Serological Studies Confirm the Novel Astrovirus HMOAstV-C as a Highly Prevalent Human Infectious Agent
Identifieur interne : 000474 ( Main/Merge ); précédent : 000473; suivant : 000475Serological Studies Confirm the Novel Astrovirus HMOAstV-C as a Highly Prevalent Human Infectious Agent
Auteurs : Peter D. Burbelo [États-Unis] ; Kathryn H. Ching [États-Unis] ; Frank Esper [États-Unis] ; Michael J. Iadarola [États-Unis] ; Eric Delwart [États-Unis] ; W. Ian Lipkin [États-Unis] ; Amit Kapoor [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Abstract
Molecular identification of a microbe is the first step in determining its prevalence of infection and pathogenic potential. Detection of specific adaptive immune responses can provide insights into whether a microbe is a human infectious agent and its epidemiology. Here we characterized human anti-IgG antibody responses by luciferase immunoprecipitation systems (LIPS) against two protein fragments derived from the capsid protein of the novel HMOAstV-C astrovirus. While antibodies to the N-terminal fragment were not informative, the C-terminal capsid fragment of HMOAstV-C showed a high frequency of immunoreactivity with serum from healthy blood donors. In contrast, a similar C-terminal capsid fragment from the related HMOAstV-A astrovirus failed to show immunoreactivity. Detailed analysis of adult serum from the United Sates using a standardized threshold demonstrated HMOAstV-C seropositivity in approximately 65% of the samples. Evaluation of serum samples from different pediatric age groups revealed that the prevalence of antibodies in 6–12 month, 1–2 year, 2–5 year and 5–10 year olds was 20%, 23%, 32% and 36%, respectively, indicating rising seroprevalence with age. Additionally, 50% (11/22) of the 0–6 month old children showed anti-HMOAstV-C antibody responses, likely reflecting maternal antibodies. Together these results document human humoral responses to HMOAstV-C and validate LIPS as a facile and effective approach for identifying humoral responses to novel infectious agents.
Url:
DOI: 10.1371/journal.pone.0022576
PubMed: 21829634
PubMed Central: 3150362
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<front><div type="abstract" xml:lang="en"><p>Molecular identification of a microbe is the first step in determining its prevalence of infection and pathogenic potential. Detection of specific adaptive immune responses can provide insights into whether a microbe is a human infectious agent and its epidemiology. Here we characterized human anti-IgG antibody responses by luciferase immunoprecipitation systems (LIPS) against two protein fragments derived from the capsid protein of the novel HMOAstV-C astrovirus. While antibodies to the N-terminal fragment were not informative, the C-terminal capsid fragment of HMOAstV-C showed a high frequency of immunoreactivity with serum from healthy blood donors. In contrast, a similar C-terminal capsid fragment from the related HMOAstV-A astrovirus failed to show immunoreactivity. Detailed analysis of adult serum from the United Sates using a standardized threshold demonstrated HMOAstV-C seropositivity in approximately 65% of the samples. Evaluation of serum samples from different pediatric age groups revealed that the prevalence of antibodies in 6–12 month, 1–2 year, 2–5 year and 5–10 year olds was 20%, 23%, 32% and 36%, respectively, indicating rising seroprevalence with age. Additionally, 50% (11/22) of the 0–6 month old children showed anti-HMOAstV-C antibody responses, likely reflecting maternal antibodies. Together these results document human humoral responses to HMOAstV-C and validate LIPS as a facile and effective approach for identifying humoral responses to novel infectious agents.</p>
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</author>
<author><name sortKey="Bosch, A" uniqKey="Bosch A">A Bosch</name>
</author>
<author><name sortKey="Pinto, Rm" uniqKey="Pinto R">RM Pinto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krishna, Nk" uniqKey="Krishna N">NK Krishna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jonassen, Cm" uniqKey="Jonassen C">CM Jonassen</name>
</author>
<author><name sortKey="Jonassen, To" uniqKey="Jonassen T">TO Jonassen</name>
</author>
<author><name sortKey="Saif, Ym" uniqKey="Saif Y">YM Saif</name>
</author>
<author><name sortKey="Snodgrass, Dr" uniqKey="Snodgrass D">DR Snodgrass</name>
</author>
<author><name sortKey="Ushijima, H" uniqKey="Ushijima H">H Ushijima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jonassen, Cm" uniqKey="Jonassen C">CM Jonassen</name>
</author>
<author><name sortKey="Jonassen, Tt" uniqKey="Jonassen T">TT Jonassen</name>
</author>
<author><name sortKey="Sveen, Tm" uniqKey="Sveen T">TM Sveen</name>
</author>
