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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Definitive radiotherapy for early stage glottic cancer by 6 MV photons</title><author><name sortKey="Tong, Chi Chung" sort="Tong, Chi Chung" uniqKey="Tong C" first="Chi-Chung" last="Tong">Chi-Chung Tong</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Au, Kwok Hung" sort="Au, Kwok Hung" uniqKey="Au K" first="Kwok-Hung" last="Au">Kwok-Hung Au</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Ngan, Roger Kai Cheong" sort="Ngan, Roger Kai Cheong" uniqKey="Ngan R" first="Roger Kai-Cheong" last="Ngan">Roger Kai-Cheong Ngan</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Cheung, Foon Yiu" sort="Cheung, Foon Yiu" uniqKey="Cheung F" first="Foon-Yiu" last="Cheung">Foon-Yiu Cheung</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chow, Sin Ming" sort="Chow, Sin Ming" uniqKey="Chow S" first="Sin-Ming" last="Chow">Sin-Ming Chow</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Fu, Yiu Tung" sort="Fu, Yiu Tung" uniqKey="Fu Y" first="Yiu-Tung" last="Fu">Yiu-Tung Fu</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Au, Joseph Siu Kei" sort="Au, Joseph Siu Kei" uniqKey="Au J" first="Joseph Siu-Kei" last="Au">Joseph Siu-Kei Au</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Law, Stephen Chun Key" sort="Law, Stephen Chun Key" uniqKey="Law S" first="Stephen Chun-Key" last="Law">Stephen Chun-Key Law</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22607730</idno><idno type="pmc">3448507</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448507</idno><idno type="RBID">PMC:3448507</idno><idno type="doi">10.1186/1758-3284-4-23</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000297</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000297</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Definitive radiotherapy for early stage glottic cancer by 6 MV photons</title><author><name sortKey="Tong, Chi Chung" sort="Tong, Chi Chung" uniqKey="Tong C" first="Chi-Chung" last="Tong">Chi-Chung Tong</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Au, Kwok Hung" sort="Au, Kwok Hung" uniqKey="Au K" first="Kwok-Hung" last="Au">Kwok-Hung Au</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Ngan, Roger Kai Cheong" sort="Ngan, Roger Kai Cheong" uniqKey="Ngan R" first="Roger Kai-Cheong" last="Ngan">Roger Kai-Cheong Ngan</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Cheung, Foon Yiu" sort="Cheung, Foon Yiu" uniqKey="Cheung F" first="Foon-Yiu" last="Cheung">Foon-Yiu Cheung</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chow, Sin Ming" sort="Chow, Sin Ming" uniqKey="Chow S" first="Sin-Ming" last="Chow">Sin-Ming Chow</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Fu, Yiu Tung" sort="Fu, Yiu Tung" uniqKey="Fu Y" first="Yiu-Tung" last="Fu">Yiu-Tung Fu</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Au, Joseph Siu Kei" sort="Au, Joseph Siu Kei" uniqKey="Au J" first="Joseph Siu-Kei" last="Au">Joseph Siu-Kei Au</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Law, Stephen Chun Key" sort="Law, Stephen Chun Key" uniqKey="Law S" first="Stephen Chun-Key" last="Law">Stephen Chun-Key Law</name><affiliation><nlm:aff id="I1">Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</nlm:aff></affiliation></author></analytic><series><title level="j">Head & Neck Oncology</title><idno type="eISSN">1758-3284</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.</p></sec><sec><title>Methods and materials</title><p>We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.</p></sec><sec><title>Results</title><p>The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.</p><p>Poorly differentiated histology and tumor biologically effective dose < 65 Gy<sub>15</sub> were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.</p></sec><sec><title>Conclusion</title><p>Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pfister, Dg" uniqKey="Pfister D">DG Pfister</name></author><author><name sortKey="Laurie, Sa" uniqKey="Laurie S">SA Laurie</name></author><author><name sortKey="Weinstein, Gs" uniqKey="Weinstein G">GS Weinstein</name></author><author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name></author><author><name sortKey="Adelstein, Dj" uniqKey="Adelstein D">DJ Adelstein</name></author><author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name></author><author><name sortKey="Clayman, Gl" uniqKey="Clayman G">GL Clayman</name></author><author><name sortKey="Fisher, Sg" uniqKey="Fisher S">SG Fisher</name></author><author><name sortKey="Forastiere, Aa" uniqKey="Forastiere A">AA Forastiere</name></author><author><name sortKey="Harrison, Lb" uniqKey="Harrison L">LB Harrison</name></author><author><name sortKey="Lefebvre, Jl" uniqKey="Lefebvre J">JL Lefebvre</name></author><author><name sortKey="Leupold, N" uniqKey="Leupold N">N Leupold</name></author><author><name sortKey="List, Ma" uniqKey="List M">MA List</name></author><author><name sortKey="O Malley, Bo" uniqKey="O Malley B">BO O'Malley</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Posner, Mr" uniqKey="Posner M">MR Posner</name></author><author><name sortKey="Schwartz, Ma" uniqKey="Schwartz M">MA Schwartz</name></author><author><name sortKey="Wolf, Gt" uniqKey="Wolf G">GT Wolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaanders, Jh" uniqKey="Kaanders J">JH Kaanders</name></author><author><name sortKey="Hordijk, Gj" uniqKey="Hordijk G">GJ Hordijk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warde, P" uniqKey="Warde P">P Warde</name></author><author><name sortKey="O Sullivan, B" uniqKey="O Sullivan B">B O'Sullivan</name></author><author><name sortKey="Bristow, Rg" uniqKey="Bristow R">RG Bristow</name></author><author><name sortKey="Panzarella, T" uniqKey="Panzarella T">T Panzarella</name></author><author><name sortKey="Keane, Tj" uniqKey="Keane T">TJ Keane</name></author><author><name sortKey="Gullane, Pj" uniqKey="Gullane P">PJ Gullane</name></author><author><name sortKey="Witterick, Ip" uniqKey="Witterick I">IP Witterick</name></author><author><name sortKey="Payne, D" uniqKey="Payne D">D Payne</name></author><author><name sortKey="Liu, Ff" uniqKey="Liu F">FF Liu</name></author><author><name sortKey="Mclean, M" uniqKey="Mclean M">M McLean</name></author><author><name sortKey="Waldron, J" uniqKey="Waldron J">J Waldron</name></author><author><name sortKey="Cummings, Bj" uniqKey="Cummings B">BJ Cummings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cellai, E" uniqKey="Cellai E">E Cellai</name></author><author><name sortKey="Frata, P" uniqKey="Frata P">P Frata</name></author><author><name sortKey="Magrini, Sm" uniqKey="Magrini S">SM Magrini</name></author><author><name sortKey="Palar, F" uniqKey="Palar F">F Palar</name></author><author><name sortKey="Barca, R" uniqKey="Barca R">R Barca</name></author><author><name sortKey="Fondelli, S" uniqKey="Fondelli S">S Fondelli</name></author><author><name sortKey="Polli, C" uniqKey="Polli C">C Polli</name></author><author><name sortKey="Livi, L" uniqKey="Livi L">L Livi</name></author><author><name sortKey="Bonetti, B" uniqKey="Bonetti B">B Bonetti</name></author><author><name sortKey="Vitali, E" uniqKey="Vitali E">E Vitali</name></author><author><name sortKey="De Stefani, A" uniqKey="De Stefani A">A De Stefani</name></author><author><name sortKey="Buglion, M" uniqKey="Buglion M">M Buglion</name></author><author><name sortKey="Biti, G" uniqKey="Biti G">G Biti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chera, Bs" uniqKey="Chera B">BS Chera</name></author><author><name sortKey="Amdur, Rj" uniqKey="Amdur R">RJ Amdur</name></author><author><name sortKey="Morris, Cg" uniqKey="Morris C">CG Morris</name></author><author><name sortKey="Kirwan, Jm" uniqKey="Kirwan J">JM Kirwan</name></author><author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frata, P" uniqKey="Frata P">P Frata</name></author><author><name sortKey="Cellai, E" uniqKey="Cellai E">E Cellai</name></author><author><name sortKey="Magrini, Sm" uniqKey="Magrini S">SM Magrini</name></author><author><name sortKey="Bonetti, B" uniqKey="Bonetti B">B Bonetti</name></author><author><name sortKey="Vitali, E" uniqKey="Vitali E">E Vitali</name></author><author><name sortKey="Tonoli, S" uniqKey="Tonoli S">S Tonoli</name></author><author><name sortKey="Buglione, M" uniqKey="Buglione M">M Buglione</name></author><author><name sortKey="Palar, F" uniqKey="Palar F">F Palar</name></author><author><name sortKey="Barca, R" uniqKey="Barca R">R Barca</name></author><author><name sortKey="Fodelli, S" uniqKey="Fodelli S">S Fodelli</name></author><author><name sortKey="Polli, C" uniqKey="Polli C">C Polli</name></author><author><name sortKey="Livi, L" uniqKey="Livi L">L Livi</name></author><author><name sortKey="Biti, G" uniqKey="Biti G">G Biti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sobin, Lh" uniqKey="Sobin L">LH Sobin</name></author><author><name sortKey="Wittekind, Ch" uniqKey="Wittekind C">CH Wittekind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fowler, Jf" uniqKey="Fowler J">JF Fowler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robertson, Ag" uniqKey="Robertson A">AG Robertson</name></author><author><name sortKey="Robertson, C" uniqKey="Robertson C">C Robertson</name></author><author><name sortKey="Boyle, P" uniqKey="Boyle P">P Boyle</name></author><author><name sortKey="Symonds, Rp" uniqKey="Symonds R">RP Symonds</name></author><author><name sortKey="Wheldon, Te" uniqKey="Wheldon T">TE Wheldon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skladowski, K" uniqKey="Skladowski K">K Skladowski</name></author><author><name sortKey="Law, Mg" uniqKey="Law M">MG Law</name></author><author><name sortKey="Maciejewski, B" uniqKey="Maciejewski B">B Maciejewski</name></author><author><name sortKey="Steel, Gg" uniqKey="Steel G">GG Steel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fowler, Jf" uniqKey="Fowler J">JF Fowler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trotti, A" uniqKey="Trotti A">A Trotti</name></author><author><name sortKey="Colevas, Ad" uniqKey="Colevas A">AD Colevas</name></author><author><name sortKey="Setser, A" uniqKey="Setser A">A Setser</name></author><author><name sortKey="Rusch, V" uniqKey="Rusch V">V Rusch</name></author><author><name sortKey="Jaques, D" uniqKey="Jaques D">D Jaques</name></author><author><name sortKey="Budach, V" uniqKey="Budach V">V Budach</name></author><author><name sortKey="Langer, C" uniqKey="Langer C">C Langer</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B Murphy</name></author><author><name sortKey="Cumberlin, R" uniqKey="Cumberlin R">R Cumberlin</name></author><author><name sortKey="Coleman, Cn" uniqKey="Coleman C">CN Coleman</name></author><author><name sortKey="Rubin, P" uniqKey="Rubin P">P Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dey, P" uniqKey="Dey P">P Dey</name></author><author><name sortKey="Arnold, D" uniqKey="Arnold D">D Arnold</name></author><author><name sortKey="Wight, R" uniqKey="Wight R">R Wight</name></author><author><name sortKey="Mackenzie, K" uniqKey="Mackenzie K">K MacKenzie</name></author><author><name sortKey="Kelly, C" uniqKey="Kelly C">C Kelly</name></author><author><name sortKey="Wilson, J" uniqKey="Wilson J">J Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vlantis, Ac" uniqKey="Vlantis A">AC Vlantis</name></author><author><name sortKey="Yu, Bk" uniqKey="Yu B">BK Yu</name></author><author><name sortKey="Tsang, Rk" uniqKey="Tsang R">RK Tsang</name></author><author><name sortKey="Kam, Mk" uniqKey="Kam M">MK Kam</name></author><author><name sortKey="Lo, Ps" uniqKey="Lo P">PS Lo</name></author><author><name sortKey="Van Hasselt, Ca" uniqKey="Van Hasselt C">CA van Hasselt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steiner, W" uniqKey="Steiner W">W Steiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Machtay, M" uniqKey="Machtay M">M Machtay</name></author><author><name sortKey="Mckenna, Mg" uniqKey="Mckenna M">MG McKenna</name></author><author><name sortKey="Weinstein, Gs" uniqKey="Weinstein G">GS Weinstein</name></author><author><name sortKey="Markiewicz, Da" uniqKey="Markiewicz D">DA Markiewicz</name></author><author><name sortKey="Krisch, Re" uniqKey="Krisch R">RE Krisch</name></author><author><name sortKey="Kligerman, Wm" uniqKey="Kligerman W">WM Kligerman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epp, Er" uniqKey="Epp E">ER Epp</name></author><author><name sortKey="Boyer, Al" uniqKey="Boyer A">AL Boyer</name></author><author><name sortKey="Doppke, Kp" uniqKey="Doppke K">KP Doppke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, Ee" uniqKey="Klein E">EE Klein</name></author><author><name sortKey="Chin, Lm" uniqKey="Chin L">LM Chin</name></author><author><name sortKey="Rice, Rk" uniqKey="Rice R">RK Rice</name></author><author><name sortKey="Mijnheer, Bj" uniqKey="Mijnheer B">BJ Mijnheer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Izuno, I" uniqKey="Izuno I">I Izuno</name></author><author><name sortKey="Sone, S" uniqKey="Sone S">S Sone</name></author><author><name sortKey="Oguchi, M" uniqKey="Oguchi M">M Oguchi</name></author><author><name sortKey="Kiyono, K" uniqKey="Kiyono K">K Kiyono</name></author><author><name sortKey="Takei, K" uniqKey="Takei K">K Takei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, Cc" uniqKey="Tong C">CC Tong</name></author><author><name sortKey="Au, Kh" uniqKey="Au K">KH Au</name></author><author><name sortKey="Ngan, Rk" uniqKey="Ngan R">RK Ngan</name></author><author><name sortKey="Chow, Sm" uniqKey="Chow S">SM Chow</name></author><author><name sortKey="Cheung Fy, Fyt" uniqKey="Cheung Fy F">FYT Cheung FY</name></author><author><name sortKey="Au, Js" uniqKey="Au J">JS Au</name></author><author><name sortKey="Law, Sc" uniqKey="Law