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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Correlation of Genotype and <italic>In Vitro</italic>
Susceptibilities of <italic>Cryptococcus gattii</italic>
Strains from the Pacific Northwest of the United States<xref ref-type="fn" rid="fn1">▿</xref>
</title>
<author><name sortKey="Iqbal, Naureen" sort="Iqbal, Naureen" uniqKey="Iqbal N" first="Naureen" last="Iqbal">Naureen Iqbal</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Debess, Emilio E" sort="Debess, Emilio E" uniqKey="Debess E" first="Emilio E." last="Debess">Emilio E. Debess</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wohrle, Ron" sort="Wohrle, Ron" uniqKey="Wohrle R" first="Ron" last="Wohrle">Ron Wohrle</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sun, Ben" sort="Sun, Ben" uniqKey="Sun B" first="Ben" last="Sun">Ben Sun</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nett, Randall J" sort="Nett, Randall J" uniqKey="Nett R" first="Randall J." last="Nett">Randall J. Nett</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ahlquist, Angela M" sort="Ahlquist, Angela M" uniqKey="Ahlquist A" first="Angela M." last="Ahlquist">Angela M. Ahlquist</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chiller, Tom" sort="Chiller, Tom" uniqKey="Chiller T" first="Tom" last="Chiller">Tom Chiller</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lockhart, Shawn R" sort="Lockhart, Shawn R" uniqKey="Lockhart S" first="Shawn R." last="Lockhart">Shawn R. Lockhart</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20007380</idno>
<idno type="pmc">2815610</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815610</idno>
<idno type="RBID">PMC:2815610</idno>
<idno type="doi">10.1128/JCM.01505-09</idno>
<date when="2009">2009</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Correlation of Genotype and <italic>In Vitro</italic>
Susceptibilities of <italic>Cryptococcus gattii</italic>
Strains from the Pacific Northwest of the United States<xref ref-type="fn" rid="fn1">▿</xref>
</title>
<author><name sortKey="Iqbal, Naureen" sort="Iqbal, Naureen" uniqKey="Iqbal N" first="Naureen" last="Iqbal">Naureen Iqbal</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Debess, Emilio E" sort="Debess, Emilio E" uniqKey="Debess E" first="Emilio E." last="Debess">Emilio E. Debess</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wohrle, Ron" sort="Wohrle, Ron" uniqKey="Wohrle R" first="Ron" last="Wohrle">Ron Wohrle</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sun, Ben" sort="Sun, Ben" uniqKey="Sun B" first="Ben" last="Sun">Ben Sun</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nett, Randall J" sort="Nett, Randall J" uniqKey="Nett R" first="Randall J." last="Nett">Randall J. Nett</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ahlquist, Angela M" sort="Ahlquist, Angela M" uniqKey="Ahlquist A" first="Angela M." last="Ahlquist">Angela M. Ahlquist</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chiller, Tom" sort="Chiller, Tom" uniqKey="Chiller T" first="Tom" last="Chiller">Tom Chiller</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lockhart, Shawn R" sort="Lockhart, Shawn R" uniqKey="Lockhart S" first="Shawn R." last="Lockhart">Shawn R. Lockhart</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical Microbiology</title>
<idno type="ISSN">0095-1137</idno>
<idno type="eISSN">1098-660X</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><italic>Cryptococcus gattii</italic>
emerged in North America in 1999 as a human and veterinary pathogen on Vancouver Island, British Columbia. The emergent subtype, VGIIa, and the closely related subtype VGIIb can now be found in the United States in Washington, Oregon, and California. We performed multilocus sequence typing and antifungal susceptibility testing on 43 isolates of <italic>C. gattii</italic>
from human patients in Oregon, Washington, California, and Idaho. In contrast to Vancouver Island, VGIIa was the most frequent but not the predominant subtype in the northwest United States. Antifungal susceptibility testing showed statistically significant differences in MICs between the subtypes. This is the first study to apply antifungal susceptibility testing to <italic>C. gattii</italic>
isolates from the Pacific Northwest and the first to make direct comparisons between subtypes.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id>
<journal-id journal-id-type="publisher-id">jcm</journal-id>
<journal-title-group><journal-title>Journal of Clinical Microbiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0095-1137</issn>
<issn pub-type="epub">1098-660X</issn>
<publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20007380</article-id>
<article-id pub-id-type="pmc">2815610</article-id>
<article-id pub-id-type="publisher-id">1505-09</article-id>
<article-id pub-id-type="doi">10.1128/JCM.01505-09</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Mycology</subject>
</subj-group>
</article-categories>
<title-group><article-title>Correlation of Genotype and <italic>In Vitro</italic>
Susceptibilities of <italic>Cryptococcus gattii</italic>
Strains from the Pacific Northwest of the United States<xref ref-type="fn" rid="fn1">▿</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Iqbal</surname>
<given-names>Naureen</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>DeBess</surname>
<given-names>Emilio E.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wohrle</surname>
<given-names>Ron</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sun</surname>
<given-names>Ben</given-names>
</name>
<xref ref-type="aff" rid="aff1">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nett</surname>
<given-names>Randall J.</given-names>
</name>
<xref ref-type="aff" rid="aff1">5</xref>
<xref ref-type="aff" rid="aff1">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ahlquist</surname>
<given-names>Angela M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chiller</surname>
<given-names>Tom</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lockhart</surname>
<given-names>Shawn R.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><collab>for the <italic>Cryptococcus gattii</italic>
Public Health Working Group</collab>
</contrib>
</contrib-group>
<aff id="aff1">Centers for Disease Control and Prevention, Atlanta, Georgia,<label>1</label>
Oregon Department of Human Services, Portland, Oregon,<label>2</label>
Washington State Department of Health, Tumwater, Washington,<label>3</label>
California Department of Public Health, Sacramento, California,<label>4</label>
Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia,<label>5</label>
Idaho Department of Health and Welfare, Boise, Idaho<label>6</label>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Mailing address: Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333. Phone: (404) 639-2569. Fax: (404) 639-3546. E-mail: <email>gyi2@cdc.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>2</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>9</day>
<month>12</month>
<year>2009</year>
</pub-date>
<volume>48</volume>
<issue>2</issue>
<fpage>539</fpage>
<lpage>544</lpage>
<history><date date-type="received"><day>5</day>
<month>8</month>
<year>2009</year>
</date>
<date date-type="rev-recd"><day>21</day>
<month>9</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>4</day>
<month>12</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010, American Society for Microbiology</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:href="zjm00210000539.pdf"></self-uri>
<abstract><p><italic>Cryptococcus gattii</italic>
emerged in North America in 1999 as a human and veterinary pathogen on Vancouver Island, British Columbia. The emergent subtype, VGIIa, and the closely related subtype VGIIb can now be found in the United States in Washington, Oregon, and California. We performed multilocus sequence typing and antifungal susceptibility testing on 43 isolates of <italic>C. gattii</italic>
from human patients in Oregon, Washington, California, and Idaho. In contrast to Vancouver Island, VGIIa was the most frequent but not the predominant subtype in the northwest United States. Antifungal susceptibility testing showed statistically significant differences in MICs between the subtypes. This is the first study to apply antifungal susceptibility testing to <italic>C. gattii</italic>
isolates from the Pacific Northwest and the first to make direct comparisons between subtypes.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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