CobaltMaghrebV1, PascalFrancis, Corpus, bibRecord, 000280

Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines

Identifieur interne : 000280 ( PascalFrancis/Corpus ); précédent : 000279; suivant : 000281

Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines

Auteurs : I. H. Hall ; C. B. Lackey ; T. D. Kistler ; R. W. Jr Durham ; E. M. Jouad ; M. Khan ; X. D. Thanh ; S. Djebbar-Sid ; O. Benali-Baitich ; G. M. Bouet

Source :

Pharmazie [ 0031-7144 ] ; 2000.

RBID : Pascal:01-0086221

Descripteurs français

Pascal (Inist)
- Activité biologique, Anticancéreux, Cytotoxicité, In vitro, Lignée cellulaire, Cellule tumorale, Homme, Animal, Souris, Lignée L1210, Inhibition, Synthèse DNA, Synthèse chimique, Cuivre Complexe, Cobalt Complexe, Complexe chloro, Complexe bromo, Complexe aqua, Coordinat organique, Semicarbazone, Thiosemicarbazone, Hétérocycle oxygène, Cycle 5 chaînons, Furane dérivé, Furfural(5-méthyl) semicarbazone, Furfural thiosemicarbazone.

English descriptors

KwdEn :
- Animal, Antineoplastic agent, Aqua complex, Biological activity, Bromo complex, Cell line, Chemical synthesis, Chloro complex, Cobalt Complexes, Copper Complexes, Cytotoxicity, DNA synthesis, Five membered ring, Furan derivatives, Human, In vitro, Inhibition, L1210 cell line, Mouse, Organic ligand, Oxygen heterocycle, Semicarbazones, Thiosemicarbazone, Tumor cell.

