Effects of Cobalt on Membrane ATPases, Oxidant, and Antioxidant Values in the Cerebrum and Cerebellum of Suckling Rats
Identifieur interne : 000199 ( Pmc/Checkpoint ); précédent : 000198; suivant : 000200Effects of Cobalt on Membrane ATPases, Oxidant, and Antioxidant Values in the Cerebrum and Cerebellum of Suckling Rats
Auteurs : Elmouldi Garoui [Tunisie] ; Ibtissem Ben Amara [Tunisie] ; Dorra Driss [Tunisie] ; Awatef Elwej [Tunisie] ; Semia Ellouze Chaabouni [Tunisie] ; Tahia Boudawara [Tunisie] ; Najiba Zeghal [Tunisie]Source :
- Biological Trace Element Research [ 0163-4984 ] ; 2013.
Abstract
Chronic overexposure to cobalt (Co) may result in neurotoxic effects, but the mechanism of Co-induced neurotoxicity is not yet well established. Our study was conducted to determine whether Co is associated to the induction of central nervous system damage in pregnant rats and their progeny. Twelve pregnant female rats were randomly divided into 2 groups: group I served as controls and group II received Co (350 mg/L, orally). Treatments started from the 14th day of pregnancy until day 14 after delivery. Co concentration in plasma was higher in the treated groups than in the controls. Exposure to Co also increased the levels of MDA, PCO, H2O2, and AOPP, while Na+K+-ATPase and Mg2+-ATPase, AChE, and BuChE activities decreased in the cerebrum and cerebellum of suckling pups. A smear without ladder formation on agarose gel was also shown in the cerebrum and cerebellum, indicating random DNA degradation. A reduction in GPx, SOD, CAT, GSH, NPSH, and vitamin C values was observed. The changes were confirmed by histological results. In conclusion, these data showed that the exposure of pregnant and lactating rats to Co resulted in the development of oxidative stress and the impairment of defense systems in the cerebrum and cerebellum of their suckling pups.
Url:
DOI: 10.1007/s12011-013-9746-0
PubMed: 23857379
PubMed Central: 3744383
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Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Driss, Dorra" sort="Driss, Dorra" uniqKey="Driss D" first="Dorra" last="Driss">Dorra Driss</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax</wicri:regionArea><wicri:noRegion>3038 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Elwej, Awatef" sort="Elwej, Awatef" uniqKey="Elwej A" first="Awatef" last="Elwej">Awatef Elwej</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Chaabouni, Semia Ellouze" sort="Chaabouni, Semia Ellouze" uniqKey="Chaabouni S" first="Semia Ellouze" last="Chaabouni">Semia Ellouze Chaabouni</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 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type="main">Effects of Cobalt on Membrane ATPases, Oxidant, and Antioxidant Values in the Cerebrum and Cerebellum of Suckling Rats</title><author><name sortKey="Garoui, Elmouldi" sort="Garoui, Elmouldi" uniqKey="Garoui E" first="Elmouldi" last="Garoui">Elmouldi Garoui</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Amara, Ibtissem Ben" sort="Amara, Ibtissem Ben" uniqKey="Amara I" first="Ibtissem Ben" last="Amara">Ibtissem Ben Amara</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Driss, Dorra" sort="Driss, Dorra" uniqKey="Driss D" first="Dorra" last="Driss">Dorra Driss</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax</wicri:regionArea><wicri:noRegion>3038 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Elwej, Awatef" sort="Elwej, Awatef" uniqKey="Elwej A" first="Awatef" last="Elwej">Awatef Elwej</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Chaabouni, Semia Ellouze" sort="Chaabouni, Semia Ellouze" uniqKey="Chaabouni S" first="Semia Ellouze" last="Chaabouni">Semia Ellouze Chaabouni</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax</wicri:regionArea><wicri:noRegion>3038 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029 Sfax</wicri:regionArea><wicri:noRegion>3029 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biological Trace Element Research</title><idno type="ISSN">0163-4984</idno><idno type="eISSN">1559-0720</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chronic overexposure to cobalt (Co) may result in neurotoxic effects, but the mechanism of Co-induced neurotoxicity is not yet well established. Our study was conducted to determine whether Co is associated to the induction of central nervous system damage in pregnant rats and their progeny. Twelve pregnant female rats were randomly divided into 2 groups: group I served as controls and group II received Co (350 mg/L, orally). Treatments started from the 14th day of pregnancy until day 14 after delivery. Co concentration in plasma was higher in the treated groups than in the controls. Exposure to Co also increased the levels of MDA, PCO, H<sub>2</sub>O<sub>2</sub>, and AOPP, while Na<sup>+</sup>K<sup>+</sup>-ATPase and Mg<sup>2+</sup>-ATPase, AChE, and BuChE activities decreased in the cerebrum and cerebellum of suckling pups. A smear without ladder formation on agarose gel was also shown in the cerebrum and cerebellum, indicating random DNA degradation. A reduction in GPx, SOD, CAT, GSH, NPSH, and vitamin C values was observed. The changes were confirmed by histological results. In conclusion, these data showed that the exposure of pregnant and lactating rats to Co resulted in the development of oxidative stress and the impairment of defense systems in the cerebrum and cerebellum of their suckling pups.