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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intercalative and nonintercalative binding of large cationic porphyrin ligands to calf thymus DNA.</title><author><name sortKey="Carvlin, M J" sort="Carvlin, M J" uniqKey="Carvlin M" first="M J" last="Carvlin">M J Carvlin</name></author><author><name sortKey="Fiel, R J" sort="Fiel, R J" uniqKey="Fiel R" first="R J" last="Fiel">R J Fiel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6889138</idno><idno type="pmc">326339</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC326339</idno><idno type="RBID">PMC:326339</idno><date when="1983">1983</date><idno type="wicri:Area/Pmc/Corpus">000218</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000218</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intercalative and nonintercalative binding of large cationic porphyrin ligands to calf thymus DNA.</title><author><name sortKey="Carvlin, M J" sort="Carvlin, M J" uniqKey="Carvlin M" first="M J" last="Carvlin">M J Carvlin</name></author><author><name sortKey="Fiel, R J" sort="Fiel, R J" uniqKey="Fiel R" first="R J" last="Fiel">R J Fiel</name></author></analytic><series><title level="j">Nucleic Acids Research</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><date when="1983">1983</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The large meso-substituted porphine, meso-tetra(4-N-methylpyridyl)porphine has been identified as a DNA-interactive ligand with a capacity for intercalation (1,2). Subsequently, the 2-N-methyl, 3-N-methyl and N-trimethylanilinium analogues of this porphyrin intercalator have been obtained for physico-chemical analyses (absorption spectroscopy, viscometry, circular dichroism, unwinding of supercoiled DNA). In this paper we discuss the factors affecting the character of porphyrin binding (intercalative, as is the case for the 4-N-methyl and 3-N-methyl porphines, versus non-intercalative, as is the case for the 2-N-methyl and N-trimethylanilinium porphines) and the impact that porphyrins' binding has upon the structure of DNA. The molecular conformation of the porphyrin ligand varies slightly within this series so that the ability of a given porphyrin to intercalate may be correlated with the arrangement of charged groups, the planarity of the porphine ring and the effective width of the individual molecules. The results from these studies indicate that sequence selective binding occurs within a small aperture of solution conditions.</p><sec><title>Images</title><fig id="F1"><graphic xlink:href="nar00362-0329-a" xlink:role="6123"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nucleic Acids Res</journal-id><journal-title>Nucleic Acids Research</journal-title><issn pub-type="ppub">0305-1048</issn><issn pub-type="epub">1362-4962</issn></journal-meta><article-meta><article-id pub-id-type="pmid">6889138</article-id><article-id pub-id-type="pmc">326339</article-id><article-categories><subj-group><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Intercalative and nonintercalative binding of large cationic porphyrin ligands to calf thymus DNA.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Carvlin</surname><given-names>M J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fiel</surname><given-names>R J</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>10</day><month>9</month><year>1983</year></pub-date><volume>11</volume><issue>17</issue><fpage>6121</fpage><lpage>6139</lpage><abstract><p>The large meso-substituted porphine, meso-tetra(4-N-methylpyridyl)porphine has been identified as a DNA-interactive ligand with a capacity for intercalation (1,2). Subsequently, the 2-N-methyl, 3-N-methyl and N-trimethylanilinium analogues of this porphyrin intercalator have been obtained for physico-chemical analyses (absorption spectroscopy, viscometry, circular dichroism, unwinding of supercoiled DNA). In this paper we discuss the factors affecting the character of porphyrin binding (intercalative, as is the case for the 4-N-methyl and 3-N-methyl porphines, versus non-intercalative, as is the case for the 2-N-methyl and N-trimethylanilinium porphines) and the impact that porphyrins' binding has upon the structure of DNA. The molecular conformation of the porphyrin ligand varies slightly within this series so that the ability of a given porphyrin to intercalate may be correlated with the arrangement of charged groups, the planarity of the porphine ring and the effective width of the individual molecules. The results from these studies indicate that sequence selective binding occurs within a small aperture of solution conditions.</p><sec><title>Images</title><fig id="F1"><graphic xlink:href="nar00362-0329-a" xlink:role="6123"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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