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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of <italic>Ureaplasma urealyticum</italic></title><author><name sortKey="Coufalik, E D" sort="Coufalik, E D" uniqKey="Coufalik E" first="E. D." last="Coufalik">E. D. Coufalik</name><affiliation><nlm:aff id="af1"> Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex, London</nlm:aff></affiliation></author><author><name sortKey="Taylor Robinson, D" sort="Taylor Robinson, D" uniqKey="Taylor Robinson D" first="D." last="Taylor-Robinson">D. Taylor-Robinson</name><affiliation><nlm:aff id="af1"> Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex, London</nlm:aff></affiliation></author><author><name sortKey="Csonka, G W" sort="Csonka, G W" uniqKey="Csonka G" first="G. W." last="Csonka">G. W. Csonka</name><affiliation><nlm:aff id="af2">The Central Middlesex Hospital, London</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">371746</idno><idno type="pmc">1045579</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1045579</idno><idno type="RBID">PMC:1045579</idno><date when="1979">1979</date><idno type="wicri:Area/Pmc/Corpus">000164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of <italic>Ureaplasma urealyticum</italic></title><author><name sortKey="Coufalik, E D" sort="Coufalik, E D" uniqKey="Coufalik E" first="E. D." last="Coufalik">E. D. Coufalik</name><affiliation><nlm:aff id="af1"> Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex, London</nlm:aff></affiliation></author><author><name sortKey="Taylor Robinson, D" sort="Taylor Robinson, D" uniqKey="Taylor Robinson D" first="D." last="Taylor-Robinson">D. Taylor-Robinson</name><affiliation><nlm:aff id="af1"> Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex, London</nlm:aff></affiliation></author><author><name sortKey="Csonka, G W" sort="Csonka, G W" uniqKey="Csonka G" first="G. W." last="Csonka">G. W. Csonka</name><affiliation><nlm:aff id="af2">The Central Middlesex Hospital, London</nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Venereal Diseases</title><idno type="ISSN">0007-134X</idno><imprint><date when="1979">1979</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The results of a double-blind therapeutic trial on 217 men with nongonococcal urethritis (NGU) show that minocycline was more effective than rifampicin. Before treatment <italic>Chlamydia trachomatis</italic> was isolated from 43% of men, <italic>Ureaplasma urealyticum</italic> from 59%, and <italic>Mycoplasma hominis</italic> from 22%. Chlamydiae and ureaplasmas were isolated less frequently from men with a recent history of NGU. Minocycline was given to 94 patients, and after treatment chlamydiae were isolated from only one of 40 initially chlamydia-positive patients and ureaplasmas from only five of 57 initially ureaplasma-positive patients. Although most patients responded clinically, failure and partial recovery rather than complete recovery were observed more often among those who were infected with ureaplasmas. Rifampicin was given to 123 patients, after which chlamydiae were isolated from only one of 53 initially chlamydia-positive men whereas ureaplasmas, insensitive to the antibiotic <italic>in vitro</italic>, were isolated from 55 of 68 men who had initially positive results. Patients infected with ureaplasmas failed to respond to rifampicin treatment significantly more often than those who were not infected. This was also observed when only patients who had never had NGU or who had not had a recent episode were considered. Furthermore, 24 (44%) of the 55 men whose ureaplasmas persisted failed to recover whereas only one (7·7%) of 13 men whose ureaplasmas disappeared did not respond to treatment. These results suggested that ureaplasmas were a cause of urethritis in some of the men (an estimated 10% at least). In addition, Reiter's disease developed in two men treated with rifampicin from whom only ureaplasmas had been isolated initially. <italic>M. hominis</italic> did not seem to have an important pathogenic role in NGU and there was evidence that ureaplasmas were an unlikely cause of urethritis in some men since the organisms persisted despite complete clinical recovery.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Vener Dis</journal-id><journal-title>British Journal of Venereal Diseases</journal-title><issn pub-type="ppub">0007-134X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">371746</article-id><article-id pub-id-type="pmc">1045579</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of <italic>Ureaplasma urealyticum</italic></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coufalik</surname><given-names>E. D.</given-names></name><xref ref-type="aff" rid="af1">*</xref></contrib><contrib contrib-type="author"><name><surname>Taylor-Robinson</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="af1">*</xref></contrib><contrib contrib-type="author"><name><surname>Csonka</surname><given-names>G. W.</given-names></name><xref ref-type="aff" rid="af2">†</xref></contrib></contrib-group><aff id="af1"><label>*</label> Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex, London</aff><aff id="af2"><label>†</label>The Central Middlesex Hospital, London</aff><pub-date pub-type="ppub"><month>02</month><year>1979</year></pub-date><volume>55</volume><issue>1</issue><fpage>36</fpage><lpage>43</lpage><abstract><p>The results of a double-blind therapeutic trial on 217 men with nongonococcal urethritis (NGU) show that minocycline was more effective than rifampicin. Before treatment <italic>Chlamydia trachomatis</italic> was isolated from 43% of men, <italic>Ureaplasma urealyticum</italic> from 59%, and <italic>Mycoplasma hominis</italic> from 22%. Chlamydiae and ureaplasmas were isolated less frequently from men with a recent history of NGU. Minocycline was given to 94 patients, and after treatment chlamydiae were isolated from only one of 40 initially chlamydia-positive patients and ureaplasmas from only five of 57 initially ureaplasma-positive patients. Although most patients responded clinically, failure and partial recovery rather than complete recovery were observed more often among those who were infected with ureaplasmas. Rifampicin was given to 123 patients, after which chlamydiae were isolated from only one of 53 initially chlamydia-positive men whereas ureaplasmas, insensitive to the antibiotic <italic>in vitro</italic>, were isolated from 55 of 68 men who had initially positive results. Patients infected with ureaplasmas failed to respond to rifampicin treatment significantly more often than those who were not infected. This was also observed when only patients who had never had NGU or who had not had a recent episode were considered. Furthermore, 24 (44%) of the 55 men whose ureaplasmas persisted failed to recover whereas only one (7·7%) of 13 men whose ureaplasmas disappeared did not respond to treatment. These results suggested that ureaplasmas were a cause of urethritis in some of the men (an estimated 10% at least). In addition, Reiter's disease developed in two men treated with rifampicin from whom only ureaplasmas had been isolated initially. <italic>M. hominis</italic> did not seem to have an important pathogenic role in NGU and there was evidence that ureaplasmas were an unlikely cause of urethritis in some men since the organisms persisted despite complete clinical recovery.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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