<author><name sortKey="Grinde, B" uniqKey="Grinde B">B Grinde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clark, B" uniqKey="Clark B">B Clark</name>
</author>
<author><name sortKey="Mckendrick, M" uniqKey="Mckendrick M">M McKendrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fodha, I" uniqKey="Fodha I">I Fodha</name>
</author>
<author><name sortKey="Chouikha, A" uniqKey="Chouikha A">A Chouikha</name>
</author>
<author><name sortKey="Peenze, I" uniqKey="Peenze I">I Peenze</name>
</author>
<author><name sortKey="De Beer, M" uniqKey="De Beer M">M De Beer</name>
</author>
<author><name sortKey="Dewar, J" uniqKey="Dewar J">J Dewar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabbay, Yb" uniqKey="Gabbay Y">YB Gabbay</name>
</author>
<author><name sortKey="Leite, Jp" uniqKey="Leite J">JP Leite</name>
</author>
<author><name sortKey="Oliveira, Ds" uniqKey="Oliveira D">DS Oliveira</name>
</author>
<author><name sortKey="Nakamura, Ls" uniqKey="Nakamura L">LS Nakamura</name>
</author>
<author><name sortKey="Nunes, Mr" uniqKey="Nunes M">MR Nunes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y Jin</name>
</author>
<author><name sortKey="Cheng, Wx" uniqKey="Cheng W">WX Cheng</name>
</author>
<author><name sortKey="Yang, Xm" uniqKey="Yang X">XM Yang</name>
</author>
<author><name sortKey="Jin, M" uniqKey="Jin M">M Jin</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tayeb, Ht" uniqKey="Tayeb H">HT Tayeb</name>
</author>
<author><name sortKey="Dela Cruz, Dm" uniqKey="Dela Cruz D">DM Dela Cruz</name>
</author>
<author><name sortKey="Al Qahtani, A" uniqKey="Al Qahtani A">A Al-Qahtani</name>
</author>
<author><name sortKey="Al Ahdal, Mn" uniqKey="Al Ahdal M">MN Al-Ahdal</name>
</author>
<author><name sortKey="Carter, Mj" uniqKey="Carter M">MJ Carter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moser, La" uniqKey="Moser L">LA Moser</name>
</author>
<author><name sortKey="Schultz Cherry, S" uniqKey="Schultz Cherry S">S Schultz-Cherry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liste, Mb" uniqKey="Liste M">MB Liste</name>
</author>
<author><name sortKey="Natera, I" uniqKey="Natera I">I Natera</name>
</author>
<author><name sortKey="Suarez, Ja" uniqKey="Suarez J">JA Suarez</name>
</author>
<author><name sortKey="Pujol, Fh" uniqKey="Pujol F">FH Pujol</name>
</author>
<author><name sortKey="Liprandi, F" uniqKey="Liprandi F">F Liprandi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkbeiner, Sr" uniqKey="Finkbeiner S">SR Finkbeiner</name>
</author>
<author><name sortKey="Allred, Af" uniqKey="Allred A">AF Allred</name>
</author>
<author><name sortKey="Tarr, Pi" uniqKey="Tarr P">PI Tarr</name>
</author>
<author><name sortKey="Klein, Ej" uniqKey="Klein E">EJ Klein</name>
</author>
<author><name sortKey="Kirkwood, Cd" uniqKey="Kirkwood C">CD Kirkwood</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Victoria, J" uniqKey="Victoria J">J Victoria</name>
</author>
<author><name sortKey="Oderinde, B" uniqKey="Oderinde B">B Oderinde</name>
</author>
<author><name sortKey="Mason, C" uniqKey="Mason C">C Mason</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kapoor, A" uniqKey="Kapoor A">A Kapoor</name>
</author>
<author><name sortKey="Slikas, E" uniqKey="Slikas E">E Slikas</name>
</author>
<author><name sortKey="Simmonds, P" uniqKey="Simmonds P">P Simmonds</name>
</author>
<author><name sortKey="Chieochansin, T" uniqKey="Chieochansin T">T Chieochansin</name>
</author>
<author><name sortKey="Naeem, A" uniqKey="Naeem A">A Naeem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kapoor, A" uniqKey="Kapoor A">A Kapoor</name>
</author>
<author><name sortKey="Victoria, J" uniqKey="Victoria J">J Victoria</name>
</author>
<author><name sortKey="Simmonds, P" uniqKey="Simmonds P">P Simmonds</name>
</author>
<author><name sortKey="Slikas, E" uniqKey="Slikas E">E Slikas</name>
</author>
<author><name sortKey="Chieochansin, T" uniqKey="Chieochansin T">T Chieochansin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkbeiner, Sr" uniqKey="Finkbeiner S">SR Finkbeiner</name>
</author>
<author><name sortKey="Kirkwood, Cd" uniqKey="Kirkwood C">CD Kirkwood</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkbeiner, Sr" uniqKey="Finkbeiner S">SR Finkbeiner</name>
</author>
<author><name sortKey="Le, Bm" uniqKey="Le B">BM Le</name>
</author>
<author><name sortKey="Holtz, Lr" uniqKey="Holtz L">LR Holtz</name>
</author>
<author><name sortKey="Storch, Ga" uniqKey="Storch G">GA Storch</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkbeiner, Sr" uniqKey="Finkbeiner S">SR Finkbeiner</name>
</author>
<author><name sortKey="Holtz, Lr" uniqKey="Holtz L">LR Holtz</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Rajendran, P" uniqKey="Rajendran P">P Rajendran</name>
