Nasopharyngeal carcinoma in the young
Identifieur interne : 001A01 ( Main/Merge ); précédent : 001A00; suivant : 001A02Nasopharyngeal carcinoma in the young
Auteurs : Martin P. Berry [Canada] ; Charles R. Smith [Canada] ; Thomas C. Brown [Canada] ; R. Derek T. Jenkin [Canada] ; Walter D. Rider [Canada]Source :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1980.
Abstract
This study reviewed 25 patients with nasopharyngeal carcinoma who were less than 30 years of age at diagnosis. Lymphoepithelionna was the histological diagnosis in all but 3. The anatomical extent of disease was described using the TNM system. Local bone destruction was present in 10 patients at diagnosis; cervical nodes were clinically positive in 88 % of patients of which 54 % were bilateral. All were treated with radical irradiation using a variety of techniques and doses. No patient received adjuvant chemotherapy. Overall survival was 70 % at 5 years and 57 % at 10 years from diagnosis. There were 5 relapses at the primary site, 2 in cervical nodes and 8 in bone or lung. Primary site relapse was not demonstrated to be dependant on T group or radiation dose, but likely related to inadequacy of original treatment volume. Distant metastases at first relapse correlated with advanced T and N and were the principal obstacle to successful treatment. Adjuvant chemotherapy is suggested as an important target for further study.
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DOI: 10.1016/0360-3016(80)90054-1
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Nasopharyngeal carcinoma in the young</title><author><name sortKey="Berry, Martin P" sort="Berry, Martin P" uniqKey="Berry M" first="Martin P." last="Berry">Martin P. Berry</name></author><author><name sortKey="Smith, Charles R" sort="Smith, Charles R" uniqKey="Smith C" first="Charles R." last="Smith">Charles R. Smith</name></author><author><name sortKey="Brown, Thomas C" sort="Brown, Thomas C" uniqKey="Brown T" first="Thomas C." last="Brown">Thomas C. Brown</name></author><author><name sortKey="Jenkin, R Derek T" sort="Jenkin, R Derek T" uniqKey="Jenkin R" first="R. Derek T." last="Jenkin">R. Derek T. Jenkin</name></author><author><name sortKey="Rider, Walter D" sort="Rider, Walter D" uniqKey="Rider W" first="Walter D." last="Rider">Walter D. 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Berry</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiation Oncology, The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:regionArea><wicri:noRegion>The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Charles R" sort="Smith, Charles R" uniqKey="Smith C" first="Charles R." last="Smith">Charles R. Smith</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:regionArea><wicri:noRegion>The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Thomas C" sort="Brown, Thomas C" uniqKey="Brown T" first="Thomas C." last="Brown">Thomas C. Brown</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:regionArea><wicri:noRegion>The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:noRegion></affiliation></author><author><name sortKey="Jenkin, R Derek T" sort="Jenkin, R Derek T" uniqKey="Jenkin R" first="R. Derek T." last="Jenkin">R. Derek T. Jenkin</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Reprint requests to: R. Derek T. Jenkin, M.B., The Princess Margaret Hospital, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9</wicri:regionArea><wicri:noRegion>M4X 1K9</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiation Oncology, The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:regionArea><wicri:noRegion>The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:noRegion></affiliation></author><author><name sortKey="Rider, Walter D" sort="Rider, Walter D" uniqKey="Rider W" first="Walter D." last="Rider">Walter D. Rider</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiation Oncology, The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:regionArea><wicri:noRegion>The Princess Margaret Hospital and The Ontario Cancer Institute</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Radiation Oncology, Biology, Physics</title><title level="j" type="abbrev">ROB</title><idno type="ISSN">0360-3016</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980">1980</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="415">415</biblScope><biblScope unit="page" to="421">421</biblScope></imprint><idno type="ISSN">0360-3016</idno></series><idno type="istex">FD6A3DA3DCCF3D370830E4AB0F5108711B03F24D</idno><idno type="DOI">10.1016/0360-3016(80)90054-1</idno><idno type="PII">0360-3016(80)90054-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-3016</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study reviewed 25 patients with nasopharyngeal carcinoma who were less than 30 years of age at diagnosis. Lymphoepithelionna was the histological diagnosis in all but 3. The anatomical extent of disease was described using the TNM system. Local bone destruction was present in 10 patients at diagnosis; cervical nodes were clinically positive in 88 % of patients of which 54 % were bilateral. All were treated with radical irradiation using a variety of techniques and doses. No patient received adjuvant chemotherapy. Overall survival was 70 % at 5 years and 57 % at 10 years from diagnosis. There were 5 relapses at the primary site, 2 in cervical nodes and 8 in bone or lung. Primary site relapse was not demonstrated to be dependant on T group or radiation dose, but likely related to inadequacy of original treatment volume. Distant metastases at first relapse correlated with advanced T and N and were the principal obstacle to successful treatment. Adjuvant chemotherapy is suggested as an important target for further study.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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