Significance of Specific Epstein‐Barr Virus IgA and Elevated IgG Antibodies to Viral Capsid Antigens in Nasopharyngeal Carcinoma Patients
Identifieur interne : 000C37 ( Istex/Curation ); précédent : 000C36; suivant : 000C38Significance of Specific Epstein‐Barr Virus IgA and Elevated IgG Antibodies to Viral Capsid Antigens in Nasopharyngeal Carcinoma Patients
Auteurs : Tuvia Hadar ; Jack Sidi ; Menashe Rahima ; Erika Rakowsky ; Ernesto Kahan ; Batya Sarov [Israël] ; Batya Sarov [Israël]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 1986-12.
English descriptors
Abstract
The feasibility of using elevated Epstein‐Barr virus (EBV) specific‐IgG antiviral capsid antigen (VCA) and IgA anti‐VCA antibody levels as an aid in diagnosis of nasopharyngeal carcinoma (NPC) was analyzed by determination of serum anti‐body titers to EBV in 54 NPC patients, 114 healthy blood donors, and 40 family members by the immunoperoxidase assay (IPA). No significant difference was found in the prevalence rate of EBV IgG anti‐VCA antibodies (titer ≥20) between the patient group and the control and family groups (100% vs 92% and 90%, respectively). The prevalence rate of elevated EBV IgG anti‐VCA titers (≥ 80, ≥ 160, ≥ 320, and≥ 640) was significantly higher in the NPC patients than in controls. For example, at an IgG titer of ≥320, the prevalence rate was 82% in the NPC patient group and 1.7% in the controls (P <0.0001). The prevalence of EBV IgA anti‐VCA antibodies (≥ 10) was significantly higher in the NPC patients than in control and family groups (82% vs 6.1% and 0%, respectively). The prevalence rate for elevated EBV IgA anti‐VCA (≥20) was found to be significantly higher (P <0.0001) in NPC patients than in the control group (70% vs 1.7%). A significantly high proportion (P = 0.0004) of NPC patients who had serum EBV IgA anti‐VCA titers of <20 had elevated IgG titers to VCA ≥ 320 (21 % vs 1.7% among controls). It appears that testing for IgG antibodies at a serum dilution of 1:320 and for IgA antibodies at a dilution of 1:20 by the IPA technique comprises the best combination for the differentiation between NPC patients and health controls (91% vs 3.4%), and it is suggested that these be used as screening markers for NPC patients.
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DOI: 10.1002/jmv.1890200405
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Tuvia Hadar<affiliation><mods:affiliation>Department of Otolaryngology and Head and Neck Surgery, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology and Head and Neck Surgery, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of and Oncology, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of and Oncology, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation><affiliation><mods:affiliation>Epidemiology and Evaluation Unit, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation>Le document en format XML
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Antibodies to Viral Capsid Antigens in Nasopharyngeal Carcinoma Patients</title><author><name sortKey="Hadar, Tuvia" sort="Hadar, Tuvia" uniqKey="Hadar T" first="Tuvia" last="Hadar">Tuvia Hadar</name><affiliation><mods:affiliation>Department of Otolaryngology and Head and Neck Surgery, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation></author><author><name sortKey="Sidi, Jack" sort="Sidi, Jack" uniqKey="Sidi J" first="Jack" last="Sidi">Jack Sidi</name><affiliation><mods:affiliation>Department of Otolaryngology and Head and Neck Surgery, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation></author><author><name sortKey="Rahima, Menashe" sort="Rahima, Menashe" uniqKey="Rahima M" first="Menashe" last="Rahima">Menashe Rahima</name><affiliation><mods:affiliation>Department of and Oncology, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation></author><author><name sortKey="Rakowsky, Erika" sort="Rakowsky, Erika" uniqKey="Rakowsky E" first="Erika" last="Rakowsky">Erika Rakowsky</name><affiliation><mods:affiliation>Department of and Oncology, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry code="subField">Aviv</wicri:noCountry></affiliation></author><author><name sortKey="Kahan, Ernesto" sort="Kahan, Ernesto" uniqKey="Kahan E" first="Ernesto" last="Kahan">Ernesto Kahan</name><affiliation><mods:affiliation>Epidemiology and Evaluation Unit, Beilinson Medical Center, Petah Tiqvah and Tel Aviv University School of Medicine, Tel Aviv</mods:affiliation><wicri:noCountry 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Med. Virol.</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1986-12">1986-12</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="329">329</biblScope><biblScope unit="page" to="339">339</biblScope></imprint><idno type="ISSN">0146-6615</idno></series><idno type="istex">9E14BD34D564FEE6884E201A4CA148D18DCCC298</idno><idno type="DOI">10.1002/jmv.1890200405</idno><idno type="ArticleID">JMV1890200405</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>EBVIgG and IgA antibodies</term><term>nasopharyngeal carcinoma</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The feasibility of using elevated Epstein‐Barr virus (EBV) specific‐IgG antiviral capsid antigen (VCA) and IgA anti‐VCA antibody levels as an aid in diagnosis of nasopharyngeal carcinoma (NPC) was analyzed by determination of serum anti‐body titers to EBV in 54 NPC patients, 114 healthy blood donors, and 40 family members by the immunoperoxidase assay (IPA). No significant difference was found in the prevalence rate of EBV IgG anti‐VCA antibodies (titer ≥20) between the patient group and the control and family groups (100% vs 92% and 90%, respectively). The prevalence rate of elevated EBV IgG anti‐VCA titers (≥ 80, ≥ 160, ≥ 320, and≥ 640) was significantly higher in the NPC patients than in controls. For example, at an IgG titer of ≥320, the prevalence rate was 82% in the NPC patient group and 1.7% in the controls (P <0.0001). The prevalence of EBV IgA anti‐VCA antibodies (≥ 10) was significantly higher in the NPC patients than in control and family groups (82% vs 6.1% and 0%, respectively). The prevalence rate for elevated EBV IgA anti‐VCA (≥20) was found to be significantly higher (P <0.0001) in NPC patients than in the control group (70% vs 1.7%). A significantly high proportion (P = 0.0004) of NPC patients who had serum EBV IgA anti‐VCA titers of <20 had elevated IgG titers to VCA ≥ 320 (21 % vs 1.7% among controls). It appears that testing for IgG antibodies at a serum dilution of 1:320 and for IgA antibodies at a dilution of 1:20 by the IPA technique comprises the best combination for the differentiation between NPC patients and health controls (91% vs 3.4%), and it is suggested that these be used as screening markers for NPC patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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