Potential protective effect of Nigella sativa crude oils towards fatty liver in rats
Identifieur interne : 001397 ( Istex/Corpus ); précédent : 001396; suivant : 001398Potential protective effect of Nigella sativa crude oils towards fatty liver in rats
Auteurs : Sahar Y. Al-Okbi ; Doha A. Mohamed ; Thanaa E. Hamed ; Thanaa E. EdrisSource :
- European Journal of Lipid Science and Technology [ 1438-7697 ] ; 2013-07.
English descriptors
- KwdEn :
Abstract
The main purpose of the present research was to study the protective effect of Nigella sativa crude oils (NCO) extracted from plain and γ‐irradiated seeds towards inflammatory fatty liver (steatohepatitis). The protective effect of the oils was tested during induction of inflammatory fatty liver in rats through feeding high fructose diet. Biochemical analyses including plasma lipids, tumor necrosis factor‐α (TNF‐α) and malondialdehyde (MDA) levels and liver fat and liver function tests were carried out to determine the efficiency of the oils. Results showed that fatty liver control group exhibited significant dyslipidemia, high plasma TNF‐α and MDA along with significant high liver triglycerides and cholesterol and liver dysfunction compared to control normal. Oral administration of NCO produced significant improvement of all parameters. No significant change in all biochemical parameters was noticed when the group given γ‐irradiated NCO was compared with that given the plain oil. Lipid analysis by GC showed that linoleic and oleic where the most abundant fatty acids constituting NCO. Volatile oils' contents were 0.1 wt% of NCO; p‐cymene and thymoquinone being the major constituents. Administration of NCO from plain or γ‐irradiated seeds produced similar and significant, but not complete, prevention of inflammatory fatty liver. Practical applications: This investigation revealed that the crude oil of Nigella sativa seed may potentially be used as dietary supplement for prevention of inflammatory fatty liver. The study also showed the chemical composition of the fixed and volatile oil fractions of the Egyptian N. sativa seeds that may be useful for further studies.
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DOI: 10.1002/ejlt.201200256
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ISTEX:CA1FBB1B736B490A9D993212491B732072EE04ABLe document en format XML
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The protective effect of the oils was tested during induction of inflammatory fatty liver in rats through feeding high fructose diet. Biochemical analyses including plasma lipids, tumor necrosis factor‐α (TNF‐α) and malondialdehyde (MDA) levels and liver fat and liver function tests were carried out to determine the efficiency of the oils. Results showed that fatty liver control group exhibited significant dyslipidemia, high plasma TNF‐α and MDA along with significant high liver triglycerides and cholesterol and liver dysfunction compared to control normal. Oral administration of NCO produced significant improvement of all parameters. No significant change in all biochemical parameters was noticed when the group given γ‐irradiated NCO was compared with that given the plain oil. Lipid analysis by GC showed that linoleic and oleic where the most abundant fatty acids constituting NCO. Volatile oils' contents were 0.1 wt% of NCO; p‐cymene and thymoquinone being the major constituents. Administration of NCO from plain or γ‐irradiated seeds produced similar and significant, but not complete, prevention of inflammatory fatty liver. Practical applications: This investigation revealed that the crude oil of Nigella sativa seed may potentially be used as dietary supplement for prevention of inflammatory fatty liver. The study also showed the chemical composition of the fixed and volatile oil fractions of the Egyptian N. sativa seeds that may be useful for further studies.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sahar Y. Al‐Okbi</name><affiliations><json:string>Food Sciences and Nutrition Department, Food Industries & Nutrition Division, Dokki, Cairo, Egypt, National Research Centre</json:string></affiliations></json:item><json:item><name>Doha A. 