Abstract

The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S³ uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 PHARAT`
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A08	`01`	`1`	`ENG`	`@1 Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines`
A11	`01`	`1`		`@1 HALL (I. H.)`
A11	`02`	`1`		`@1 LACKEY (C. B.)`
A11	`03`	`1`		`@1 KISTLER (T. D.)`
A11	`04`	`1`		`@1 DURHAM (R. W. JR)`
A11	`05`	`1`		`@1 JOUAD (E. M.)`
A11	`06`	`1`		`@1 KHAN (M.)`
A11	`07`	`1`		`@1 THANH (X. D.)`
A11	`08`	`1`		`@1 DJEBBAR-SID (S.)`
A11	`09`	`1`		`@1 BENALI-BAITICH (O.)`
A11	`10`	`1`		`@1 BOUET (G. M.)`
A14	`01`			`@1 Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina @2 Chapel Hill @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A14	`02`			`@1 Laboratoire de Chimie de Coordination , Faculte de Pharmacie @2 Angers @3 FRA @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 10 aut.`
A14	`03`			`@1 Laboratoire de Chimie de Coordination, USTHB, Institut de Chimie @2 Alger @3 DZA @Z 9 aut.`
A20				`@1 937-941`
A21				`@1 2000`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 3582 @5 354000093716840120`
A44				`@0 0000 @1 © 2001 INIST-CNRS. All rights reserved.`
A45				`@0 32 ref.`
A47	`01`	`1`		`@0 01-0086221`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Pharmazie`
A66	`01`			`@0 DEU`
C01	`01`		`ENG`	@0 The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S³ uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.
C02	`01`	`X`		`@0 002B02R01`
C03	`01`	`X`	`FRE`	`@0 Activité biologique @5 01`
C03	`01`	`X`	`ENG`	`@0 Biological activity @5 01`
C03	`01`	`X`	`SPA`	`@0 Actividad biológica @5 01`
C03	`02`	`X`	`FRE`	`@0 Anticancéreux @5 02`
C03	`02`	`X`	`ENG`	`@0 Antineoplastic agent @5 02`
C03	`02`	`X`	`SPA`	`@0 Anticanceroso @5 02`
C03	`03`	`X`	`FRE`	`@0 Cytotoxicité @5 03`
C03	`03`	`X`	`ENG`	`@0 Cytotoxicity @5 03`
C03	`03`	`X`	`SPA`	`@0 Citotoxicidad @5 03`
C03	`04`	`X`	`FRE`	`@0 In vitro @5 04`
C03	`04`	`X`	`ENG`	`@0 In vitro @5 04`
C03	`04`	`X`	`SPA`	`@0 In vitro @5 04`
C03	`05`	`X`	`FRE`	`@0 Lignée cellulaire @5 05`
C03	`05`	`X`	`ENG`	`@0 Cell line @5 05`
C03	`05`	`X`	`SPA`	`@0 Línea celular @5 05`
C03	`06`	`X`	`FRE`	`@0 Cellule tumorale @5 06`
C03	`06`	`X`	`ENG`	`@0 Tumor cell @5 06`
C03	`06`	`X`	`SPA`	`@0 Célula tumoral @5 06`
C03	`07`	`X`	`FRE`	`@0 Homme @5 07`
C03	`07`	`X`	`ENG`	`@0 Human @5 07`
C03	`07`	`X`	`SPA`	`@0 Hombre @5 07`
C03	`08`	`X`	`FRE`	`@0 Animal @5 08`
C03	`08`	`X`	`ENG`	`@0 Animal @5 08`
C03	`08`	`X`	`SPA`	`@0 Animal @5 08`
C03	`09`	`X`	`FRE`	`@0 Souris @5 09`
C03	`09`	`X`	`ENG`	`@0 Mouse @5 09`
