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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential effect of zinc on the vertebrate GABAA-receptor complex.</title>
<author><name sortKey="Smart, T G" sort="Smart, T G" uniqKey="Smart T" first="T. G." last="Smart">T. G. Smart</name>
</author>
<author><name sortKey="Constanti, A" sort="Constanti, A" uniqKey="Constanti A" first="A." last="Constanti">A. Constanti</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">2163276</idno>
<idno type="pmc">1917556</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917556</idno>
<idno type="RBID">PMC:1917556</idno>
<date when="1990">1990</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential effect of zinc on the vertebrate GABAA-receptor complex.</title>
<author><name sortKey="Smart, T G" sort="Smart, T G" uniqKey="Smart T" first="T. G." last="Smart">T. G. Smart</name>
</author>
<author><name sortKey="Constanti, A" sort="Constanti, A" uniqKey="Constanti A" first="A." last="Constanti">A. Constanti</name>
</author>
</analytic>
<series><title level="j">British Journal of Pharmacology</title>
<idno type="ISSN">0007-1188</idno>
<imprint><date when="1990">1990</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>1. gamma-Aminobutyric acid (GABA) responses were recorded from rat superior cervical ganglia (SCG) in culture using the whole cell recording technique. 2. Zinc (50-300 microM) reversibly antagonized the GABA response in embryonic and young post-natal neurones, while neurones cultured from adult animals were far less sensitive and occasionally resistant to zinc blockade. Cadmium (100-300 microM) also antagonised the GABA response, while barium (100 microM-2 mM) was ineffective. 3. The differential blocking effect of zinc on cultured neurones of different ages also occurred in intact SCG tissue. 4. The GABA log dose-response curve constructed with foetal or adult cultured neurones was reduced in a non-competitive manner by zinc. This inhibition was minimally affected by the membrane potential. 5. The GABA response recorded intracellularly from guinea-pig pyriform cortical slices was enhanced by zinc (300-500 microM), which occurred concurrently with a decrease in the input conductance of the cell. The enhancement was unaffected by prior blockade of the GABA uptake carrier by 1 mM nipecotic acid. This phenomenon could be reproduced by barium (300 microM) and cadmium (300 microM). 6. We conclude that the vertebrate neuronal GABAA-receptor becomes less sensitive to zinc with neural (GABAA-receptor?) development, and the enhanced GABA response recorded in the CNS is a consequence of the reduction in the input conductance and not due to a direct effect on the receptor complex.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Pharmacol</journal-id>
<journal-title>British Journal of Pharmacology</journal-title>
<issn pub-type="ppub">0007-1188</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">2163276</article-id>
<article-id pub-id-type="pmc">1917556</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Differential effect of zinc on the vertebrate GABAA-receptor complex.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Smart</surname>
<given-names>T. G.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Constanti</surname>
<given-names>A.</given-names>
</name>
</contrib>
</contrib-group>
<aff>Department of Pharmacology, School of Pharmacy, London.</aff>
<pub-date pub-type="ppub"><month>4</month>
<year>1990</year>
</pub-date>
<volume>99</volume>
<issue>4</issue>
<fpage>643</fpage>
<lpage>654</lpage>
<abstract><p>1. gamma-Aminobutyric acid (GABA) responses were recorded from rat superior cervical ganglia (SCG) in culture using the whole cell recording technique. 2. Zinc (50-300 microM) reversibly antagonized the GABA response in embryonic and young post-natal neurones, while neurones cultured from adult animals were far less sensitive and occasionally resistant to zinc blockade. Cadmium (100-300 microM) also antagonised the GABA response, while barium (100 microM-2 mM) was ineffective. 3. The differential blocking effect of zinc on cultured neurones of different ages also occurred in intact SCG tissue. 4. The GABA log dose-response curve constructed with foetal or adult cultured neurones was reduced in a non-competitive manner by zinc. This inhibition was minimally affected by the membrane potential. 5. The GABA response recorded intracellularly from guinea-pig pyriform cortical slices was enhanced by zinc (300-500 microM), which occurred concurrently with a decrease in the input conductance of the cell. The enhancement was unaffected by prior blockade of the GABA uptake carrier by 1 mM nipecotic acid. This phenomenon could be reproduced by barium (300 microM) and cadmium (300 microM). 6. We conclude that the vertebrate neuronal GABAA-receptor becomes less sensitive to zinc with neural (GABAA-receptor?) development, and the enhanced GABA response recorded in the CNS is a consequence of the reduction in the input conductance and not due to a direct effect on the receptor complex.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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