The urinary excretion of phenobarbitone and pentobarbitone in the horse
Identifieur interne : 001C58 ( Main/Merge ); précédent : 001C57; suivant : 001C59The urinary excretion of phenobarbitone and pentobarbitone in the horse
Auteurs : J. D. Nicholson [Royaume-Uni]Source :
- Biochemical Pharmacology [ 0006-2952 ] ; 1968.
Abstract
The urinary excretion of phenobarbitone and pentobarbitone in the horse has been investigated. About 11 % phenobarbitone was recovered in the 72 hr following oral administration, and the only metabolite detected was the P-hydroxyphenobarbitone glucuronide conjugate. Pentobarbitone was not detected in horse urine, but was excreted as the 5-ethyl-5-(3-hydroxy-1-methylbutyl)barbituric acids and 5-ethyl-5-(1-methyl-3-carboxypropyl) barbituric acid. The alcohol metabolites, which were not conjugated with glucuronic acid, were completely excreted within 21 hr following oral dosage and constituted 33 per cent of the administered pentobarbitone.
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DOI: 10.1016/0006-2952(68)90150-0
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