S">SC Law</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franchin, G" uniqKey="Franchin G">G Franchin</name></author><author><name sortKey="Minatel, E" uniqKey="Minatel E">E Minatel</name></author><author><name sortKey="Gobitti, C" uniqKey="Gobitti C">C Gobitti</name></author><author><name sortKey="Talamini, R" uniqKey="Talamini R">R Talamini</name></author><author><name sortKey="Vaccher, E" uniqKey="Vaccher E">E Vaccher</name></author><author><name sortKey="Sartor, G" uniqKey="Sartor G">G Sartor</name></author><author><name sortKey="Politi, D" uniqKey="Politi D">D Politi</name></author><author><name sortKey="Trovo, Mg" uniqKey="Trovo M">MG Trovö</name></author><author><name sortKey="Barzan, L" uniqKey="Barzan L">L Barzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name></author><author><name sortKey="Forster, K" uniqKey="Forster K">K Forster</name></author><author><name sortKey="Wong, Pf" uniqKey="Wong P">PF Wong</name></author><author><name sortKey="Morrison, Wh" uniqKey="Morrison W">WH Morrison</name></author><author><name sortKey="Schechter, Nr" uniqKey="Schechter N">NR Schechter</name></author><author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccoul, Ed" uniqKey="Mccoul E">ED McCoul</name></author><author><name sortKey="Har El, G" uniqKey="Har El G">G Har-El</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smee, Ri" uniqKey="Smee R">RI Smee</name></author><author><name sortKey="Meagher, Ns" uniqKey="Meagher N">NS Meagher</name></author><author><name sortKey="Williams, Jr" uniqKey="Williams J">JR Williams</name></author><author><name sortKey="Broadley, K" uniqKey="Broadley K">K Broadley</name></author><author><name sortKey="Bridger, Gp" uniqKey="Bridger G">GP Bridger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akimoto, T" uniqKey="Akimoto T">T Akimoto</name></author><author><name sortKey="Nonaka, T" uniqKey="Nonaka T">T Nonaka</name></author><author><name sortKey="Kitamoto, Y" uniqKey="Kitamoto Y">Y Kitamoto</name></author><author><name sortKey="Ishikawa, H" uniqKey="Ishikawa H">H Ishikawa</name></author><author><name sortKey="Ninomiya, H" uniqKey="Ninomiya H">H Ninomiya</name></author><author><name sortKey="Chikamatsu, K" uniqKey="Chikamatsu K">K Chikamatsu</name></author><author><name sortKey="Furuya, N" uniqKey="Furuya N">N Furuya</name></author><author><name sortKey="Hayakawa, K" uniqKey="Hayakawa K">K Hayakawa</name></author><author><name sortKey="Mitsuhashi, N" uniqKey="Mitsuhashi N">N Mitsuhashi</name></author><author><name sortKey="Nakano, T" uniqKey="Nakano T">T Nakano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishimura, G" uniqKey="Nishimura G">G Nishimura</name></author><author><name sortKey="Tsukuda, M" uniqKey="Tsukuda M">M Tsukuda</name></author><author><name sortKey="Mikami, Y" uniqKey="Mikami Y">Y Mikami</name></author><author><name sortKey="Matsuda, H" uniqKey="Matsuda H">H Matsuda</name></author><author><name sortKey="Horiuchi, C" uniqKey="Horiuchi C">C Horiuchi</name></author><author><name sortKey="Taguchi, T" uniqKey="Taguchi T">T Taguchi</name></author><author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M Takahashi</name></author><author><name sortKey="Kawakami, M" uniqKey="Kawakami M">M Kawakami</name></author><author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M Watanabe</name></author><author><name sortKey="Niho, T" uniqKey="Niho T">T Niho</name></author><author><name sortKey="Abo, H" uniqKey="Abo H">H Abo</name></author><author><name sortKey="Yamomoto, S" uniqKey="Yamomoto S">S Yamomoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murakami, R" uniqKey="Murakami R">R Murakami</name></author><author><name sortKey="Nishimura, R" uniqKey="Nishimura R">R Nishimura</name></author><author><name sortKey="Baba, Y" uniqKey="Baba Y">Y Baba</name></author><author><name sortKey="Yumoto, E" uniqKey="Yumoto E">E Yumoto</name></author><author><name sortKey="Oya, N" uniqKey="Oya N">N Oya</name></author><author><name sortKey="Ymashita, Y" uniqKey="Ymashita Y">Y Ymashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirasawa, N" uniqKey="Hirasawa N">N Hirasawa</name></author><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name></author><author><name sortKey="Ishihara, S" uniqKey="Ishihara S">S Ishihara</name></author><author><name sortKey="Kubota, S" uniqKey="Kubota S">S Kubota</name></author><author><name sortKey="Itoh, J" uniqKey="Itoh J">J Itoh</name></author><author><name sortKey="Fujimoto, Y" uniqKey="Fujimoto Y">Y Fujimoto</name></author><author><name sortKey="Nakashima, T" uniqKey="Nakashima T">T Nakashima</name></author><author><name sortKey="Naganawa, S" uniqKey="Naganawa S">S Naganawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feigenberg, Sj" uniqKey="Feigenberg S">SJ Feigenberg</name></author><author><name sortKey="Lango, M" uniqKey="Lango M">M Lango</name></author><author><name sortKey="Nicolaou, N" uniqKey="Nicolaou N">N Nicolaou</name></author><author><name sortKey="Ridge, Ja" uniqKey="Ridge J">JA Ridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez, D" uniqKey="Gomez D">D Gomez</name></author><author><name sortKey="Cahlon, O" uniqKey="Cahlon O">O Cahlon</name></author><author><name sortKey="Mechalakos, J" uniqKey="Mechalakos J">J Mechalakos</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenthal, Di" uniqKey="Rosenthal D">DI Rosenthal</name></author><author><name sortKey="Fuller, Cd" uniqKey="Fuller C">CD Fuller</name></author><author><name sortKey="Barker, Jl" uniqKey="Barker J">JL Barker</name></author><author><name sortKey="Mason, B" uniqKey="Mason B">B Mason</name></author><author><name sortKey="Garcia, Ja" uniqKey="Garcia J">JA Garcia</name></author><author><name sortKey="Lewin, Js" uniqKey="Lewin J">JS Lewin</name></author><author><name sortKey="Holsinger, Fc" uniqKey="Holsinger F">FC Holsinger</name></author><author><name sortKey="Stasney, Cr" uniqKey="Stasney C">CR Stasney</name></author><author><name sortKey="Frank, Sj" uniqKey="Frank S">SJ Frank</name></author><author><name sortKey="Schwartz, Dl" uniqKey="Schwartz D">DL Schwartz</name></author><author><name sortKey="Morrison, Wh" uniqKey="Morrison W">WH Morrison</name></author><author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name></author><author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chera, Bs" uniqKey="Chera B">BS Chera</name></author><author><name sortKey="Amdur, Rj" uniqKey="Amdur R">RJ Amdur</name></author><author><name sortKey="Morris, Cg" uniqKey="Morris C">CG Morris</name></author><author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tiong, Ac" uniqKey="Tiong A">AC Tiong</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name></author><author><name sortKey="O Sullivan, B" uniqKey="O Sullivan B">B O'Sullivan</name></author><author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Dawson, La" uniqKey="Dawson L">LA Dawson</name></author><author><name sortKey="Cho, J" uniqKey="Cho J">J Cho</name></author><author><name sortKey="Gilbert, R" uniqKey="Gilbert R">R Gilbert</name></author><author><name sortKey="Breen, S" uniqKey="Breen S">S Breen</name></author><author><name sortKey="Waldron, Jn" uniqKey="Waldron J">JN Waldron</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Head Neck Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Head Neck Oncol</journal-id><journal-title-group><journal-title>Head & Neck Oncology</journal-title></journal-title-group><issn pub-type="epub">1758-3284</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22607730</article-id><article-id pub-id-type="pmc">3448507</article-id><article-id pub-id-type="publisher-id">1758-3284-4-23</article-id><article-id pub-id-type="doi">10.1186/1758-3284-4-23</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Definitive radiotherapy for early stage glottic cancer by 6 MV photons</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Tong</surname><given-names>Chi-Chung</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>chichungtong@hkcr.org</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Au</surname><given-names>Kwok-Hung</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>akhz01@ha.org.hk</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Ngan</surname><given-names>Roger Kai-Cheong</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>ngankc@ha.org.hk</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Cheung</surname><given-names>Foon-Yiu</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>cheungfy@ha.org.hk</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Chow</surname><given-names>Sin-Ming</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>sinmingchow@hkcr.org</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Fu</surname><given-names>Yiu-Tung</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>fuyt@ha.org.hk</email></contrib><contrib contrib-type="author" id="A7"><name><surname>Au</surname><given-names>Joseph Siu-Kei</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>ausk@ha.org.hk</email></contrib><contrib contrib-type="author" id="A8"><name><surname>Law</surname><given-names>Stephen Chun-Key</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>lawck@ha.org.hk</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>18</day><month>5</month><year>2012</year></pub-date><volume>4</volume><fpage>23</fpage><lpage>23</lpage><history><date date-type="received"><day>22</day><month>4</month><year>2012</year></date><date date-type="accepted"><day>29</day><month>4</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012 Tong et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>Tong et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.headandneckoncology.org/content/4/1/23"></self-uri><abstract><sec><title>Purpose</title><p>To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.</p></sec><sec><title>Methods and materials</title><p>We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.</p></sec><sec><title>Results</title><p>The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.</p><p>Poorly differentiated histology and tumor biologically effective dose < 65 Gy<sub>15</sub> were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.</p></sec><sec><title>Conclusion</title><p>Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.</p></sec></abstract><kwd-group><kwd>T1/T2N0 glottic cancer</kwd><kwd>Radiotherapy</kwd><kwd>6MV photons</kwd><kwd>Biologically effective dose</kwd></kwd-group></article-meta><notes><p>PUBLISHER'S NOTE: Based on the information available to BioMed Central, this article was apparently handled and peer reviewed only by Waseem Jerjes, an Editor-in-Chief of the journal at that time. There were no other peer reviewers.</p></notes></front><body><sec sec-type="intro"><title>Introduction</title><p>Laryngeal cancer is the third most common head and neck (H&N) cancer in Hong Kong. According to Hong Kong Cancer Registry, the age-standardized incidence rate was 2.3 per 100,000 in 2007[<xref ref-type="bibr" rid="B1">1</xref>].</p><p>In western countries, definitive radiotherapy (RT) and conservative surgery (endoscopic laser surgery/open organ preserving surgery) are accepted standard treatment modalities for early stage laryngeal cancers. The axiom of treatment aims for cure with laryngeal preservation and maintain optimal quality of life like voice quality and swallowing. The choice of treatment depends on availability of facilities and medical expertise, as well as patient’s preference and the cost of treatment [<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B3">3</xref>].</p><p>A survey conducted to eleven Asian regions/countries about management strategy of early laryngeal cancer revealed that around half of the countries/regions, especially those follow the British stream, like Hong Kong and Singapore, primary radiotherapy remained a mainstay treatment modality [<xref ref-type="bibr" rid="B4">4</xref>]. In Hong Kong, around 95% of early glottic cancer (GC) patients were treated by primary radiotherapy (RT) alone.</p><p>For definitive RT, there is extensive published data regarding management of early GC with Cobalt-60 or 2-4 MV photons. Factors studied for prognostic importance for local failure included pretreatment hemoglobulin [<xref ref-type="bibr" rid="B5">5</xref>], sex [<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B6">6</xref>], T category [<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B7">7</xref>], histology differentiation [<xref ref-type="bibr" rid="B7">7</xref>], anterior commissure involvement [<xref ref-type="bibr" rid="B6">6</xref>], subglottic extension [<xref ref-type="bibr" rid="B5">5</xref>], tumor bulk [<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B6">6</xref>,<xref ref-type="bibr" rid="B8">8</xref>], fraction dose size [<xref ref-type="bibr" rid="B7">7</xref>] and overall treatment time [<xref ref-type="bibr" rid="B7">7</xref>].</p><p>The reported treatment outcome of early GC by primary RT with 6MV photons is limited. We present our institution’s experience in this report.</p></sec><sec sec-type="materials|methods"><title>Methods and materials</title><sec><title>Patient characteristics</title><p>In Hong Kong, most citizens are not covered by medical insurance and their medical care is provided mainly by the public care system funded by the Government. The Queen Elizabeth Hospital is one of the major public tertiary referral centers.</p><p>In May 2010, we conducted a retrospective review of laryngeal cancer patients referred to our center over a 23 year period for radical treatment between January 1983 to December 2005. A total of 1256 consecutive patients were identified. According to the Hong Kong Cancer Registry, about a quarter of laryngeal cancer cases diagnosed in Hong Kong over that period had been treated in our institution.