C03	`09`	`X`	`SPA`	`@0 Ratón @5 09`
C03	`10`	`X`	`FRE`	`@0 Lignée L1210 @5 10`
C03	`10`	`X`	`ENG`	`@0 L1210 cell line @5 10 @6 L«1210» cell line`
C03	`10`	`X`	`SPA`	`@0 Célula L1210 @5 10`
C03	`11`	`X`	`FRE`	`@0 Inhibition @5 11`
C03	`11`	`X`	`ENG`	`@0 Inhibition @5 11`
C03	`11`	`X`	`SPA`	`@0 Inhibición @5 11`
C03	`12`	`X`	`FRE`	`@0 Synthèse DNA @5 12`
C03	`12`	`X`	`ENG`	`@0 DNA synthesis @5 12`
C03	`12`	`X`	`SPA`	`@0 Síntesis ADN @5 12`
C03	`13`	`X`	`FRE`	`@0 Synthèse chimique @5 16`
C03	`13`	`X`	`ENG`	`@0 Chemical synthesis @5 16`
C03	`13`	`X`	`SPA`	`@0 Síntesis química @5 16`
C03	`14`	`X`	`FRE`	`@0 Cuivre Complexe @2 NC @2 NA @5 17`
C03	`14`	`X`	`ENG`	`@0 Copper Complexes @2 NC @2 NA @5 17`
C03	`14`	`X`	`SPA`	`@0 Cobre Complejo @2 NC @2 NA @5 17`
C03	`15`	`X`	`FRE`	`@0 Cobalt Complexe @2 NC @2 NA @5 18`
C03	`15`	`X`	`ENG`	`@0 Cobalt Complexes @2 NC @2 NA @5 18`
C03	`15`	`X`	`SPA`	`@0 Cobalto Complejo @2 NC @2 NA @5 18`
C03	`16`	`X`	`FRE`	`@0 Complexe chloro @5 20`
C03	`16`	`X`	`ENG`	`@0 Chloro complex @5 20`
C03	`16`	`X`	`SPA`	`@0 Complejo cloro @5 20`
C03	`17`	`X`	`FRE`	`@0 Complexe bromo @5 21`
C03	`17`	`X`	`ENG`	`@0 Bromo complex @5 21`
C03	`17`	`X`	`SPA`	`@0 Complejo bromo @5 21`
C03	`18`	`X`	`FRE`	`@0 Complexe aqua @5 22`
C03	`18`	`X`	`ENG`	`@0 Aqua complex @5 22`
C03	`18`	`X`	`SPA`	`@0 Complejo aqua @5 22`
C03	`19`	`X`	`FRE`	`@0 Coordinat organique @5 24`
C03	`19`	`X`	`ENG`	`@0 Organic ligand @5 24`
C03	`19`	`X`	`SPA`	`@0 Ligando orgánico @5 24`
C03	`20`	`X`	`FRE`	`@0 Semicarbazone @5 25`
C03	`20`	`X`	`ENG`	`@0 Semicarbazones @5 25`
C03	`20`	`X`	`SPA`	`@0 Semicarbazona @5 25`
C03	`21`	`X`	`FRE`	`@0 Thiosemicarbazone @5 26`
C03	`21`	`X`	`ENG`	`@0 Thiosemicarbazone @5 26`
C03	`21`	`X`	`SPA`	`@0 Tiosemicarbazona @5 26`
C03	`22`	`X`	`FRE`	`@0 Hétérocycle oxygène @5 27`
C03	`22`	`X`	`ENG`	`@0 Oxygen heterocycle @5 27`
C03	`22`	`X`	`SPA`	`@0 Heterociclo oxígeno @5 27`
C03	`23`	`X`	`FRE`	`@0 Cycle 5 chaînons @5 28`
C03	`23`	`X`	`ENG`	`@0 Five membered ring @5 28`
C03	`23`	`X`	`SPA`	`@0 Ciclo 5 eslabones @5 28`
C03	`24`	`X`	`FRE`	`@0 Furane dérivé @5 29`
C03	`24`	`X`	`ENG`	`@0 Furan derivatives @5 29`
C03	`24`	`X`	`SPA`	`@0 Furano derivado @5 29`
C03	`25`	`X`	`FRE`	`@0 Furfural(5-méthyl) semicarbazone @2 NK @2 FC @4 INC @5 62`
C03	`26`	`X`	`FRE`	`@0 Furfural thiosemicarbazone @2 NK @2 FC @4 INC @5 63`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Métal transition Complexe @2 NC @2 NA @5 19`
C07	`04`	`X`	`ENG`	`@0 Transition metal Complexes @2 NC @2 NA @5 19`
C07	`04`	`X`	`SPA`	`@0 Metal transición Complejo @2 NC @2 NA @5 19`
N21				`@1 063`

