Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression of tenascin-C in aseptic loosening of total hip replacement</title><author><name sortKey="Konttinen, Y" sort="Konttinen, Y" uniqKey="Konttinen Y" first="Y." last="Konttinen">Y. Konttinen</name></author><author><name sortKey="Li, T" sort="Li, T" uniqKey="Li T" first="T." last="Li">T. Li</name></author><author><name sortKey="Michelsson, O" sort="Michelsson, O" uniqKey="Michelsson O" first="O." last="Michelsson">O. Michelsson</name></author><author><name sortKey="Xu, J" sort="Xu, J" uniqKey="Xu J" first="J." last="Xu">J. Xu</name></author><author><name sortKey="Sorsa, T" sort="Sorsa, T" uniqKey="Sorsa T" first="T." last="Sorsa">T. Sorsa</name></author><author><name sortKey="Santavirta, S" sort="Santavirta, S" uniqKey="Santavirta S" first="S." last="Santavirta">S. Santavirta</name></author><author><name sortKey="Imai, S" sort="Imai, S" uniqKey="Imai S" first="S." last="Imai">S. Imai</name></author><author><name sortKey="Virtanen, I" sort="Virtanen, I" uniqKey="Virtanen I" first="I." last="Virtanen">I. Virtanen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">9893574</idno><idno type="pmc">1752487</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752487</idno><idno type="RBID">PMC:1752487</idno><date when="1998">1998</date><idno type="wicri:Area/Pmc/Corpus">000303</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000303</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Expression of tenascin-C in aseptic loosening of total hip replacement</title><author><name sortKey="Konttinen, Y" sort="Konttinen, Y" uniqKey="Konttinen Y" first="Y." last="Konttinen">Y. Konttinen</name></author><author><name sortKey="Li, T" sort="Li, T" uniqKey="Li T" first="T." last="Li">T. Li</name></author><author><name sortKey="Michelsson, O" sort="Michelsson, O" uniqKey="Michelsson O" first="O." last="Michelsson">O. Michelsson</name></author><author><name sortKey="Xu, J" sort="Xu, J" uniqKey="Xu J" first="J." last="Xu">J. Xu</name></author><author><name sortKey="Sorsa, T" sort="Sorsa, T" uniqKey="Sorsa T" first="T." last="Sorsa">T. Sorsa</name></author><author><name sortKey="Santavirta, S" sort="Santavirta, S" uniqKey="Santavirta S" first="S." last="Santavirta">S. Santavirta</name></author><author><name sortKey="Imai, S" sort="Imai, S" uniqKey="Imai S" first="S." last="Imai">S. Imai</name></author><author><name sortKey="Virtanen, I" sort="Virtanen, I" uniqKey="Virtanen I" first="I." last="Virtanen">I. Virtanen</name></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>OBJECTIVE</italic>—To assess if the bonding interlayer between the implant and bone in aseptic loosening of total hip replacement (THR) is qualitatively deteriorated by excessive accumulation of anti-adhesive glycoprotein, tenascin-C.
<italic>METHODS</italic>—Alkaline phosphatase-anti-alkaline phosphatase (APAAP) method was used for immunohistochemical staining of tenascin-C in interface tissue and control synovial tissue.
<italic>RESULTS</italic>—Tenascin-C was found to be a major component of the extracellular matrix at a hitherto unrecognised site, namely the synovial membrane-like interface tissue between implant and bone in aseptic loosening of THR. The overall tenascin-C staining (median score 4.0) was greatly increased in aseptic loosening compared with synovial membrane (median score 2.0; p<0.001) and fibrous capsule (median score 2.0; p<0.001) from primary THR operations. Topological analysis disclosed that tenascin-C was also found at the critical implant-interface and interface-bone surfaces.
<italic>CONCLUSION</italic>—Local tenascin-C expression is increased as a result of a chronic foreign body type reaction associated with excessive cytokine production and tissue injury mediated by microtrauma and neutral endoproteinases. This qualitative and topological deterioration of the bonding interlayer by an increase of anti-adhesive tenascin-C expression may inadvertantly contribute to loosening.
Keywords: tenascin; aseptic loosening; total hip replacement </p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-title>Annals of the Rheumatic Diseases</journal-title><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn></journal-meta><article-meta><article-id pub-id-type="pmid">9893574</article-id><article-id pub-id-type="pmc">1752487</article-id><article-categories><subj-group subj-group-type="heading"><subject>Extended Reports</subject></subj-group></article-categories><title-group><article-title>Expression of tenascin-C in aseptic loosening of total hip replacement</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Konttinen</surname><given-names>Y.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Michelsson</surname><given-names>O.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sorsa</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Santavirta</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Imai</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Virtanen</surname><given-names>I.</given-names></name></contrib></contrib-group><aff>Department of Medicine, Helsinki University Central Hospital, Finland.</aff><pub-date pub-type="ppub"><month>10</month><year>1998</year></pub-date><volume>57</volume><issue>10</issue><fpage>619</fpage><lpage>623</lpage><self-uri xlink:role="pdf" xlink:type="simple" xlink:href="http://ard.bmj.com/cgi/reprint/57/10/619.pdf"></self-uri><self-uri xlink:role="abstract" xlink:type="simple" xlink:href="http://ard.bmj.com/cgi/content/abstract/57/10/619"></self-uri><self-uri xlink:role="fulltext" xlink:type="simple" xlink:href="http://ard.bmj.com/cgi/content/full/57/10/619"></self-uri><abstract><p><italic>OBJECTIVE</italic>—To assess if the bonding interlayer between the implant and bone in aseptic loosening of total hip replacement (THR) is qualitatively deteriorated by excessive accumulation of anti-adhesive glycoprotein, tenascin-C.
<italic>METHODS</italic>—Alkaline phosphatase-anti-alkaline phosphatase (APAAP) method was used for immunohistochemical staining of tenascin-C in interface tissue and control synovial tissue.
<italic>RESULTS</italic>—Tenascin-C was found to be a major component of the extracellular matrix at a hitherto unrecognised site, namely the synovial membrane-like interface tissue between implant and bone in aseptic loosening of THR. The overall tenascin-C staining (median score 4.0) was greatly increased in aseptic loosening compared with synovial membrane (median score 2.0; p<0.001) and fibrous capsule (median score 2.0; p<0.001) from primary THR operations. Topological analysis disclosed that tenascin-C was also found at the critical implant-interface and interface-bone surfaces.
<italic>CONCLUSION</italic>—Local tenascin-C expression is increased as a result of a chronic foreign body type reaction associated with excessive cytokine production and tissue injury mediated by microtrauma and neutral endoproteinases. This qualitative and topological deterioration of the bonding interlayer by an increase of anti-adhesive tenascin-C expression may inadvertantly contribute to loosening.
Keywords: tenascin; aseptic loosening; total hip replacement </p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000303 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000303 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= CobaltMaghrebV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.32. |  |