Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum toll-like receptors are potential biomarkers of radiation pneumonia in locally advanced NSCLC</title>
<author><name sortKey="Lan, Fengming" sort="Lan, Fengming" uniqKey="Lan F" first="Fengming" last="Lan">Fengming Lan</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Department of Radiation Oncology, Tianjin Hospital</institution>
<addr-line>Tianjin 300190, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yue, Xiao" sort="Yue, Xiao" uniqKey="Yue X" first="Xiao" last="Yue">Xiao Yue</name>
<affiliation><nlm:aff id="au2"><institution>Tianjin Huanhu Hospital, Tianjin Neurosurgery Institute</institution>
<addr-line>Tianjin 300060, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ren, Gang" sort="Ren, Gang" uniqKey="Ren G" first="Gang" last="Ren">Gang Ren</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Yingjie" sort="Wang, Yingjie" uniqKey="Wang Y" first="Yingjie" last="Wang">Yingjie Wang</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xia, Tingyi" sort="Xia, Tingyi" uniqKey="Xia T" first="Tingyi" last="Xia">Tingyi Xia</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25550856</idno>
<idno type="pmc">4270563</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270563</idno>
<idno type="RBID">PMC:4270563</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000308</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000308</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serum toll-like receptors are potential biomarkers of radiation pneumonia in locally advanced NSCLC</title>
<author><name sortKey="Lan, Fengming" sort="Lan, Fengming" uniqKey="Lan F" first="Fengming" last="Lan">Fengming Lan</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Department of Radiation Oncology, Tianjin Hospital</institution>
<addr-line>Tianjin 300190, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yue, Xiao" sort="Yue, Xiao" uniqKey="Yue X" first="Xiao" last="Yue">Xiao Yue</name>
<affiliation><nlm:aff id="au2"><institution>Tianjin Huanhu Hospital, Tianjin Neurosurgery Institute</institution>
<addr-line>Tianjin 300060, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ren, Gang" sort="Ren, Gang" uniqKey="Ren G" first="Gang" last="Ren">Gang Ren</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Yingjie" sort="Wang, Yingjie" uniqKey="Wang Y" first="Yingjie" last="Wang">Yingjie Wang</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xia, Tingyi" sort="Xia, Tingyi" uniqKey="Xia T" first="Tingyi" last="Xia">Tingyi Xia</name>
<affiliation><nlm:aff id="au1"><institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Clinical and Experimental Pathology</title>
<idno type="eISSN">1936-2625</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Objective: Toll-like receptors (TLRs) are highly or lowly expressed in a wide variety of tumors and exhibit either pro-tumor or anti-tumor activities. In the present study, we investigate whether there are relationships between the expressions of TLRs and the occurrence of radiation pneumonia in advanced NSCLC patients treated with radiotherapy. Materials and methods: 76 patients diagnosed with NSCLC and 50 healthy controls were recruited from Oct 2012 to Jan 2014. The expressions of serum TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were detected by ELISA techniques. Fisher exact test, χ<sup>2</sup>
test, ROC working curve and Cox regression model were applied to analyze all data. Results: serum TLR1, TLR2, TLR4, and TLR9 exhibited a relative high expression level in NSCLC patients compared with healthy controls. Importantly, pre-neutrophil granulocyte ratio was associated with the expression of TLR1, TLR2, and TLR4. Moreover, the patients with high ratio of neutrophil granulocyte significantly increased the occurrence of fever in comparison to normal neutrophil ratio in NSCLC patients during the course of radiotherapy. We further evaluated the containing of TLRs when patients had temperatures and found serum TLR1, TLR2 and TLR4 were over-expressed. Finally, 26 of 76 patients were diagnosed with different stages of radiation induced pneumonia; as a result, the contents of TLR1 and TLR4 before radiotherapy were identified as independent significances with pneumonia occurrence. Conclusions: The pretreatment levels of TLR1 and TLR4 have the predictive value to be clinically potential biomarkers of pneumonia risk in locally advanced NSCLC.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Clin Exp Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Clin Exp Pathol</journal-id>
<journal-id journal-id-type="publisher-id">ijcep</journal-id>
<journal-title-group><journal-title>International Journal of Clinical and Experimental Pathology</journal-title>
</journal-title-group>
<issn pub-type="epub">1936-2625</issn>
<publisher><publisher-name>e-Century Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25550856</article-id>
<article-id pub-id-type="pmc">4270563</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Serum toll-like receptors are potential biomarkers of radiation pneumonia in locally advanced NSCLC</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lan</surname>
<given-names>Fengming</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au3">3</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yue</surname>
<given-names>Xiao</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ren</surname>
<given-names>Gang</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Yingjie</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xia</surname>
<given-names>Tingyi</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>Department of Radiation Oncology, PLA Airforce General Hospital</institution>
<addr-line>Beijing 100142, China</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>Tianjin Huanhu Hospital, Tianjin Neurosurgery Institute</institution>
<addr-line>Tianjin 300060, China</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Department of Radiation Oncology, Tianjin Hospital</institution>
<addr-line>Tianjin 300190, China</addr-line>
</aff>
</contrib-group>
<author-notes><corresp><bold>Address correspondence to:</bold>
Dr. Tingyi Xia, Department of Radiation Oncology, Air Force General Hospital, Beijing 100036, People’s Republic of China. Tel: (+86) 10-68434886; Fax: (+86) 10-68434886; E-mail: <email>xiatingyi1959@163.com</email>
</corresp>
<fn id="fn1"><label>*</label>
<p>Equal contributors.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>7</volume>
<issue>11</issue>
<fpage>8087</fpage>
<lpage>8095</lpage>
<history><date date-type="received"><day>10</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>31</day>
<month>10</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>IJCEP Copyright © 2014</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p>Objective: Toll-like receptors (TLRs) are highly or lowly expressed in a wide variety of tumors and exhibit either pro-tumor or anti-tumor activities. In the present study, we investigate whether there are relationships between the expressions of TLRs and the occurrence of radiation pneumonia in advanced NSCLC patients treated with radiotherapy. Materials and methods: 76 patients diagnosed with NSCLC and 50 healthy controls were recruited from Oct 2012 to Jan 2014. The expressions of serum TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were detected by ELISA techniques. Fisher exact test, χ<sup>2</sup>
test, ROC working curve and Cox regression model were applied to analyze all data. Results: serum TLR1, TLR2, TLR4, and TLR9 exhibited a relative high expression level in NSCLC patients compared with healthy controls. Importantly, pre-neutrophil granulocyte ratio was associated with the expression of TLR1, TLR2, and TLR4. Moreover, the patients with high ratio of neutrophil granulocyte significantly increased the occurrence of fever in comparison to normal neutrophil ratio in NSCLC patients during the course of radiotherapy. We further evaluated the containing of TLRs when patients had temperatures and found serum TLR1, TLR2 and TLR4 were over-expressed. Finally, 26 of 76 patients were diagnosed with different stages of radiation induced pneumonia; as a result, the contents of TLR1 and TLR4 before radiotherapy were identified as independent significances with pneumonia occurrence. Conclusions: The pretreatment levels of TLR1 and TLR4 have the predictive value to be clinically potential biomarkers of pneumonia risk in locally advanced NSCLC.</p>
</abstract>
<kwd-group><kwd>NSCLC</kwd>
<kwd>clinical biomarkers</kwd>
<kwd>serum toll-like receptors</kwd>
<kwd>radiation pneumonia risk</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000308 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000308 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= CobaltMaghrebV1 |flux= Pmc |étape= Corpus |type= RBID |clé= |texte= }}
![]() | This area was generated with Dilib version V0.6.32. | ![]() |