</p><p>Out of the 1256 patients, there were 695 previously untreated patients with T1N0 and T2N0 GC. Six hundred and sixty- two were male and 33 female patients, with a male: female ratio of 20:1. Six hundred and eighty two (98%) were Chinese and 13 (2%) came from other ethic backgrounds. Age ranged from 35 to 94 (median: 65). As the treatment of choice at our institution for stage I and II GC has always been primary RT alone, this represented a relatively unselected cohort of patients.</p></sec><sec><title>Staging</title><p>All patients had full physical examination, routine blood counts, renal and liver function tests, chest x ray, endoscopic examination and biopsy for histology diagnosis. Computed tomography (CT) scan of larynx and neck was performed in 661 (95%) patients. All patients were restaged according to TNM 2002 classification [<xref ref-type="bibr" rid="B9">9</xref>]. Table <xref ref-type="table" rid="T1">1</xref> summarizes the patient and tumor parameters.</p><table-wrap position="float" id="T1"><label>Table 1</label><caption><p>Patient and tumor parameters</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th align="left" valign="bottom"><bold>Parameter</bold><hr></hr></th><th align="center" valign="bottom"><bold>T1N0</bold><hr></hr></th><th align="center" valign="bottom"><bold>T2N0</bold><hr></hr></th></tr><tr><th align="left"> </th><th align="center"><bold>Patient no. (%)</bold></th><th align="center"><bold>Patient no. (%)</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="bottom">All stages<hr></hr></td><td align="center" valign="bottom">433<hr></hr></td><td align="center" valign="bottom">262<hr></hr></td></tr><tr><td align="left" valign="bottom">T1a<hr></hr></td><td align="center" valign="bottom">324 (74.8%)<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td></tr><tr><td align="left" valign="bottom">T1b<hr></hr></td><td align="center" valign="bottom">109 (25.1%)<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td></tr><tr><td align="left" valign="bottom">Gender<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Male<hr></hr></td><td align="center" valign="bottom">413 (95.3%)<hr></hr></td><td align="center" valign="bottom">249 (93.8%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Female<hr></hr></td><td align="center" valign="bottom">20 (4.6%)<hr></hr></td><td align="center" valign="bottom">13 (4.9%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Grade<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Well differentiated<hr></hr></td><td align="center" valign="bottom">154 (35.5%)<hr></hr></td><td align="center" valign="bottom">64 (24.4%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Mod differentiated<hr></hr></td><td align="center" valign="bottom">273 (63.0%)<hr></hr></td><td align="center" valign="bottom">179 (68.3%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Poorly differentiated<hr></hr></td><td align="center" valign="bottom">6 (1.3%)<hr></hr></td><td align="center" valign="bottom">19 (7.2%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Anterior commissure involved<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">197 (45.4%)<hr></hr></td><td align="center" valign="bottom">186 (71%)<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom">236 (54.1%)<hr></hr></td><td align="center" valign="bottom">76 (29%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Impaired mobility<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">Not apply<hr></hr></td><td align="center" valign="bottom">51 (19.4%)<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">211 (80.5%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Sub-glottic extension<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">Not apply<hr></hr></td><td align="center" valign="bottom">80 (31%)<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">182 (69%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Hb level<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">< 13 g/dL<hr></hr></td><td align="center" valign="bottom">45 (10.4%)<hr></hr></td><td align="center" valign="bottom">28 (10.6%)<hr></hr></td></tr><tr><td align="left">≥ 13 g/dL</td><td align="center">388 (89.6%)</td><td align="center">234 (91.4%)</td></tr></tbody></table><table-wrap-foot><p><italic>Abbreviations:</italic> no. = number; Hb = Hemoglobin.</p></table-wrap-foot></table-wrap></sec><sec><title>Radiotherapy treatment</title><p>All patients were treated exclusively with 6-MV photons. They were treated in a supine position, immobilized with a customized neck cast. All patients received a continuous course of RT with once-daily fractionation, 5 fractions per week. All fields are equally weighted and treated in each fraction. Appropriate wedge filters were used to improve the dose homogeneity. 0.5 cm wax bolus was used for disease involving the anterior commissure (AC). Table <xref ref-type="table" rid="T2">2</xref> summarizes the treatment parameters.</p><table-wrap position="float" id="T2"><label>Table 2</label><caption><p>Treatment parameters</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th align="left" valign="bottom"><bold>Parameters</bold><hr></hr></th><th align="center" valign="bottom"><bold>Stage T1N0</bold><hr></hr></th><th align="center" valign="bottom"><bold>Stage T2N0</bold><hr></hr></th></tr><tr><th align="left"> </th><th align="center"><bold>(433) Patients (%)</bold></th><th align="center"><bold>(262) Patients (%)</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="bottom">Field size (cm2)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">< 30.5<hr></hr></td><td align="center" valign="bottom">215 (49.6)<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td></tr><tr><td align="left" valign="bottom">30.5- 35.5<hr></hr></td><td align="center" valign="bottom">165 (38.1)<hr></hr></td><td align="center" valign="bottom">106 (40.4)<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 35.5<hr></hr></td><td align="center" valign="bottom">53 (12.2)<hr></hr></td><td align="center" valign="bottom">156 (59.5)<hr></hr></td></tr><tr><td align="left" valign="bottom">A. Dose fraction size<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">2.5 Gy<hr></hr></td><td align="center" valign="bottom">177 (40.8)<hr></hr></td><td align="center" valign="bottom">86 (32.8)<hr></hr></td></tr><tr><td align="left" valign="bottom">Total dose (Gy)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">55<hr></hr></td><td align="center" valign="bottom">30 (6.9)<hr></hr></td><td align="center" valign="bottom">7 (2.7)<hr></hr></td></tr><tr><td align="left" valign="bottom">57.5<hr></hr></td><td align="center" valign="bottom">134 (30.9)<hr></hr></td><td align="center" valign="bottom">63 (24.0)<hr></hr></td></tr><tr><td align="left" valign="bottom">60<hr></hr></td><td align="center" valign="bottom">13 (3.0)<hr></hr></td><td align="center" valign="bottom">16 (6.1)<hr></hr></td></tr><tr><td align="left" valign="bottom">Tx duration (days)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">30<hr></hr></td><td align="center" valign="bottom">25 (5.7)<hr></hr></td><td align="center" valign="bottom">22 (8.4)<hr></hr></td></tr><tr><td align="left" valign="bottom">31-34<hr></hr></td><td align="center" valign="bottom">141 (32.5)<hr></hr></td><td align="center" valign="bottom">45 (17.1)<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 35<hr></hr></td><td align="center" valign="bottom">11 (2.5)<hr></hr></td><td align="center" valign="bottom">19 (7.2)<hr></hr></td></tr><tr><td align="left" valign="bottom">BEDcGy<sub>15</sub> (cGy)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Median<hr></hr></td><td align="center" valign="bottom">6520<hr></hr></td><td align="center" valign="bottom">6580<hr></hr></td></tr><tr><td align="left" valign="bottom">range<hr></hr></td><td align="center" valign="bottom">6058- 6820<hr></hr></td><td align="center" valign="bottom">6160- 6820<hr></hr></td></tr><tr><td align="left" valign="bottom">B. Dose fraction size<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">2.0 Gy<hr></hr></td><td align="center" valign="bottom">256 (59.1)<hr></hr></td><td align="center" valign="bottom">176 (67.1)<hr></hr></td></tr><tr><td align="left" valign="bottom">Total dose (Gy)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">64<hr></hr></td><td align="center" valign="bottom">52 (12.0)<hr></hr></td><td align="center" valign="bottom">24 (9.1)<hr></hr></td></tr><tr><td align="left" valign="bottom">66<hr></hr></td><td align="center" valign="bottom">202 (46.6)<hr></hr></td><td align="center" valign="bottom">109 (41.6)<hr></hr></td></tr><tr><td align="left" valign="bottom">68<hr></hr></td><td align="center" valign="bottom">2 (0.46)<hr></hr></td><td align="center" valign="bottom">2 (0.7)<hr></hr></td></tr><tr><td align="left" valign="bottom">70<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">41 (15.6)<hr></hr></td></tr><tr><td align="left" valign="bottom">Tx duration (days)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">≤45<hr></hr></td><td align="center" valign="bottom">48 (11.0)<hr></hr></td><td align="center" valign="bottom">18 (6.8)<hr></hr></td></tr><tr><td align="left" valign="bottom">46- 50<hr></hr></td><td align="center" valign="bottom">203 (46.8)<hr></hr></td><td align="center" valign="bottom">110 (42.0)<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 51<hr></hr></td><td align="center" valign="bottom">5 (1.15)<hr></hr></td><td align="center" valign="bottom">48 (18.3)<hr></hr></td></tr><tr><td align="left" valign="bottom">BEDcGy<sub>15</sub> (cGy)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Median<hr></hr></td><td align="center" valign="bottom">6340<hr></hr></td><td align="center" valign="bottom">6520<hr></hr></td></tr><tr><td align="left">range</td><td align="center">6040- 6700</td><td align="center">6040- 6910</td></tr></tbody></table><table-wrap-foot><p><italic>Abbreviations</italic>: Tx = treatment; BED = biologically effective dose.</p></table-wrap-foot></table-wrap></sec><sec><title>Field size and set up</title><sec><title>T1N0</title><p>All patients with T1 disease were treated with parallel-opposed fields, to cover the glottic larynx with 1-2 cm margins. The field size was obtained by multiplying the field length by the field height. They ranged from 22- 38.5 cm<sup>2</sup> (median: 27.5 cm<sup>2</sup>). Typically, the superior border was placed at around the superior border of the thyroid cartilage, the inferior border was placed at around the bottom of the cricoid cartilage, the anterior border extending beyond the skin surface and the posterior border stopping at the anterior border of the vertebral body of cervical spine. Elective nodal irradiation was not given.</p></sec><sec><title>T2N0</title><p>Two hundred and thirty eight (90.8%) of T2 patients were treated with parallel opposed fields. Although the initial field sizes ranged from 35 to 72 cm<sup>2</sup> (median: 42), 82% of patients were treated with 42 cm<sup>2</sup> (6 cm x 7 cm) or smaller portals.</p><p>Twenty one (8%) patients were treated with a single anterior appositional field, in which electron beam were used after the initial 30 Gy given by 6 MV photon beam. Three (1.1%) patients were treated with a three- field technique by adding an anterior field to two opposing fields.</p></sec></sec><sec><title>Dose and fractionation</title><p>Dose was prescribed at the midline along the central axis or recalculated at the ICRU reference point. Between the period of 1983- 1988 and 1996- 2005, patients were treated with a fraction size of 2.0 Gy whereas during 1989- 1995, a fraction size of 2.5 Gy was utilized because of constraints in linear accelerator machine in the hospital.</p><p>To allow comparison of dose prescribed in different periods, we opted to compute the tumor biologically effective dose (BED) by using the standard linear quadratic formula (LQ) with time factors corrected [<xref ref-type="bibr" rid="B10">10</xref>]:</p><p><disp-formula id="bmcM1"><label>(1)</label><mml:math id="M1" name="1758-3284-4-23-i1" overflow="scroll"><mml:mrow><mml:mtext>Tumor BED</mml:mtext><mml:mo>=</mml:mo><mml:mi>n</mml:mi><mml:mi>d</mml:mi><mml:mfenced open="(" close=")"><mml:mrow><mml:mn>1</mml:mn><mml:mo>+</mml:mo><mml:mi>d</mml:mi><mml:mo>/</mml:mo><mml:mfenced open="[" close="]"><mml:mrow><mml:mi>α</mml:mi><mml:mo>/</mml:mo><mml:mi>β</mml:mi></mml:mrow></mml:mfenced></mml:mrow></mml:mfenced><mml:mo>–</mml:mo><mml:msub><mml:mtext>log</mml:mtext><mml:mtext>e</mml:mtext></mml:msub><mml:mspace width="0.11em"></mml:mspace><mml:mn>2</mml:mn><mml:mspace width="0.25em"></mml:mspace><mml:mfenced open="(" close=")"><mml:mrow><mml:mi>T</mml:mi><mml:mo>–</mml:mo><mml:mi>T</mml:mi><mml:mtext>k</mml:mtext></mml:mrow></mml:mfenced><mml:mo>/</mml:mo><mml:mi>α</mml:mi><mml:mi>T</mml:mi><mml:mtext>p</mml:mtext></mml:mrow></mml:math></disp-formula></p><p>where <italic>n</italic> fractions of <italic>d</italic> Gy are given in an overall time of <italic>T</italic> days and kick off time (<italic>T</italic>k) for tumor repopulation. We assume α/β = 15 for laryngeal cancer[<xref ref-type="bibr" rid="B11">11</xref>], <italic>T</italic>k = 28 for tumor [<xref ref-type="bibr" rid="B12">12</xref>], <italic>T</italic>p = average cell number doubling time during continuing radiation, 3 days for tumor [<xref ref-type="bibr" rid="B13">13</xref>]. Alpha (α) = 0.35 Gy<sup>-1</sup>[<xref ref-type="bibr" rid="B13">13</xref>][coefficient of non-repairable injury, log cell kill (exponentially-based logs) per gray of dose].</p><sec><title>T1N0</title><p>During 1983-1988 and 1996-2005, the dose-fractionation schedule was 66 Gy in 33 fractions whereas during 1989- 1995, the schedule was 57.5 Gy in 23 fractions.