Evaluation of iron oxide nanoparticle biocompatibility
Identifieur interne : 000488 ( Main/Exploration ); précédent : 000487; suivant : 000489Evaluation of iron oxide nanoparticle biocompatibility
Auteurs : Amel Hanini [France, Tunisie] ; Alain Schmitt [France] ; Kamel Kacem [Tunisie] ; François Chau [France] ; Souad Ammar [France] ; Julie Gavard [France]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2011.
Abstract
Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe2O3 nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe2O3 can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe2O3 nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe2O3 could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.
Url:
DOI: 10.2147/IJN.S17574
PubMed: 21589646
PubMed Central: 3090275
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe<sub>2</sub>
O<sub>3</sub>
nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe<sub>2</sub>
O<sub>3</sub>
can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe<sub>2</sub>
O<sub>3</sub>
nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe<sub>2</sub>
O<sub>3</sub>
could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.</p>
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