</author>
<author><name sortKey="Franz, Cj" uniqKey="Franz C">CJ Franz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkbeiner, Sr" uniqKey="Finkbeiner S">SR Finkbeiner</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Ruone, S" uniqKey="Ruone S">S Ruone</name>
</author>
<author><name sortKey="Conrardy, C" uniqKey="Conrardy C">C Conrardy</name>
</author>
<author><name sortKey="Gregoricus, N" uniqKey="Gregoricus N">N Gregoricus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Ching, Kh" uniqKey="Ching K">KH Ching</name>
</author>
<author><name sortKey="Bush, Er" uniqKey="Bush E">ER Bush</name>
</author>
<author><name sortKey="Han, Bl" uniqKey="Han B">BL Han</name>
</author>
<author><name sortKey="Iadarola, Mj" uniqKey="Iadarola M">MJ Iadarola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Ching, Kh" uniqKey="Ching K">KH Ching</name>
</author>
<author><name sortKey="Mattson, Tl" uniqKey="Mattson T">TL Mattson</name>
</author>
<author><name sortKey="Light, Js" uniqKey="Light J">JS Light</name>
</author>
<author><name sortKey="Bishop, Lr" uniqKey="Bishop L">LR Bishop</name>
</author>
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</author>
<author><name sortKey="Goldman, R" uniqKey="Goldman R">R Goldman</name>
</author>
<author><name sortKey="Mattson, Tl" uniqKey="Mattson T">TL Mattson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Ching, Kh" uniqKey="Ching K">KH Ching</name>
</author>
<author><name sortKey="Klimavicz, Cm" uniqKey="Klimavicz C">CM Klimavicz</name>
</author>
<author><name sortKey="Iadarola, Mj" uniqKey="Iadarola M">MJ Iadarola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Bren, Ke" uniqKey="Bren K">KE Bren</name>
</author>
<author><name sortKey="Ching, Kh" uniqKey="Ching K">KH Ching</name>
</author>
<author><name sortKey="Gogineni, Es" uniqKey="Gogineni E">ES Gogineni</name>
</author>
<author><name sortKey="Kottilil, S" uniqKey="Kottilil S">S Kottilil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Ramanathan, R" uniqKey="Ramanathan R">R Ramanathan</name>
</author>
<author><name sortKey="Klion, Ad" uniqKey="Klion A">AD Klion</name>
</author>
<author><name sortKey="Iadarola, Mj" uniqKey="Iadarola M">MJ Iadarola</name>
</author>
<author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramanathan, R" uniqKey="Ramanathan R">R Ramanathan</name>
</author>
<author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Groot, S" uniqKey="Groot S">S Groot</name>
</author>
<author><name sortKey="Iadarola, Mj" uniqKey="Iadarola M">MJ Iadarola</name>
</author>
<author><name sortKey="Neva, Fa" uniqKey="Neva F">FA Neva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Issa, At" uniqKey="Issa A">AT Issa</name>
</author>
<author><name sortKey="Ching, Kh" uniqKey="Ching K">KH Ching</name>
</author>
<author><name sortKey="Cohen, Ji" uniqKey="Cohen J">JI Cohen</name>
</author>
<author><name sortKey="Iadarola, Mj" uniqKey="Iadarola M">MJ Iadarola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Leahy, Hp" uniqKey="Leahy H">HP Leahy</name>
</author>
<author><name sortKey="Groot, S" uniqKey="Groot S">S Groot</name>
</author>
<author><name sortKey="Bishop, Lr" uniqKey="Bishop L">LR Bishop</name>
</author>
<author><name sortKey="Miley, W" uniqKey="Miley W">W Miley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burbelo, Pd" uniqKey="Burbelo P">PD Burbelo</name>
</author>
<author><name sortKey="Bren, Ke" uniqKey="Bren K">KE Bren</name>
</author>
<author><name sortKey="Ching, Kh" uniqKey="Ching K">KH Ching</name>
</author>
<author><name sortKey="Gogineni, Es" uniqKey="Gogineni E">ES Gogineni</name>
</author>
<author><name sortKey="Kottilil, S" uniqKey="Kottilil S">S Kottilil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leung, J" uniqKey="Leung J">J Leung</name>
</author>
<author><name sortKey="Esper, F" uniqKey="Esper F">F Esper</name>
</author>
<author><name sortKey="Weibel, C" uniqKey="Weibel C">C Weibel</name>
</author>
<author><name sortKey="Kahn, Js" uniqKey="Kahn J">JS Kahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heininger, U" uniqKey="Heininger U">U Heininger</name>
</author>
<author><name sortKey="Desgrandchamps, D" uniqKey="Desgrandchamps D">D Desgrandchamps</name>
</author>
<author><name sortKey="Schaad, Ub" uniqKey="Schaad U">UB Schaad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quan, Pl" uniqKey="Quan P">PL Quan</name>
</author>
<author><name sortKey="Wagner, Ta" uniqKey="Wagner T">TA Wagner</name>
</author>
<author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name>
</author>
<author><name sortKey="Torgerson, Tr" uniqKey="Torgerson T">TR Torgerson</name>
</author>
<author><name sortKey="Hornig, M" uniqKey="Hornig M">M Hornig</name>
</author>
</analytic>
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