</p></sec><sec><title>T2N0</title><p>During 1983 – 1988, the dose- fractionation schedule was 66 Gy in 33 fractions whereas during 1989-1995, the schedule was 57.5 Gy in 23 fractions. Since 1996, we have prescribed up to 70 Gy in 35 fractions for all T2 disease.</p></sec></sec><sec><title>Follow up and assessment</title><p>All patients underwent evaluation of response to treatment by endoscopy examination at 6 to 8 weeks after completion of RT treatment. Patients were regularly seen once every three months during the initial 2 years and then six-monthly up to 5 years and then yearly thereafter.</p></sec><sec><title>Complications</title><p>Acute and chronic complications were scored according to the Common Terminology Criteria for Adverse Events version 3.0 [<xref ref-type="bibr" rid="B14">14</xref>].</p></sec><sec><title>Statistical analysis</title><p>Local and neck failure was defined as clinically/radiological detectable disease in larynx and cervical lymph node (LN) respectively. Distant metastasis (DM) was defined as clinically or radiologically detectable disease outside the larynx and cervical LN. Clinicopathologic parameters that were analyzed included age (<61 vs. 61-70 vs. >71), gender (male vs. female), pre-treatment hemoglobin (Hb) level (<13.0 vs. ≥13.0 g/dl), T sub-stage (T1a vs. T1b) [for T1 disease], impaired cord mobility (yes vs. no) [for T2 disease], tumor grading (well vs. moderate vs. poorly differentiated squamous cell carcinoma) and involvement of AC (yes vs. no). Treatment parameters included dose fraction size (2.0 Gy vs. 2.5 Gy), BEDGy<sub>15</sub> given (<65.0 Gy<sub>15</sub> vs. ≥ 65.0 Gy<sub>15</sub>), treatment field size in cm<sup>2</sup> (< 30.5 vs. 30.5 – 35.5 vs. > 35.5), and treatment period (1983- 1990 vs. 1991- 2000 vs. 2001- 2005).</p><p>All time-related events were measured from date of the first RT treatment. The actuarial local control (LC) rate, ultimate LC rate, cause- specific survival (CSS) and overall survival (OS) were calculated by the Kaplan-Meier method. Difference of the endpoints of patient cohorts stratified by various prognostic factors were evaluated by the Log- rank test. Cox proportional hazard model was used for both univariate and multivariate analysis to determine the hazard ratios and significance of potential risk factors for LC and CSS. All statistical tests were two-sided and performed at the 0.05 level of significance (<italic>p</italic> value). Only factors with a level of significance less than 0.05 in univariate analysis would be further analyzed in the multivariate analysis. We used SPSS, version 15.0, (SPSS Inc.,Chicago, IL) for all statistical analyses.</p></sec></sec><sec sec-type="results"><title>Results</title><sec><title>Local and neck control</title><p>The clinical course of this patient cohort is shown in Figure <xref ref-type="fig" rid="F1">1</xref>. The median follow- up period was 10.5 years (range: 3.3-26 years). LC after primary RT is depicted in Figure <xref ref-type="fig" rid="F2">2</xref>. The 5-year and 10-year actuarial LC rates were as follows: T1A, 92% and 91%; T1B, 89% and 87%; T2, 79% and 77% respectively.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>Clinical course.</bold><italic>Abbreviations:</italic> pts = patients; RT = radiotherapy; TL = total Laryngectomy; RND = radical neck dissection; PLO = pharyngolaryngectomy; 1st = First; 2nd = Second.</p></caption><graphic xlink:href="1758-3284-4-23-1"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Actuarial local control.</p></caption><graphic xlink:href="1758-3284-4-23-2"></graphic></fig><p>Complete response was achieved in 679 (97.6%) patients, while 16 (2.3%) patients (3 T1 and 13 T2) had residual disease at vocal cord(s). Seventy three (10.5%) among the 679 patients who achieved complete response had first relapse with a median time of 15 months. The first sites of relapse included: vocal cord(s) only in 68 (10%) patients (38 T1 and 30 T2), regional LN only in 2 (0.2%) patients (2 T2), vocal cord(s) plus regional LN in 3 (0.4%) patients (3 T2).</p><p>Table <xref ref-type="table" rid="T3">3</xref> showed parameters that have prognostic significance on LC. For T1 disease, on multivariate analysis, LC was adversely affected by the poorly differentiated histology (Hazard Ratio [HR]: 7.5, <italic>p</italic> = 0.035), involvement of AC (HR: 2.34, <italic>p</italic> = 0.011), fraction dose size of 2.0 Gy (HR: 2.17, <italic>p</italic> = 0.035) and tumor BED Gy<sub>15</sub> < 65.0 Gy<sub>15</sub> (HR: 3.38, <italic>p</italic> = 0.017).</p><table-wrap position="float" id="T3"><label>Table 3</label><caption><p>Univariate and multivariate analysis of factors affecting local control</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th colspan="5" align="center"><bold>T1N0</bold></th><th colspan="4" align="center"><bold>T2N0</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="bottom"><bold>Parameters</bold><hr></hr></td><td align="center" valign="bottom"><bold>Event/pts</bold><hr></hr></td><td align="center" valign="bottom"><bold>Uni-variate</bold><hr></hr></td><td colspan="2" align="center" valign="bottom"><bold>Multivariate analysis</bold><hr></hr></td><td rowspan="2" align="center" valign="bottom"><bold>Event/pts</bold><hr></hr></td><td align="center" valign="bottom"><bold>Uni-variate</bold><hr></hr></td><td colspan="2" align="center" valign="bottom"><bold>Multivariate analysis</bold><hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"><bold><italic>P</italic></bold><bold>value</bold><hr></hr></td><td align="center" valign="bottom"><bold>Hazard ratio (95% CI)</bold><hr></hr></td><td align="center" valign="bottom"><bold><italic>P</italic></bold><bold>value</bold><hr></hr></td><td align="center" valign="bottom"><bold><italic>P</italic></bold><bold>value</bold><hr></hr></td><td align="center" valign="bottom"><bold>Hazard ratio (95% CI)</bold><hr></hr></td><td align="center" valign="bottom"><bold><italic>P</italic></bold><bold>value</bold><hr></hr></td></tr><tr><td align="left" valign="bottom">Age<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom"><61<hr></hr></td><td align="center" valign="bottom">18/142<hr></hr></td><td align="center" valign="bottom">0.302<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">22/90<hr></hr></td><td align="center" valign="bottom">0.747<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">61-70<hr></hr></td><td align="center" valign="bottom">15/153<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">23/103<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">>70<hr></hr></td><td align="center" valign="bottom">9/138<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">13/69<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Sex<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Male<hr></hr></td><td align="center" valign="bottom">41/413<hr></hr></td><td align="center" valign="bottom">0.445<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">55/249<hr></hr></td><td align="center" valign="bottom">0.831<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">Female<hr></hr></td><td align="center" valign="bottom">1/20<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">3/13<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Substage<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">T1A<hr></hr></td><td align="center" valign="bottom">28/324<hr></hr></td><td align="center" valign="bottom">0.24<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td></tr><tr><td align="left" valign="bottom">T1B<hr></hr></td><td align="center" valign="bottom">14/109<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Grade<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Well diff<hr></hr></td><td align="center" valign="bottom">9/154<hr></hr></td><td align="center" valign="bottom">0.0001*<hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom">0.035*<hr></hr></td><td align="center" valign="bottom">10/64<hr></hr></td><td align="center" valign="bottom">0.025*<hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Moderate diff<hr></hr></td><td align="center" valign="bottom">29/273<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1.91 (1.2- 3.85)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">40/179<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">2.4 (1.7- 3.2)<hr></hr></td><td align="center" valign="bottom">0.022*<hr></hr></td></tr><tr><td align="left" valign="bottom">Poorly diff<hr></hr></td><td align="center" valign="bottom">4/6<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">7.5<break></break>(3.42- 5.24)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">8/19<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">4.3<break></break>(2.6- 8.9)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Impaired Cord mobility<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">yes<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">11/51<hr></hr></td><td align="center" valign="bottom">0.53<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">47/211<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Subglottic Extension<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">23/80<hr></hr></td><td align="center" valign="bottom">0.038*<hr></hr></td><td align="center" valign="bottom">2.15 (1.78-5.51)<hr></hr></td><td align="center" valign="bottom">0.027*<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">35/182<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Hb (g/dL)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">< 13.0<hr></hr></td><td align="center" valign="bottom">6/45<hr></hr></td><td align="center" valign="bottom">0.367<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">15/28<hr></hr></td><td align="center" valign="bottom">0.001*<hr></hr></td><td align="center" valign="bottom">3.78 (1.34-8.40)<hr></hr></td><td align="center" valign="bottom">0.031*<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 13.0<hr></hr></td><td align="center" valign="bottom">36/388<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">43/234<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">AC<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom">14/236<hr></hr></td><td align="center" valign="bottom">0.004*<hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom">0.011*<hr></hr></td><td align="center" valign="bottom">12/76<hr></hr></td><td align="center" valign="bottom">0.129<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">28/197<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">2.34 (1.21-4.52)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">46/186<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Field size (cm<sup>2</sup>)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom"><30.5<hr></hr></td><td align="center" valign="bottom">35/215<hr></hr></td><td align="center" valign="bottom">0.534<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">0.138<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">30.5- 35.5<hr></hr></td><td align="center" valign="bottom">7/165<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">26/106<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">> 35.5<hr></hr></td><td align="center" valign="bottom">0/53<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">32/156<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Dose size<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">2.0 Gy<hr></hr></td><td align="center" valign="bottom">32/256<hr></hr></td><td align="center" valign="bottom">0.021*<hr></hr></td><td align="center" valign="bottom">2.17 (1.28- 4.18)<hr></hr></td><td align="center" valign="bottom">0.035*<hr></hr></td><td align="center" valign="bottom">45/176<hr></hr></td><td align="center" valign="bottom">0.042*<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">2.5 Gy<hr></hr></td><td align="center" valign="bottom">10/177<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">13/86<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">BEDGy<sub>15</sub><hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">< 65.0<hr></hr></td><td align="center" valign="bottom">36/315<hr></hr></td><td align="center" valign="bottom">0.025*<hr></hr></td><td align="center" valign="bottom">3.38 (1.29- 7.83)<hr></hr></td><td align="center" valign="bottom">0.017*<hr></hr></td><td align="center" valign="bottom">12/76<hr></hr></td><td align="center" valign="bottom">0.022*<hr></hr></td><td align="center" valign="bottom">1.8 (1.2- 5.74)<hr></hr></td><td align="center" valign="bottom">0.038*<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 65.0<hr></hr></td><td align="center" valign="bottom">6/118<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">46/186<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Tx period<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">1983- 1990<hr></hr></td><td align="center" valign="bottom">10/115<hr></hr></td><td align="center" valign="bottom">0.643<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">17/75<hr></hr></td><td align="center" valign="bottom">0.336<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">1991- 2000<hr></hr></td><td align="center" valign="bottom">25/224<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">29/142<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left">2001- 2005</td><td align="center">7/94</td><td align="center"> </td><td align="center"> </td><td align="center"> </td><td align="center">12/45</td><td align="center"> </td><td align="center"> </td><td align="center"> </td></tr></tbody></table><table-wrap-foot><p><italic>Abbreviations</italic>: pts = patients; Hb = hemoglobin; Tx = treatment; diff = differentiated; AC = anterior commissure; BED = biologically effective dose; * = statistically significant; NS = not significant.