[Hypothyroidism after external radiotherapy. Fifteen cases].
Identifieur interne : 000B42 ( Main/Exploration ); précédent : 000B41; suivant : 000B43[Hypothyroidism after external radiotherapy. Fifteen cases].
Auteurs : N. Kaffel [Tunisie] ; M. Mnif ; J. Daoud ; M. AbidSource :
- Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [ 1278-3218 ] ; 2001.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Dosimétrie en radiothérapie, Facteurs temps, Femelle, Humains, Hypothyroïdie (étiologie), Maladie de Hodgkin (radiothérapie), Mâle, Radiothérapie (), Radiothérapie (effets indésirables), Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du cerveau (radiothérapie), Tumeurs du larynx (radiothérapie), Tumeurs du sein (radiothérapie), Études rétrospectives.
- MESH :
- effets indésirables : Radiothérapie.
- radiothérapie : Maladie de Hodgkin, Tumeurs du cerveau, Tumeurs du larynx, Tumeurs du sein.
- étiologie : Hypothyroïdie.
- Adulte, Adulte d'âge moyen, Dosimétrie en radiothérapie, Facteurs temps, Femelle, Humains, Mâle, Radiothérapie, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Brain Neoplasms (radiotherapy), Breast Neoplasms (radiotherapy), Female, Hodgkin Disease (radiotherapy), Humans, Hypothyroidism (etiology), Laryngeal Neoplasms (radiotherapy), Male, Middle Aged, Radiotherapy (adverse effects), Radiotherapy (methods), Radiotherapy Dosage, Retrospective Studies, Time Factors.
- MESH :
- adverse effects : Radiotherapy.
- etiology : Hypothyroidism.
- methods : Radiotherapy.
- radiotherapy : Brain Neoplasms, Breast Neoplasms, Hodgkin Disease, Laryngeal Neoplasms.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Radiotherapy Dosage, Retrospective Studies, Time Factors.
Abstract
Hypothyroidism frequency is estimated to be between 10 and 45% after radiotherapy alone, and 40 to 67% after radiotherapy associated with thyroidectomy. This hypothyroidism is infraclinical in 60% of the cases. Our study concerned 15 cases of hypothyroidism after external radiotherapy delivered between and 1991 and 1999. An irradiation of the cervical, cerebral and thorax regions was indicated for different types of cancers. Larynx carcinoma epidermoid was the most frequent cancer (seven cases); the radiation treatment used cobalt 60 with conventional fractionation, i.e., 2 Gy per treatment, five treatments a week. In nine cases, the hypothyroidism was discovered during a systematic examination; it was clinically evident in the six remaining cases. Hypothyroidism appeared after an irradiation dose average of 50 Gy (extremes 30-65 Gy). The average duration of the irradiation was about 7 weeks and the hypothyroidism appeared in a mean 22 months. In all cases, the substituting treatment was initiated with a favorable progression. Faced with the risk of hypothyroidism, it is necessary to check patients who have undergone external irradiation of the neck.
PubMed: 11446082
Affiliations:
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Le document en format XML
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Fifteen cases].</title><author><name sortKey="Kaffel, N" sort="Kaffel, N" uniqKey="Kaffel N" first="N" last="Kaffel">N. Kaffel</name><affiliation wicri:level="1"><nlm:affiliation>Service d'endocrinologie, CHU Hédi Chaker, 3029 Sfax, Tunisie.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service d'endocrinologie, CHU Hédi Chaker, 3029 Sfax</wicri:regionArea><wicri:noRegion>3029 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Mnif, M" sort="Mnif, M" uniqKey="Mnif M" first="M" last="Mnif">M. Mnif</name></author><author><name sortKey="Daoud, J" sort="Daoud, J" uniqKey="Daoud J" first="J" last="Daoud">J. Daoud</name></author><author><name sortKey="Abid, M" sort="Abid, M" uniqKey="Abid M" first="M" last="Abid">M. Abid</name></author></analytic><series><title level="j">Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique</title><idno type="ISSN">1278-3218</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Brain Neoplasms (radiotherapy)</term><term>Breast Neoplasms (radiotherapy)</term><term>Female</term><term>Hodgkin Disease (radiotherapy)</term><term>Humans</term><term>Hypothyroidism (etiology)</term><term>Laryngeal Neoplasms (radiotherapy)</term><term>Male</term><term>Middle Aged</term><term>Radiotherapy (adverse effects)</term><term>Radiotherapy (methods)</term><term>Radiotherapy Dosage</term><term>Retrospective Studies</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dosimétrie en radiothérapie</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hypothyroïdie (étiologie)</term><term>Maladie de Hodgkin (radiothérapie)</term><term>Mâle</term><term>Radiothérapie ()</term><term>Radiothérapie (effets indésirables)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du cerveau (radiothérapie)</term><term>Tumeurs du larynx (radiothérapie)</term><term>Tumeurs du sein (radiothérapie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypothyroidism</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Brain Neoplasms</term><term>Breast Neoplasms</term><term>Hodgkin Disease</term><term>Laryngeal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Maladie de Hodgkin</term><term>Tumeurs du cerveau</term><term>Tumeurs du larynx</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hypothyroïdie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Radiotherapy Dosage</term><term>Retrospective Studies</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dosimétrie en radiothérapie</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Radiothérapie</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypothyroidism frequency is estimated to be between 10 and 45% after radiotherapy alone, and 40 to 67% after radiotherapy associated with thyroidectomy. This hypothyroidism is infraclinical in 60% of the cases. Our study concerned 15 cases of hypothyroidism after external radiotherapy delivered between and 1991 and 1999. An irradiation of the cervical, cerebral and thorax regions was indicated for different types of cancers. Larynx carcinoma epidermoid was the most frequent cancer (seven cases); the radiation treatment used cobalt 60 with conventional fractionation, i.e., 2 Gy per treatment, five treatments a week. In nine cases, the hypothyroidism was discovered during a systematic examination; it was clinically evident in the six remaining cases. Hypothyroidism appeared after an irradiation dose average of 50 Gy (extremes 30-65 Gy). The average duration of the irradiation was about 7 weeks and the hypothyroidism appeared in a mean 22 months. In all cases, the substituting treatment was initiated with a favorable progression. Faced with the risk of hypothyroidism, it is necessary to check patients who have undergone external irradiation of the neck.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Abid, M" sort="Abid, M" uniqKey="Abid M" first="M" last="Abid">M. Abid</name><name sortKey="Daoud, J" sort="Daoud, J" uniqKey="Daoud J" first="J" last="Daoud">J. Daoud</name><name sortKey="Mnif, M" sort="Mnif, M" uniqKey="Mnif M" first="M" last="Mnif">M. Mnif</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Kaffel, N" sort="Kaffel, N" uniqKey="Kaffel N" first="N" last="Kaffel">N. Kaffel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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