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gault, N" uniqKey="Gault N">N Gault</name></author><author><name sortKey="Sandre, C" uniqKey="Sandre C">C Sandre</name></author><author><name sortKey="Poncy, Jl" uniqKey="Poncy J">JL Poncy</name></author><author><name sortKey="Moulin, C" uniqKey="Moulin C">C Moulin</name></author><author><name sortKey="Lefaix, Jl" uniqKey="Lefaix J">JL Lefaix</name></author><author><name sortKey="Bresson, C" uniqKey="Bresson C">C Bresson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karovic, O" uniqKey="Karovic O">O Karovic</name></author><author><name sortKey="Tonazzini, I" uniqKey="Tonazzini I">I Tonazzini</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biol Trace Elem Res</journal-id><journal-id journal-id-type="iso-abbrev">Biol Trace Elem Res</journal-id><journal-title-group><journal-title>Biological Trace Element Research</journal-title></journal-title-group><issn pub-type="ppub">0163-4984</issn><issn pub-type="epub">1559-0720</issn><publisher><publisher-name>Springer US</publisher-name><publisher-loc>Boston</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23857379</article-id><article-id pub-id-type="pmc">3744383</article-id><article-id pub-id-type="publisher-id">9746</article-id><article-id pub-id-type="doi">10.1007/s12011-013-9746-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Effects of Cobalt on Membrane ATPases, Oxidant, and Antioxidant Values in the Cerebrum and Cerebellum of Suckling Rats</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Garoui</surname><given-names>Elmouldi</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Amara</surname><given-names>Ibtissem Ben</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Driss</surname><given-names>Dorra</given-names></name><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Elwej</surname><given-names>Awatef</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chaabouni</surname><given-names>Semia Ellouze</given-names></name><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Boudawara</surname><given-names>Tahia</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Zeghal</surname><given-names>Najiba</given-names></name><address><phone>+216-74-274600</phone><fax>+216-74-274437</fax><email>najiba.zeghal@tunet.tn</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</aff><aff id="Aff2"><label></label>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</aff><aff id="Aff3"><label></label>Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029 Sfax, Tunisia</aff></contrib-group><pub-date pub-type="epub"><day>16</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="ppub"><year>2013</year></pub-date><volume>154</volume><issue>3</issue><fpage>387</fpage><lpage>395</lpage><history><date date-type="received"><day>25</day><month>1</month><year>2013</year></date><date date-type="accepted"><day>25</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>© The Author(s) 2013</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p></license></permissions><abstract id="Abs1"><p>Chronic overexposure to cobalt (Co) may result in neurotoxic effects, but the mechanism of Co-induced neurotoxicity is not yet well established. Our study was conducted to determine whether Co is associated to the induction of central nervous system damage in pregnant rats and their progeny. Twelve pregnant female rats were randomly divided into 2 groups: group I served as controls and group II received Co (350 mg/L, orally). Treatments started from the 14th day of pregnancy until day 14 after delivery. Co concentration in plasma was higher in the treated groups than in the controls. Exposure to Co also increased the levels of MDA, PCO, H<sub>2</sub>O<sub>2</sub>, and AOPP, while Na<sup>+</sup>K<sup>+</sup>-ATPase and Mg<sup>2+</sup>-ATPase, AChE, and BuChE activities decreased in the cerebrum and cerebellum of suckling pups. A smear without ladder formation on agarose gel was also shown in the cerebrum and cerebellum, indicating random DNA degradation. A reduction in GPx, SOD, CAT, GSH, NPSH, and vitamin C values was observed. The changes were confirmed by histological results. In conclusion, these data showed that the exposure of pregnant and lactating rats to Co resulted in the development of oxidative stress and the impairment of defense systems in the cerebrum and cerebellum of their suckling pups.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Cobalt chloride</kwd><kwd>Suckling rats</kwd><kwd>Cerebrum</kwd><kwd>Cerebellum</kwd><kwd>Antioxidant enzyme profiles</kwd><kwd>Histological studies</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media New York 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Tunisie</li></country></list><tree><country name="Tunisie"><noRegion><name sortKey="Garoui, Elmouldi" sort="Garoui, Elmouldi" uniqKey="Garoui E" first="Elmouldi" last="Garoui">Elmouldi Garoui</name></noRegion><name sortKey="Amara, Ibtissem Ben" sort="Amara, Ibtissem Ben" uniqKey="Amara I" first="Ibtissem Ben" last="Amara">Ibtissem Ben Amara</name><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><name sortKey="Chaabouni, Semia Ellouze" sort="Chaabouni, Semia Ellouze" uniqKey="Chaabouni S" first="Semia Ellouze" last="Chaabouni">Semia Ellouze Chaabouni</name><name sortKey="Driss, Dorra" sort="Driss, Dorra" uniqKey="Driss D" first="Dorra" last="Driss">Dorra Driss</name><name sortKey="Elwej, Awatef" sort="Elwej, Awatef" uniqKey="Elwej A" first="Awatef" last="Elwej">Awatef Elwej</name><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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