</p></table-wrap-foot></table-wrap><p>For T2 disease, on multivariate analysis, LC was adversely affected by poorly differentiated grading (HR: 4.3, <italic>p</italic> = 0.022), Hb < 13.0 (HR: 3.78, <italic>p</italic> = 0.031), subglottic extension (HR: 2.15, <italic>p</italic> = 0.027) and tumor BED Gy<sub>15</sub> < 65.0 Gy<sub>15</sub> (HR: 1.8, <italic>p</italic> = 0.038).</p></sec><sec><title>Salvage surgery and ultimate control</title><p>Table <xref ref-type="table" rid="T4">4</xref> showed the details of the radical salvage surgery performed for the 83 patients with residual disease or first relapses. Ultimate disease control was achieved in 678 (97.5%) patients. The 10-year ultimate LC rates for T1 and T2 disease was 97.6% and 97.4% respectively. Larynx preservation was achieved in 606 (87%) patients.</p><table-wrap position="float" id="T4"><label>Table 4</label><caption><p>Salvage surgery performed</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th rowspan="2" align="center" valign="bottom"><bold>Stage</bold><hr></hr></th><th rowspan="2" align="center" valign="bottom"><bold>No of pts</bold><hr></hr></th><th rowspan="2" colspan="4" align="center" valign="bottom"><bold>1</bold><sup><bold>st</bold></sup><bold> Failures pts</bold><hr></hr></th><th colspan="4" align="center" valign="bottom"><bold>Types of 1</bold><sup><bold>st</bold></sup><bold> salvage surgery</bold><hr></hr></th><th align="center" valign="bottom"><bold>2nd Relapse Pts</bold><hr></hr></th><th align="center" valign="bottom"><bold>2nd salvage surgery</bold><hr></hr></th><th rowspan="2" align="center" valign="bottom"><bold>Ultimate failure Pts (%)</bold><hr></hr></th></tr><tr><th colspan="4" align="center" valign="bottom"><bold>(No. salvaged/No. attempted)</bold><hr></hr></th><th align="center" valign="bottom"> <hr></hr></th><th align="center" valign="bottom"><bold>(No salvage/attempted)</bold><hr></hr></th></tr><tr><th align="center"> </th><th align="center"> </th><th align="center"><bold>local</bold></th><th align="center"><bold>LN</bold></th><th align="center"><bold>Local + LN</bold></th><th align="center"><bold>Total (%)</bold></th><th align="center"><bold>TL</bold></th><th align="center"><bold>RND</bold></th><th align="center"><bold>TL + RND</bold></th><th align="center"><bold>Not fit/refused surgery</bold></th><th align="center"> </th><th align="center"> </th><th align="center"> </th></tr></thead><tbody valign="top"><tr><td align="center" valign="bottom">T1<hr></hr></td><td align="center" valign="bottom">433<hr></hr></td><td align="center" valign="bottom">39<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">39 (9)<hr></hr></td><td align="center" valign="bottom">36<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">3<hr></hr></td><td align="center" valign="bottom">7<hr></hr></td><td align="center" valign="bottom">0/7<hr></hr></td><td align="center" valign="bottom">10 (2.3)<hr></hr></td></tr><tr><td align="center">T2</td><td align="center">262</td><td align="center">45</td><td align="center">2</td><td align="center">3</td><td align="center">50 (19%)</td><td align="center">43</td><td align="center">2</td><td align="center">2</td><td align="center">3</td><td align="center">3</td><td align="center">2/3 (PLO)</td><td align="center">7 (2.6)</td></tr></tbody></table><table-wrap-foot><p>Abbreviations: No = number; pts = patients; 1<sup>st</sup> = first; 2<sup>nd</sup> = second; LN = lymph node; TL = total Laryngectomy RND = radical neck dissection; PLO = pharynolaryngectomy.</p></table-wrap-foot></table-wrap></sec><sec><title>Survival</title><p>At the last follow up, 272 patients had died: 15 from glottic carcinomas, 118 from second malignancy and 138 from intercurrent disease. Figures <xref ref-type="fig" rid="F3">3</xref> and <xref ref-type="fig" rid="F4">4</xref> showed the OS and CSS for the entire cohort respectively. For T1 disease, multi-variate analysis showed involvement of AC is the only independent adverse factor for CSS (HR: 3.7, <italic>p</italic> = 0.045). For T2 disease, haemoglobin <13.0 is the only independent adverse factor for CSS (HR: 2.8, <italic>p</italic> = 0.028) [Table <xref ref-type="table" rid="T5">5</xref>].</p><fig id="F3" position="float"><label>Figure 3</label><caption><p>Overall survival.</p></caption><graphic xlink:href="1758-3284-4-23-3"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>Cause specific survival.</p></caption><graphic xlink:href="1758-3284-4-23-4"></graphic></fig><table-wrap position="float" id="T5"><label>Table 5</label><caption><p>Univariate and multivariate analysis of factors affecting cause specific survival</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th colspan="5" align="center" valign="bottom"><bold>T1N0</bold><hr></hr></th><th colspan="4" align="center" valign="bottom"><bold>T2N0</bold><hr></hr></th></tr><tr><th rowspan="2" align="center"><bold>Parameters</bold></th><th rowspan="2" align="center"><bold>Event/pts</bold></th><th align="center" valign="bottom"><bold>Uni-variate</bold><hr></hr></th><th colspan="2" align="center" valign="bottom"><bold>Multivariate analysis</bold><hr></hr></th><th align="center" valign="bottom"><bold>Event/pts</bold><hr></hr></th><th align="center" valign="bottom"><bold>Uni-variate</bold><hr></hr></th><th colspan="2" align="center" valign="bottom"><bold>Multivariate analysis</bold><hr></hr></th></tr><tr><th align="center"><bold><italic>P</italic></bold><bold>value</bold></th><th align="center"><bold>Hazard ratio (95% CI)</bold></th><th align="center"><bold><italic>P</italic></bold><bold>value</bold></th><th align="center"> </th><th align="center"><bold><italic>P</italic></bold><bold>value</bold></th><th align="center"><bold>Hazard ratio (95%CI)</bold></th><th align="center"><bold><italic>P</italic></bold><bold>value</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="bottom">Age<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom"><61<hr></hr></td><td align="center" valign="bottom">4/142<hr></hr></td><td align="center" valign="bottom">0.897<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">0/90<hr></hr></td><td align="center" valign="bottom">0.224<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">61-70<hr></hr></td><td align="center" valign="bottom">3/153<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">3/103<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">>70<hr></hr></td><td align="center" valign="bottom">3/138<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">2/69<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Sex<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Male<hr></hr></td><td align="center" valign="bottom">10/413<hr></hr></td><td align="center" valign="bottom">0.459<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">5/249<hr></hr></td><td align="center" valign="bottom">0.61<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">Female<hr></hr></td><td align="center" valign="bottom">0/20<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">0/13<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Substage<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">T1A<hr></hr></td><td align="center" valign="bottom">7/324<hr></hr></td><td align="center" valign="bottom">0.53<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td></tr><tr><td align="left" valign="bottom">T1B<hr></hr></td><td align="center" valign="bottom">3/109<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Grade<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Well diff<hr></hr></td><td align="center" valign="bottom">3/154<hr></hr></td><td align="center" valign="bottom">0.825<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">1/63<hr></hr></td><td align="center" valign="bottom">0.721<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">Mod diff<hr></hr></td><td align="center" valign="bottom">7/273<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">3/179<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Poorly diff<hr></hr></td><td align="center" valign="bottom">0/6<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1/20<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Impaired Cord mobility<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">yes<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">1/51<hr></hr></td><td align="center" valign="bottom">0.84<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">4/211<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Subglottic Extension<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">2/80<hr></hr></td><td align="center" valign="bottom">0.56<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">3/182<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Hb (g/ dL)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">< 13.0<hr></hr></td><td align="center" valign="bottom">1/45<hr></hr></td><td align="center" valign="bottom">0.76<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">1/28<hr></hr></td><td align="center" valign="bottom">0.022*<hr></hr></td><td align="center" valign="bottom">2.8 (1.5-7.8)<hr></hr></td><td align="center" valign="bottom">0.028*<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 13.0<hr></hr></td><td align="center" valign="bottom">9/388<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">4/234<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">AC<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">No<hr></hr></td><td align="center" valign="bottom">2/236<hr></hr></td><td align="center" valign="bottom">0.026*<hr></hr></td><td align="center" valign="bottom">1<hr></hr></td><td align="center" valign="bottom">0.045*<hr></hr></td><td align="center" valign="bottom">1/76<hr></hr></td><td align="center" valign="bottom">0.712<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">Yes<hr></hr></td><td align="center" valign="bottom">8/197<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">3.7 (1.20-18.5)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">4/186<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Field size (cm<sup>2</sup>)<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom"><30.5<hr></hr></td><td align="center" valign="bottom">6/217<hr></hr></td><td align="center" valign="bottom">0.642<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">0<hr></hr></td><td align="center" valign="bottom">0.42<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">30.5- 35.5<hr></hr></td><td align="center" valign="bottom">4/165<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">2/106<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">> 35.5<hr></hr></td><td align="center" valign="bottom">0/53<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">3/156<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Dose size<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">2.0 Gy<hr></hr></td><td align="center" valign="bottom">7/256<hr></hr></td><td align="center" valign="bottom">0.463<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">4/176<hr></hr></td><td align="center" valign="bottom">0.513<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">2.5 Gy<hr></hr></td><td align="center" valign="bottom">3/177<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1/86<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">BED Gy<sub>15</sub><hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">< 65.0<hr></hr></td><td align="center" valign="bottom">8/315<hr></hr></td><td align="center" valign="bottom">0.661<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">4/175<hr></hr></td><td align="center" valign="bottom">0.534<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">≥ 65.0<hr></hr></td><td align="center" valign="bottom">2/118<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">1/87<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Tx period<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">1983- 1990<hr></hr></td><td align="center" valign="bottom">1/115<hr></hr></td><td align="center" valign="bottom">0.287<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td><td align="center" valign="bottom">0/75<hr></hr></td><td align="center" valign="bottom">0. 334<hr></hr></td><td align="center" valign="bottom">-<hr></hr></td><td align="center" valign="bottom">NS<hr></hr></td></tr><tr><td align="left" valign="bottom">1991- 2000<hr></hr></td><td align="center" valign="bottom">6/224<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">4/142<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left">2001- 2005</td><td align="center">3/94</td><td align="center"> </td><td align="center"> </td><td align="center"> </td><td align="center">1/45</td><td align="center"> </td><td align="center"> </td><td align="center"> </td></tr></tbody></table><table-wrap-foot><p><italic>Abbreviations</italic>: pts = patients; Hb = hemoglobin; Tx = treatment; diff = differentiated AC = anterior commissure; BED = biologically effective dose; * = statistically significant; NS = not significant.</p></table-wrap-foot></table-wrap></sec><sec><title>Complications</title><p>Regarding acute radiation toxicity, there was no incidence of grade 3 or higher acute complications in T1 disease. For T2 disease, 9 (1.2%) patients experienced grade 3 acute radiation toxicity, with an incidence of 9/86 [10.4%] in patients treated with 2.5 Gy compared with none in those treated with 2.0 Gy (chi-square test value: <italic>p</italic> = 0.001). Eight of them had severe odynophagia and grade III confluent mucositis, requiring nasogastric tube feeding or admission for intravenous fluid supplement. All of them needed treatment interruption of more than 4 treatment days. One patient developed grade IV laryngeal edema and necessitated temporary tracheostomy during the last week of RT and ultimately treatment was prematurely terminated after 55 Gy delivered over 22 fractions. There is no treatment death related to acute radiation toxicity. For chronic complication, no clinical or radiological chondroradionecrosis that warrants laryngectomy has been observed.