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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intensity modulated proton therapy treatment planning using single-field optimization: The impact of monitor unit constraints on plan quality</title><author><name sortKey="Zhu, X R" sort="Zhu, X R" uniqKey="Zhu X" first="X. R." last="Zhu">X. R. Zhu</name></author><author><name sortKey="Sahoo, N" sort="Sahoo, N" uniqKey="Sahoo N" first="N." last="Sahoo">N. Sahoo</name></author><author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name></author><author><name sortKey="Robertson, D" sort="Robertson, D" uniqKey="Robertson D" first="D." last="Robertson">D. Robertson</name></author><author><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20384258</idno><idno type="pmc">2837732</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837732</idno><idno type="RBID">PMC:2837732</idno><idno type="doi">10.1118/1.3314073</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intensity modulated proton therapy treatment planning using single-field optimization: The impact of monitor unit constraints on plan quality</title><author><name sortKey="Zhu, X R" sort="Zhu, X R" uniqKey="Zhu X" first="X. R." last="Zhu">X. R. Zhu</name></author><author><name sortKey="Sahoo, N" sort="Sahoo, N" uniqKey="Sahoo N" first="N." last="Sahoo">N. Sahoo</name></author><author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name></author><author><name sortKey="Robertson, D" sort="Robertson, D" uniqKey="Robertson D" first="D." last="Robertson">D. Robertson</name></author><author><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name></author></analytic><series><title level="j">Medical Physics</title><idno type="ISSN">0094-2405</idno><idno type="eISSN">0094-2405</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Purpose:</bold> To investigate the effect of monitor unit (MU) constraints on the dose distribution created by intensity modulated proton therapy (IMPT) treatment planning using single-field optimization (SFO).</p><p><bold>Methods:</bold> Ninety-four energies between 72.5 and 221.8 MeV are available for scanning beam IMPT delivery at our institution. The minimum and maximum MUs for delivering each pencil beam (spot) are 0.005 and 0.04, respectively. These MU constraints are not considered during optimization by the treatment planning system; spots are converted to deliverable MUs during postprocessing. Treatment plans for delivering uniform doses to rectangular volumes with and without MU constraints were generated for different target doses, spot spacings, spread-out Bragg peak (SOBP) widths, and ranges in a homogeneous phantom. Four prostate cancer patients were planned with and without MU constraints using different spot spacings. Rounding errors were analyzed using an in-house software tool.</p><p><bold>Results:</bold> From the phantom study, the authors have found that both the number of spots that have rounding errors and the magnitude of the distortion of the dose distribution from the ideally optimized distribution increases as the field dose, spot spacing, and range decrease and as the SOBP width increases. From our study of patient plans, it is clear that as the spot spacing decreases the rounding error increases, and the dose coverage of the target volume becomes unacceptable for very small spot spacings.</p><p><bold>Conclusions:</bold> Constraints on deliverable MU for each spot could create a significant distortion from the ideally optimized dose distributions for IMPT fields using SFO. To eliminate this problem, the treatment planning system should incorporate the MU constraints in the optimization process and the delivery system should reliably delivery smaller minimum MUs.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Phys</journal-id><journal-title-group><journal-title>Medical Physics</journal-title></journal-title-group><issn pub-type="ppub">0094-2405</issn><issn pub-type="epub">0094-2405</issn><publisher><publisher-name>American Association of Physicists in Medicine</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20384258</article-id><article-id pub-id-type="pmc">2837732</article-id><article-id pub-id-type="publisher-id">032003MPH</article-id><article-id pub-id-type="doi">10.1118/1.3314073</article-id><article-categories><subj-group subj-group-type="heading"><subject>Radiation Therapy Physics</subject></subj-group></article-categories><title-group><article-title>Intensity modulated proton therapy treatment planning using single-field optimization: The impact of monitor unit constraints on plan quality</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>X. R.</given-names></name><xref ref-type="author-notes" rid="n1">a)</xref></contrib><contrib contrib-type="author"><name><surname>Sahoo</surname><given-names>N.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>X.