Increased senile plaques without microglia in Alzheimer's disease
Identifieur interne : 001416 ( Main/Exploration ); précédent : 001415; suivant : 001417Increased senile plaques without microglia in Alzheimer's disease
Auteurs : T. Ohgami [Japon] ; T. Kitamoto [Japon] ; R. W. Shin [Japon] ; Y. Kaneko [Japon] ; K. Ogomori [Japon] ; J. Tateishi [Japon]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1991-02-01.
Abstract
Summary: To clarify the association of microglia with senile plaques, the brains from 13 patients with Alzheimer's disease (AD) and 23 nondemented aged controls were investigated immunohistochemically by a double-labeling method using anti-β-protein antiserum and anti-ferritin antibody, which is a recently reported microglia marker. In addition, a quantitative analysis was performed. The senile plaques which appeared initially in the nondemented aged controls consisted of a diffuse type without any amyloid cores and these were found in the group aged 50–59 years. The great majority of them were found to contain no ferritin-positive microglia. The number and proportion (percentage) of microglia-containing diffuse plaques increased with age. Classical and compact plaques began to appear in the brains of the group aged 70 years and over, and practically all of them contained microglia. These results suggest that microglia are not associated with initial plaque formation, but correlate with amyloid core formation. In AD, the most prominent feature was that the diffuse plaques, which contained either no or only a few ferritin-positive microglia, increased markedly.
Url:
DOI: 10.1007/BF00305864
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001254
- to stream Istex, to step Curation: 000D66
- to stream Istex, to step Checkpoint: 000C19
- to stream Main, to step Merge: 001469
- to stream Main, to step Curation: 001416
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased senile plaques without microglia in Alzheimer's disease</title><author><name sortKey="Ohgami, T" sort="Ohgami, T" uniqKey="Ohgami T" first="T." last="Ohgami">T. Ohgami</name></author><author><name sortKey="Kitamoto, T" sort="Kitamoto, T" uniqKey="Kitamoto T" first="T." last="Kitamoto">T. Kitamoto</name></author><author><name sortKey="Shin, R W" sort="Shin, R W" uniqKey="Shin R" first="R. W." last="Shin">R. W. Shin</name></author><author><name sortKey="Kaneko, Y" sort="Kaneko, Y" uniqKey="Kaneko Y" first="Y." last="Kaneko">Y. Kaneko</name></author><author><name sortKey="Ogomori, K" sort="Ogomori, K" uniqKey="Ogomori K" first="K." last="Ogomori">K. Ogomori</name></author><author><name sortKey="Tateishi, J" sort="Tateishi, J" uniqKey="Tateishi J" first="J." last="Tateishi">J. Tateishi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:392F400F5D410EA8015CA10C9F25F961D816379E</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1007/BF00305864</idno><idno type="url">https://api.istex.fr/document/392F400F5D410EA8015CA10C9F25F961D816379E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001254</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001254</idno><idno type="wicri:Area/Istex/Curation">000D66</idno><idno type="wicri:Area/Istex/Checkpoint">000C19</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000C19</idno><idno type="wicri:doubleKey">0001-6322:1991:Ohgami T:increased:senile:plaques</idno><idno type="wicri:Area/Main/Merge">001469</idno><idno type="wicri:Area/Main/Curation">001416</idno><idno type="wicri:Area/Main/Exploration">001416</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Increased senile plaques without microglia in Alzheimer's disease</title><author><name sortKey="Ohgami, T" sort="Ohgami, T" uniqKey="Ohgami T" first="T." last="Ohgami">T. Ohgami</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 812, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Kyowa Toxicological Research Laboratories Co., 2540 Fujimagari, 755, Ube, Yamaguchi</wicri:regionArea><wicri:noRegion>Yamaguchi</wicri:noRegion></affiliation></author><author><name sortKey="Kitamoto, T" sort="Kitamoto, T" uniqKey="Kitamoto T" first="T." last="Kitamoto">T. Kitamoto</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 812, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Shin, R W" sort="Shin, R W" uniqKey="Shin R" first="R. W." last="Shin">R. W. Shin</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 812, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Kaneko, Y" sort="Kaneko, Y" uniqKey="Kaneko Y" first="Y." last="Kaneko">Y. Kaneko</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 812, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Ogomori, K" sort="Ogomori, K" uniqKey="Ogomori K" first="K." last="Ogomori">K. Ogomori</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 812, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Tateishi, J" sort="Tateishi, J" uniqKey="Tateishi J" first="J." last="Tateishi">J. Tateishi</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 812, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-02-01">1991-02-01</date><biblScope unit="volume">81</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="242">242</biblScope><biblScope unit="page" to="247">247</biblScope></imprint><idno type="ISSN">0001-6322</idno></series><idno type="istex">392F400F5D410EA8015CA10C9F25F961D816379E</idno><idno type="DOI">10.1007/BF00305864</idno><idno type="ArticleID">BF00305864</idno><idno type="ArticleID">Art2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: To clarify the association of microglia with senile plaques, the brains from 13 patients with Alzheimer's disease (AD) and 23 nondemented aged controls were investigated immunohistochemically by a double-labeling method using anti-β-protein antiserum and anti-ferritin antibody, which is a recently reported microglia marker. In addition, a quantitative analysis was performed. The senile plaques which appeared initially in the nondemented aged controls consisted of a diffuse type without any amyloid cores and these were found in the group aged 50–59 years. The great majority of them were found to contain no ferritin-positive microglia. The number and proportion (percentage) of microglia-containing diffuse plaques increased with age. Classical and compact plaques began to appear in the brains of the group aged 70 years and over, and practically all of them contained microglia. These results suggest that microglia are not associated with initial plaque formation, but correlate with amyloid core formation. In AD, the most prominent feature was that the diffuse plaques, which contained either no or only a few ferritin-positive microglia, increased markedly.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Kyūshū</li><li>Préfecture de Fukuoka</li></region><settlement><li>Fukuoka</li></settlement><orgName><li>Université de Kyūshū</li></orgName></list><tree><country name="Japon"><region name="Kyūshū"><name sortKey="Ohgami, T" sort="Ohgami, T" uniqKey="Ohgami T" first="T." last="Ohgami">T. Ohgami</name></region><name sortKey="Kaneko, Y" sort="Kaneko, Y" uniqKey="Kaneko Y" first="Y." last="Kaneko">Y. Kaneko</name><name sortKey="Kitamoto, T" sort="Kitamoto, T" uniqKey="Kitamoto T" first="T." last="Kitamoto">T. Kitamoto</name><name sortKey="Ogomori, K" sort="Ogomori, K" uniqKey="Ogomori K" first="K." last="Ogomori">K. Ogomori</name><name sortKey="Ohgami, T" sort="Ohgami, T" uniqKey="Ohgami T" first="T." last="Ohgami">T. Ohgami</name><name sortKey="Shin, R W" sort="Shin, R W" uniqKey="Shin R" first="R. W." last="Shin">R. W. Shin</name><name sortKey="Tateishi, J" sort="Tateishi, J" uniqKey="Tateishi J" first="J." last="Tateishi">J. Tateishi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001416 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001416 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= CobaltMaghrebV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:392F400F5D410EA8015CA10C9F25F961D816379E
|texte= Increased senile plaques without microglia in Alzheimer's disease
}}
| This area was generated with Dilib version V0.6.32. |  |