</p></sec></sec><sec sec-type="discussion"><title>Discussion</title><p>The debate on the optimal treatment options for early GC has a long history, mainly because of absence of definitive prospective randomized trials for comparing the various treatment options [<xref ref-type="bibr" rid="B15">15</xref>]. A survey conducted in eleven regions/countries in Asia revealed that in regions following the ‘British school’ like Hong Kong and Singapore, RT alone has remained the primary treatment modality for early laryngeal cancers [<xref ref-type="bibr" rid="B4">4</xref>]. Vlantis et al. reviewed the treatment results of laryngeal carcinoma in a single institution in Hong Kong [<xref ref-type="bibr" rid="B16">16</xref>]. For early stage (T1 & T2) glottic lesions, primary RT remained their mainstay of treatment.</p><p>As laser surgery become more popular since Steiner’s landmark report [<xref ref-type="bibr" rid="B17">17</xref>], it is expected that it will be more popular in local localities.</p><p>Focusing on primary irradiation, in many RT centers, Cobalt 60 or 2-4 MV X-rays machines have been decommissioned. It is anticipated that 6 MV photon beams generated by LA will become the prevailing workhorse for treatment in clinical practice [<xref ref-type="bibr" rid="B18">18</xref>]. Table <xref ref-type="table" rid="T6">6</xref> summarizes the published outcome results of early GC treated with 6 MV photons.</p><table-wrap position="float" id="T6"><label>Table 6</label><caption><p>Published local control and survival rate of early GC treated with 6 MV definite radiotherapy</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th align="left"><bold>Author (year)</bold></th><th align="center"><bold>Patient number</bold></th><th align="center"><bold>Local Control (%)</bold></th><th align="center"><bold>OS (%)</bold></th><th align="center"><bold>CSS (%)</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="bottom">[ref]<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">5 year*, 10 year #<hr></hr></td><td align="center" valign="bottom">5 year *, 10 year#<hr></hr></td><td align="center" valign="bottom">5 year*, 10 year#<hr></hr></td></tr><tr><td align="left" valign="bottom">Warde et al. [<xref ref-type="bibr" rid="B5">5</xref>]<hr></hr></td><td align="center" valign="bottom">T1 + T2: 72<hr></hr></td><td align="center" valign="bottom">T1a: 91*<hr></hr></td><td align="center" valign="bottom">T1 + T2: 75.8*<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T1b: 82*<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2: 69*<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Lee et al. [<xref ref-type="bibr" rid="B18">18</xref>]<hr></hr></td><td align="center" valign="bottom">T1: 86<hr></hr></td><td align="center" valign="bottom">T1a: 82.2*<hr></hr></td><td align="center" valign="bottom">T1: 85*<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2: 29<hr></hr></td><td align="center" valign="bottom">T1b: 76.2*<hr></hr></td><td align="center" valign="bottom">T2: 74*<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2: 68.1*<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Franchin et al. [<xref ref-type="bibr" rid="B23">23</xref>]<hr></hr></td><td align="center" valign="bottom">T1: 323<hr></hr></td><td align="center" valign="bottom">T1: 90#<hr></hr></td><td align="center" valign="bottom">T1: 66#<hr></hr></td><td align="center" valign="bottom">NA<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2: 87<hr></hr></td><td align="center" valign="bottom">T2: 78#<hr></hr></td><td align="center" valign="bottom">T2: 55#<hr></hr></td><td align="center" valign="bottom"> <hr></hr></td></tr><tr><td align="left" valign="bottom">Cellai & Frata et al. [<xref ref-type="bibr" rid="B6">6</xref>,<xref ref-type="bibr" rid="B7">7</xref>]<hr></hr></td><td align="center" valign="bottom">T1: 35<hr></hr></td><td align="center" valign="bottom">T1: 84*, 83#<hr></hr></td><td align="center" valign="bottom">T1: 77*, 57#<hr></hr></td><td align="center" valign="bottom">T1: 95*, 93#<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2: 68<hr></hr></td><td align="center" valign="bottom">T2: 73*, 70#<hr></hr></td><td align="center" valign="bottom">T2: 59*, 37#<hr></hr></td><td align="center" valign="bottom">T2: 89*, 86#<hr></hr></td></tr><tr><td align="left" valign="bottom">Chera et al. [<xref ref-type="bibr" rid="B8">8</xref>]<hr></hr></td><td align="center" valign="bottom">T1 + T2: 23<hr></hr></td><td align="center" valign="bottom">T1a: 94*, 93#<hr></hr></td><td align="center" valign="bottom">T1 a: 82*, 62#<hr></hr></td><td align="center" valign="bottom">T1a: 97*, 97#<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T1b: 93*, 91#<hr></hr></td><td align="center" valign="bottom">T1b: 83*, 57#<hr></hr></td><td align="center" valign="bottom">T1b: 99*, 95#<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2a: 80*, 80#<hr></hr></td><td align="center" valign="bottom">T2a: 76*, 51#<hr></hr></td><td align="center" valign="bottom">T2a: 94*, 93#<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T2b: 70*, 67#<hr></hr></td><td align="center" valign="bottom">T2b: 78*, 49#<hr></hr></td><td align="center" valign="bottom">T2b: 90*, 84#<hr></hr></td></tr><tr><td align="left" valign="bottom">Current series<hr></hr></td><td align="center" valign="bottom">T1: 433<hr></hr></td><td align="center" valign="bottom">T1a: 92*, 91#<hr></hr></td><td align="center" valign="bottom">T1: 89*, 74#<hr></hr></td><td align="center" valign="bottom">T1: 98*, 97#<hr></hr></td></tr><tr><td align="left" valign="bottom"> <hr></hr></td><td align="center" valign="bottom"> <hr></hr></td><td align="center" valign="bottom">T1b: 89*, 87#<hr></hr></td><td align="center" valign="bottom">T2: 89*, 70#<hr></hr></td><td align="center" valign="bottom">T2: 98*, 97#<hr></hr></td></tr><tr><td align="left"> </td><td align="center">T2: 262</td><td align="center">T2: 79*, 77#</td><td align="center"> </td><td align="center"> </td></tr></tbody></table><table-wrap-foot><p><italic>Abbreviations</italic>: yr = year; NA = not available; OS = overall survival; CSS = cause specific survival.</p></table-wrap-foot></table-wrap><p>There have been concerns about possible tumor under-dosage when using 6MV or higher energy photons for early GC. It has been reported that the lack of electronic equilibrium at the air- tissue interface in the laryngeal air cavity is more pronounced with both higher- energy X rays and with small field size [<xref ref-type="bibr" rid="B19">19</xref>]. The other issue is the lack of adequate buildup tissue in the area where the neck is thin [<xref ref-type="bibr" rid="B20">20</xref>]. Izuno et al. observed a significant inferior 5-year LC rate for T1N0 GC patients when treated with 8/10-MV photons compared to Co60 (60% vs. 88%)[<xref ref-type="bibr" rid="B21">21</xref>].</p><sec><title>Factors affecting local control</title><sec><title>T1 disease</title><p>The factors of AC involvement, fraction dose size and time dose factor affecting the LC rate of T1 disease has been discussed in a separate article [<xref ref-type="bibr" rid="B22">22</xref>].</p></sec><sec><title>T2 disease</title><p>As noted, the LC rate of T2 disease treated with fractional dose size of 2.5 Gy was superior to those treated with fraction size of 2.0 Gy. However, this significance is lost in multi-variate analysis. We believe that the tumor BEDGy<sub>15</sub> is the key factor to explain the significant difference which is confirmed by the multi-variate analysis.</p><p>As shown in Table <xref ref-type="table" rid="T7">7</xref>, the fractionation schedule of 2.5 Gy x 23 daily fractions can achieve a tumor BEDGy<sub>15</sub> ≥ 65 Gy<sub>15,</sub> however, it can also be associated with a significant higher incidence of grade 3 acute radiation toxicity as shown by the higher BEDGy<sub>10</sub> for acute mucosa and larger treatment field size in T2 disease.</p><table-wrap position="float" id="T7"><label>Table 7</label><caption><p>Tumor, acute mucosal and late normal BED for two fractionation scheme</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th align="center"><bold>Dose size (Gy)</bold></th><th align="center"><bold>Fraction number</bold></th><th align="center"><bold>Total dose (Gy)</bold></th><th align="center"><bold>Overall treatment time (OTT) in days</bold></th><th align="center"><bold>Tumor BED </bold><bold>(Gy</bold><sub><bold>15</bold></sub><bold>)</bold></th><th align="center"><bold>Acute Mucosal BED</bold><bold>(Gy</bold><sub><bold>10</bold></sub><bold>)</bold><bold>(aim 59-63 Gy</bold><sub><bold>10</bold></sub><bold>)</bold>[<xref ref-type="bibr" rid="B13">13</xref>]</th><th align="center"><bold>Late normal BED </bold><bold>(Gy</bold><sub><bold>3</bold></sub><bold>)</bold><bold>(aim <117 Gy</bold><sub><bold>3</bold></sub><bold>)</bold>[<xref ref-type="bibr" rid="B13">13</xref>]</th></tr></thead><tbody valign="top"><tr><td align="center" valign="bottom">2.0<hr></hr></td><td align="center" valign="bottom">35<hr></hr></td><td align="center" valign="bottom">70<hr></hr></td><td align="center" valign="bottom">47<hr></hr></td><td align="center" valign="bottom">66.79<hr></hr></td><td align="center" valign="bottom">52.32<hr></hr></td><td align="center" valign="bottom">117<hr></hr></td></tr><tr><td align="center">2.5</td><td align="center">23</td><td align="center">57.5</td><td align="center">31</td><td align="center">65.28</td><td align="center">52.87</td><td align="center">105.4</td></tr></tbody></table><table-wrap-foot><p><italic>Abbreviations:</italic> BED <italic>=</italic> biologically effective dose.</p></table-wrap-foot></table-wrap><p>Unlike our recommendation of using a fraction size of 2.5 Gy for T1 disease [<xref ref-type="bibr" rid="B22">22</xref>], our current practice for T2 disease is to prescribe 70 Gy in 35 fractions, 2 Gy per fraction, 5 daily fractions per week. This can achieve a tumor BED ≥ 65 Gy<sub>15</sub> without an excess of grade 3 acute mucosal toxicity.</p><p>Anaemia, poor differentiation of tumor grade and subglottic extension are known reported adverse prognostic factors in LC of GC [<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B7">7</xref>,<xref ref-type="bibr" rid="B8">8</xref>] .</p><p>The impact of impaired cord mobility on LC of T2N0 GC is still controversial. Our data is consistent with other published results that reported no prognostic significance on LC [<xref ref-type="bibr" rid="B23">23</xref>,<xref ref-type="bibr" rid="B24">24</xref>] . However, other studies, including a meta-analysis did suggest its adverse impact on LC [<xref ref-type="bibr" rid="B7">7</xref>,<xref ref-type="bibr" rid="B25">25</xref>,<xref ref-type="bibr" rid="B26">26</xref>].</p><p>In view of the relatively inferior LC rate of T2 compared with T1 disease, more intensive treatment strategies are being explored. The role of bid hyperfractionation schedule will become clear when the mature result of RTOG 95 -12 study become available. Another approach is the use of concurrent chemotherapy. Nevertheless, there are some data showing improvement of LC by platinum/5FU based regimens [<xref ref-type="bibr" rid="B27">27</xref>,<xref ref-type="bibr" rid="B28">28</xref>] but others showed conflicting results [<xref ref-type="bibr" rid="B29">29</xref>,<xref ref-type="bibr" rid="B30">30</xref>].</p><p>There are still controversies over the use of Intensity- Modulated Radiotherapy (IMRT) for early stage GC. Feigenberg et al. warned about the treatment failure seen in patient with early GC who received definite RT with IMRT technique [<xref ref-type="bibr" rid="B31">31</xref>]. Their concerns were mainly errors due to contouring errors and organ motion.</p><p>Some technical studies revealed IMRT technique permit more irradiation dose sparing at carotid arteries and might have favorable implication on long term risk of cerebrovascular accident [<xref ref-type="bibr" rid="B32">32</xref>,<xref ref-type="bibr" rid="B33">33</xref>]. However, others still continue to recommend conventional RT fields and technique for treatment of patient with early stage GC [<xref ref-type="bibr" rid="B34">34</xref>,<xref ref-type="bibr" rid="B35">35</xref>].</p></sec></sec></sec><sec sec-type="conclusions"><title>Conclusion</title><p>To the best of our knowledge, our report is the largest study on RT outcomes in early GC primarily treated with 6 MV photons. Both the LC and CSS rates of T1 and T2 disease in our series are comparable with other reported data. This reassures the efficacy of 6 MV photons used in primary RT for early GC. Nevertheless, the results of the current report is a retrospective, single institution study and therefore can be subjected to biases, especially other known significant prognostic factors including tumor volume and smoking details are lacking. Prospective measurement of voice quality is also not available in this retrospective review.</p></sec><sec><title>Competing interests</title><p>The authors declare that they have no competing interests.</p></sec><sec><title>Authors’ contributions</title><p>CCT participated in the study’s design and coordination, performed acquisition of data and drafted the manuscript. KHA and FYC participated in data analysis and revised the manuscript. RKCN and SMC participated in study’s design and revised the manuscript. JSKA, YTF and SCKL revised manuscript critically for important intellectual content. All authors read and approved the final manuscript.