id="b60-opth-3-543"><label>60.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goldberg</surname>
<given-names>RA</given-names>
</name>
<name><surname>Kim</surname>
<given-names>AJ</given-names>
</name>
<name><surname>Kerivan</surname>
<given-names>KM</given-names>
</name>
</person-group>
<article-title>The lacrimal keyhole, orbital door jamb, and basin of the inferior orbital fissure. Three areas of deep bone in the lateral orbit</article-title>
<source>Arch Ophthalmol</source>
<year>1998</year>
<volume>116</volume>
<issue>12</issue>
<fpage>1618</fpage>
<lpage>1624</lpage>
<pub-id pub-id-type="pmid">9869791</pub-id>
</mixed-citation>
</ref>
<ref id="b61-opth-3-543"><label>61.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Forbes</surname>
<given-names>G</given-names>
</name>
<name><surname>Gorman</surname>
<given-names>CA</given-names>
</name>
<name><surname>Brennan</surname>
<given-names>MD</given-names>
</name>
<name><surname>Gehring</surname>
<given-names>DG</given-names>
</name>
<name><surname>Ilstrup</surname>
<given-names>DM</given-names>
</name>
<name><surname>Earnest</surname>
<given-names>F</given-names>
<suffix>4th</suffix>
</name>
</person-group>
<article-title>Ophthalmopathy of Graves’ disease: computerized volume measurements of the orbital fat and muscle</article-title>
<source>AJNR Am J Neuroradiol</source>
<year>1986</year>
<volume>7</volume>
<issue>4</issue>
<fpage>651</fpage>
<lpage>656</lpage>
<pub-id pub-id-type="pmid">3088943</pub-id>
</mixed-citation>
</ref>
<ref id="b62-opth-3-543"><label>62.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Trokel</surname>
<given-names>S</given-names>
</name>
<name><surname>Kazim</surname>
<given-names>M</given-names>
</name>
<name><surname>Moore</surname>
<given-names>S</given-names>
</name>
</person-group>
<article-title>Orbital fat removal. Decompression for Graves orbitopathy</article-title>
<source>Ophthalmology</source>
<year>1993</year>
<volume>100</volume>
<issue>5</issue>
<fpage>674</fpage>
<lpage>682</lpage>
<pub-id pub-id-type="pmid">8493010</pub-id>
</mixed-citation>
</ref>
<ref id="b63-opth-3-543"><label>63.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nunery</surname>
<given-names>WR</given-names>
</name>
<name><surname>Nunery</surname>
<given-names>CW</given-names>
</name>
<name><surname>Martin</surname>
<given-names>RT</given-names>
</name>
<name><surname>Truong</surname>
<given-names>TV</given-names>
</name>
<name><surname>Osborn</surname>
<given-names>DR</given-names>
</name>
</person-group>
<article-title>The risk of diplopia following orbital floor and medial wall decompression in subtypes of ophthalmic Graves’ disease</article-title>
<source>Ophthal Plast Reconstr Surg</source>
<year>1997</year>
<volume>13</volume>
<issue>3</issue>
<fpage>153</fpage>
<lpage>160</lpage>
</mixed-citation>
</ref>
<ref id="b64-opth-3-543"><label>64.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shorr</surname>
<given-names>N</given-names>
</name>
<name><surname>Seiff</surname>
<given-names>SR</given-names>
</name>
</person-group>
<article-title>The four stages of surgical rehabilitation of the patient with dysthyroid ophthalmopathy</article-title>
<source>Ophthalmology</source>
<year>1986</year>
<volume>93</volume>
<issue>4</issue>
<fpage>476</fpage>
<lpage>483</lpage>
<pub-id pub-id-type="pmid">3703522</pub-id>
</mixed-citation>
</ref>
<ref id="b65-opth-3-543"><label>65.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lueder</surname>
<given-names>GT</given-names>
</name>
<name><surname>Scott</surname>
<given-names>WE</given-names>
</name>
<name><surname>Kutschke</surname>
<given-names>PJ</given-names>
</name>
<name><surname>Keech</surname>
<given-names>RV</given-names>
</name>
</person-group>
<article-title>Long-term results of adjustable suture surgery for strabismus secondary to thyroid ophthalmopathy</article-title>
<source>Ophthalmology</source>
<year>1992</year>
<volume>99</volume>
<issue>6</issue>
<fpage>993</fpage>
<lpage>997</lpage>
<pub-id pub-id-type="pmid">1630789</pub-id>
</mixed-citation>
</ref>
<ref id="b66-opth-3-543"><label>66.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bartalena</surname>
<given-names>L</given-names>
</name>
<name><surname>Pinchera</surname>
<given-names>A</given-names>
</name>