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Robertson</surname><given-names>D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>H.</given-names></name></contrib><aff>Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Choi</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>A. K.</given-names></name></contrib><aff>Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Gillin</surname><given-names>M. T.</given-names></name></contrib><aff>Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030</aff></contrib-group><author-notes><fn id="n1"><label>a)</label><p>Electronic mail: <email>xrzhu@mdanderson.org</email></p></fn></author-notes><pub-date pub-type="ppub"><month>3</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>19</day><month>2</month><year>2010</year></pub-date><volume>37</volume><issue>3</issue><fpage>1210</fpage><lpage>1219</lpage><history><date date-type="received"><day>24</day><month>7</month><year>2009</year></date><date date-type="rev-recd"><day>07</day><month>1</month><year>2010</year></date><date date-type="accepted"><day>20</day><month>1</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010 American Association of Physicists in Medicine</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>American Association of Physicists in Medicine</copyright-holder></permissions><abstract><p><bold>Purpose:</bold> To investigate the effect of monitor unit (MU) constraints on the dose distribution created by intensity modulated proton therapy (IMPT) treatment planning using single-field optimization (SFO).</p><p><bold>Methods:</bold> Ninety-four energies between 72.5 and 221.8 MeV are available for scanning beam IMPT delivery at our institution. The minimum and maximum MUs for delivering each pencil beam (spot) are 0.005 and 0.04, respectively. These MU constraints are not considered during optimization by the treatment planning system; spots are converted to deliverable MUs during postprocessing. Treatment plans for delivering uniform doses to rectangular volumes with and without MU constraints were generated for different target doses, spot spacings, spread-out Bragg peak (SOBP) widths, and ranges in a homogeneous phantom. Four prostate cancer patients were planned with and without MU constraints using different spot spacings. Rounding errors were analyzed using an in-house software tool.</p><p><bold>Results:</bold> From the phantom study, the authors have found that both the number of spots that have rounding errors and the magnitude of the distortion of the dose distribution from the ideally optimized distribution increases as the field dose, spot spacing, and range decrease and as the SOBP width increases. From our study of patient plans, it is clear that as the spot spacing decreases the rounding error increases, and the dose coverage of the target volume becomes unacceptable for very small spot spacings.</p><p><bold>Conclusions:</bold> Constraints on deliverable MU for each spot could create a significant distortion from the ideally optimized dose distributions for IMPT fields using SFO. To eliminate this problem, the treatment planning system should incorporate the MU constraints in the optimization process and the delivery system should reliably delivery smaller minimum MUs.</p></abstract><kwd-group><kwd>spot scanning proton therapy</kwd><kwd>IMPT</kwd><kwd>treatment planning</kwd><kwd>single-field optimization</kwd><kwd>monitor unit constraints</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>CCC information</meta-name><meta-value>0094-2405/2010/37(3)/1210/10/$30.00</meta-value></custom-meta><custom-meta><meta-name>sisac</meta-name><meta-value>0094-2405()37:3L.1210;1</meta-value></custom-meta><custom-meta><meta-name>edcode</meta-name><meta-value>09-586R2</meta-value></custom-meta><custom-meta><meta-name>aipkey</meta-name><meta-value>1.3314073</meta-value></custom-meta><custom-meta><meta-name>spin</meta-name><meta-value><named-content content-type="el-docanal"><named-content content-type="el-pacs"><named-content content-type="att-pacsyr">2010</named-content><named-content content-type="el-pacscode">8753Jw</named-content><named-content content-type="el-pacscode">8755de</named-content><named-content content-type="el-pacscode">8755dk</named-content></named-content></named-content><named-content content-type="el-jouidx"><named-content content-type="el-country">US</named-content><named-content content-type="el-totalidx">5</named-content><named-content content-type="el-addidx">cancer</named-content><named-content content-type="el-addidx">dosimetry</named-content><named-content content-type="el-addidx">intensity modulation</named-content><named-content content-type="el-addidx">phantoms</named-content><named-content content-type="el-addidx">radiation therapy</named-content></named-content></meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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