</p></sec></body><back><ref-list><ref id="B1"><mixed-citation publication-type="other"><comment>[<ext-link ext-link-type="uri" xlink:href="http://www3.ha.org.hk/cancereg/statistics.html">http://www3.ha.org.hk/cancereg/statistics.html</ext-link>]</comment></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><name><surname>Pfister</surname><given-names>DG</given-names></name><name><surname>Laurie</surname><given-names>SA</given-names></name><name><surname>Weinstein</surname><given-names>GS</given-names></name><name><surname>Mendenhall</surname><given-names>WM</given-names></name><name><surname>Adelstein</surname><given-names>DJ</given-names></name><name><surname>Ang</surname><given-names>KK</given-names></name><name><surname>Clayman</surname><given-names>GL</given-names></name><name><surname>Fisher</surname><given-names>SG</given-names></name><name><surname>Forastiere</surname><given-names>AA</given-names></name><name><surname>Harrison</surname><given-names>LB</given-names></name><name><surname>Lefebvre</surname><given-names>JL</given-names></name><name><surname>Leupold</surname><given-names>N</given-names></name><name><surname>List</surname><given-names>MA</given-names></name><name><surname>O'Malley</surname><given-names>BO</given-names></name><name><surname>Patel</surname><given-names>S</given-names></name><name><surname>Posner</surname><given-names>MR</given-names></name><name><surname>Schwartz</surname><given-names>MA</given-names></name><name><surname>Wolf</surname><given-names>GT</given-names></name><article-title>American Society of Clinical Oncology Clinical Practice Guideline for the Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer</article-title><source>J Clin Oncol</source><year>2006</year><volume>24</volume><fpage>3693</fpage><lpage>3704</lpage><pub-id pub-id-type="doi">10.1200/JCO.2006.07.4559</pub-id><pub-id pub-id-type="pmid">16832122</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><name><surname>Kaanders</surname><given-names>JH</given-names></name><name><surname>Hordijk</surname><given-names>GJ</given-names></name><article-title>Carcinoma of the larynx: the Dutch national guideline for diagnostics, treatment, supportive care and rehabilitation</article-title><source>Radiother Oncol</source><year>2002</year><volume>63</volume><fpage>299</fpage><lpage>307</lpage><pub-id pub-id-type="doi">10.1016/S0167-8140(02)00073-7</pub-id><pub-id pub-id-type="pmid">12142094</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><name><surname>Wei</surname><given-names>W</given-names></name><article-title>Management of early carcinoma of the larynx: the Asian perspective</article-title><source>ENT News</source><year>2000</year><volume>9</volume><fpage>18</fpage><lpage>19</lpage></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><name><surname>Warde</surname><given-names>P</given-names></name><name><surname>O'Sullivan</surname><given-names>B</given-names></name><name><surname>Bristow</surname><given-names>RG</given-names></name><name><surname>Panzarella</surname><given-names>T</given-names></name><name><surname>Keane</surname><given-names>TJ</given-names></name><name><surname>Gullane</surname><given-names>PJ</given-names></name><name><surname>Witterick</surname><given-names>IP</given-names></name><name><surname>Payne</surname><given-names>D</given-names></name><name><surname>Liu</surname><given-names>FF</given-names></name><name><surname>McLean</surname><given-names>M</given-names></name><name><surname>Waldron</surname><given-names>J</given-names></name><name><surname>Cummings</surname><given-names>BJ</given-names></name><article-title>T1/T2 Glottic Cancer Managed by External Beam Radiotherapy: The Influence of Pretreatment Hemoglobin on Local Control</article-title><source>Int J Radiat Oncol Biol Phys</source><year>1998</year><volume>41</volume><fpage>347</fpage><lpage>353</lpage><pub-id pub-id-type="doi">10.1016/S0360-3016(98)00062-5</pub-id><pub-id pub-id-type="pmid">9607350</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><name><surname>Cellai</surname><given-names>E</given-names></name><name><surname>Frata</surname><given-names>P</given-names></name><name><surname>Magrini</surname><given-names>SM</given-names></name><name><surname>Palar</surname><given-names>F</given-names></name><name><surname>Barca</surname><given-names>R</given-names></name><name><surname>Fondelli</surname><given-names>S</given-names></name><name><surname>Polli</surname><given-names>C</given-names></name><name><surname>Livi</surname><given-names>L</given-names></name><name><surname>Bonetti</surname><given-names>B</given-names></name><name><surname>Vitali</surname><given-names>E</given-names></name><name><surname>De Stefani</surname><given-names>A</given-names></name><name><surname>Buglion</surname><given-names>M</given-names></name><name><surname>Biti</surname><given-names>G</given-names></name><article-title>Radical radiotherapy for early glottic cancer: Results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2005</year><volume>63</volume><fpage>1378</fpage><lpage>1386</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2005.05.018</pub-id><pub-id pub-id-type="pmid">16095847</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><name><surname>Chera</surname><given-names>BS</given-names></name><name><surname>Amdur</surname><given-names>RJ</given-names></name><name><surname>Morris</surname><given-names>CG</given-names></name><name><surname>Kirwan</surname><given-names>JM</given-names></name><name><surname>Mendenhall</surname><given-names>WM</given-names></name><article-title>T1N0 to T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Definitive Radiotherapy</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2010</year><volume>78</volume><fpage>461</fpage><lpage>466</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2009.08.066</pub-id><pub-id pub-id-type="pmid">20153124</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="journal"><name><surname>Frata</surname><given-names>P</given-names></name><name><surname>Cellai</surname><given-names>E</given-names></name><name><surname>Magrini</surname><given-names>SM</given-names></name><name><surname>Bonetti</surname><given-names>B</given-names></name><name><surname>Vitali</surname><given-names>E</given-names></name><name><surname>Tonoli</surname><given-names>S</given-names></name><name><surname>Buglione</surname><given-names>M</given-names></name><name><surname>Palar</surname><given-names>F</given-names></name><name><surname>Barca</surname><given-names>R</given-names></name><name><surname>Fodelli</surname><given-names>S</given-names></name><name><surname>Polli</surname><given-names>C</given-names></name><name><surname>Livi</surname><given-names>L</given-names></name><name><surname>Biti</surname><given-names>G</given-names></name><article-title>Radical radiotherapy for early glottic cancer: Results in a series of 1087 patients from two Italian radiation oncology centers. II. The case of T2N0 disease</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2005</year><volume>63</volume><fpage>1387</fpage><lpage>1394</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2005.05.013</pub-id><pub-id pub-id-type="pmid">16115737</pub-id></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="book"><name><surname>Sobin</surname><given-names>LH</given-names></name><name><surname>Wittekind</surname><given-names>CH</given-names></name><source>UICC TNM Classification of malignant tumours</source><year>2002</year><edition>6</edition><publisher-name>John Wiley & Sons, New York</publisher-name></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><name><surname>Fowler</surname><given-names>JF</given-names></name><article-title>The linear-quadratic formula and progress in fractionated radiotherapy</article-title><source>Br J Radiol</source><year>1989</year><volume>62</volume><fpage>679</fpage><lpage>694</lpage><pub-id pub-id-type="doi">10.1259/0007-1285-62-740-679</pub-id><pub-id pub-id-type="pmid">2670032</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="journal"><name><surname>Robertson</surname><given-names>AG</given-names></name><name><surname>Robertson</surname><given-names>C</given-names></name><name><surname>Boyle</surname><given-names>P</given-names></name><name><surname>Symonds</surname><given-names>RP</given-names></name><name><surname>Wheldon</surname><given-names>TE</given-names></name><article-title>The effect of differing radiotherapyeutic schedules on the response of glottic carcinoma of the larynx</article-title><source>Eur J Cancer B Oral Oncol</source><year>1993</year><volume>29A</volume><issue>4</issue><fpage>501</fpage><lpage>510</lpage></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="journal"><name><surname>Skladowski</surname><given-names>K</given-names></name><name><surname>Law</surname><given-names>MG</given-names></name><name><surname>Maciejewski</surname><given-names>B</given-names></name><name><surname>Steel</surname><given-names>GG</given-names></name><article-title>Planned and unplanned gaps in radiotherapy: The importance of gap position and gap duration</article-title><source>Radiother Oncol</source><year>1994</year><volume>30</volume><issue>2</issue><fpage>109</fpage><lpage>120</lpage><pub-id pub-id-type="doi">10.1016/0167-8140(94)90039-6</pub-id><pub-id pub-id-type="pmid">8184108</pub-id></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="journal"><name><surname>Fowler</surname><given-names>JF</given-names></name><article-title>21 years of Biologically Effective Dose</article-title><source>Br J Radiol</source><year>2010</year><volume>83</volume><fpage>554</fpage><lpage>568</lpage><pub-id pub-id-type="doi">10.1259/bjr/31372149</pub-id><pub-id pub-id-type="pmid">20603408</pub-id></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="journal"><name><surname>Trotti</surname><given-names>A</given-names></name><name><surname>Colevas</surname><given-names>AD</given-names></name><name><surname>Setser</surname><given-names>A</given-names></name><name><surname>Rusch</surname><given-names>V</given-names></name><name><surname>Jaques</surname><given-names>D</given-names></name><name><surname>Budach</surname><given-names>V</given-names></name><name><surname>Langer</surname><given-names>C</given-names></name><name><surname>Murphy</surname><given-names>B</given-names></name><name><surname>Cumberlin</surname><given-names>R</given-names></name><name><surname>Coleman</surname><given-names>CN</given-names></name><name><surname>Rubin</surname><given-names>P</given-names></name><article-title>CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment</article-title><source>Semin Radiat Oncol</source><year>2003</year><volume>13</volume><issue>3</issue><fpage>176</fpage><lpage>181</lpage><pub-id pub-id-type="doi">10.1016/S1053-4296(03)00031-6</pub-id><pub-id pub-id-type="pmid">12903007</pub-id></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="book"><name><surname>Dey</surname><given-names>P</given-names></name><name><surname>Arnold</surname><given-names>D</given-names></name><name><surname>Wight</surname><given-names>R</given-names></name><name><surname>MacKenzie</surname><given-names>K</given-names></name><name><surname>Kelly</surname><given-names>C</given-names></name><name><surname>Wilson</surname><given-names>J</given-names></name><source>Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer (Review)</source><year>2010</year><publisher-name>The Cochrane, Library</publisher-name></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="journal"><name><surname>Vlantis</surname><given-names>AC</given-names></name><name><surname>Yu</surname><given-names>BK</given-names></name><name><surname>Tsang</surname><given-names>RK</given-names></name><name><surname>Kam</surname><given-names>MK</given-names></name><name><surname>Lo</surname><given-names>PS</given-names></name><name><surname>van Hasselt</surname><given-names>CA</given-names></name><article-title>Laryngeal carcinoma: five-year survival and patterns of failure in 202 consecutive patients treated with primary or post-operative radiotherapy in Hong Kong</article-title><source>J Laryngol Otol</source><year>2006</year><volume>120</volume><fpage>397</fpage><lpage>404</lpage><pub-id pub-id-type="pmid">16696880</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><name><surname>Steiner</surname><given-names>W</given-names></name><article-title>Results of curative laser microsurgery of laryngeal carcinomas</article-title><source>Am J Otolaryngol</source><year>1993</year><volume>14</volume><fpage>116</fpage><lpage>121</lpage><pub-id pub-id-type="doi">10.1016/0196-0709(93)90050-H</pub-id><pub-id pub-id-type="pmid">8484476</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="journal"><name><surname>Lee</surname><given-names>JH</given-names></name><name><surname>Machtay</surname><given-names>M</given-names></name><name><surname>McKenna</surname><given-names>MG</given-names></name><name><surname>Weinstein</surname><given-names>GS</given-names></name><name><surname>Markiewicz</surname><given-names>DA</given-names></name><name><surname>Krisch</surname><given-names>RE</given-names></name><name><surname>Kligerman</surname><given-names>WM</given-names></name><article-title>Radiotherapy with 6-megavolt photons for early glottic carcinoma: Potential impact of extension to the posterior vocal cord</article-title><source>Am J Otolaryngol</source><year>2001</year><volume>22</volume><issue>1</issue><fpage>43</fpage><lpage>54</lpage><pub-id pub-id-type="doi">10.1053/ajot.2001.20679</pub-id><pub-id pub-id-type="pmid">11172214</pub-id></mixed-citation></ref><ref id="B19"><mixed-citation publication-type="journal"><name><surname>Epp</surname><given-names>ER</given-names></name><name><surname>Boyer</surname><given-names>AL</given-names></name><name><surname>Doppke</surname><given-names>KP</given-names></name><article-title>Underdosing of lesions resulting from lack of electronic equilibrium in upper respiratory air cavities irradiated by 10 MV X- ray beams</article-title><source>Int J Radiat Oncol Biol Phys</source><year>1977</year><volume>2</volume><fpage>613</fpage><lpage>619</lpage><pub-id pub-id-type="doi">10.1016/0360-3016(77)90040-2</pub-id><pub-id pub-id-type="pmid">408306</pub-id></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><name><surname>Klein</surname><given-names>EE</given-names></name><name><surname>Chin</surname><given-names>LM</given-names></name><name><surname>Rice</surname><given-names>RK</given-names></name><name><surname>Mijnheer</surname><given-names>BJ</given-names></name><article-title>The influence of air cavities on interface doses for photon beams</article-title><source>Int J Radiat Oncol Biol Phys</source><year>1993</year><volume>27</volume><issue>2</issue><fpage>419</fpage><lpage>427</lpage><pub-id pub-id-type="doi">10.1016/0360-3016(93)90255-T</pub-id><pub-id pub-id-type="pmid">8407418</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="journal"><name><surname>Izuno</surname><given-names>I</given-names></name><name><surname>Sone</surname><given-names>S</given-names></name><name><surname>Oguchi</surname><given-names>M</given-names></name><name><surname>Kiyono</surname><given-names>K</given-names></name><name><surname>Takei</surname><given-names>K</given-names></name><article-title>Treatment of early vocal cord carcinoma with 60 CO gamma rays, 8/10 MV X-rays, or 4 MV X-rays – are the results different?