Format Inist (serveur)

NO :	PASCAL 01-0086221 INIST
ET :	Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines
AU :	HALL (I. H.); LACKEY (C. B.); KISTLER (T. D.); DURHAM (R. W. JR); JOUAD (E. M.); KHAN (M.); THANH (X. D.); DJEBBAR-SID (S.); BENALI-BAITICH (O.); BOUET (G. M.)
AF :	Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina/Chapel Hill/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.); Laboratoire de Chimie de Coordination , Faculte de Pharmacie/Angers/France (5 aut., 6 aut., 7 aut., 8 aut., 10 aut.); Laboratoire de Chimie de Coordination, USTHB, Institut de Chimie/Alger/Algérie (9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Pharmazie; ISSN 0031-7144; Coden PHARAT; Allemagne; Da. 2000; Vol. 55; No. 12; Pp. 937-941; Bibl. 32 ref.
LA :	Anglais
EA :	The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S³ uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.
CC :	002B02R01
FD :	Activité biologique; Anticancéreux; Cytotoxicité; In vitro; Lignée cellulaire; Cellule tumorale; Homme; Animal; Souris; Lignée L1210; Inhibition; Synthèse DNA; Synthèse chimique; Cuivre Complexe; Cobalt Complexe; Complexe chloro; Complexe bromo; Complexe aqua; Coordinat organique; Semicarbazone; Thiosemicarbazone; Hétérocycle oxygène; Cycle 5 chaînons; Furane dérivé; Furfural(5-méthyl) semicarbazone; Furfural thiosemicarbazone
FG :	Rodentia; Mammalia; Vertebrata; Métal transition Complexe
ED :	Biological activity; Antineoplastic agent; Cytotoxicity; In vitro; Cell line; Tumor cell; Human; Animal; Mouse; L1210 cell line; Inhibition; DNA synthesis; Chemical synthesis; Copper Complexes; Cobalt Complexes; Chloro complex; Bromo complex; Aqua complex; Organic ligand; Semicarbazones; Thiosemicarbazone; Oxygen heterocycle; Five membered ring; Furan derivatives
EG :	Rodentia; Mammalia; Vertebrata; Transition metal Complexes
SD :	Actividad biológica; Anticanceroso; Citotoxicidad; In vitro; Línea celular; Célula tumoral; Hombre; Animal; Ratón; Célula L1210; Inhibición; Síntesis ADN; Síntesis química; Cobre Complejo; Cobalto Complejo; Complejo cloro; Complejo bromo; Complejo aqua; Ligando orgánico; Semicarbazona; Tiosemicarbazona; Heterociclo oxígeno; Ciclo 5 eslabones; Furano derivado
LO :	INIST-3582.354000093716840120
ID :	01-0086221

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Pascal:01-0086221

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<author><name sortKey="Benali Baitich, O" sort="Benali Baitich, O" uniqKey="Benali Baitich O" first="O." last="Benali-Baitich">O. Benali-Baitich</name>
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<author><name sortKey="Bouet, G M" sort="Bouet, G M" uniqKey="Bouet G" first="G. M." last="Bouet">G. M. Bouet</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines</title>
<author><name sortKey="Hall, I H" sort="Hall, I H" uniqKey="Hall I" first="I. H." last="Hall">I. H. Hall</name>
<affiliation><inist:fA14 i1="01"><s1>Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina</s1>
<s2>Chapel Hill</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<author><name sortKey="Lackey, C B" sort="Lackey, C B" uniqKey="Lackey C" first="C. B." last="Lackey">C. B. Lackey</name>
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<author><name sortKey="Kistler, T D" sort="Kistler, T D" uniqKey="Kistler T" first="T. D." last="Kistler">T. D. Kistler</name>
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<author><name sortKey="Durham, R W Jr" sort="Durham, R W Jr" uniqKey="Durham R" first="R. W. Jr" last="Durham">R. W. Jr Durham</name>
<affiliation><inist:fA14 i1="01"><s1>Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina</s1>
<s2>Chapel Hill</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jouad, E M" sort="Jouad, E M" uniqKey="Jouad E" first="E. M." last="Jouad">E. M. Jouad</name>
<affiliation><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Khan, M" sort="Khan, M" uniqKey="Khan M" first="M." last="Khan">M. Khan</name>
<affiliation><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Thanh, X D" sort="Thanh, X D" uniqKey="Thanh X" first="X. D." last="Thanh">X. D. Thanh</name>
<affiliation><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Djebbar Sid, S" sort="Djebbar Sid, S" uniqKey="Djebbar Sid S" first="S." last="Djebbar-Sid">S. Djebbar-Sid</name>
<affiliation><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Benali Baitich, O" sort="Benali Baitich, O" uniqKey="Benali Baitich O" first="O." last="Benali-Baitich">O. Benali-Baitich</name>
<affiliation><inist:fA14 i1="03"><s1>Laboratoire de Chimie de Coordination, USTHB, Institut de Chimie</s1>
<s2>Alger</s2>
<s3>DZA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bouet, G M" sort="Bouet, G M" uniqKey="Bouet G" first="G. M." last="Bouet">G. M. Bouet</name>
<affiliation><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Pharmazie</title>
<title level="j" type="abbreviated">Pharmazie</title>
<idno type="ISSN">0031-7144</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Pharmazie</title>
<title level="j" type="abbreviated">Pharmazie</title>
<idno type="ISSN">0031-7144</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Antineoplastic agent</term>
<term>Aqua complex</term>
<term>Biological activity</term>
<term>Bromo complex</term>
<term>Cell line</term>
<term>Chemical synthesis</term>
<term>Chloro complex</term>
<term>Cobalt Complexes</term>
<term>Copper Complexes</term>
<term>Cytotoxicity</term>
<term>DNA synthesis</term>
<term>Five membered ring</term>
<term>Furan derivatives</term>
<term>Human</term>
<term>In vitro</term>
<term>Inhibition</term>
<term>L1210 cell line</term>
<term>Mouse</term>
<term>Organic ligand</term>
<term>Oxygen heterocycle</term>
<term>Semicarbazones</term>
<term>Thiosemicarbazone</term>
<term>Tumor cell</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Activité biologique</term>
<term>Anticancéreux</term>
<term>Cytotoxicité</term>
<term>In vitro</term>
<term>Lignée cellulaire</term>
<term>Cellule tumorale</term>
<term>Homme</term>
<term>Animal</term>
<term>Souris</term>
<term>Lignée L1210</term>
<term>Inhibition</term>
<term>Synthèse DNA</term>
<term>Synthèse chimique</term>
<term>Cuivre Complexe</term>
<term>Cobalt Complexe</term>
<term>Complexe chloro</term>
<term>Complexe bromo</term>
<term>Complexe aqua</term>
<term>Coordinat organique</term>
<term>Semicarbazone</term>
<term>Thiosemicarbazone</term>
<term>Hétérocycle oxygène</term>
<term>Cycle 5 chaînons</term>
<term>Furane dérivé</term>
<term>Furfural(5-méthyl) semicarbazone</term>
<term>Furfural thiosemicarbazone</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S<sup>3</sup>
 uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0031-7144</s0>
</fA01>
<fA02 i1="01"><s0>PHARAT</s0>
</fA02>
<fA03 i2="1"><s0>Pharmazie</s0>
</fA03>
<fA05><s2>55</s2>
</fA05>
<fA06><s2>12</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>HALL (I. H.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LACKEY (C. B.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>KISTLER (T. D.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>DURHAM (R. W. JR)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>JOUAD (E. M.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>KHAN (M.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>THANH (X. D.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>DJEBBAR-SID (S.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>BENALI-BAITICH (O.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>BOUET (G. M.)</s1>
</fA11>
<fA14 i1="01"><s1>Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina</s1>
<s2>Chapel Hill</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Laboratoire de Chimie de Coordination, USTHB, Institut de Chimie</s1>
<s2>Alger</s2>
<s3>DZA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA20><s1>937-941</s1>
</fA20>
<fA21><s1>2000</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>3582</s2>
<s5>354000093716840120</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2001 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>32 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>01-0086221</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Pharmazie</s0>
</fA64>
<fA66 i1="01"><s0>DEU</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S<sup>3</sup>
 uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02R01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Activité biologique</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Biological activity</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Actividad biológica</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Anticancéreux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Antineoplastic agent</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Anticanceroso</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Cytotoxicité</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Cytotoxicity</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Citotoxicidad</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>In vitro</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>In vitro</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>In vitro</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Lignée cellulaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Cell line</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Línea celular</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Cellule tumorale</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Tumor cell</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Célula tumoral</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Human</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Souris</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Mouse</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Ratón</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Lignée L1210</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>L1210 cell line</s0>