<name><surname>Marcocci</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Management of Graves’ ophthalmopathy: reality and perspectives</article-title>
<source>Endocr Rev</source>
<year>2000</year>
<volume>21</volume>
<issue>2</issue>
<fpage>168</fpage>
<lpage>199</lpage>
<pub-id pub-id-type="pmid">10782363</pub-id>
</mixed-citation>
</ref>
<ref id="b67-opth-3-543"><label>67.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prummel</surname>
<given-names>MF</given-names>
</name>
<name><surname>Mourits</surname>
<given-names>MP</given-names>
</name>
<name><surname>Berghout</surname>
<given-names>A</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Prednisone and cyclosporine in the treatment of severe Graves’ ophthalmopathy</article-title>
<source>N Engl J Med</source>
<year>1989</year>
<volume>321</volume>
<issue>20</issue>
<fpage>1353</fpage>
<lpage>1359</lpage>
<pub-id pub-id-type="pmid">2519530</pub-id>
</mixed-citation>
</ref>
<ref id="b68-opth-3-543"><label>68.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>El Fassi</surname>
<given-names>D</given-names>
</name>
<name><surname>Nielsen</surname>
<given-names>CH</given-names>
</name>
<name><surname>Hasselbalch</surname>
<given-names>HC</given-names>
</name>
<name><surname>Hegedüs</surname>
<given-names>L</given-names>
</name>
</person-group>
<article-title>Treatment-resistant severe, active Graves’ ophthalmopathy successfully treated with B lymphocyte depletion</article-title>
<source>Thyroid</source>
<year>2006</year>
<volume>16</volume>
<issue>7</issue>
<fpage>709</fpage>
<lpage>710</lpage>
<pub-id pub-id-type="pmid">16889501</pub-id>
</mixed-citation>
</ref>
<ref id="b69-opth-3-543"><label>69.</label>
<mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paridaens</surname>
<given-names>D</given-names>
</name>
<name><surname>van den Bosch</surname>
<given-names>WA</given-names>
</name>
<name><surname>van der Loos</surname>
<given-names>TL</given-names>
</name>
<name><surname>Krenning</surname>
<given-names>EP</given-names>
</name>
<name><surname>van Hagen</surname>
<given-names>PM</given-names>
</name>
</person-group>
<article-title>The effect of etanercept on Graves’ ophthalmopathy: a pilot study</article-title>
<source>Eye</source>
<year>2005</year>
<volume>19</volume>
<issue>12</issue>
<fpage>1286</fpage>
<lpage>1289</lpage>
<pub-id pub-id-type="pmid">15550932</pub-id>
</mixed-citation>
</ref>
</ref-list>
</back>
<floats-group><fig id="f1-opth-3-543" position="float"><label>Figure 1</label>
<caption><p>Rundle’s curve mapping increase in disease activity or severity followed by a reduction over time.</p>
</caption>
<graphic xlink:href="opth-3-543f1"></graphic>
</fig>
<fig id="f2-opth-3-543" position="float"><label>Figure 2</label>
<caption><p>Severe inflammation and proptosis with classic “stare” of thyroid eye disease may be prominent in the active phase of disease.</p>
</caption>
<graphic xlink:href="opth-3-543f2"></graphic>
</fig>
<fig id="f3-opth-3-543" position="float"><label>Figure 3</label>
<caption><p>Esotropia strabismus is a common manifestation of medial rectus enlargement in thyroid eye disease.</p>
</caption>
<graphic xlink:href="opth-3-543f3"></graphic>
</fig>
<fig id="f4-opth-3-543" position="float"><label>Figure 4</label>
<caption><p>CT imaging of extraocular muscle enlargement at orbital apex.</p>
</caption>
<graphic xlink:href="opth-3-543f4"></graphic>
</fig>
<fig id="f5-opth-3-543" position="float"><label>Figures 5 (left) and 6 (right)</label>
<caption><p>Pre- and post-operative orbital decompression images document a marked decrease in proptosis.</p>
</caption>
<graphic xlink:href="opth-3-543f5"></graphic>
</fig>
<fig id="f6-opth-3-543" position="float"><label>Figures 7 (left) and 8 (right)</label>
<caption><p>Pre- and post-operative strabismus surgery images document improvement of motor alignment.</p>
</caption>
<graphic xlink:href="opth-3-543f6"></graphic>
</fig>
<fig id="f7-opth-3-543" position="float"><label>Figures 9 (left) and 10 (right)</label>
<caption><p>Pre- and post-operative eyelid retraction repair images document improvement of eyelid position.</p>
</caption>
<graphic xlink:href="opth-3-543f7"></graphic>
</fig>
<table-wrap id="t1-opth-3-543" position="float"><label>Table 1</label>
<caption><p>Clinical activity or severity may be assessed with either the Clinical Activity Score (CAS) or the NOSPECS severity assessment</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Clinical Activity Score (CAS)</bold>