</article-title><source>Acta Oncol</source><year>1990</year><volume>29</volume><issue>5</issue><fpage>637</fpage><lpage>639</lpage><pub-id pub-id-type="doi">10.3109/02841869009090067</pub-id><pub-id pub-id-type="pmid">2206580</pub-id></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="journal"><name><surname>Tong</surname><given-names>CC</given-names></name><name><surname>Au</surname><given-names>KH</given-names></name><name><surname>Ngan</surname><given-names>RK</given-names></name><name><surname>Chow</surname><given-names>SM</given-names></name><name><surname>Cheung FY</surname><given-names>FYT</given-names></name><name><surname>Au</surname><given-names>JS</given-names></name><name><surname>Law</surname><given-names>SC</given-names></name><article-title>Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons</article-title><source>Radiat Oncol</source><year>2011</year><volume>6</volume><fpage>53</fpage><pub-id pub-id-type="doi">10.1186/1748-717X-6-53</pub-id><pub-id pub-id-type="pmid">21600025</pub-id></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><name><surname>Franchin</surname><given-names>G</given-names></name><name><surname>Minatel</surname><given-names>E</given-names></name><name><surname>Gobitti</surname><given-names>C</given-names></name><name><surname>Talamini</surname><given-names>R</given-names></name><name><surname>Vaccher</surname><given-names>E</given-names></name><name><surname>Sartor</surname><given-names>G</given-names></name><name><surname>Politi</surname><given-names>D</given-names></name><name><surname>Trovö</surname><given-names>MG</given-names></name><name><surname>Barzan</surname><given-names>L</given-names></name><article-title>Radiotherapy for patients with early-stage glottic carcinoma: univariate and multivariate analyses in a group of consecutive, unselected patients</article-title><source>Cancer</source><year>2003</year><volume>98</volume><issue>4</issue><fpage>765</fpage><lpage>772</lpage><pub-id pub-id-type="doi">10.1002/cncr.11575</pub-id><pub-id pub-id-type="pmid">12910521</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><name><surname>Garden</surname><given-names>AS</given-names></name><name><surname>Forster</surname><given-names>K</given-names></name><name><surname>Wong</surname><given-names>PF</given-names></name><name><surname>Morrison</surname><given-names>WH</given-names></name><name><surname>Schechter</surname><given-names>NR</given-names></name><name><surname>Ang</surname><given-names>KK</given-names></name><article-title>Results of radiotherapy for T2N0 glottic carcinoma: does the "2" stand for twice-daily treatment?</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2003</year><volume>55</volume><issue>2</issue><fpage>322</fpage><lpage>328</lpage><pub-id pub-id-type="doi">10.1016/S0360-3016(02)03938-X</pub-id><pub-id pub-id-type="pmid">12527044</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="journal"><name><surname>McCoul</surname><given-names>ED</given-names></name><name><surname>Har-El</surname><given-names>G</given-names></name><article-title>Meta-analysis of Impaired Vocal Cord Mobility as a Prognostic Factor in T2 Glottic Carcinoma</article-title><source>Arch Otolaryngol Head Neck Surg</source><year>2009</year><volume>135</volume><issue>5</issue><fpage>479</fpage><lpage>486</lpage><pub-id pub-id-type="doi">10.1001/archoto.2009.47</pub-id><pub-id pub-id-type="pmid">19451470</pub-id></mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><name><surname>Smee</surname><given-names>RI</given-names></name><name><surname>Meagher</surname><given-names>NS</given-names></name><name><surname>Williams</surname><given-names>JR</given-names></name><name><surname>Broadley</surname><given-names>K</given-names></name><name><surname>Bridger</surname><given-names>GP</given-names></name><article-title>Role of radiotherapy in early glottic carcinoma</article-title><source>Head & Neck</source><year>2010</year><volume>32</volume><issue>7</issue><fpage>850</fpage><lpage>859</lpage><pub-id pub-id-type="pmid">20029987</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><name><surname>Akimoto</surname><given-names>T</given-names></name><name><surname>Nonaka</surname><given-names>T</given-names></name><name><surname>Kitamoto</surname><given-names>Y</given-names></name><name><surname>Ishikawa</surname><given-names>H</given-names></name><name><surname>Ninomiya</surname><given-names>H</given-names></name><name><surname>Chikamatsu</surname><given-names>K</given-names></name><name><surname>Furuya</surname><given-names>N</given-names></name><name><surname>Hayakawa</surname><given-names>K</given-names></name><name><surname>Mitsuhashi</surname><given-names>N</given-names></name><name><surname>Nakano</surname><given-names>T</given-names></name><article-title>Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2006</year><volume>64</volume><issue>4</issue><fpage>995</fpage><lpage>1001</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2005.10.003</pub-id><pub-id pub-id-type="pmid">16406396</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><name><surname>Nishimura</surname><given-names>G</given-names></name><name><surname>Tsukuda</surname><given-names>M</given-names></name><name><surname>Mikami</surname><given-names>Y</given-names></name><name><surname>Matsuda</surname><given-names>H</given-names></name><name><surname>Horiuchi</surname><given-names>C</given-names></name><name><surname>Taguchi</surname><given-names>T</given-names></name><name><surname>Takahashi</surname><given-names>M</given-names></name><name><surname>Kawakami</surname><given-names>M</given-names></name><name><surname>Watanabe</surname><given-names>M</given-names></name><name><surname>Niho</surname><given-names>T</given-names></name><name><surname>Abo</surname><given-names>H</given-names></name><name><surname>Yamomoto</surname><given-names>S</given-names></name><article-title>Efficacy of Concurrent Chemoradiotherapy for T1 and T2 Laryngeal Squamous Cell Carcinoma Regarding Organ Preservation</article-title><source>Anticancer Res</source><year>2009</year><volume>29</volume><issue>2</issue><fpage>661</fpage><lpage>666</lpage><pub-id pub-id-type="pmid">19331217</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="journal"><name><surname>Murakami</surname><given-names>R</given-names></name><name><surname>Nishimura</surname><given-names>R</given-names></name><name><surname>Baba</surname><given-names>Y</given-names></name><name><surname>Yumoto</surname><given-names>E</given-names></name><name><surname>Oya</surname><given-names>N</given-names></name><name><surname>Ymashita</surname><given-names>Y</given-names></name><article-title>Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system</article-title><source>Acta Oncologica</source><year>2006</year><volume>45</volume><fpage>162</fpage><lpage>167</lpage><pub-id pub-id-type="doi">10.1080/02841860500490269</pub-id><pub-id pub-id-type="pmid">16546861</pub-id></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><name><surname>Hirasawa</surname><given-names>N</given-names></name><name><surname>Itoh</surname><given-names>Y</given-names></name><name><surname>Ishihara</surname><given-names>S</given-names></name><name><surname>Kubota</surname><given-names>S</given-names></name><name><surname>Itoh</surname><given-names>J</given-names></name><name><surname>Fujimoto</surname><given-names>Y</given-names></name><name><surname>Nakashima</surname><given-names>T</given-names></name><name><surname>Naganawa</surname><given-names>S</given-names></name><article-title>Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis</article-title><source>Head & Neck Oncology</source><year>2010</year><volume>2</volume><fpage>20</fpage><pub-id pub-id-type="doi">10.1186/1758-3284-2-20</pub-id><pub-id pub-id-type="pmid">20673360</pub-id></mixed-citation></ref><ref id="B31"><mixed-citation publication-type="journal"><name><surname>Feigenberg</surname><given-names>SJ</given-names></name><name><surname>Lango</surname><given-names>M</given-names></name><name><surname>Nicolaou</surname><given-names>N</given-names></name><name><surname>Ridge</surname><given-names>JA</given-names></name><article-title>Intensity-Modulated Radiotherapy for Early Larynx Cancer: Is There a Role?</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2007</year><volume>68</volume><issue>1</issue><fpage>2</fpage><lpage>3</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2007.01.006</pub-id><pub-id pub-id-type="pmid">17448864</pub-id></mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><name><surname>Gomez</surname><given-names>D</given-names></name><name><surname>Cahlon</surname><given-names>O</given-names></name><name><surname>Mechalakos</surname><given-names>J</given-names></name><name><surname>Lee</surname><given-names>N</given-names></name><article-title>An investigation of intensity- modulated radiation therapy versus conventional two-dimensional and 3D-conformal radiation therapy for early stage larynx cancer</article-title><source>Radiat Oncol</source><year>2010</year><volume>5</volume><fpage>74</fpage><pub-id pub-id-type="doi">10.1186/1748-717X-5-74</pub-id><pub-id pub-id-type="pmid">20796303</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><name><surname>Rosenthal</surname><given-names>DI</given-names></name><name><surname>Fuller</surname><given-names>CD</given-names></name><name><surname>Barker</surname><given-names>JL</given-names></name><name><surname>Mason</surname><given-names>B</given-names></name><name><surname>Garcia</surname><given-names>JA</given-names></name><name><surname>Lewin</surname><given-names>JS</given-names></name><name><surname>Holsinger</surname><given-names>FC</given-names></name><name><surname>Stasney</surname><given-names>CR</given-names></name><name><surname>Frank</surname><given-names>SJ</given-names></name><name><surname>Schwartz</surname><given-names>DL</given-names></name><name><surname>Morrison</surname><given-names>WH</given-names></name><name><surname>Garden</surname><given-names>AS</given-names></name><name><surname>Ang</surname><given-names>KK</given-names></name><article-title>Simple Carotid-Sparing Intensity-Modulated Radiotherapy Technique and Preliminary Experience for T1–2 Glottic Cancer</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2010</year><volume>77</volume><issue>2</issue><fpage>455</fpage><lpage>461</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2009.04.061</pub-id><pub-id pub-id-type="pmid">19679406</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><name><surname>Chera</surname><given-names>BS</given-names></name><name><surname>Amdur</surname><given-names>RJ</given-names></name><name><surname>Morris</surname><given-names>CG</given-names></name><name><surname>Mendenhall</surname><given-names>WM</given-names></name><article-title>Carotid-Sparing Intensity- Modulated Radiotherapy for Early-Stage Squamous Cell Carcinoma of the True Vocal Cord</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2010</year><volume>77</volume><fpage>1380</fpage><lpage>1385</lpage><pub-id pub-id-type="doi">10.1016/j.ijrobp.2009.07.1687</pub-id><pub-id pub-id-type="pmid">19942356</pub-id></mixed-citation></ref><ref id="B35"><mixed-citation publication-type="journal"><name><surname>Tiong</surname><given-names>AC</given-names></name><name><surname>Huang</surname><given-names>S</given-names></name><name><surname>O'Sullivan</surname><given-names>B</given-names></name><name><surname>Xu</surname><given-names>W</given-names></name><name><surname>Kim</surname><given-names>J</given-names></name><name><surname>Dawson</surname><given-names>LA</given-names></name><name><surname>Cho</surname><given-names>J</given-names></name><name><surname>Gilbert</surname><given-names>R</given-names></name><name><surname>Breen</surname><given-names>S</given-names></name><name><surname>Waldron</surname><given-names>JN</given-names></name><article-title>Outcomes for T2N0M0 Glottic Squamous Cell Carcinoma Treated with IMRT Compared with Conventional Parallel Opposed Fields</article-title><source>Int J Radiat Oncol Biol Phys</source><year>2011</year><volume>81</volume><fpage>S106</fpage><lpage>S107</lpage></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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