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The protective effect of the oils was tested during induction of inflammatory fatty liver in rats through feeding high fructose diet. Biochemical analyses including plasma lipids, tumor necrosis factor‐α (TNF‐α) and malondialdehyde (MDA) levels and liver fat and liver function tests were carried out to determine the efficiency of the oils. Results showed that fatty liver control group exhibited significant dyslipidemia, high plasma TNF‐α and MDA along with significant high liver triglycerides and cholesterol and liver dysfunction compared to control normal. Oral administration of NCO produced significant improvement of all parameters. No significant change in all biochemical parameters was noticed when the group given γ‐irradiated NCO was compared with that given the plain oil. Lipid analysis by GC showed that linoleic and oleic where the most abundant fatty acids constituting NCO. Volatile oils' contents were 0.1 wt% of NCO; p‐cymene and thymoquinone being the major constituents. Administration of NCO from plain or γ‐irradiated seeds produced similar and significant, but not complete, prevention of inflammatory fatty liver. Practical applications: This investigation revealed that the crude oil of Nigella sativa seed may potentially be used as dietary supplement for prevention of inflammatory fatty liver. 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The protective effect of the oils was tested during induction of inflammatory fatty liver in rats through feeding high fructose diet. Biochemical analyses including plasma lipids, tumor necrosis factor‐α (TNF‐α) and malondialdehyde (MDA) levels and liver fat and liver function tests were carried out to determine the efficiency of the oils. Results showed that fatty liver control group exhibited significant dyslipidemia, high plasma TNF‐α and MDA along with significant high liver triglycerides and cholesterol and liver dysfunction compared to control normal. Oral administration of NCO produced significant improvement of all parameters. No significant change in all biochemical parameters was noticed when the group given γ‐irradiated NCO was compared with that given the plain oil. Lipid analysis by GC showed that linoleic and oleic where the most abundant fatty acids constituting NCO. Volatile oils' contents were 0.1 wt% of NCO; p‐cymene and thymoquinone being the major constituents. Administration of NCO from plain or γ‐irradiated seeds produced similar and significant, but not complete, prevention of inflammatory fatty liver. Practical applications: This investigation revealed that the crude oil of Nigella sativa seed may potentially be used as dietary supplement for prevention of inflammatory fatty liver. The study also showed the chemical composition of the fixed and volatile oil fractions of the Egyptian N. sativa seeds that may be useful for further studies.</p></abstract><abstract style="graphical"><p>Increased consumption of fructose leads to increased hepatic fat deposition and triggers inflammatory factors, which are closely related to nonalcoholic fatty liver. Oral administration of Nigella crude oil produced significant improvement of all parameters associated with this disease indicating inhibitory activity and protection againest non‐alcoholic fatty liver.fx1</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Crude oil</term></item><item><term>Fatty liver</term></item><item><term>Liver protection</term></item><item><term>Nigella sativa</term></item><item><term>γ‐Irradiation</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-07-11">Received</change><change when="2013-03-01">Registration</change><change when="2013-07-04">Created</change><change when="2013-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CA1FBB1B736B490A9D993212491B732072EE04AB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" xml:lang="en" type="serialArticle" xml:id="ejlt201200256"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1438-9312</doi><issn type="print">1438-7697</issn><issn type="electronic">1438-9312</issn><idGroup><id type="product" value="EJLT"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY">European Journal of Lipid Science and Technology</title><title type="short">Eur. J. Lipid Sci. Technol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi registered="yes">10.1002/ejlt.v115.7</doi><copyright ownership="publisher">© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><numberingGroup><numbering type="journalVolume" number="115">115</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2013-07">July 2013</coverDate></publicationMeta><publicationMeta level="unit" position="130" type="article" status="forIssue"><doi>10.1002/ejlt.201200256</doi><idGroup><id type="unit" value="EJLT201200256"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2012-07-11"></event><event type="manuscriptRevised" date="2013-01-30"></event><event type="manuscriptAccepted" date="2013-03-01"></event><event type="xmlCreated" agent="Thomson Digital" date="2013-07-04"></event><event type="publishedOnlineAccepted" date="2013-03-18"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-05-31"></event><event type="firstOnline" date="2013-05-31"></event><event type="publishedOnlineFinalForm" date="2013-07-08"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">774</numbering><numbering type="pageLast">782</numbering></numberingGroup><correspondenceTo><lineatedText><line><b>Correspondence:</b> Prof. Amr E. Edris, Aroma & Flavor Chemistry Department, Food Industries & Nutrition Division, National Research Centre, Dokki, 12622 Cairo, Egypt</line><line><b>E‐mail:</b> <email>amr_edris@hotmail.com</email></line><line><b>Fax:</b> 2‐02‐33370931</line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJLT.EJLT201200256.