</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Score determined by sum of the symptoms and signs in a patient with TED at a given visit</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Spontaneous retrobulbar pain</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Pain on attempted up-gaze or down-gaze</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Redness of the eyelids</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Redness of the conjunctiva</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Swelling of the eyelids</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Inflammation of the caruncle and/or plica</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Edema of the conjunctiva</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>NOSPECS Severity Assessment</bold>
</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 0</td>
<td valign="top" align="left" rowspan="1" colspan="1">No signs or symptoms</td>
<td valign="top" align="left" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 1</td>
<td valign="top" align="left" rowspan="1" colspan="1">Only signs, no symptoms</td>
<td valign="top" align="left" rowspan="1" colspan="1">Lid aperture (mm)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 2</td>
<td valign="top" align="left" rowspan="1" colspan="1">Soft tissue involvement</td>
<td valign="top" align="left" rowspan="1" colspan="1">Swelling, redness</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 3</td>
<td valign="top" align="left" rowspan="1" colspan="1">Proptosis</td>
<td valign="top" align="left" rowspan="1" colspan="1">Exophthalmos (mm)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 4</td>
<td valign="top" align="left" rowspan="1" colspan="1">Extraocular muscle involvement</td>
<td valign="top" align="left" rowspan="1" colspan="1">Ductions (degrees), diplopia score (0, no diplopia; 1, intermittent: diplopia in primary position of gaze when tired or awake; 2, inconstant: diplopia at extremes of gaze; 3, constant: diplopia always present)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 5</td>
<td valign="top" align="left" rowspan="1" colspan="1">Corneal involvement</td>
<td valign="top" align="left" rowspan="1" colspan="1">Punctate keratopathy, ulceration</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Class 6</td>
<td valign="top" align="left" rowspan="1" colspan="1">Sight loss</td>
<td valign="top" align="left" rowspan="1" colspan="1">Optic nerve involvement: changes in visual acuity, color vision, visual fields, or optic disk</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="t2-opth-3-543" position="float"><label>Table 2</label>
<caption><p>Proposed methyprednisolone dosing regimens</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"><bold>Author</bold>
</th>
<th valign="top" align="left" rowspan="1" colspan="1"><bold>Proposed methylprednisolone dosing regimen</bold>
</th>
</tr>
</thead>
<tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Kahaly<xref ref-type="bibr" rid="b40-opth-3-543">40</xref>
</td>
<td valign="top" align="left" rowspan="1" colspan="1">iv methylprednisolone once weekly; 0.5 g, then 0.25 g, 6 wk each (4.5 g total)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">van Geest<xref ref-type="bibr" rid="b41-opth-3-543">41</xref>
</td>
<td valign="top" align="left" rowspan="1" colspan="1">iv methylprednisolone 500 mg, over 3 consecutive days, in 4 cycles at 4 weekly intervals (6 g total)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Marcocci<xref ref-type="bibr" rid="b42-opth-3-543">42</xref>
</td>
<td valign="top" align="left" rowspan="1" colspan="1">iv methylprednisolone; 15 mg/kg for 4 cycles and then 7.5 mg/kg for 4 cycles; each cycle consisted of 2 infusions on alternate days at 2-week intervals (9 to 12 g total)</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000495 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000495 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= CobaltMaghrebV1 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:2770865 |texte= Update on thyroid eye disease and management }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:19898626" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a CobaltMaghrebV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |