Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny
Identifieur interne : 000040 ( PascalFrancis/Corpus ); précédent : 000039; suivant : 000041Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny
Auteurs : El Mouldi Garoui ; Afef Troudi ; Hamadi Fetoui ; Nejla Soudani ; Tahia Boudawara ; Najiba ZeghalSource :
- Experimental and toxicologic pathology : (Print) [ 0940-2993 ] ; 2012.
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- Pascal (Inist)
English descriptors
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Abstract
The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl2 in drinking water; group 3 received 350 ppm CoCl2 in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.
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Format Inist (serveur)
| NO : | PASCAL 12-0441031 INIST |
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| ET : | Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny |
| AU : | GAROUI (El Mouldi); TROUDI (Afef); FETOUI (Hamadi); SOUDANI (Nejla); BOUDAWARA (Tahia); ZEGHAL (Najiba) |
| AF : | Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax/Tunisie (1 aut., 2 aut., 3 aut., 4 aut., 6 aut.); Histopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, University of Sfax/Tunisie (5 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Experimental and toxicologic pathology : (Print); ISSN 0940-2993; Allemagne; Da. 2012; Vol. 64; No. 7-8; Pp. 837-846; Bibl. 1 p.1/4 |
| LA : | Anglais |
| EA : | The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl2 in drinking water; group 3 received 350 ppm CoCl2 in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period. |
| CC : | 002B24O |
| FD : | Propolis; Cobalt; Toxicité; Néphrotoxicité; Animal adulte; Rat; Descendance; Chlorure de cobalt; Gestation; Allaitement; Antioxydant; Propriété; Anatomopathologie |
| FG : | Rodentia; Mammalia; Vertebrata |
| ED : | Propolis; Cobalt; Toxicity; Nephrotoxicity; Adult animal; Rat; Progeny; Cobalt chloride; Pregnancy; Breast feeding; Antioxidant; Properties; Anatomic pathology |
| EG : | Rodentia; Mammalia; Vertebrata |
| SD : | Propóleos; Cobalto; Toxicidad; Nefrotoxicidad; Animal adulto; Rata; Descendencia; Cobalto cloruro; Gestación; Lactancia; Antioxidante; Propiedad; Anatomía patológica |
| LO : | INIST-13623.354000505399240240 |
| ID : | 12-0441031 |
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sort="Fetoui, Hamadi" uniqKey="Fetoui H" first="Hamadi" last="Fetoui">Hamadi Fetoui</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Soudani, Nejla" sort="Soudani, Nejla" uniqKey="Soudani N" first="Nejla" last="Soudani">Nejla Soudani</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><affiliation><inist:fA14 i1="02"><s1>Histopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0441031</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0441031 INIST</idno><idno type="RBID">Pascal:12-0441031</idno><idno type="wicri:Area/PascalFrancis/Corpus">000040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny</title><author><name sortKey="Garoui, El Mouldi" sort="Garoui, El Mouldi" uniqKey="Garoui E" first="El Mouldi" last="Garoui">El Mouldi Garoui</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Troudi, Afef" sort="Troudi, Afef" uniqKey="Troudi A" first="Afef" last="Troudi">Afef Troudi</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fetoui, Hamadi" sort="Fetoui, Hamadi" uniqKey="Fetoui H" first="Hamadi" last="Fetoui">Hamadi Fetoui</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Soudani, Nejla" sort="Soudani, Nejla" uniqKey="Soudani N" first="Nejla" last="Soudani">Nejla Soudani</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><affiliation><inist:fA14 i1="02"><s1>Histopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name><affiliation><inist:fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Experimental and toxicologic pathology : (Print)</title><title level="j" type="abbreviated">Exp. toxicol. pathol. : (Print)</title><idno type="ISSN">0940-2993</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental and toxicologic pathology : (Print)</title><title level="j" type="abbreviated">Exp. toxicol. pathol. : (Print)</title><idno type="ISSN">0940-2993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult animal</term><term>Anatomic pathology</term><term>Antioxidant</term><term>Breast feeding</term><term>Cobalt</term><term>Cobalt chloride</term><term>Nephrotoxicity</term><term>Pregnancy</term><term>Progeny</term><term>Properties</term><term>Propolis</term><term>Rat</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Propolis</term><term>Cobalt</term><term>Toxicité</term><term>Néphrotoxicité</term><term>Animal adulte</term><term>Rat</term><term>Descendance</term><term>Chlorure de cobalt</term><term>Gestation</term><term>Allaitement</term><term>Antioxydant</term><term>Propriété</term><term>Anatomopathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl<sub>2</sub> in drinking water; group 3 received 350 ppm CoCl<sub>2</sub> in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0940-2993</s0></fA01><fA03 i2="1"><s0>Exp. toxicol. pathol. : (Print)</s0></fA03><fA05><s2>64</s2></fA05><fA06><s2>7-8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny</s1></fA08><fA11 i1="01" i2="1"><s1>GAROUI (El Mouldi)</s1></fA11><fA11 i1="02" i2="1"><s1>TROUDI (Afef)</s1></fA11><fA11 i1="03" i2="1"><s1>FETOUI (Hamadi)</s1></fA11><fA11 i1="04" i2="1"><s1>SOUDANI (Nejla)</s1></fA11><fA11 i1="05" i2="1"><s1>BOUDAWARA (Tahia)</s1></fA11><fA11 i1="06" i2="1"><s1>ZEGHAL (Najiba)</s1></fA11><fA14 i1="01"><s1>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Histopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, University of Sfax</s1><s3>TUN</s3><sZ>5 aut.</sZ></fA14><fA20><s1>837-846</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13623</s2><s5>354000505399240240</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>12-0441031</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Experimental and toxicologic pathology : (Print)</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl<sub>2</sub> in drinking water; group 3 received 350 ppm CoCl<sub>2</sub> in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.</s0></fC01><fC02 i1="01" i2="X"><s0>002B24O</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Propolis</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Propolis</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Propóleos</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Cobalt</s0><s2>NC</s2><s5>03</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cobalt</s0><s2>NC</s2><s5>03</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Cobalto</s0><s2>NC</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Toxicité</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Toxicity</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Toxicidad</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Néphrotoxicité</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nephrotoxicity</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Nefrotoxicidad</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Animal adulte</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Adult animal</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Animal adulto</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Rat</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Rat</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Rata</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Descendance</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Progeny</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Descendencia</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Chlorure de cobalt</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Cobalt chloride</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Cobalto cloruro</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Gestation</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Pregnancy</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Gestación</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Allaitement</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Breast feeding</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Lactancia</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Antioxydant</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Antioxidant</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Antioxidante</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Propriété</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Properties</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Propiedad</s0><s5>20</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Anatomopathologie</s0><s5>21</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Anatomic pathology</s0><s5>21</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Anatomía patológica</s0><s5>21</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>345</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0441031 INIST</NO><ET>Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny</ET><AU>GAROUI (El Mouldi); TROUDI (Afef); FETOUI (Hamadi); SOUDANI (Nejla); BOUDAWARA (Tahia); ZEGHAL (Najiba)</AU><AF>Animal Physiology Laboratory, U/R 08-73, Sciences Faculty, BP 1171, 3000 Sfax, University of Sfax/Tunisie (1 aut., 2 aut., 3 aut., 4 aut., 6 aut.); Histopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, University of Sfax/Tunisie (5 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Experimental and toxicologic pathology : (Print); ISSN 0940-2993; Allemagne; Da. 2012; Vol. 64; No. 7-8; Pp. 837-846; Bibl. 1 p.1/4</SO><LA>Anglais</LA><EA>The aim of this study was to evaluate the biochemical changes in cobalt-exposed rats and to investigate the potential role of Tunisian propolis against the cobalt-induced renal damages. Twenty-four pregnant Wistar rats were divided into four groups and were treated as follows: group 1 (control) received distilled water; group 2 received 350 ppm of CoCl<sub>2</sub> in drinking water; group 3 received 350 ppm CoCl<sub>2</sub> in drinking water and a propolis-supplemented diet (1 g/100 g of diet); group 4 received a propolis-supplemented diet (1 g/100 g of diet) without cobalt. In the cobalt group, a significant decrease in body, absolute and relative weights was noted when compared to controls. The administration of cobalt to pregnant rats from the 14th day of pregnancy until day 14 after delivery resulted in an increased level of renal malondialdehyde, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in lactating rats and their pups. A statistically significant increase in plasma urea and creatinine serum levels was seen in treated female rats and their pups. Histopathologically, the cobalt-administration induced degenerative changes in the kidney of lactating rats and their pups. When compared with cobalt-treated rats, those receiving the propolis supplementation (along with cobalt-treatment) had lower malondialdehyde levels, higher antioxidant activities and the cobalt-related histopathological changes in the kidneys were at lower severity.Our results suggested that the propolis might be a potential candidate agent against cobalt-induced nephrotoxicity in adult and juvenile rats when administered to female rats during the late pregnancy and the early postnatal period.</EA><CC>002B24O</CC><FD>Propolis; Cobalt; Toxicité; Néphrotoxicité; Animal adulte; Rat; Descendance; Chlorure de cobalt; Gestation; Allaitement; Antioxydant; Propriété; Anatomopathologie</FD><FG>Rodentia; Mammalia; Vertebrata</FG><ED>Propolis; Cobalt; Toxicity; Nephrotoxicity; Adult animal; Rat; Progeny; Cobalt chloride; Pregnancy; Breast feeding; Antioxidant; Properties; Anatomic pathology</ED><EG>Rodentia; Mammalia; Vertebrata</EG><SD>Propóleos; Cobalto; Toxicidad; Nefrotoxicidad; Animal adulto; Rata; Descendencia; Cobalto cloruro; Gestación; Lactancia; Antioxidante; Propiedad; Anatomía patológica</SD><LO>INIST-13623.354000505399240240</LO><ID>12-0441031</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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