<s5>10</s5>
<s6>L«1210» cell line</s6>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Célula L1210</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Inhibition</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Inhibition</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Inhibición</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Synthèse DNA</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>DNA synthesis</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Síntesis ADN</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Synthèse chimique</s0>
<s5>16</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Chemical synthesis</s0>
<s5>16</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Síntesis química</s0>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Cuivre Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>17</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Copper Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>17</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Cobre Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Cobalt Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>18</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Cobalt Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>18</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Cobalto Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>18</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Complexe chloro</s0>
<s5>20</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Chloro complex</s0>
<s5>20</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Complejo cloro</s0>
<s5>20</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Complexe bromo</s0>
<s5>21</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Bromo complex</s0>
<s5>21</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Complejo bromo</s0>
<s5>21</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Complexe aqua</s0>
<s5>22</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Aqua complex</s0>
<s5>22</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Complejo aqua</s0>
<s5>22</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Coordinat organique</s0>
<s5>24</s5>
</fC03>
<fC03 i1="19" i2="X" l="ENG"><s0>Organic ligand</s0>
<s5>24</s5>
</fC03>
<fC03 i1="19" i2="X" l="SPA"><s0>Ligando orgánico</s0>
<s5>24</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Semicarbazone</s0>
<s5>25</s5>
</fC03>
<fC03 i1="20" i2="X" l="ENG"><s0>Semicarbazones</s0>
<s5>25</s5>
</fC03>
<fC03 i1="20" i2="X" l="SPA"><s0>Semicarbazona</s0>
<s5>25</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Thiosemicarbazone</s0>
<s5>26</s5>
</fC03>
<fC03 i1="21" i2="X" l="ENG"><s0>Thiosemicarbazone</s0>
<s5>26</s5>
</fC03>
<fC03 i1="21" i2="X" l="SPA"><s0>Tiosemicarbazona</s0>
<s5>26</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>Hétérocycle oxygène</s0>
<s5>27</s5>
</fC03>
<fC03 i1="22" i2="X" l="ENG"><s0>Oxygen heterocycle</s0>
<s5>27</s5>
</fC03>
<fC03 i1="22" i2="X" l="SPA"><s0>Heterociclo oxígeno</s0>
<s5>27</s5>
</fC03>
<fC03 i1="23" i2="X" l="FRE"><s0>Cycle 5 chaînons</s0>
<s5>28</s5>
</fC03>
<fC03 i1="23" i2="X" l="ENG"><s0>Five membered ring</s0>
<s5>28</s5>
</fC03>
<fC03 i1="23" i2="X" l="SPA"><s0>Ciclo 5 eslabones</s0>
<s5>28</s5>
</fC03>
<fC03 i1="24" i2="X" l="FRE"><s0>Furane dérivé</s0>
<s5>29</s5>
</fC03>
<fC03 i1="24" i2="X" l="ENG"><s0>Furan derivatives</s0>
<s5>29</s5>
</fC03>
<fC03 i1="24" i2="X" l="SPA"><s0>Furano derivado</s0>
<s5>29</s5>
</fC03>
<fC03 i1="25" i2="X" l="FRE"><s0>Furfural(5-méthyl) semicarbazone</s0>
<s2>NK</s2>
<s2>FC</s2>
<s4>INC</s4>
<s5>62</s5>
</fC03>
<fC03 i1="26" i2="X" l="FRE"><s0>Furfural thiosemicarbazone</s0>
<s2>NK</s2>
<s2>FC</s2>
<s4>INC</s4>
<s5>63</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Métal transition Complexe</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>19</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Transition metal Complexes</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>19</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Metal transición Complejo</s0>
<s2>NC</s2>
<s2>NA</s2>
<s5>19</s5>
</fC07>
<fN21><s1>063</s1>
</fN21>
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<server><NO>PASCAL 01-0086221 INIST</NO>
<ET>Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines</ET>
<AU>HALL (I. H.); LACKEY (C. B.); KISTLER (T. D.); DURHAM (R. W. JR); JOUAD (E. M.); KHAN (M.); THANH (X. D.); DJEBBAR-SID (S.); BENALI-BAITICH (O.); BOUET (G. M.)</AU>
<AF>Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina/Chapel Hill/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.); Laboratoire de Chimie de Coordination , Faculte de Pharmacie/Angers/France (5 aut., 6 aut., 7 aut., 8 aut., 10 aut.); Laboratoire de Chimie de Coordination, USTHB, Institut de Chimie/Alger/Algérie (9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Pharmazie; ISSN 0031-7144; Coden PHARAT; Allemagne; Da. 2000; Vol. 55; No. 12; Pp. 937-941; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S<sup>3</sup>
 uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.</EA>
<CC>002B02R01</CC>
<FD>Activité biologique; Anticancéreux; Cytotoxicité; In vitro; Lignée cellulaire; Cellule tumorale; Homme; Animal; Souris; Lignée L1210; Inhibition; Synthèse DNA; Synthèse chimique; Cuivre Complexe; Cobalt Complexe; Complexe chloro; Complexe bromo; Complexe aqua; Coordinat organique; Semicarbazone; Thiosemicarbazone; Hétérocycle oxygène; Cycle 5 chaînons; Furane dérivé; Furfural(5-méthyl) semicarbazone; Furfural thiosemicarbazone</FD>
<FG>Rodentia; Mammalia; Vertebrata; Métal transition Complexe</FG>
<ED>Biological activity; Antineoplastic agent; Cytotoxicity; In vitro; Cell line; Tumor cell; Human; Animal; Mouse; L1210 cell line; Inhibition; DNA synthesis; Chemical synthesis; Copper Complexes; Cobalt Complexes; Chloro complex; Bromo complex; Aqua complex; Organic ligand; Semicarbazones; Thiosemicarbazone; Oxygen heterocycle; Five membered ring; Furan derivatives</ED>
<EG>Rodentia; Mammalia; Vertebrata; Transition metal Complexes</EG>
<SD>Actividad biológica; Anticanceroso; Citotoxicidad; In vitro; Línea celular; Célula tumoral; Hombre; Animal; Ratón; Célula L1210; Inhibición; Síntesis ADN; Síntesis química; Cobre Complejo; Cobalto Complejo; Complejo cloro; Complejo bromo; Complejo aqua; Ligando orgánico; Semicarbazona; Tiosemicarbazona; Heterociclo oxígeno; Ciclo 5 eslabones; Furano derivado</SD>
<LO>INIST-3582.354000093716840120</LO>
<ID>01-0086221</ID>
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Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines

Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines

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