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Potential protective effect of <i>Nigella sativa</i> crude oils towards fatty liver in rats</title><title type="short">Prevention of fatty liver by <i>Nigella sativa</i> oil</title></titleGroup><creators><creator xml:id="ejlt201200256-cr-0001" creatorRole="author" affiliationRef="#ejlt201200256-aff-0001"><personName><givenNames>Sahar Y.</givenNames> <familyName>Al‐Okbi</familyName></personName></creator><creator xml:id="ejlt201200256-cr-0002" creatorRole="author" affiliationRef="#ejlt201200256-aff-0001"><personName><givenNames>Doha A.</givenNames> <familyName>Mohamed</familyName></personName></creator><creator xml:id="ejlt201200256-cr-0003" creatorRole="author" affiliationRef="#ejlt201200256-aff-0001"><personName><givenNames>Thanaa E.</givenNames> <familyName>Hamed</familyName></personName></creator><creator xml:id="ejlt201200256-cr-0004" creatorRole="author" affiliationRef="#ejlt201200256-aff-0002" corresponding="yes"><personName><honorifics>Prof.</honorifics><givenNames>Amr E.</givenNames> <familyName>Edris</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="ejlt201200256-aff-0001" countryCode="EG"><orgDiv>Food Sciences and Nutrition Department</orgDiv><orgName>Food Industries & Nutrition Division</orgName><address><city>National Research Centre</city><countryPart>Dokki, Cairo, Egypt</countryPart></address></affiliation><affiliation xml:id="ejlt201200256-aff-0002" countryCode="EG"><orgDiv>Aroma & Flavor Chemistry Department</orgDiv><orgName>Food Industries & Nutrition Division</orgName><address><city>National Research Centre</city><countryPart>Dokki, Cairo, Egypt</countryPart></address></affiliation></affiliationGroup><keywordGroup type="author" xml:lang="en"><keyword xml:id="ejlt201200256-kwd-0001">Crude oil</keyword><keyword xml:id="ejlt201200256-kwd-0002">Fatty liver</keyword><keyword xml:id="ejlt201200256-kwd-0003">Liver protection</keyword><keyword xml:id="ejlt201200256-kwd-0004"><i>Nigella sativa</i></keyword><keyword xml:id="ejlt201200256-kwd-0005">γ‐Irradiation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="ejlt201200256-sec-0001"><p>The main purpose of the present research was to study the protective effect of <i>Nigella sativa</i> crude oils (NCO) extracted from plain and γ‐irradiated seeds towards inflammatory fatty liver (steatohepatitis). The protective effect of the oils was tested during induction of inflammatory fatty liver in rats through feeding high fructose diet. Biochemical analyses including plasma lipids, tumor necrosis factor‐α (TNF‐α) and malondialdehyde (MDA) levels and liver fat and liver function tests were carried out to determine the efficiency of the oils. Results showed that fatty liver control group exhibited significant dyslipidemia, high plasma TNF‐α and MDA along with significant high liver triglycerides and cholesterol and liver dysfunction compared to control normal. Oral administration of NCO produced significant improvement of all parameters. No significant change in all biochemical parameters was noticed when the group given γ‐irradiated NCO was compared with that given the plain oil. Lipid analysis by GC showed that linoleic and oleic where the most abundant fatty acids constituting NCO. Volatile oils' contents were 0.1 wt% of NCO; <i>p</i>‐cymene and thymoquinone being the major constituents. Administration of NCO from plain or γ‐irradiated seeds produced similar and significant, but not complete, prevention of inflammatory fatty liver.</p><p><b>Practical applications</b>: This investigation revealed that the crude oil of <i>Nigella sativa</i> seed may potentially be used as dietary supplement for prevention of inflammatory fatty liver. The study also showed the chemical composition of the fixed and volatile oil fractions of the Egyptian <i>N. sativa</i> seeds that may be useful for further studies.</p></section></abstract><abstract type="graphical"><p>Increased consumption of fructose leads to increased hepatic fat deposition and triggers inflammatory factors, which are closely related to nonalcoholic fatty liver. Oral administration of Nigella crude oil produced significant improvement of all parameters associated with this disease indicating inhibitory activity and protection againest non‐alcoholic fatty liver.fx1 <blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" copyright="Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim" href="urn:x-wiley:14387697:media:ejlt201200256:ejlt201200256-content"></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Potential protective effect of Nigella sativa crude oils towards fatty liver in rats</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Prevention of fatty liver by Nigella sativa oil</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Potential protective effect of Nigella sativa crude oils towards fatty liver in rats</title></titleInfo><name type="personal"><namePart type="given">Sahar Y.</namePart><namePart type="family">Al‐Okbi</namePart><affiliation>Food Sciences and Nutrition Department, Food Industries & Nutrition Division, Dokki, Cairo, Egypt, National Research Centre</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Doha A.</namePart><namePart type="family">Mohamed</namePart><affiliation>Food Sciences and Nutrition Department, Food Industries & Nutrition Division, Dokki, Cairo, Egypt, National Research Centre</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thanaa E.</namePart><namePart type="family">Hamed</namePart><affiliation>Food Sciences and Nutrition Department, Food Industries & Nutrition Division, Dokki, Cairo, Egypt, National Research Centre</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof.</namePart><namePart type="family">Edris</namePart><affiliation>Aroma & Flavor Chemistry Department, Food Industries & Nutrition Division, Dokki, Cairo, Egypt, National Research Centre</affiliation><affiliation>Prof. Amr E. Edris, Aroma & Flavor Chemistry Department, Food Industries & Nutrition Division, National Research Centre, Dokki, 12622 Cairo, Egypt 2‐02‐33370931</affiliation><affiliation>E-mail: amr_edris@hotmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-07</dateIssued><dateCreated encoding="w3cdtf">2013-07-04</dateCreated><dateCaptured encoding="w3cdtf">2012-07-11</dateCaptured><dateValid encoding="w3cdtf">2013-03-01</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The main purpose of the present research was to study the protective effect of Nigella sativa crude oils (NCO) extracted from plain and γ‐irradiated seeds towards inflammatory fatty liver (steatohepatitis). The protective effect of the oils was tested during induction of inflammatory fatty liver in rats through feeding high fructose diet. Biochemical analyses including plasma lipids, tumor necrosis factor‐α (TNF‐α) and malondialdehyde (MDA) levels and liver fat and liver function tests were carried out to determine the efficiency of the oils. Results showed that fatty liver control group exhibited significant dyslipidemia, high plasma TNF‐α and MDA along with significant high liver triglycerides and cholesterol and liver dysfunction compared to control normal. Oral administration of NCO produced significant improvement of all parameters. No significant change in all biochemical parameters was noticed when the group given γ‐irradiated NCO was compared with that given the plain oil. Lipid analysis by GC showed that linoleic and oleic where the most abundant fatty acids constituting NCO. Volatile oils' contents were 0.1 wt% of NCO; p‐cymene and thymoquinone being the major constituents. Administration of NCO from plain or γ‐irradiated seeds produced similar and significant, but not complete, prevention of inflammatory fatty liver. Practical applications: This investigation revealed that the crude oil of Nigella sativa seed may potentially be used as dietary supplement for prevention of inflammatory fatty liver. The study also showed the chemical composition of the fixed and volatile oil fractions of the Egyptian N. sativa seeds that may be useful for further studies.</abstract><abstract type="graphical">Increased consumption of fructose leads to increased hepatic fat deposition and triggers inflammatory factors, which are closely related to nonalcoholic fatty liver. Oral administration of Nigella crude oil produced significant improvement of all parameters associated with this disease indicating inhibitory activity and protection againest non‐alcoholic fatty liver.fx1</abstract><subject lang="en"><genre>keywords</genre><topic>Crude oil</topic><topic>Fatty liver</topic><topic>Liver protection</topic><topic>Nigella sativa</topic><topic>γ‐Irradiation</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Lipid Science and Technology</title></titleInfo><titleInfo type="abbreviated"><title>Eur. J. Lipid Sci. Technol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1438-7697</identifier><identifier type="eISSN">1438-9312</identifier><identifier type="DOI">10.1002/(ISSN)1438-9312</identifier><identifier type="PublisherID">EJLT</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>774</start><end>782</end><total>9</total></extent></part></relatedItem><identifier type="istex">CA1FBB1B736B490A9D993212491B732072EE04AB</identifier><identifier type="DOI">10.1002/ejlt.201200256</identifier><identifier type="ArticleID">EJLT201200256</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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